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RAD-Seq-derived SSR markers: a new paradigm for genetic analysis and construction of genetically improved production populations in Pinus koraiensis.
RAD-Seq-derived SSR markers: a new paradigm for genetic analysis and construction of genetically improved production populations in Pinus koraiensis.
Fuente:Bmc Plant Biology
Tipo de trabajo:Orientaciones y guía
Extracto:
The utilization of RAD-seq
technology enables the development of SSR markers and the screening of
polymorphic primers, thereby providing a robust tool for research pertaining to
genetic diversity analysis and the identification of germplasm in Pinus
koraiensis. The plus tree population in Xiaobeihu exhibits a considerable degree
of genetic diversity, with no notable genetic differentiation. The construction
of production populations via the developed SSR markers in combination with cone
production from plus trees results in a reasonable population size and a mating
system, thereby providing a scientific basis and technical support for the
evaluation of Pinus koraiensis germplasm resources and advanced-generation
improvement efforts. Furthermore, this study provides a reference and guidance
for the development and application of SSR markers in other tree species.
Claves:Pinus koraiensis, Genetic differentiation, Plus tree, Production populations, SSR
Cita:BMC Plant Biol 2025 Feb 22; 25 (1) : 238.
Autor/es:Yan, Pingyu (a) Zhang, Wanying (b)
institución:(a) State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, China. (b) State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Analysis of temporal survival trends: considerations and best practice.
Analysis of temporal survival trends: considerations and best practice.
Fuente:Bmc Medical Research Methodology
Extracto:
The methods and interpretation thereof are exemplified on patients
with diffuse large B-cell lymphoma from the Danish lymphoma registry.
Claves:Causality, Diffuse large B-cell lymphoma, Healthcare monitoring, Mediation analysis
Cita:BMC Med Res Methodol 2025 Feb 22; 25 (1) : 51.
Autor/es:Simonsen, Mikkel Runason (a) Gjærde, Lars Klingen (b)
institución:(a) Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark. mikkel.simonsen@rn.dk. (b) Department of Mathemathical Sciences, Aalborg University, Aalborg, Denmark. mikkel.simonsen@rn.dk.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Evolution of morphological traits of Dendrobium sensu lato (Orchidaceae)-an attempt to resolve phylogenetic relationships in nominal and morphologically convergent sections.
Evolution of morphological traits of Dendrobium sensu lato (Orchidaceae)-an attempt to resolve phylogenetic relationships in nominal and morphologically convergent sections.
Fuente:Bmc Plant Biology
Extracto:
We conclude that convergent evolution likely occurred among
Dendrobium sensu lato representatives, and that many floral traits may have
resulted from adaptations to pollinators. This has led to numerous classification
problems within the genus. We have not received a clear answer to the question of
how to classify species across the genus. Therefore, in this study, we focused
primarily on the nominal section.
Autor/es:Burzacka-Hinz, Aleksandra (a) Dudek, Magdalena (b)
institución:(a) Department of Plant Taxonomy and Nature Conservation, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, Gdańsk, 80308, Poland. (b) Department of Plant Taxonomy and Nature Conservation, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, Gdańsk, 80308, Poland. magdalena.dudek@ug.edu.pl.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Painful considerations in exercise-management for rotator cuff related shoulder pain
Painful considerations in exercise-management for rotator cuff related shoulder pain
Fuente:Bmc Musculoskeletal Disorders
Tipo de trabajo:Revisión
Extracto:
This review reveals substantial reporting deficiencies
regarding pain-related prescription parameters in RCTs addressing RCRSP with
resistance exercise. The identified parameters varied widely, reflecting a lack
of consensus and evidence-based guidance in the literature and in a clinical
setting. To advance our understanding on the role of pain-related prescription
parameters, more consistent reporting of these parameters in future research is
warranted. TRIAL REGISTRATION: Published on the Open Science Framework 28.02.24:
osf.io/a52kn.
Cita:BMC Musculoskelet Disord 2025 Feb 22; 26 (1) : 180.
