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Machine learning analysis of gene expression profiles of pyroptosis-related differentially expressed genes in ischemic stroke revealed potential targets for drug repurposing.
Machine learning analysis of gene expression profiles of pyroptosis-related differentially expressed genes in ischemic stroke revealed potential targets for drug repurposing.
Fuente:Scientific Reports
Extracto:
In conclusion, this investigation underscores
the pivotal role of pyroptosis pathways in ischemic stroke and identifies
pertinent targets for therapeutic development and drug repurposing.
Claves:Differentially expressed genes, Drug repurposing, Ischemic stroke, Machine learning, Pyroptosis
Cita:Sci Rep 2025 Feb 27; 15 (1) : 7035.
Autor/es:Hei, Changchun (a) Li, Xiaowen (b)
institución:(a) Key Laboratory for Craniocerebral Diseases of Ningxia Hui Autonomous Region, Department of Human Anatomy, Histology and Embryology, Ningxia Medical University, Yinchuan, China. (b) Key Laboratory for Craniocerebral Diseases of Ningxia Hui Autonomous Region, Department of Human Anatomy, Histology and Embryology, Ningxia Medical University, Yinchuan, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A snapshot of country-specific dietary habits and obesity in European children: the Feel4Diabetes study.
A snapshot of country-specific dietary habits and obesity in European children: the Feel4Diabetes study.
Fuente:European Journal of Pediatrics
Tipo de trabajo:Guía
Extracto:
Dietary intake varied by country and obesity degree among European children.
Across the six countries, children's diets did not align with food-based dietary
guidelines. These findings underscore the need for interventions promoting
healthier eating habits among European children. TRIAL REGISTRATION: The
Feel4Diabetes-study is registered with the clinical trials registry
(NCT02393872), http://clinicaltrials.gov What is Known: • Childhood obesity is a
growing concern across Europe, with some variations in food consumption observed
between European countries • Previous studies have highlighted the role of diet
in childhood obesity, but few have examined cross-country comparisons while
accounting for gender and BMI status. WHAT IS NEW: • This study provides a
comprehensive cross-country analysis of children's dietary intake, considering
gender, BMI status, and adherence to European dietary guidelines. • New insights
into gender differences in sweets consumption and the positive association
between BMI and food intake (such as soft drinks and sweets) are presented, which
can inform targeted dietary interventions.
institución:(a) Growth, Exercise, Nutrition and Development (GENUD) Research Group, University of Zaragoza, Zaragoza, Spain. (b) Growth, Exercise, Nutrition and Development (GENUD) Research Group, University of Zaragoza, Zaragoza, Spain. lmoreno@unizar.es.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Abdominal volume index is associated with higher oxidized LDL, high blood pressure and lower HDL among obese adults.
Abdominal volume index is associated with higher oxidized LDL, high blood pressure and lower HDL among obese adults.
Fuente:Bmc Endocrine Disorders
Tipo de trabajo:Estudio clínico
Extracto:
In the current study, we comprehensively investigated the
association between AVI with cardio-metabolic health in young obese adults and
accordingly, AVI was unfavorably associated with metabolic health among obese
adults. Further studies are needed to elaborate the underlying mechanisms.
CLINICAL TRIAL NUMBER: Not applicable.
Autor/es:Alanazi, Mansuor Ahmed (a) Alshehri, Khaled (b)
institución:(a) Department of Family Medicine, University of Tabuk, Tabuk, Saudi Arabia. mansuorahmedalanazi@gmail.com. (b) Department of Internal Medicine, University of Tabuk, Tabuk, 47713, Saudi Arabia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association among measurements obtained using portable ultrasonography with sex, body mass index, and age in a large sample of adult population.
Association among measurements obtained using portable ultrasonography with sex, body mass index, and age in a large sample of adult population.
Fuente:Journal of Translational Medicine
Extracto:
This study is the first
to report the mean values of SAT-related quantitative and qualitative
measurements (thickness and EG) in various body sites assessed through ultrasound
and their associations with sex, BMI, and age in a large cohort. These findings
could prove valuable in clinical practice for precise monitoring of nutritional
and/or training interventions, as well as for a more comprehensive evaluation of
nutritional status.
