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Evaluation of microRNAs as liquid biopsy markers in adrenocortical tumors.
Evaluation of microRNAs as liquid biopsy markers in adrenocortical tumors.
Fuente:Frontiers in Endocrinology
Extracto:
This study
supports the potential of a liquid biopsy approach as an innovative method for
diagnosing and monitoring patients with ATs, offering a complementary tool to
existing diagnostic methods.
institución:(a) First Department of Internal Medicine, European Reference Network on Rare Endocrine Conditions (ENDO-ERN), Laikon General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. (b) First Department of Internal Medicine, European Reference Network on Rare Endocrine Conditions (ENDO-ERN), Laikon General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
Autor/es:Oktay, Mehmet Ali (a) Çamurdan, Mahmut Orhun (b)
institución:(a) Department of Pediatric Endocrinology, Faculty of Medicine, Gazi University, Ankara, Türkiye. (b) Department of Pediatric Endocrinology, Faculty of Medicine, Gazi University, Ankara, Türkiye.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Ultrasound and histopathological assessment of benign, borderline, and malignant thyroid tumors in pediatric patients
Ultrasound and histopathological assessment of benign, borderline, and malignant thyroid tumors in pediatric patients
Fuente:Frontiers in Endocrinology
Tipo de trabajo:Revisión
Extracto:
Because of the significant overlap in sonographic features
among benign, borderline, and certain malignant thyroid lesions in pediatric
patients, ultrasonography alone is insufficient for accurate risk stratification.
This overlap necessitates referrals for fine-needle aspiration biopsy (FNAB) in
children more frequently than in adults. Future studies utilizing artificial
intelligence (AI) to predict clinical outcomes in thyroid nodule diagnostics may
offer new advancements, particularly given the increasing number of pediatric
patients with solid thyroid lesions.
institución:(a) Department of Pediatric and Adolescent Endocrinology, Chair of Pediatrics, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland. (b) Department of Pediatric and Adolescent Endocrinology, University Children Hospital in Krakow, Krakow, Poland.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Autor/es:Wróbel, Tomasz M (a) Grudzińska, Angelika (b)
institución:(a) Department of Synthesis and Chemical Technology of Pharmaceutical Substances, Medical University of Lublin, Lublin, Poland. (b) Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Childhood Lifestyle Behaviors and Mental Health Symptoms in Adolescence.
Childhood Lifestyle Behaviors and Mental Health Symptoms in Adolescence.
Fuente:Jama Network Open
Tipo de trabajo:Estudio de cohortes
Extracto:
AND RELEVANCE: This cohort study of Finnish children and
adolescents found that higher PA and lower ST from childhood were associated with
perceived stress and depressive symptoms in adolescence. These findings emphasize
reducing screen time and increasing PA to promote mental health in youth.
Cita:JAMA Netw Open 2025 Feb 3; 8 (2) : e2460012.
Autor/es:Haapala, Eero A (a) Leppänen, Marja H (b)
institución:(a) Sports and Exercise Medicine, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland. (b) Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Automated Insulin Delivery in Adults With Type 2 Diabetes
Automated Insulin Delivery in Adults With Type 2 Diabetes
Fuente:Jama Network Open
Tipo de trabajo:Estudio clínico aleatorizado
Extracto:
AND RELEVANCE: In this nonrandomized clinical trial, HbA1c
levels were lower in a diverse cohort of adults with type 2 diabetes following
AID initiation, suggesting that AID may be a beneficial and safe option for
people with type 2 diabetes using insulin. TRIAL REGISTRATION: ClinicalTrials.gov
Identifier: NCT05815342.
Cita:JAMA Netw Open 2025 Feb 3; 8 (2) : e2459348.
Autor/es:Pasquel, Francisco J (a) Davis, Georgia M (b)
institución:(a) Emory University School of Medicine, Atlanta, Georgia. (b) Emory University School of Medicine, Atlanta, Georgia.
