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While most of the selected texts belong to original articles,
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Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer's disease: a neuropsychological data-driven approach.
Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer's disease: a neuropsychological data-driven approach.
Fuente:Alzheimer's Research & Therapy
Extracto:
A neuropsychological data-driven method to phenotype EOAD individuals
uncovered a more detailed understanding of the presenting heterogeneity in this
atypical AD sample compared to clinical judgment alone. Clinicians and patients
may over-report memory dysfunction at the expense of non-memory symptoms. These
findings have important implications for diagnostic accuracy and treatment
considerations.
institución:(a) Frontotemporal Disorders Unit and Massachusetts Alzheimer's Disease Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Charlestown, Boston, MA, 02129, USA. dputcha@mgh.harvard.edu. (b) Frontotemporal Disorders Unit and Massachusetts Alzheimer's Disease Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Charlestown, Boston, MA, 02129, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
By examining current guidelines, ethical
considerations, and practical cases, this paper aims to offer insights into
fostering fair and transparent authorship practices in the field of clinical
oncology.
Coping strategies utilized by patients with cervical cancer: an explorative qualitative study at the Ocean Road Cancer Institute in Dar es Salaam, Tanzania.
Coping strategies utilized by patients with cervical cancer: an explorative qualitative study at the Ocean Road Cancer Institute in Dar es Salaam, Tanzania.
Fuente:Bmc Women's Health
Extracto:
Cervical cancer patients employ a
diverse array of coping strategies to manage their condition. While many
strategies observed were adaptive, some proved to be maladaptive, underscoring
the importance of ongoing assessments to bolster adaptive coping mechanisms among
this population.
Claves:Cervical cancer, Coping mechanisms, Coping strategies, Women
Cita:BMC Womens Health 2025 Feb 11; 25 (1) : 59.
Autor/es:Ambikile, Joel Seme (a) Msengi, Emanueli Amosi (b)
institución:(a) Department of Clinical Nursing, Muhimbili University of Health and Allied Sciences, United Nations Road, P. O. Box 65001, Dar es Salaam, Tanzania. joelambikile@yahoo.com. (b) Muhimbili University of Health and Allied Sciences, United Nations Road, P. O. Box 65001, Dar es Salaam, Tanzania.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Is There a Need to Reassess Protein Intake Recommendations Following Metabolic Bariatric Surgery?
Is There a Need to Reassess Protein Intake Recommendations Following Metabolic Bariatric Surgery?
Fuente:Current Obesity Reports
Tipo de trabajo:Guía
Extracto:
Ultimately, in alignment with recent literature, a more
specific and personalized dietary protein approach should be examined.
Claves:Health outcomes, Metabolic Bariatric Surgery, Obesity, Protein Requirements
Cita:Curr Obes Rep 2025 Jan 29; 14 (1) : 15.
Autor/es:Ben-Porat, Tair (a) Lahav, Yair (b)
institución:(a) School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel. tairbp20@gmail.com. (b) Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine and Sylvan Adams Sports Institute, Tel-Aviv, Israel.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The role of renal dual-energy computed tomography in exploring the gouty kidney: the RENODECT study.
The role of renal dual-energy computed tomography in exploring the gouty kidney: the RENODECT study.
Fuente:Annals of Medicine
Extracto:
DECT is unable
to detect genuine monosodium urate crystal deposits in kidneys and renal artery
walls, and but can characterize chronic asymptomatic urolithiasis.
institución:(a) Department of Rheumatology, Lille Catholic University, Saint-Philibert Hospital, ETHICS laboratory, Lille, EA, France. (b) Department of Rheumatology, Lille Catholic University, Saint-Philibert Hospital, ETHICS laboratory, Lille, EA, France.
Conflicto:No potential conflict of interest was reported by the author(s).
Examining priorities and investments made through the Global Financing Facility for maternal and newborn health: a sub-analysis on quality.
Examining priorities and investments made through the Global Financing Facility for maternal and newborn health: a sub-analysis on quality.
Fuente:Global Health Action
Extracto:
The
GFF is at the forefront of investing in MNH globally and provides an important
opportunity to explicitly link health systems investments and quality
interventions within the MNH continuum of care for optimal impact.
