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Effect of Exercise, MitoQ, and Their Combination on Inflammatory and Gene Expression in Women with Multiple Sclerosis.
Effect of Exercise, MitoQ, and Their Combination on Inflammatory and Gene Expression in Women with Multiple Sclerosis.
Fuente:Iranian Journal of Allergy, Asthma, and Immunology
Extracto:
These findings
suggest that exercise and MitoQ, either alone or combined, can modulate various
biological pathways implicated in MS pathogenesis.
Autor/es:Alifarsangi, Atena (a) Khaksari, Mohammad (b)
institución:(a) Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran. alifarsangi.atena@yahoo.com. (b) Endocrinology and Metabolism Research Center, Kerman University of Medical Sciences, Kerman, Iran. mkhaksari@kmu.ac.ir.
Extracto:
This case underscores the
importance of considering rare malignancies like liposarcoma of the gallbladder
in the differential diagnosis of abdominal masses. Early diagnosis through
imaging and histopathological confirmation is crucial for optimal management.
Complete surgical excision remains the cornerstone of treatment, particularly for
well-differentiated subtypes, which generally have favorable prognoses. The
findings highlight the need for multidisciplinary care and further research into
genetic and molecular mechanisms to guide future targeted treatments.
institución:(a) The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei Province, China. (b) Department of Hepatobiliary & Pancreas Surgery, Yichang Central People's Hospital, Yichang, Hubei Province, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Long-term clinical outcome of 103 patients with acromegaly after pituitary surgery.
Long-term clinical outcome of 103 patients with acromegaly after pituitary surgery.
Fuente:Pituitary
Tipo de trabajo:Revisión
Extracto:
About half of the patients had
biochemical control of acromegaly 1-year post-surgery. Treatment patterns
reflected the complexity of post-surgical management and provided an overview of
the long-term clinical progression in patients with acromegaly following
pituitary surgery.
Claves:Acromegaly, Growth hormone, Pituitary adenoma, Pituitary neuroendocrine tumor, Transsphenoidal surgery
Cita:Pituitary 2025 Feb 22; 28 (2) : 33.
Autor/es:Pennlund, Anna (a) Esposito, Daniela (b)
institución:(a) Department of Clinical Pathology, Sahlgrenska University Hospital, Gula stråket 8, Gothenburg, 413 45, Sweden. anna.pennlund@gu.se. (b) Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. anna.pennlund@gu.se.
Conflicto:Declarations. Institutional review board statement: The study was approved by the Swedish Ethical Review Authority (Etikprövningsmyndigheten) (Dnr: 2019–04779). Competing interests: A.P., T.O.B., T.S., T.H., H.C., and G.J. has no conflict of interest to declare. D.E. has received lecture fees from Ipsen, Pfizer AB and Recordati Rare Disease. D.S.O. has been a consultant for Sandoz, Ipsen, and Pfizer; has received unrestricted...
ted grants from Sandoz and Pfizer; and is an employee at AstraZeneca as of 8 August 2021.
institución:(a) Department of Specialized Medicine, Internal Medicine, Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada. (b) Faculty of Agriculture and Food Sciences, School of Nutrition, Laval University, Quebec City, Quebec, Canada.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Gender Disparity in Lipid Testing Among Over 0.5 Million Adults from Pakistan: Females are Tested Much Later Despite Higher LDL-Cholesterol Levels.
Gender Disparity in Lipid Testing Among Over 0.5 Million Adults from Pakistan: Females are Tested Much Later Despite Higher LDL-Cholesterol Levels.
Fuente:Global Heart
Tipo de trabajo:Guía
Extracto:
This study highlights the gender disparity in lipid testing in
Pakistan, where females undergo lipid testing later in life, despite higher lipid
levels compared to males.
Assessment of skeletal muscle alterations and circulating myokines in metabolic dysfunction-associated steatotic liver disease: A cross-sectional study.
Assessment of skeletal muscle alterations and circulating myokines in metabolic dysfunction-associated steatotic liver disease: A cross-sectional study.
