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Standard of prevention for infectious diseases' prevention clinical trials during pandemics: learning lessons for global policies from biomedical HIV prevention clinical trials and a case study of COVID-19.
Standard of prevention for infectious diseases' prevention clinical trials during pandemics: learning lessons for global policies from biomedical HIV prevention clinical trials and a case study of COVID-19.
Fuente:Frontiers in Public Health
Tipo de trabajo:Estudio clínico
Extracto:
Regional and country
level regulatory provisions on these issues can provide critical guidance for
research design and implementation.
Claves:HIV prevention, best practices, epidemics, infectious diseases, outbreaks, pandemics, stakeholder engagement, standard of prevention
institución:(a) Department of Child Dental Health, Obafemi Awolowo University, Ile-Ife, Nigeria. (b) Division of Infectious Diseases and Global Public Health, School of Medicine, University of California, San Diego, La Jolla, CA, United States.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor RZ declared a past co-authorship with the authors MF and NN.
Discussions on Human Enhancement Meet Science: A Quantitative Analysis.
Discussions on Human Enhancement Meet Science: A Quantitative Analysis.
Fuente:Science and Engineering Ethics
Extracto:
We conclude that a large part of the discourse
surrounding human enhancement is inflected with "science-fictional habits of
mind." Our findings point to the need for a more science-informed approach in
discussions on enhancing human life.
Autor/es:Żuradzki, Tomasz (a) Bystranowski, Piotr (b)
institución:(a) Jagiellonian University, Institute of Philosophy & Interdisciplinary Centre for Ethics, ul. Grodzka 52, Kraków, 31-044, Poland. t.zuradzki@uj.edu.pl. (b) Jagiellonian University, Interdisciplinary Centre for Ethics, ul. Grodzka 52, Kraków, 31-044, Poland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Psychometric validation and cultural adaptation of the Persian Galveston orientation and amnesia test and orientation-log for assessing traumatic brain injury.
Psychometric validation and cultural adaptation of the Persian Galveston orientation and amnesia test and orientation-log for assessing traumatic brain injury.
Fuente:Scientific Reports
Extracto:
The interviews revealed significant
cultural considerations that must be considered when the scales are translated
and validated to ensure their validity and reliability in diverse cultural
contexts and prevent bias.
Autor/es:Eghbali, Mohammad (a) Hassan Zadeh Tabatabaei, Mahgol Sadat (b)
institución:(a) Department of Nursing, School of Nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran. (b) Sina Trauma and Surgery Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Inverse association between dietary flavonoid intake and nocturia in middle-aged and older adults from NHANES 2007-2010.
Inverse association between dietary flavonoid intake and nocturia in middle-aged and older adults from NHANES 2007-2010.
Fuente:Scientific Reports
Extracto:
Our study revealed an
inverse association between dietary flavonoid intake and nocturia in middle-aged
and older adults, and anthocyanins, flavan-3-ols and flavonols were protectively
associated with nocturia.
Claves:Diet, Flavonoids, Middle-aged and older adults, NHANES, Nocturia
Cita:Sci Rep 2025 Feb 5; 15 (1) : 4423.
Autor/es:Cai, Yu (a) Liang, Ying-Chao (b)
institución:(a) The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China. (b) The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Behavioural components and delivery features of early childhood obesity prevention interventions
Behavioural components and delivery features of early childhood obesity prevention interventions
Fuente:The International Journal of Behavioral Nutrition and Physical Activity
Tipo de trabajo:Revisión sistemática
Extracto:
Our study provides the most comprehensive description of the
behaviour change content of complex interventions targeting early childhood
obesity prevention available to date. Our analysis revealed that interventions
targeted multiple behaviour domains, with significant variation in delivery
features. Despite the diverse range of BCTs coded, five BCTs were consistently
identified across domains, though certain BCTs were more prevalent in specific
domains. These findings can be used to examine effectiveness of components and
inform intervention development and evaluation in future trials. TRIAL
REGISTRATION: PROSPERO registration no. CRD42020177408.