Autor/es:Raulline Ullern, Kaspar (a) Richardsen, Magnus (b)
institución:(a) Faculty of Health and Social Sciences, Western Norway University of Applied Sciences, Bergen, 5063, Norway. Kaspar.ullern@gmail.com. (b) Faculty of Health and Social Sciences, Western Norway University of Applied Sciences, Bergen, 5063, Norway. Magnusrichardsen1998@gmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Determinants of self-rated health in socioeconomically disadvantaged women: a cross-sectional study in Iran.
Determinants of self-rated health in socioeconomically disadvantaged women: a cross-sectional study in Iran.
Fuente:Bmc Public Health
Extracto:
The study of disadvantaged women revealed a significant
influence of physical health on their overall sense of well-being. The findings
suggest that education and anxiety have impacts on self-rated health of both
diseased and healthy women. To improve the well-being of disadvantaged women,
providing accessible physical and mental health support, along with expanding
educational opportunities, would be beneficial.
Claves:Disadvantaged, Health, Iran, Socioeconomic status
institución:(a) Department of Medical Ethics and Philosophy of Health, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. (b) Health Policy Research Center, Institute of Health, Shiraz Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Malaria in a metropolitan region of Southern Germany: past, present and future perspectives on a protozoan infection with the potential of re-appearance in Central Europe.
Malaria in a metropolitan region of Southern Germany: past, present and future perspectives on a protozoan infection with the potential of re-appearance in Central Europe.
Fuente:Malaria Journal
Extracto:
Future autochthonous transmission of malaria parasites
in Erlangen is possible, although re-establishment of a natural transmission
cycle is currently unlikely. In order to avoid unexpected autochthonous malaria,
surveillance and prevention measures should be considered. Patients with fever
after visiting endemic areas need to be analysed for Plasmodium infection.
institución:(a) Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Wasserturmstraße 3/5, 91054, Erlangen, Germany. jan.esse@uk-erlangen.de. (b) Institute for the History and Ethics of Medicine, FAU Erlangen-Nürnberg, Glückstraße 10, 91054, Erlangen, Germany.
Conflicto:Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of the Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg on March 05, 2024 (24-53-Br). The need for written informed consent was waived. Competing interests: Biogents AG (Silke Göttler) produces and distributes traps against mosquitoes for private and scientific use.
Oxytocin in horse saliva: validation of a highly sensitive assay and a pilot report about changes in equine gastric ulcer syndrome.
Oxytocin in horse saliva: validation of a highly sensitive assay and a pilot report about changes in equine gastric ulcer syndrome.
Fuente:Bmc Veterinary Research
Extracto:
This report validates a new assay that can measure
oxytocin in saliva in horses in a precise and accurate way. The lower oxytocin
values in horses with EGGD and both EGGD and ESGD than in horses with ESGD,
horses with other diseases, and healthy horses could indicate a possible relation
of oxytocin with this disease.
Claves:Biomarker, EGUS, Horse
Cita:BMC Vet Res 2025 Feb 22; 21 (1) : 90.
Autor/es:Botía, María (a) Muñoz-Prieto, Alberto (b)
institución:(a) Interdisciplinary Laboratory of Clinical Analysis (INTERLAB-UMU), Department of Animal Medicine and Surgery, Veterinary School, Regional Campus of International Excellence Mare Nostrum, University of Murcia, 30100, Murcia, Spain. (b) Interdisciplinary Laboratory of Clinical Analysis (INTERLAB-UMU), Department of Animal Medicine and Surgery, Veterinary School, Regional Campus of International Excellence Mare Nostrum, University of Murcia, 30100, Murcia, Spain. alberto.munoz@um.es.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Virtual reality for assessment in undergraduate nursing and medical education - a systematic review.
Virtual reality for assessment in undergraduate nursing and medical education - a systematic review.
Fuente:Bmc Medical Education
Tipo de trabajo:Revisión sistemática
Extracto:
The use of VR in
medical education assessment shows promise, particularly for emergency scenarios
and performance-based tasks related to core competencies such as Patient Care,
Interpersonal and Communication Skills, and Medical Knowledge. While this
technology offers opportunities to automate assessments and reduce examiner
workload, challenges related to software, costs, and feasibility must be
addressed. Additionally, aligning learning objectives, teaching methods, and VR
assessments through constructive alignment is essential to ensure effective
implementation as both a teaching and evaluation tool.