Fuente:World Journal of Gastroenterology
Extracto:
SMAs were uncommon in the patients with MASLD studied. Higher serum
levels of irisin and FGF21 were detected in patients with advanced liver
steatosis and fibrosis, respectively, with potential implications as biomarkers.
Cita:World J Gastroenterol 2025 Feb 21; 31 (7) : 100039.
Autor/es:Real Martinez, Yolanda (a) Fernandez-Garcia, Carlos Ernesto (b)
institución:(a) Servicio Aparato Digestivo, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa, Universidad Autónoma de Madrid, Madrid 28006, Spain. yrealm@gmail.com. (b) Unidad de Investigación, Hospital Universitario Santa Cristina, Instituto de Investigación Sanitaria La Princesa, Madrid 28009, Spain.
Conflicto:Conflict-of-interest statement: This research was funded by Persan Farma Laboratoires. Also, this work was supported by contract CP19/00032 from Instituto de Salud Carlos III (ISCIII, Spain) and Fondo Europeo para el Desarrollo Regional (FEDER), and CIBERDEM (ISCIII) to AGR. CEFG was supported by a Sara-Borrell postdoctoral contract (CD20/00199) from ISCIII/FEDER (Spain). AB was supported by a research contract (PEJ-2020-AI/BMD-18301) funded...
by Comunidad de Madrid (Spain).
Serum adropin levels as a potential biomarker for predicting diabetic kidney disease progression.
Serum adropin levels as a potential biomarker for predicting diabetic kidney disease progression.
Fuente:Frontiers in Endocrinology
Extracto:
The above findings suggest that
serum adropin could be applied as a potential biomarker for predicting CKD
progression in subjects with T2D. Further research is needed to validate these
results and explore the underlying mechanisms.
institución:(a) Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan. (b) College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Utilizing bioinformatics and machine learning to identify CXCR4 gene-related therapeutic targets in diabetic foot ulcers.
Utilizing bioinformatics and machine learning to identify CXCR4 gene-related therapeutic targets in diabetic foot ulcers.
Fuente:Frontiers in Endocrinology
Extracto:
The
findings suggest that CXCR4 and its related pathways play an important role in
the pathogenesis of DFUs, providing a new perspective on targeted therapy for
wound healing in diabetic patients. Further validation of the role of CXCR4 is
expected to establish it as an important target in DFU management.
institución:(a) Department of Dermatology, Zhaotong Hospital of Traditional Chinese Medicine, Zhaotong, Yunnan, China. (b) Department of Endocrinology, Zhaotong Hospital of Traditional Chinese Medicine, Zhaotong, Yunnan, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Efficacy in Japanese adults with growth hormone deficiency receiving weekly somapacitan or daily growth hormone: results from phase 3 REAL 1 trial.
Efficacy in Japanese adults with growth hormone deficiency receiving weekly somapacitan or daily growth hormone: results from phase 3 REAL 1 trial.
Fuente:Frontiers in Endocrinology
Tipo de trabajo:Estudio clínico
Extracto:
In Japanese treatment-naïve individuals with AGHD, once-weekly
somapacitan demonstrated similar efficacy and safety to daily GH after 34 weeks
of treatment. Somapacitan provides an effective alternative to daily GH in AGHD.
CLINICAL TRIAL REGISTRATION: http://www.clinicaltrials.gov, identifier
NCT02229851.
Autor/es:Otsuka, Fumio (a) Rasmussen, Michael Højby (b)
institución:(a) Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. (b) Clinical Drug Development, Novo Nordisk A/S, Søborg, Denmark.
Conflicto:Author MR, TE, and CS are employed by the company Novo Nordisk. FO has received consulting fees and speaker honoraria from Novo Nordisk. ST has received payment for lectures and presentations from Novo Nordisk, Pfizer, and JCR Pharmaceuticals. GJ has served as a consultant for Novo Nordisk and Astra Zeneca, and has received lecture fees from Novo Nordisk and Pfizer....