Autor/es:Johnson, Brittany J (a) Chadwick, Paul M (b)
institución:(a) College of Nursing and Health Sciences, Flinders University, Caring Futures Institute, Adelaide, Australia. brittany.johnson@flinders.edu.au. (b) Centre for Behaviour Change, University College London, London, UK.
Conflicto:Declarations. Ethics approval and consent to participate: Ethics approval was obtained from University of Sydney Human Research Ethics Committee (project no. 2020/273) and Flinders University Social and Behavioural Research Ethics Committee (project no. HREC CIA2133-1) to perform secondary analyses. Consent for publication: Not applicable. Competing interests: Authors listed as Trial Representatives in the acknowledgements are investigators of eligible trials, however...
these authors were not involved in the screening, data extraction, initial coding of the interventions, analysis or drafting of the manuscript. AKV currently has an investigator-initiated research grant from Bobbie Baby, Inc. LS is advisor to Medeloop, Inc.
Social participation challenges and facilitators among Chinese stroke survivors: a qualitative descriptive study.
Social participation challenges and facilitators among Chinese stroke survivors: a qualitative descriptive study.
Fuente:Bmc Public Health
Extracto:
Stroke survivors perceived varying degrees of changes in their
social participation. Specifically, this study identifies the influence of
prevalent cultural values on survivors' participation behaviors, indicating that
cultural beliefs and the associated effects on health outcomes should be taken
into consideration when developing interventions to enhance social participation
after stroke. Potential interventions to empower survivors could aim to improve
their stroke-related knowledge, provide psychological encouragement, incorporate
skills training to improve communication with family members, and organise peer
support groups to augment social support networks.
Claves:Challenges and facilitators, Cultural values, Qualitative study: social participation, Social support, Stroke survivors
institución:(a) School of Nursing, Yangzhou University, 136#, Hanjiang Middle Road, Yangzhou, Jiangsu Province Mainland, China. (b) Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Esther Lee Building, Shatin, N.T., Hong Kong SAR, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The impact of death and caring for the dying and their families on surgeons - an AI assisted systematic scoping review.
The impact of death and caring for the dying and their families on surgeons - an AI assisted systematic scoping review.
Fuente:Bmc Surgery
Tipo de trabajo:Revisión
Extracto:
This AI assisted SSR in SEBA
confirms that surgeons do suffer from the cumulative effects of caring for dying
patients and their families and from the death of the patient and supporting the
family and members of the interprofessional team and trainees. Without timely and
personalized support surgeons are prone to depression, burnout, and substance
abuse, and compromises to patient and family experiences, outcomes, safety and
satisfaction. The need for effective longitudinal and personalized assessment
tools is clear.
Cita:BMC Surg 2025 Feb 5; 25 (1) : 56.
Autor/es:Tan, Jun Rong (a) Ong, Yun Ting (b)
institución:(a) Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block, Level 11, Block 1E, Kent Ridge Road, Singapore, 119228, Singapore. (b) Division of Cancer Education, National Cancer Centre Singapore, 30 Hospital Boulevard, Singapore, 168583, Singapore.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Management of volume load for patients undergoing hemodialysis via WeChat and home monitoring in China: a protocol for a cluster-randomized trial.
Management of volume load for patients undergoing hemodialysis via WeChat and home monitoring in China: a protocol for a cluster-randomized trial.
Fuente:Bmc Nephrology
Extracto:
Registered
13 March 2024.
Claves:Hemodialysis, Home monitoring, Interdialytic weight gain, Protocol, Volume overload, WeChat
Cita:BMC Nephrol 2025 Feb 6; 26 (1) : 58.
Autor/es:Wang, Xiaocui (a) Yan, Bonan (b)
institución:(a) Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, China. (b) Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Clinical outcome analysis for surgical fixation versus conservative treatment on rib fractures
Clinical outcome analysis for surgical fixation versus conservative treatment on rib fractures
Fuente:World Journal of Emergency Surgery Wjes
Tipo de trabajo:Metanálisis
Extracto:
SSRF
reduces mortality in patients with multiple rib fractures compared to
conservative management, particularly in those with flail chest and in patients
over 60 years of age. It also offers benefits in terms of pneumonia incidence and
DMV for patients with flail chest. Early SSRF may significantly reduce HLOS and
DMV. However, careful screening of appropriate candidates is crucial to maximize
the benefits of SSRF.
institución:(a) Department of Cardiothoracic Surgery, Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China. (b) Department of Cardiothoracic Surgery, Jinling Hospital, School of Medicine, Southeast University, Nanjing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
AI-based medical ethics education: examining the potential of large language models as a tool for virtue cultivation.