Autor/es:Neher, Andrea N (a) Bühlmann, Florian (b)
institución:(a) Department of Emergency Medicine, Inselspital, Bern University Hospital, University of Bern, Rosenbühlgasse 27, Bern, CH-3010, Switzerland. andrea.neher@extern.insel.ch. (b) Graduate School for Health Sciences, University of Bern, Bern, Switzerland. andrea.neher@extern.insel.ch.
Conflicto:Declarations. This systematic review was registered in PROSPERO (CRD42023490861) and utilized the MERSQI Tool instead of the Cochrane Risk-of-Bias-Tool (as initially registered) for assessing data quality due to the inclusion of a wide range of study designs. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: TCS holds the endowed professorship of emergency telemedicine...
at the University of Bern sponsored by the Touring Club Switzerland. The sponsor has no influence on the research or decision to publish. All other authors have nothing to disclose.
Time to recovery from severe acute malnutrition and predictors among children aged 6-59 months at public hospitals: retrospective follow-up study.
Time to recovery from severe acute malnutrition and predictors among children aged 6-59 months at public hospitals: retrospective follow-up study.
Fuente:Scientific Reports
Extracto:
Therefore, special attention should be given to children
who have marasmus, comorbidities like pneumonia, and anemia to shorten their
recovery time from their severe acute malnutrition status.
Claves:Awi Zone, Children, Public hospital, Recovery time, Severe acute malnutrition
institución:(a) College of Medicine and Health Science, School of Health Sciences, Department of Pediatrics and Child Health Nursing, Bahir Dar University, P.O. Box 79, Bahir Dar, Ethiopia. (b) GAMBY Medical and Business College, Textile Road, P.O. Box. 209, Bahir Dar, Ethiopia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Altered interactive dynamics of gaze behavior during face-to-face interaction in autistic individuals: a dual eye-tracking study.
Altered interactive dynamics of gaze behavior during face-to-face interaction in autistic individuals: a dual eye-tracking study.
Fuente:Molecular Autism
Tipo de trabajo:Estudio clínico
Extracto:
By tracking the gaze
behavior of two interacting individuals, this study reveals specific
atypicalities in the interactive dynamics of gaze behavior in a subset of
autistic individuals, potentially informing diagnostic and therapeutic decisions.
More broadly, our study highlights the added value of dual eye-tracking in
elucidating the interactive nature of social encounters in both neurodiverse and
neurotypical individuals. TRIAL REGISTRATION: The study was registered as a
clinical trial before starting data collection (
https://drks.de/search/en/trial/DRKS00018957 ; Registration Date: 12/17/2019).
Claves:Autism spectrum, Dual eye-tracking, Naturalistic gaze behavior, Social interaction
Cita:Mol Autism 2025 Feb 22; 16 (1) : 12.
Autor/es:Tönsing, Daniel (a) Schiller, Bastian (b)
institución:(a) Department of Psychology, Laboratory for Biological Psychology, Clinical Psychology, and Psychotherapy, University of Freiburg, Freiburg, Germany. daniel.toensing@unibas.ch. (b) Department of Psychology, Laboratory for Biological Psychology, Clinical Psychology, and Psychotherapy, University of Freiburg, Freiburg, Germany. bastianschiller@web.de.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
FBF1 maintains stem cell-like properties in breast cancer via PI3K/AKT/SOX2 axis.
FBF1 maintains stem cell-like properties in breast cancer via PI3K/AKT/SOX2 axis.
Fuente:Stem Cell Research & Therapy
Extracto:
Collectively, we identified a potential CSCs regulator and
suggested a novel mechanism by which FBF1 governs cancer cell stemness. This
study thus introduces an effective target for the diagnosis and treatment of
breast cancer.
Claves:Breast cancer, Cancer stem cell, FBF1, SOX2, Stemness
Cita:Stem Cell Res Ther 2025 Feb 23; 16 (1) : 83.