Conflicto:Conflict of Interest Disclosures: Dr Pasquel reported receiving grants through the institution from Insulet, Tandem Diabetes Care, Ideal Medical Technologies, Novo Nordisk, and Dexcom; receiving consulting fees from Dexcom; receiving consulting fees to the institution from Insulet; and serving as associate editor for JAMA Network Open outside the submitted work. Dr Davis reported receiving grants from Insulet during the conduct...
of the study as well as consulting for Medscape and receiving grants from Insulet outside the submitted work. Dr Huffman reported receiving speaker fees from Novo Nordisk and receiving research funding from Novo Nordisk, Arrowhead, Eli Lilly and Co, Biomea, CeCur, 89Bio, Gann & Lee, AstraZeneca, Kowa, Boehringer Ingelheim, and Fortrea outside the submitted work. Dr Peters reported receiving grants from Insulet during the conduct of the study; receiving research support from Abbott Diabetes Care; serving on advisory boards for Vertex and Medscape; and owning stock option in Omada Health outside the submitted work. Dr Parker reported receiving personal fees from Insulet during the conduct of the study; receiving research support from Corcept; receiving consulting fees and serving on the advisory board of Corcept; and receiving speaker fees from Novo Nordisk outside the submitted work. Dr Laffel reported receiving grants from Insulet during the conduct of the study; receiving consulting fees from Insulet, Novo Nordisk, Eli Lilly and Co, Roche, Janssen Pharmaceuticals, Dexcom, Boehringer Ingelheim, Medtronic, Vertex, and Provention Bio; receiving grants from Tandem Diabetes, Medtronic, and Dexcom; and receiving personal fees for serving on the advisory boards of Sequel Med Tech, Vertex, Tandem Diabetes, and Medtronic outside the submitted work. Dr Castorino reported receiving research support to the institution from Insulet, Dexcom, Medtronic, Abbott Diabetes, and MannKind; and receiving speaker, consulting, and other personal fees from Dexcom; and serving as a consultant and on the advisory board for MannKind outside the submitted work. Ms Kruger reported receiving grants from Tandem, Abbott, Insulet, Novo Nordisk, BetaBionics, and Embecta; receiving advisory and speaker fees from Abbott, Novo Nordisk, Eli Lilly and Co, and CeQur; receiving speaker fees from Dexcom; and receiving advisory fees from MannKind, Medtronic, Structure, Embecta, Insulet, and Pendulum outside the submitted work. Dr Dungan reported receiving grants paid to the employer from Insulet during the conduct of the study as well as receiving consulting fees from Eli Lilly and Co, Dexcom, Medscape, Oppenheimer, UpToDate, Elsevier, Med Learning Group, Impact Education, and Insulet and grants paid to the employer from Dexcom, Abbott, and Sanofi outside the submitted work. Dr Kipnes reported receiving research support from 89bio, Medtronic, Abbott, Akero Therapeutics, AstraZeneca, BioMea, Carmot, Dexcom, Fusion, Abbvie, Amgen, Biolinq, Diamyd, Endogenex, Fractyl, Gilead, Insulet, IONIS Pharmaceuticals, Kowa, MannKind, Novo Nordisk, Pfizer, Reata, Sinocare, Tandem, Trial Net, vTv Therapeutics, Zucara Therapeutics, Zydus, Boehringer Ingelheim, Corcept, and Eli Lilly and Co; receiving consulting fees from Corcept and Capillary Biomedical; serving on the advisory board of AP Stem and Corcept; and serving on the clinical events committee for the Jaeb Center for Health Research Foundation. Dr Jauch reported receiving grants from Insulet and Carmot Therapeutics during the conduct of the study. Dr Oser reported receiving a contract from Insulet study during the conduct of the study; consulting through the University of Colorado for Dexcom, Blue Circle Health, and MedScape; grants through the University of Colorado from the Helmsley Charitable Trust, the National Institute of Diabetes and Digestive and Kidney Diseases, Dexcom, and Abbott outside the submitted work. Dr Shah reported receiving grants and consulting from Insulet during the conduct of the study; grants from Dexcom and Enable Bioscience; and personal fees from Dexcom, Embecta, Ascensia Diabetes Care, Eli Lilly and Co, Sanofi, Novo Nordisk, Tandem Diabetes Care, Sequel Medtech, Genomelink, and Lumosfit outside the submitted work. Dr Horowitz reported receiving research support from Insulet and Bayer; receiving consulting fees from AbbVie; and serving on the speaker’s bureau for Eli Lilly and Co and Novo Nordisk. Dr Carlson reported grants to the institution from Medtronic, Insulet, Tandem, Abbott, Dexcom, MannKind, Novo Nordisk, Eli Lilly and Co, and Sanofi; receiving personal fees paid to the institution from Insulet, Tandem, Abbott, and Novo Nordisk; serving on