The authors declare that this study received funding from Novo Nordisk. The funder had the following involvement in the study: study design, collection, analysis, and interpretation of data, as well as data checking of information provided in the manuscript.
MCAM is a prognostic biomarker in patients with liver cirrhosis and HCC.
MCAM is a prognostic biomarker in patients with liver cirrhosis and HCC.
Fuente:Hepatology Communications
Extracto:
Collectively, our study suggests sMCAM as a blood biomarker
of a liver microenvironment that drives the progression of liver disease in
patients with liver cirrhosis and HCC.
Cita:Hepatol Commun 2024 Oct 1; 8 (10)
Autor/es:Stockinger, Eva (a) Luxenburger, Hendrik (b)
institución:(a) Department of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, Freiburg University Medical Center), Faculty of Medicine, University of Freiburg, Freiburg, Germany. (b) MOTI-VATE-Programme, Graduate School, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Conflicto:Dominik Bettinger is on the speaker’s bureau for Gore and Falk Foundation. He received grants from Abbvie. Simon Johannes Garing received grants from Ipsen, Gilead, and Schwiete Foundation. Friedrich Foerster advises and is on the speaker’s bureau for AstraZeneca and Roche. He advises BMS and Eisai. He is on the speakers’ bureau for MSD and Pfizer. He received grants from...
s from Merck KGaA and Servier. Bertram Bengsch advises for Roche. The remaining authors have no conflicts to report.
Adult height of children born small for gestational age treated with growth hormone and gonadotropin-releasing hormone analogs in Southern Brazil.
Adult height of children born small for gestational age treated with growth hormone and gonadotropin-releasing hormone analogs in Southern Brazil.
Fuente:Archives of Endocrinology and Metabolism
Extracto:
In this cohort of children
born SGA with short stature, rhGH treatment effectively improved adult height.
Given the diverse causes of being born SGA, the response to rhGH therapy may
vary.
Claves:Infant, adult, body height, growth hormone, human growth hormone, small for gestational age
Cita:Arch Endocrinol Metab 2025 Feb 24; 69 (1) : e230513.
Autor/es:Pinto, Luís Eduardo Cruvinel (a) Cardoso-Demartini, Adriane de Andre (b)
institución:(a) Setor de Endocrinologia Pediátrica Professor Romolo Sandrini, Departamento de Pediatria do Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brasil. (b) Setor de Endocrinologia Pediátrica Professor Romolo Sandrini, Departamento de Pediatria do Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brasil.
Conflicto:Disclosure: no potential conflict of interest relevant to this article was reported.
Impact of Hydroxy-Methyl-Butyrate Supplementation on Malnourished Patients Assessed Using AI-Enhanced Ultrasound Imaging.
Impact of Hydroxy-Methyl-Butyrate Supplementation on Malnourished Patients Assessed Using AI-Enhanced Ultrasound Imaging.
Fuente:Journal of Cachexia, Sarcopenia and Muscle
Extracto:
The use of
an HMB-enriched ONS in DRM patients, combined with AI-based ultrasound imaging
for follow-up, significantly improved their nutritional status, muscle mass and
muscle quality as assessed by echogenicity.
institución:(a) Centro de Investigación of Endocrinología, Nutrición Facultad de Medicina, Departamento de Endocrinología Nutrición Hospital Clínico, Universitario de Valladolid, Valladolid, Spain. (b) DAWAKO Medtech SL, Parc Cientìfic de la Universitat de Valencia, Paterna, Valencia, Spain.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
In case of incomplete resection, tumor recurrence and persistent
symptoms may necessitate adjunctive drug therapy and radiation therapy.
Cita:Medicine (Baltimore) 2025 Feb 21; 104 (8) : e41623.
Autor/es:Song, Shuyue (a) Zhao, Yuyang (b)
institución:(a) School of Clinical Medicine, Shandong Second Medical University, Weifang, China. (b) School of Clinical Medicine, Shandong Second Medical University, Weifang, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Relationship of comprehensive dietary antioxidant index and hypothyroidism risk: evidence from the National Health and Nutrition Examination Surveys 2007-2012.