Autor/es:Guo, Chunlei (a) Li, Shuang (b)
institución:(a) Henan Key Laboratory of Immunology and Targeted Drugs, School of Medical Technology, Xinxiang Medical University, Xinxiang, 453003, Henan, China. chunleier@163.com. (b) Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Medical Technology, Xinxiang Medical University, Xinxiang, 453003, Henan, China. chunleier@163.com.
Conflicto:Declarations. Ethics approval and consent to participate: Mice were used according to federal guidelines, and all animal procedures were approved by the Animal Ethical and Welfare Committee of Xinxiang Medical University (Project title: The mechanism of FBF1 promotes stemness and metastasis of breast cancer cell; approval number: XYLL-20190026; date of approval: January 2nd, 2019). Consent for publication: All authors confirm...
their consent for publication. Competing interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Data stewardship and curation practices in AI-based genomics and automated microscopy image analysis for high-throughput screening studies: promoting robust and ethical AI applications.
Data stewardship and curation practices in AI-based genomics and automated microscopy image analysis for high-throughput screening studies: promoting robust and ethical AI applications.
Fuente:Human Genomics
Tipo de trabajo:Revisión
Extracto:
These findings explored the current
practices and challenges in data stewardship, offering a roadmap for
strengthening the governance, security, and ethical use of AI in genomics and
microscopy. While robust governance frameworks and ethical practices have
established a foundation for data integrity and transparency, there remains an
urgent need for collaborative efforts to develop interoperable platforms and
transparent data-sharing policies. Additionally, evolving legal and ethical
frameworks will be crucial to addressing emerging challenges posed by AI
technologies. Fostering transparency, accountability, and ethical responsibility
within the research community will be key to ensuring trust and driving ethically
sound scientific advancements.
Claves:Artificial intelligence, Data curation, Data stewardship, Genomics, Microscopy image analysis, Scoping review
institución:(a) Academy of Wellness and Human Development, Faculty of Arts and Social Sciences, Hong Kong Baptist University, Hong Kong SAR, China. (b) Department of Information Science, College of Informatics, University of Gondar, Gondar, Ethiopia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A cross-sectional study evaluating the screening, diagnosis and management of advanced HIV disease at the AIDS support organization service centre in Mbarara City, Southwestern Uganda.
A cross-sectional study evaluating the screening, diagnosis and management of advanced HIV disease at the AIDS support organization service centre in Mbarara City, Southwestern Uganda.
Fuente:Bmc Infectious Diseases
Extracto:
This study
demonstrates that the prevalence of AHD remains high, and the implementation of
the AHD intervention package remains sub-optimal. The Ministry of Health and
partners need to strengthen implementation strategies to improve the screening,
diagnosis, and management of AHD.
Claves:Advanced HIV disease, Management, Prevalence
institución:(a) School of Health Sciences, Division of Population Health, Health Services Research and Primary Care, The University of Manchester, Oxford road, Manchester, UK. paddytmjwm@gmail.com. (b) School of Health Sciences, Division of Population Health, Health Services Research and Primary Care, The University of Manchester, Oxford road, Manchester, UK.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Unveiling the Genetic and Phenotypic Landscape of a Chinese Cohort With Retinitis Pigmentosa.
Unveiling the Genetic and Phenotypic Landscape of a Chinese Cohort With Retinitis Pigmentosa.
Fuente:Molecular Genetics & Genomic Medicine
Tipo de trabajo:Guía
Extracto:
The findings of this study offer valuable insights
into the genetic variants responsible for RP in affected individuals, which can
be utilized for genetic counseling and diagnosis. This underscores the
significance of genetic testing in the management and treatment of RP.
Design, synthesis and pharmacological evaluation of 1,4-naphthoquinone- 1,2,3-triazole hybrids as new anticancer agents with multi-kinase inhibitory activity.
Design, synthesis and pharmacological evaluation of 1,4-naphthoquinone- 1,2,3-triazole hybrids as new anticancer agents with multi-kinase inhibitory activity.
Fuente:Scientific Reports
Extracto:
The results of
this study indicate that 1,4-naphthoquinone derivatives could have promising
anticancer potential as multi-kinase inhibitors.