Autor/es:Annunziata, Giuseppe (a) Verde, Ludovica (b)
institución:(a) Facoltà di Scienze Umane, della Formazione e dello Sport, Università Telematica Pegaso, Via Porzio, Centro Direzionale, Isola F2, Naples, 80143, Italy. (b) Department of Public Health, University of Naples Federico II, Via Sergio Pansini 5, Naples, 80131, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Clinical and economic burden of achondroplasia in the United States: results from a retrospective, observational study.
Clinical and economic burden of achondroplasia in the United States: results from a retrospective, observational study.
Fuente:Orphanet Journal of Rare Diseases
Extracto:
Individuals
with achondroplasia are characterized by a higher comorbidity burden and
substantially higher HCRU and related costs relative to matched controls. The
results also suggest that despite high HCRU and costs, individuals with
achondroplasia likely are not seen by providers early enough nor are they
necessarily seen by appropriate specialists, indicating a need for improved care
and disease management.
institución:(a) Division of Pediatric Endocrinology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. (b) Pfizer Inc., New York, NY, USA.
Conflicto:Declarations. Ethics approval and consent to participate: Since the study did not entail collection, use, or transmittal of identifiable data, it was exempt from the requirement for institutional review board approval. Consent for publication: Not applicable. Competing interests: NM is on the advisory board of BioMarin and is also on the advisory board of Pfizer. JA, CLB, JFC, PNE, JL,...
AS and MPW are employees and stockholders of Pfizer Inc.
Prevalence and risk of cognitive impairment among patients with asthma
Prevalence and risk of cognitive impairment among patients with asthma
Fuente:Brain and Behavior
Tipo de trabajo:Revisión sistemática
Extracto:
This review
found a notable association between asthma and an increased risk of cognitive
decline, including dementia and Alzheimer's disease. These findings highlight the
importance of integrating cognitive health assessments into asthma care. Further
research is required to understand this relationship and develop effective
treatments. Emphasizing a holistic approach to asthma management, these findings
highlight the need to consider both respiratory and cognitive health for
comprehensive patient care.
institución:(a) Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India. (b) Evidence for Policy and Learning, Global Center for Evidence Synthesis, Chandigarh, India.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Postprandial triglyceride levels affecting postprandial thyroid stimulating hormone levels may be responsible for the increased postprandial thyroid stimulating hormone levels in people with reduced lipid tolerance.
Postprandial triglyceride levels affecting postprandial thyroid stimulating hormone levels may be responsible for the increased postprandial thyroid stimulating hormone levels in people with reduced lipid tolerance.
Fuente:Frontiers in Endocrinology
Tipo de trabajo:Estudio clínico
Extracto:
After a
high-fat meal is consumed, the postprandial TSH level is influenced by the
postprandial TG level, which may be the reason for the decreased thyroid function
in the population with reduced lipid tolerance. CLINICAL TRIAL REGISTRATION:
http://www.chictr.org.cn/index.aspx, identifier ChiCTR1800019514.
institución:(a) Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, China. (b) Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, Hebei, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
A retrospective study of risk factors for thrombosis in patients with ITP.
A retrospective study of risk factors for thrombosis in patients with ITP.
Fuente:Hematology (amsterdam, Netherlands)
Extracto:
Thrombotic events can occur at all stages of
ITP with a higher percentage in chronic ITP. Coronary artery disease,
dyslipidemia and TPO-RAs treatment are independent risk factors related to
thrombosis in ITP patients.
Claves:ITP, risk factor, thrombosis
Cita:Hematology 2025 Dec; 30 (1) : 2472461.
Autor/es:Zhou, Fan (a) Zhang, Shiqi (b)
institución:(a) Department of Hematology, the Second Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China. (b) Department of Hematology, the Second Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China.
Autor/es:Pardali, Eleni C (a) Kontouli, Katerina-Maria (b)
institución:(a) Unit of Immunonutrition and Clinical Nutrition, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis campus, Biopolis, Larissa, Greece. (b) Department of Primary Education, School of Education, University of Ioannina, Ioannina, Greece.
Conflicto:Declarations. Ethical approval: All procedures followed ethical standards per the 1964 Helsinki Declaration and its amendments. The present study was approved by the Larissa Hospital Scientific Board (9/3/2023/10749). Informed consent: Informed consent was obtained from the guardians of both patients to publish this article. Disclaimer: No part of this manuscript, including text and graphics, is copied or published elsewhere in...
whole or in part. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ Conflict of interest: The authors declare no relevant conflict of interest.