AI-based medical ethics education: examining the potential of large language models as a tool for virtue cultivation.
Fuente:Bmc Medical Education
Extracto:
The study involved a
comprehensive exploration of the function of LLMs in medical ethics education,
positing that tools such as ChatGPT can profoundly enhance the learning
experience in the future. This is achieved through tailored, interactive
educational encounters while addressing the ethical nuances of their use in
educational settings.
institución:(a) Graduate School of Humanities and Social Sciences, Hiroshima University, Higashi-Hiroshima, Japan. (b) Uehiro Division for Applied Ethics, Graduate School of Humanities and Social Sciences, Hiroshima University, Higashi-Hiroshima, Japan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
What's the role of kindness in the healthcare context? A scoping review.
What's the role of kindness in the healthcare context? A scoping review.
Fuente:Bmc Health Services Research
Tipo de trabajo:Revisión
Extracto:
The need for additional research on kindness in healthcare arises
from a complex and dynamic healthcare environment, where the concept of kindness
holds the potential to revolutionize the quality of care and the well-being of
healthcare providers. The interest of the various countries in the 4 thematic
categories proposed by the study and the performance results of healthcare
organizations promoting kindness compared to others without this focus also bear
further consideration.
Cita:BMC Health Serv Res 2025 Feb 5; 25 (1) : 207.
Autor/es:Greco, Angela (a) González-Ortiz, Laura G (b)
institución:(a) Ospedale Regionale Di Locarno, Ente Ospedaliero Cantonale, Casella Postale, Locarno, CH, 6601, Switzerland. pierangela.greco@eoc.ch. (b) Università Degli Studi Di Roma Tor Vergata, Via Cracovia, 50, Rome, 00133, Italy. pierangela.greco@eoc.ch.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Is surgery superior for distal ulna fractures? a comprehensive systematic review and meta-analysis.
Is surgery superior for distal ulna fractures? a comprehensive systematic review and meta-analysis.
Fuente:Journal of Orthopaedic Surgery and Research
Tipo de trabajo:Revisión sistemática
Extracto:
While surgical
management may offer a higher union rate, the choice of treatment should be
individualized, balancing the potential benefits against the risks of surgery, as
ORIF implants are typically associated with higher ulnar-sided pain rates and
limited ulnar deviation due to implant prominence. Future research should focus
on standardizing study designs to improve the quality of evidence in the
management of distal ulna fractures. LEVEL OF EVIDENCE I: Evidence from a
meta-analysis and systematic review from all relevant studies.
institución:(a) Traumatology and Orthopedics Department B, Mohammed VI University Hospital, Marrakesh, Morocco. z.chabihi@gmail.com. (b) Laboratory of Clinical and Epidemiological Research in Bone and Joint Pathology, Marrakesh, Morocco. z.chabihi@gmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Indications, contributing factors, and short-term outcomes of pneumonectomy: an 8-year retrospective study in a resource-limited setting.
Indications, contributing factors, and short-term outcomes of pneumonectomy: an 8-year retrospective study in a resource-limited setting.
Fuente:Journal of Cardiothoracic Surgery
Extracto:
ND RECOMMENDATIONS: In our
setting, pneumonectomy is most commonly performed for inflammatory conditions.