Claves:1,4-Naphthoquinone derivatives, Antitumoral agents, CDK2 inhibitor, Drug design, Targeted therapy
Cita:Sci Rep 2025 Feb 24; 15 (1) : 6639.
Autor/es:Mardaneh, Pegah (a) Pirhadi, Somayeh (b)
institución:(a) Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. (b) Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Environmental characteristics shape macroinvertebrate community structure across spatiotemporal scales in a subtropical African river system.
Environmental characteristics shape macroinvertebrate community structure across spatiotemporal scales in a subtropical African river system.
Fuente:Scientific Reports
Extracto:
This knowledge will assist on
how to effectively manage and safeguard these systems against further
deterioration from anthropogenic activities.
Claves:Diversity matrices, Macroinvertebrate community structure, Multivariate analysis, Sediment, Water
Cita:Sci Rep 2025 Feb 24; 15 (1) : 6595.
Autor/es:Munyai, Linton F (a) Gumede, Busisiwe P (b)
institución:(a) Aquatic Systems Research Group, School of Biology and Environmental Sciences, University of Mpumalanga, Nelspruit, 1200, South Africa. munyailinton@gmail.com. (b) Aquatic Systems Research Group, School of Biology and Environmental Sciences, University of Mpumalanga, Nelspruit, 1200, South Africa.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) School of Software Engineering, Xiamen University of Technology, Xiamen, 361024, China. (b) School of Computer and Information Engineering, Xiamen University of Technology, Xiamen, 361024, China. 2322071020@stu.xmut.edu.cn.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Cognitive performance classification of older patients using machine learning and electronic medical records.
Cognitive performance classification of older patients using machine learning and electronic medical records.
Fuente:Scientific Reports
Extracto:
Integrating these ML-driven approaches into primary care settings may facilitate
the early identification of older patients who could benefit from further
cognitive assessments.
Claves:Dementia, Electronic medical records, MCI, Machine learning
institución:(a) Łukasiewicz Research Network-Krakow Institute of Technology, Zakopianska Str. 73, 30-418, Krakow, Poland. monika.richter-laskowska@kit.lukasiewicz.gov.pl. (b) Łukasiewicz Research Network-Krakow Institute of Technology, Zakopianska Str. 73, 30-418, Krakow, Poland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Establishment and evaluation of a predictive model for immune reconstitution in people living with HIV after antiretroviral therapy.
Establishment and evaluation of a predictive model for immune reconstitution in people living with HIV after antiretroviral therapy.
Fuente:Bmc Infectious Diseases
Extracto:
This study
successfully developed a prediction model with robust performance. This model has
considerable potential to aid clinicians in tailoring treatment strategies, which
could enhance outcomes and quality of life for PLWH.
Claves:ART, HIV, Immune reconstitution, Model evaluation, Nomogram, Predictive model
Cita:BMC Infect Dis 2025 Feb 24; 25 (1) : 264.
Autor/es:Li, Na (a) Li, Rui (b)
institución:(a) School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan, 650500, China. (b) State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Advanced lung cancer inflammation index: a key predictor of hepatic steatosis and fibrosis severity.
Advanced lung cancer inflammation index: a key predictor of hepatic steatosis and fibrosis severity.
Fuente:Bmc Gastroenterology
Extracto:
The findings
suggest a positive correlation between elevated ALI levels and the levels of CAP
and LSM. Maintaining ALI within an appropriate range may help mitigate the
prevalence of hepatic steatosis and hepatic fibrosis.
Claves:Advanced lung cancer inflammation index, Hepatic fibrosis, Hepatic steatosis
Cita:BMC Gastroenterol 2025 Feb 24; 25 (1) : 106.
Autor/es:Liu, Yajie (a) Wang, Ruilin (b)
institución:(a) Department of Spleen, Stomach, Liver and Gallbladder Diseases, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Henan, China. (b) Department of Traditional Chinese Medicine and Liver Diseases, Fifth Medical Center, PLA General Hospital, Beijing, China. wrl7905@163.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