The Utilization of Electronic Consultations (eConsults) to Address Emerging Questions Related to Long COVID-19 in Ontario, Canada: Mixed Methods Analysis.
The Utilization of Electronic Consultations (eConsults) to Address Emerging Questions Related to Long COVID-19 in Ontario, Canada: Mixed Methods Analysis.
Fuente:Jmir Human Factors
Tipo de trabajo:Orientaciones y guía
Extracto:
The long COVID groups provided rapid
access to a multispecialty service that facilitated the avoidance of unnecessary
face-to-face referrals. An assessment of eConsults highlighted 5 common question
types, providing insight into potential gaps in knowledge among PCPs that could
help guide medical education and policy.
Claves:COVID specialist, COVID-19, COVID-19 vaccination, Canada, assessment, consultation, diagnosis, eConsult, electronic consultation, long COVID, medical education, mixed methods analysis, patient, primary care, specialist, symptom, teleconsultation, vaccination, web-based consultation, web-based consultations
Cita:JMIR Hum Factors 2025 Feb 28; 12 : e58582.
Autor/es:Singh, Jatinderpreet (a) Quon, Michael (b)
institución:(a) Department of Family Medicine, Queen's University, Kingston, ON, Canada. (b) Department of Family Medicine, University of Ottawa, Ottawa, ON, Canada.
A five-drug class model using routinely available clinical features to optimise prescribing in type 2 diabetes: a prediction model development and validation study.
A five-drug class model using routinely available clinical features to optimise prescribing in type 2 diabetes: a prediction model development and validation study.
Fuente:Lancet (london, England)
Tipo de trabajo:Estudio clínico
Extracto:
FUNDING: UK Medical Research Council.
Cita:Lancet 2025 Mar 1; 405 (10480) : 701-714.
Autor/es:Dennis, John M (a) Young, Katherine G (b)
institución:(a) Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK. Electronic address: j.dennis@exeter.ac.uk. (b) Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.
Conflicto:Declaration of interests JMD is supported by a Wellcome Trust Early-Career Award (227070/Z/23/Z). KGY and TJM were previously supported by Research England's Expanding Excellence in England (E3) fund. APM declares previous research funding from Eli Lilly, Pfizer, and AstraZeneca. ERP declares personal fees from Illumina, Eli Lilly, and Novo Nordisk. RRH is an Emeritus National Institute for Health and Care...
Research (NIHR) Senior Investigator, and reports personal fees from AstraZeneca, Eli Lilly, and Novartis. NS declares personal fees from Abbott Laboratories, AbbVie, Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Hanmi Pharmaceuticals, Janssen, Menarini-Ricerche, Novartis, Novo Nordisk, Pfizer, Roche Diagnostics, and Sanofi, and grants to his university from AstraZeneca, Boehringer Ingelheim, Novartis, and Roche Diagnostics. ATH and BMS are supported by the NIHR Exeter Clinical Research Facility and AF is supported by the NIHR Oxford Biomedical Research Centre. AGJ was previously supported by an NIHR Clinician Scientist Fellowship (CS-2015-15-018) and declares research funding to his university from the UK Medical Research Council, Diabetes UK, Breakthrough T1D (formerly JDRF), the European Foundation for the Study of Diabetes, and the Novo Nordisk Foundation. PC and LMG declare no competing interests. Representatives from GSK, Takeda, Janssen, Quintiles, AstraZeneca, and Sanofi attended meetings as part of the industry group involved with the MASTERMIND Consortium. No industry representatives were involved in the writing of the manuscript or analysis of data. For all authors, all aforementioned declarations are outside the submitted work; all authors declare that there are no other relationships or activities that could appear to have influenced the submitted work.
Incident type 2 diabetes and its risk factors in men and women aged 40-60 years from four sub-Saharan African countries: results from the AWI-Gen study.
Incident type 2 diabetes and its risk factors in men and women aged 40-60 years from four sub-Saharan African countries: results from the AWI-Gen study.
Fuente:The Lancet. Global Health
Tipo de trabajo:Metanálisis
Extracto:
FUNDING: National Institutes of Health, Department of Science
and Innovation (South Africa), and the South African Medical Research Council.
Cita:Lancet Glob Health 2025 Mar; 13 (3) : e459-e466.