Significant factors associated with the procedure include a history of
tuberculosis treatment, intraoperative blood loss > 500 mL, and surgical
duration > 180 min. To reduce the need for pneumonectomy, strategies should focus
on tuberculosis prevention, screening, and proper patient evaluation and
diagnosis before treatment, to prevent extensive lung damage that often
necessitates this procedure.
institución:(a) Department of Surgery, Adama Hospital Medical College, Adama, Ethiopia. mekananfs@gmail.com. (b) Department of Surgery, Addis Ababa University, Addis Ababa, Ethiopia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
This study provides valuable insights for academics,
industry practitioners, and policymakers to harness transformative potential of
AI in finance. This research offers a foundation for future studies and practical
applications by addressing key gaps and promoting interdisciplinary and ethical
approaches in a rapidly evolving field.
Extracto:
Despite the
broadening of search criteria to capture the evolving nature of AI in health
care, the review underscores a significant gap in focused studies on the required
competencies. Moreover, the review highlights the critical role of regulatory
bodies such as the US Food and Drug Administration in facilitating the adoption
of AI technologies by establishing trust and standardizing algorithms. Key areas
were identified for developing competencies among health care professionals for
the implementation of AI, including: AI fundamentals knowledge (more focused on
assessing the accuracy, reliability, and validity of AI algorithms than on more
technical abilities such as programming or mathematics), data analysis skills
(including data acquisition, cleaning, visualization, management, and
governance), and ethical and legal considerations. In an AI-enhanced health care
landscape, the ability to humanize patient care through effective communication
is paramount. This balance ensures that while AI streamlines tasks and
potentially increases patient interaction time, health care professionals
maintain a focus on compassionate care, thereby leveraging AI to enhance, rather
than detract from, the patient experience. .
Autor/es:Gazquez-Garcia, Javier (a) Sánchez-Bocanegra, Carlos Luis (b)
institución:(a) Servicio Andaluz de Salud, Distrito Sanitario Almeria, Almeria, Spain. (b) Faculty of Health Sciences, Universidad Oberta de Catalunya (UOC), Barcelona, Spain.
Transplant Patients' Perceptions About Participating in First-in-Human Pig Kidney Xenotransplant Clinical Trials: A Mixed Methods Study.
Transplant Patients' Perceptions About Participating in First-in-Human Pig Kidney Xenotransplant Clinical Trials: A Mixed Methods Study.
Fuente:Xenotransplantation
Extracto:
Transplant programs planning xenotransplant trials should anticipate
these types of concerns for optimizing human subject protections and conducting a
robust informed consent process.
institución:(a) Department of Surgery, and Center for Biomedical Ethics and Society, Vanderbilt University Medical Center, Nashville, Tennessee, USA. (b) Senior Research Scholar, The Hastings Center, Garrison, New York, USA.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Expansion of induced pluripotent stem cells under consideration of bioengineering aspects: part 1.
Expansion of induced pluripotent stem cells under consideration of bioengineering aspects: part 1.
Fuente:Applied Microbiology and Biotechnology
Extracto:
KEY POINTS: • Ns1u can be used as a scale-up criterion for hiPSC
cultivations in MC-operated stirred bioreactors • Uniform distribution and
attachment of cells to the MCs are crucial for efficient expansion • Perfusion is
advantageous and supports the cultivation of hiPSCs.
Cita:Appl Microbiol Biotechnol 2025 Feb 6; 109 (1) : 37.
Autor/es:Schneider, Samuel Lukas (a) Teale, Misha Alexander (b)
institución:(a) Centre for Cell Cultivation Techniques, Tissue Engineering, and Medical Biology, Institute of Chemistry and Biotechnology, ZHAW Zurich University of Applied Sciences, Grüentalstrasse 14, 8820, Wädenswil, Switzerland. (b) Centre for Cell Cultivation Techniques, Tissue Engineering, and Medical Biology, Institute of Chemistry and Biotechnology, ZHAW Zurich University of Applied Sciences, Grüentalstrasse 14, 8820, Wädenswil, Switzerland.
Conflicto:Declarations. Ethical approval: This article does not contain studies performed on human or animal participants by any of the manuscript's authors. Conflict of interest: M.A.T., S.L.S., S.S., D.E., and R.E. declare no competing interests. J.K., M.P., and M.F.Q.S. are employees of Bayer AG.
Expansion of induced pluripotent stem cells under consideration of bioengineering aspects: part 2.
Expansion of induced pluripotent stem cells under consideration of bioengineering aspects: part 2.