the advisory board for MannKind and Zealand; and being an employee of International Diabetes Center at Park Nicollet. Dr Warren reported receiving grants from Medtronic during the conduct of the study and receiving grants from Eli Lilly and Co, Novo Nordisk, AstraZeneca, Amgen, Insulet, Novartis, Diasome, and Sensionics; serving on the advisory board of Eli Lilly and Co; receiving consulting fees from Insulet, Medtronic, Eli Lilly and Co, Novo Nordisk, Boehringer Ingelheim, Amgen, AbbVie, Regeneron, Bayer, Biomea, and AstraZeneca; and receiving speaker honoraria from Eli Lilly and Co, Amgen, and Abbott outside the submitted work. Dr Buse reported receiving personal fees from Dexcom during the conduct of the study; receiving personal fees from Alkahest, Altimmune, Anji, Aqua Medical Inc, AstraZeneca, Boehringer Ingelheim, CeQur, Corcept Therapeutics, Eli Lilly, Embecta, GentiBio, Glyscend, Insulet, Mediflix, Medscape, Medtronic MiniMed, Mellitus Health, Metsera, Moderna, Novo Nordisk, Pendulum Therapeutics, Praetego, ReachMD, Stability Health, Tandem, Terns Inc, and Vertex; owning stock options in Glyscend, Mellitus Health, Pendulum Therapeutics, Praetego, and Stability Health; and receiving research support from Bayer, Boehringer-Ingelheim, Carmot, Corcept, Dexcom, Lilly, Insulet, MannKind, Novo Nordisk, and vTv Therapeutics outside the submitted work. Dr Blevins reported receiving research support from Boehringer Ingelheim, vTv Therapeutics, Tandem, Dexcom, MannKind, Eli Lilly and Co, Novo Nordisk, Insulet, Medtronic, and Abbott; serving on the speaker bureau for Dexcom, Eli Lilly and Co, and Novo Nordisk; and serving as an advisor to MannKind and Insulet during the conduct of the study. Dr Bajaj reported receiving personal fees from Insulet during the conduct of the study; receiving research support from Eli Lilly and Co and Novo Nordisk; receiving consulting fees from Dexcom and Eli Lilly and Co; and serving as an advisory board member for Eli Lilly and Co outside the submitted work. Dr Kollman reported receiving grants to the institution from Insulet during the conduct of the study and receiving grants to the institution from Tandem, Juvenile Diabetics Research Foundation, MannKind, BT1D, and Dexcom outside the submitted work. Dr Ly reported being employed by and owning stock in Insulet. Dr Beck reported receiving grants from Insulet during the conduct of the study; receiving grants, study supplies, and consulting fees to the institution from Insulet, Tandem, and Beta Bionics; receiving grant funding and study supplies to the institution from Dexcom; grant funding to the institution from Bigfoot Biomedical, Embecta, Sequel Med Tech, and MannKind; receiving consulting fees and study supplies to the institution from Novo Nordisk; receiving consulting fees to the institution from Vertex, Hagar, Ypsomed, Sanofi, and Zucara; and receiving study supplies from Medtronic, Ascencia, Roche, and Eli Lilly and Co outside the submitted work. No other disclosures were reported.
Risk factors associated with the recurrence of diabetic foot ulcers
Risk factors associated with the recurrence of diabetic foot ulcers
Fuente:Plos One
Tipo de trabajo:Metanálisis
Extracto:
Our meta-analysis identified the following important risk factors
for diabetic foot ulcer recurrence: male sex, smoking history, living alone,
plantar ulcer, diabetic retinopathy, diabetic nephropathy, diabetic peripheral
neuropathy, foot deformity, and peripheral arterial disease. Understanding these
factors and their impact on ulcer recurrence is crucial for multidisciplinary
teams to develop management and treatment plans for diabetic foot ulcer patients.
Cita:PLoS One 2025; 20 (2) : e0318216.
Autor/es:Lin, Chunmei (a) Tian, Jianqing (b)
institución:(a) Department of Endocrinology and Metabolism, Fujian Medical University Xiamen Humanity Hospital, Xiamen, Fujian Province, People's Republic of China. (b) Department of Endocrinology and Metabolism, Fujian Medical University Xiamen Humanity Hospital, Xiamen, Fujian Province, People's Republic of China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Validation of ICD-10 codes used to identify the main reason for hospitalization due to hyponatremia in Sweden.
Validation of ICD-10 codes used to identify the main reason for hospitalization due to hyponatremia in Sweden.
Fuente:Plos One
Tipo de trabajo:Revisión
Extracto:
The current study showed that 19
diagnoses out of 20 were correct implying a high validity. Thus, a principal
diagnosis of hyponatremia, appears to be a useful measure in clinical and
epidemiological studies aiming to target a clinically relevant consequence of
hyponatremia in hospitalized patients.