Relationship of comprehensive dietary antioxidant index and hypothyroidism risk: evidence from the National Health and Nutrition Examination Surveys 2007-2012.
Fuente:Bmc Endocrine Disorders
Extracto:
High CDAI was related to low hypothyroidism risk among U.S. adults. Our finding
showed that the intake of an antioxidant-rich dietary is a potential method to
reduce the risk of hypothyroidism.
Identification and functional analysis of NPR2 truncating mutations in two Chinese families with short stature.
Identification and functional analysis of NPR2 truncating mutations in two Chinese families with short stature.
Fuente:Bmc Pediatrics
Extracto:
Our study identified two
loss-of-function mutations of the NPR2 gene in two Chinese families and offered
new insights on the pathogenesis of short stature caused by NPR2 truncating
mutations.
Claves:Loss-of-function, NPR2 gene, Short stature, Truncated proteins, Truncating mutations
Cita:BMC Pediatr 2025 Feb 24; 25 (1) : 130.
Autor/es:Wei, Shuoshuo (a) Li, Rong (b)
institución:(a) Department of Endocrinology, Genetics and Metabolism, Affiliated Hospital of Jining Medical University, 89 Guhuai Road, Jining, Shandong, 272029, P.R. China. (b) Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, P.R. China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Endocrinology, Huaihe Hospital of Henan University, Kaifeng, 475000, China. (b) Department of Nephrology, Huaihe Hospital of Henan University, Kaifeng, 475000, China.
Conflicto:Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: Kaifeng Science and Technology Development Plan in 2024 (Key science and technology projects)-2403029.
Predicting In-Hospital Fall Risk Using Machine Learning With Real-Time Location System and Electronic Medical Records.
Predicting In-Hospital Fall Risk Using Machine Learning With Real-Time Location System and Electronic Medical Records.
Fuente:Journal of Cachexia, Sarcopenia and Muscle
Extracto:
This study
underscores the capability of utilizing RTLS to predict in-hospital falls by
tracking the changes of patients' physical activity through a machine learning
approach. This may improve early fall risk detection during hospitalization,
thereby preventing falls and enhancing patient safety.
Claves:in‐hospital fall risk prediction, machine learning, real‐time location system
institución:(a) Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Republic of Korea. (b) Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Republic of Korea.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Lifestyle Changes and Remission in Patients With New-Onset Type 2 Diabetes
Lifestyle Changes and Remission in Patients With New-Onset Type 2 Diabetes
Fuente:Journal of Korean Medical Science
Tipo de trabajo:Estudio de cohortes
Extracto:
We confirmed associations
between a healthy lifestyle and diabetic remission in new-onset type 2 diabetes
patients. The results of this study suggest that improving lifestyle after
diabetes diagnosis may contribute to disease remission.
Claves:Alcohol Drinking, Diabetes Mellitus, Type 2, Exercise, Lifestyle Changes, Prevention and Control, Smoking
Cita:J Korean Med Sci 2025 Feb 24; 40 (7) : e24.
Autor/es:Kim, Jinyoung (a) Kim, Bongseong (b)
institución:(a) Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. (b) Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Conflicto:The authors have no potential conflicts of interest to disclose.
Association of high-sensitivity C-reactive protein with hepatic fibrosis in patients with metabolic dysfunction-associated steatotic liver disease.
Association of high-sensitivity C-reactive protein with hepatic fibrosis in patients with metabolic dysfunction-associated steatotic liver disease.
Fuente:Frontiers in Immunology
Extracto:
The present study demonstrated a significant correlation between
hsCRP levels and the degree of hepatic fibrosis in patients with MASLD, with
notable dose-response relationships and subgroup differences.
institución:(a) Department of Pathology, Changzhou Third People's Hospital, Changzhou, China. (b) Changzhou Clinical College, Xuzhou Medical University, Changzhou, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