Autor/es:Chikwati, Raylton P (a) Crowther, Nigel J (b)
institución:(a) Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: raylton.chikwati@wits.ac.za. (b) Department of Chemical Pathology, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Conflicto:Declaration of interests We declare no competing interests.
The role of advanced glycation end products between thyroid function and diabetic nephropathy and metabolic disorders.
The role of advanced glycation end products between thyroid function and diabetic nephropathy and metabolic disorders.
Fuente:Scientific Reports
Extracto:
The findings suggest that
HRFs such as HDL, TyG and TC should be prioritized when evaluating indicators
related to DN to effectively reduce DN in Chinese patients with high health risk
levels. Comprehensive indicators may be an effective and practical. method to
evaluate the metabolic progression of DN. Optimizing thyroid function management
may be a new strategy to prevent and treat DN and may help reduce the risk of
AGE-related complications in people with diabetes. This study highlights the
important role of AGEs in the relationship between TSH and DN. In addition,
future studies should further explore how to improve the management and
prevention of DN by regulating TSH.Among the leading causes of disability and
death in patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes
(T2DM), chronic kidney disease (CKD) occupies a certain position. Multi-factor
intervention targeting advanced glycation end products (AGEs), blood glucose,
blood pressure and lipids can reduce the morbidity and mortality of diabetic
nephropathy (DN) in T2DM patients through thyroid stimulating hormone (TSH),
which plays an important role in the pathological process of metabolic diseases
such as DN. AGEs, as a key factor in metabolic regulation, may affect the
formation and function of the thyroid gland; However, in DN, the correlation
between AGEs and TSH has not been clarified. We hypothesized that AGEs aggravated
the negative effect of TSH on DN. The.
institución:(a) Department of Endocrinology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. zy18356056506@163.com. (b) Department of Endocrinology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Liver fatty acid-binding protein point-of-care testing detects heat-induced organ damage: a pilot study in Japanese male self-defense force personnel.
Liver fatty acid-binding protein point-of-care testing detects heat-induced organ damage: a pilot study in Japanese male self-defense force personnel.
Fuente:Scientific Reports
Extracto:
In conclusion, the L-FABP POC kit may be useful as
a screening tool for detecting heat-induced organ damage, which would prevent
prolonged organ dysfunction.
institución:(a) Department of Nephrology and Endocrinology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan. hgoto@ndmc.ac.jp. (b) Department of Internal Medicine, Self-Defense Force (SDF) Central Hospital, Setagaya, Tokyo, 154-8532, Japan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Identification of BTK as an immune-related biomarker for Hashimoto's thyroiditis by integrated bioinformatic analysis.
Identification of BTK as an immune-related biomarker for Hashimoto's thyroiditis by integrated bioinformatic analysis.
Fuente:Bmc Immunology
Extracto:
This study identified BTK was significantly increased in HT patients,
which might be the involved in the pathogenesis of HT by regulating plasma cells
and represented a potential immune-related biomarker of HT.
institución:(a) Department of Endocrinology, The Affiliated People's Hospital of Jiangsu University, Zhenjiang Medical School of Nanjing Medical University, Zhenjiang, 212002, China. (b) Department of Endocrinology, The Affiliated People's Hospital of Jiangsu University, Zhenjiang Medical School of Nanjing Medical University, Zhenjiang, 212002, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Comprehensive evaluation of diabetes subtypes in a European cohort reveals stronger differences of lifestyle, education and psychosocial parameters compared to metabolic or inflammatory factors.
Comprehensive evaluation of diabetes subtypes in a European cohort reveals stronger differences of lifestyle, education and psychosocial parameters compared to metabolic or inflammatory factors.
Fuente:Cardiovascular Diabetology
Extracto:
The study validates the ANDIS classification framework's
applicability not only at the time point of manifestation but also in cohorts
with pre-existing diabetes. While we did not find major differences regarding the
classical metabolic, microbial and nutritional parameters, we identified several
significant associations with lifestyle factors. Our findings underscore the
importance of personalized, subtype-specific therapies not solely focusing on
anthropometric and laboratory markers but comprehensively addressing the
patient's own personality and situation of life.
Claves:Diabetes subtypes, Diet, Education, Exercise, Gut microbiota, Secondary disease risk
Cita:Cardiovasc Diabetol 2025 Feb 28; 24 (1) : 99.