Cita:PLoS One 2025; 20 (2) : e0318927.
Autor/es:Bergh Fahlén, Cecilia (a) Issa, Issa (b)
institución:(a) Department of Clinical Science and Education at Södersjukhuset, Karolinska Institutet, Stockholm, Sweden. (b) Department of Internal Medicine, Section of Diabetes and Endocrinology, Södersjukhuset, Stockholm, Sweden.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Dysregulation of amino acid and lipid metabolism in patients with spondyloarthritis.
Dysregulation of amino acid and lipid metabolism in patients with spondyloarthritis.
Fuente:The Journal of International Medical Research
Extracto:
Our data suggest that patients
with SpA exhibit significant disruptions in amino acid and lipid metabolism. The
large number of identified metabolites offers promising opportunities, both for
discovering new SpA biomarkers and for gaining a deeper understanding of the
pathophysiology of these chronic inflammatory diseases.
Cita:J Int Med Res 2025 Feb; 53 (2) : 3000605251313949.
Autor/es:Remus, Constantin (a) Hoffmeister, Meike (b)
institución:(a) Department of Internal Medicine I - Cardiology, Nephrology and Internal Intensive Medicine, Brandenburg University Hospital, Brandenburg Medical School (Theodor Fontane), 14770 Brandenburg an der Havel, Germany. (b) Institute of Biochemistry, Brandenburg Medical School (Theodor Fontane), 14770 Brandenburg an der Havel, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Clinical Relevance of ATRX/DAXX Gene Mutations and ALT in Functioning Pancreatic Neuroendocrine Tumors.
Clinical Relevance of ATRX/DAXX Gene Mutations and ALT in Functioning Pancreatic Neuroendocrine Tumors.
Fuente:Endocrine Pathology
Extracto:
Although ATRX/DAXX mutation and ALT assessment may
currently not be the standard of care in routine diagnostic pathology practice,
the use of DAXX/ATRX immunohistochemistry at least can be encouraged not only for
non-functioning but also for functioning PanNETs.
Autor/es:van T Veld, Brenna R (a) Hackeng, Wenzel M (b)
institución:(a) Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands. (b) Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Early increase in carotid intima-media thickness in women with childhood-onset type 1 diabetes compared with healthy peers: the Norwegian Atherosclerosis and Childhood Diabetes study.
Early increase in carotid intima-media thickness in women with childhood-onset type 1 diabetes compared with healthy peers: the Norwegian Atherosclerosis and Childhood Diabetes study.
Fuente:Bmj Open Diabetes Research & Care
Tipo de trabajo:Estudio de cohortes
Extracto:
Young
women with childhood-onset type 1 diabetes of relatively short diabetes duration
had a higher mean cIMT over a 10-year period compared with their healthy female
controls, with values similar to males.
Claves:Carotid Intima-Media Thickness, Diabetes Mellitus, Type 1, Glycated Hemoglobin A, Women's Health
Cita:BMJ Open Diabetes Res Care 2025 Feb 16; 13 (1)
institución:(a) Division of Pediatric and Adolescent Medicine, Ullevål Universitetssykehus, Oslo, Norway aidasi@uio.no. (b) University of Oslo Faculty of Medicine, Oslo, Norway.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Familial glucocorticoid deficiency: genetic insights and treatment strategies in resource-limited settings.
Familial glucocorticoid deficiency: genetic insights and treatment strategies in resource-limited settings.
Fuente:Bmj Case Reports
Extracto:
This case highlights the potential of
next-generation sequencing tools in identifying hereditary adrenal insufficiency,
enabling timely intervention and improved patient care.
Claves:Adrenal disorders, Genetic screening / counselling, Neonatal and paediatric intensive care
Cita:BMJ Case Rep 2025 Feb 16; 18 (2)
Autor/es:Tresa, Anu (a) Jahagirdar, Rahul (b)
institución:(a) Department of Pediatrics, Bharati Vidyapeeth Deemed University Medical College, Pune, Maharashtra, India. (b) Department of Pediatrics, Bharati Vidyapeeth Deemed University Medical College, Pune, Maharashtra, India rjahagirdar@gmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Models of care and associated targeted implementation strategies for cancer survivorship support in Europe
Models of care and associated targeted implementation strategies for cancer survivorship support in Europe
Fuente:Bmj Open
Tipo de trabajo:Revisión
Extracto:
The Action involves representatives from most countries across Europe
which will assist with the dissemination of the work to key stakeholders.