Fuente:Applied Microbiology and Biotechnology
Extracto:
Key Points
•Bioengineering characterizations allowed the identification of operating ranges
that supported satisfactory hiPSC expansion •Both the Xpansion(®) 10 multiplate
and Ascent™ 1 m(2) fixed-bed reactor accommodated the production of almost 5 ×
10(9) viable cells within 5 days •Exposing the hiPSCs to a median wall shear
stress of up to 8.2 × 10(-5) N cm(-2) did not impair quality.
Cita:Appl Microbiol Biotechnol 2025 Feb 6; 109 (1) : 38.
Autor/es:Teale, Misha Alexander (a) Schneider, Samuel Lukas (b)
institución:(a) Centre for Cell Cultivation Techniques, Tissue Engineering, and Medical Biology, Institute of Chemistry and Biotechnology, ZHAW Zurich University of Applied Sciences, Grüentalstrasse 14, 8820, Wädenswil, Switzerland. (b) Centre for Cell Cultivation Techniques, Tissue Engineering, and Medical Biology, Institute of Chemistry and Biotechnology, ZHAW Zurich University of Applied Sciences, Grüentalstrasse 14, 8820, Wädenswil, Switzerland.
Conflicto:Declarations. Ethical approval: This article does not contain studies performed on human or animal participants by any of the manuscript’s authors. Conflict of interest: M.A.T., S.L.S., S.S., D.E., and R.E. declare no competing interests. J.K., M.P., and M.F.Q.S. are employees of Bayer AG.
Dietary supplementation of Astragalus polysaccharide or its nanoparticles enhances testicular hemodynamics, echotexture, scrotal circumference, concentration of testosterone, estradiol, nitric oxide, and total antioxidant capacity, and semen quality in mature Ossimi rams.
Dietary supplementation of Astragalus polysaccharide or its nanoparticles enhances testicular hemodynamics, echotexture, scrotal circumference, concentration of testosterone, estradiol, nitric oxide, and total antioxidant capacity, and semen quality in mature Ossimi rams.
Fuente:Bmc Veterinary Research
Extracto:
So, it could be recommended as
a dietary supplementation (2 g/ram/day) for enhancing the reproductive
performance of rams.
institución:(a) Department of Theriogenology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt. (b) Department of Theriogenology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Patients' and plastic surgeons' experiences with an online patient decision aid for breast reconstruction: considerations for nationwide implementation.
Patients' and plastic surgeons' experiences with an online patient decision aid for breast reconstruction: considerations for nationwide implementation.
Fuente:Bmc Medical Informatics and Decision Making
Extracto:
As the BR pDA was highly valued by its end users, the identified
factors for implementation should be taken into account.
Claves:Breast neoplasms, Breast reconstruction, Implementation, Informational needs, Patient decision aid, Process evaluation, Shared decision making, eHealth
Cita:BMC Med Inform Decis Mak 2025 Feb 6; 25 (1) : 62.
Autor/es:Stege, Jacqueline A Ter (a) Engelhardt, Ellen G (b)
institución:(a) Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands. (b) Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Conflicto:Declarations. Ethics approval and consent to participate: This research protocol was examined by the accredited Medical Research Ethics Committee of the Netherlands Cancer Institute. They concluded that, considering the length and nature of the questionnaires, the obligation to fulfil the specific requirements of the Dutch law for Medical Research Involving Human Subjects was waived (reference: METC17.0652). Local approval was obtained...
from participating hospitals. All participating patients signed an informed consent form. This study was conducted in accordance with local laws and regulations. Consent for publication: No details, images, or videos of patients are presented in the manuscript. The people depicted in Fig. 1 are co-authors and a colleague who have consented to the use of their image for the purpose of this study. Competing interests: R. The is co-founder and CEO of ZorgKeuzeLab. K. Karssen is co-founder and technical director of ZorgKeuzeLab. After trial completion, ZorgKeuzeLab will request user fees from hospitals to implement the decision aid. Under certain conditions, the NKI-AVL will receive a percentage of these user fees. None of the other authors have competing interests.