Autor/es:Rohmann, Nathalie (a) Epe, Johannes (b)
institución:(a) Institute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein (UKSH) - Campus Kiel, Düsternbrooker Weg 17, 24105, Kiel, Germany. (b) Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine I, University Medical Center Schleswig-Holstein - Campus Kiel, Kiel, Germany.
Conflicto:Declarations. Ethical approval: The study was approved by the ethical committee from the Department of Medicine, Kiel University (A156/03, 2011/07/28). All procedures were executed in accordance with the Helsinki Declaration. Written informed consent was obtained from all participants before inclusion in the study. Consent for publication: Not applicable, as no identifiable human data or images are included in this manuscript....
Conflict of interests: The authors have no conflicting interests to declare.
Lipid-lowering therapy and LDL target attainment in type 2 diabetes: trends from the Italian Associations of Medical Diabetologists database.
Lipid-lowering therapy and LDL target attainment in type 2 diabetes: trends from the Italian Associations of Medical Diabetologists database.
Fuente:Cardiovascular Diabetology
Tipo de trabajo:Guía
Extracto:
While LDL-c
management in Italian patients with T2DM has improved, significant gaps remain,
particularly for very high-risk individuals. Expanding the use of advanced
therapies like PCSK9 inhibitors and adhering more closely to guideline-based
recommendations are critical to improve cardiovascular risk in this population.
Acute hepatic porphyria in Denmark; a retrospective study.
Acute hepatic porphyria in Denmark; a retrospective study.
Fuente:Orphanet Journal of Rare Diseases
Extracto:
As reported internationally, AHP is more commonly diagnosed and
symptomatic in women, and AIP was the most frequent AHP subtype. Those with an
elevated urinary baseline PBG secretion were more likely to report AHP-related
symptoms.
Autor/es:Wagner, Magnus Emil Ulrich (a) Frost, Morten (b)
institución:(a) Department of Endocrinology, Odense University Hospital, Kløvervænget 6, Entrance 93, Level 4, DK-5000, Odense C, Denmark. (b) Department of Endocrinology, Odense University Hospital, Kløvervænget 6, Entrance 93, Level 4, DK-5000, Odense C, Denmark.
Conflicto:Declarations. Ethics approval and consent to participate: This was obtained from the hospital’s legal department prior to start. Consent for publication: All authors agree to submit this manuscript to Orphanet J of Rare Diseases. Competing interests: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.
The associations between evening eating and quality of energy and macronutrients and obesity: the National Health and Nutrition Examination Survey (NHANES), 2003-2016.
The associations between evening eating and quality of energy and macronutrients and obesity: the National Health and Nutrition Examination Survey (NHANES), 2003-2016.
Fuente:Nutrition Journal
Extracto:
In conclusion,
with this nationally representative sample of U.S adults, this study demonstrated
that excessive intake of energy at dinner than breakfast during a day was
associated with a greater risk of obesity, mainly from low-quality carbohydrates,
fat, SFAs, and USFA. This study emphasized the importance of diet quality and
evening eating in the prevention of obesity.
Claves:Energy, Energy distribution throughout a day, Food sources, Macronutrients, Meal timing, Obesity
Cita:Nutr J 2025 Feb 28; 24 (1) : 33.
Autor/es:Hou, Wanying (a) Wang, Weiqi (b)
institución:(a) Department of Nutrition and Food Hygiene, School of Public Health, Key Laboratory of Precision Nutrition and Health, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, China. (b) Department of Endocrinology and Metabolism, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The Promise of Adjunct Medications in Improving Type 1 Diabetes Outcomes: Glucagon-Like Peptide Receptor Agonists.
The Promise of Adjunct Medications in Improving Type 1 Diabetes Outcomes: Glucagon-Like Peptide Receptor Agonists.
Fuente:Journal of Diabetes Science and Technology
Extracto:
Despite these
challenges, GLP-1 RAs offer significant therapeutic benefits, making them a
promising adjunct to insulin therapy for improving clinical outcomes in T1D
management.
Claves:glucagon-like peptide receptor agonists, liraglutide, semaglutide, tirzepatide, type 1 diabetes
institución:(a) Division of Pediatric Endocrinology & Diabetes, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA. (b) Division of Pediatric Endocrinology & Diabetes, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Conflicto:Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