Claves:Delivery of Health Care, Integrated, Health Services, Health policy, International health services, Patient-Centered Care, Review
Cita:BMJ Open 2025 Feb 16; 15 (2) : e085456.
Autor/es:Prue, Gillian (a) Czamanski-Cohen, Johanna (b)
institución:(a) Medical Biology Centre, Queens University Belfast School of Nursing and Midwifery, Belfast, UK. (b) School of Creative Arts Therapies, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Autoimmune pancreatitis, pancreatic and extrapancreatic cancer (AIPPEAR)
Autoimmune pancreatitis, pancreatic and extrapancreatic cancer (AIPPEAR)
Fuente:Bmj Open
Tipo de trabajo:Estudio multicéntrico
Extracto:
TRIAL
REGISTRATION NUMBER: NCT06328101.
Claves:EPIDEMIOLOGY, ONCOLOGY, Pancreatic disease
Cita:BMJ Open 2025 Feb 16; 15 (2) : e086824.
Autor/es:Cardinal von Widdern, Julian (a) Knoph, Cecilie Siggaard (b)
institución:(a) Department for Internal Medicine I (Gastroenterology, Pulmonology), University Hospital Halle Department of Internal Medicine, Halle, Germany juliancvw@gmail.com. (b) Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Integration of transcriptome and Mendelian randomization analyses in exploring the extracellular vesicle-related biomarkers of diabetic kidney disease.
Integration of transcriptome and Mendelian randomization analyses in exploring the extracellular vesicle-related biomarkers of diabetic kidney disease.
Fuente:Renal Failure
Extracto:
This study identified two EV-associated biomarkers, CMAS and RGS10,
linked to DKD and elucidated their potential roles in disease progression. These
results offer valuable insights for further exploration of DKD pathogenesis and
the development of new therapeutic targets.
institución:(a) Second Department of Nephrology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China. (b) Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Conflicto:The authors declare that they have no competing interest.
institución:(a) Department of Nuclear Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. (b) Department of Nuclear Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Case report: Diagnosis of impaired consciousness in a cancer patient using immune checkpoint inhibitors.
Case report: Diagnosis of impaired consciousness in a cancer patient using immune checkpoint inhibitors.
Fuente:Frontiers in Immunology
Extracto:
This clinical case emphasizes the
importance of the systematic study of consciousness impairment in cancer
patients, and of considering multiple IRAEs that could lead to changes in
oncological therapy when establishing possible etiologies.
Autor/es:Cathalifaud, Daniel (a) Basáez, Cristóbal (b)
institución:(a) Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. (b) Departamento de Medicina Interna, Hospital Clínico Red de Salud UC-Christus, Santiago, Chile.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Case report: A case of type 1 diabetes with diabetic ketoacidosis induced by envafolimab treatment in hepatocellular carcinoma.
Case report: A case of type 1 diabetes with diabetic ketoacidosis induced by envafolimab treatment in hepatocellular carcinoma.
Fuente:Frontiers in Immunology
Extracto:
Recognizing the limitations of current
understanding, there is a clear call for further research, particularly on
identifying biomarkers that may predict adverse reactions to immunotherapy, to
guide precision medicine and improve patient safety.
institución:(a) Department of Pharmacy, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. (b) Department of Hepatobiliary-Pancreatic and Liver Transplantation, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Evaluation of thyroid ultrasound reports' quality in the Community of Madrid, Spain.
Evaluation of thyroid ultrasound reports' quality in the Community of Madrid, Spain.
Fuente:European Thyroid Journal
Extracto:
Most thyroid ultrasound reports issued in the
Community of Madrid provide insufficient data to make management decisions
regarding thyroid nodules.
High glycemic variability serves as an independent risk factor for postoperative infection-related complications in patients undergoing radical surgery for gastric, colon, and rectal cancer.
High glycemic variability serves as an independent risk factor for postoperative infection-related complications in patients undergoing radical surgery for gastric, colon, and rectal cancer.
Fuente:Medicine
Extracto:
And the nomogram prediction model confirmed its capable
for predicting infection-related complications.
Cita:Medicine (Baltimore) 2025 Feb 14; 104 (7) : e41602.
Autor/es:Yang, Zhensong (a) Jiang, Fangjie (b)
institución:(a) Department of Gastrointestinal Surgery, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Shandong, China. (b) Qingdao Medical College, Qingdao University, Shandong, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