Claves:Global Financing Facility, Global Financing Facility for Women, Children and Adolescents: Examining National Priorities, Processes and Investments, Maternal and newborn health, content analysis, health systems strengthening, quality of care
Cita:Glob Health Action 2024 Dec 31; 17 (1) : 2406486.
Autor/es:Kumar, Meghan Bruce (a) Kinney, Mary (b)
institución:(a) Department of Nursing, Midwifery and Health, Northumbria University, Newcastle upon Tyne, UK. (b) Department of Health System and Research Ethics, KEMRI-Wellcome Trust Programme, Nairobi, Kenya.
Conflicto:No potential conflict of interest was reported by the author(s).
Judges versus artificial intelligence in juror decision-making in criminal trials: Evidence from two pre-registered experiments.
Judges versus artificial intelligence in juror decision-making in criminal trials: Evidence from two pre-registered experiments.
Fuente:Plos One
Tipo de trabajo:Revisión
Extracto:
Across both
experiments, participants showed no preference for deferring to human judges' or
AI judgments when making sentencing decisions. While suspended sentences were
more common in cases with mitigating circumstances, this tendency was unrelated
to the judgment source. These findings suggest that jurors do not inherently
avoid algorithmic judgments and may consider AI opinions on par with those of
human judges in certain contexts. However, whether this leads to improved
decision-making quality remains an open question, as objectivity (a strength of
AI) and emotional considerations (a safeguard for fairness) may interact in
complex ways during juror deliberations. Future research should further explore
how these factors influence juror attitudes and decisions in diverse trial
scenarios, taking into account potential biases in existing literature.
Cita:PLoS One 2025; 20 (1) : e0318486.
Autor/es:Watamura, Eiichiro (a) Liu, Yichen (b)
institución:(a) Graduate School of Human Sciences, Osaka University, Suita, Osaka, Japan. (b) Graduate School of Human Sciences, Osaka University, Suita, Osaka, Japan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature
Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature
Fuente:Rmd Open
Tipo de trabajo:Consenso
Extracto:
Those results demonstrate the heterogeneity of labels used to describe CPPD
condition concepts, with wide variation in condition labels in the medical
literature. This work provides the rationale and basis to achieve agreement about
CPPD technical nomenclature.
Autor/es:Jauffret, Charlotte (a) Adinolfi, Antonella (b)
institución:(a) Rheumatology Department, Lille Catholic University, Saint Philibert Hospital, EA 7446 - ETHICS, Lille, France. (b) University of Lille, ULR 2694 - METRICS, CERIM, Lille, France.
Conflicto:Competing interests: GF has received a research grant from Eli Lilly for an Investigator Initiated Trial. Others: none.
Re-architecture for requirements of academic space development in the universities: design and validitation of RASD questionnaire.
Re-architecture for requirements of academic space development in the universities: design and validitation of RASD questionnaire.
Fuente:Scientific Reports
Extracto:
Perhaps the choice of this term
is appropriate because we also need changes in universities, by combining
science, re-engineering, cultural considerations, and an artistic integration of
all factors influencing academic development.
Claves:Academic space development, Higher education, Requirements, University
institución:(a) Department of E-Learning in Medical Sciences, Virtual School and Center of Excellence in E-Learning, Shiraz University of Medical Sciences, Shiraz, Iran. Karimian@sums.ac.ir. (b) Department of Leadership and Educational management, Faculty of Psychology and Educational Sciences, Shahid Beheshti University, Tehran, Iran. M-abolghasemi@sbu.ac.ir.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
COVID-19 status and utilisation of essential maternal and child healthcare services during the pandemic in Ahmedabad, India.
COVID-19 status and utilisation of essential maternal and child healthcare services during the pandemic in Ahmedabad, India.
Fuente:Bmc Pregnancy and Childbirth
Extracto:
Utilisation of essential maternal and child healthcare services was lower among
women who were COVID-19 positive compared to those who were not. Social and
health system determinants for disrupting healthcare services during the pandemic
were fear of infection and unavailability of the health workforce. Health
planners and policymakers are encouraged to take into consideration of these
findings while building resilient health care for managing future pandemics.
Claves:Ahmedabad, COVID-19 pandemic, Disruption, Healthcare service utilisation, India, Maternal & child healthcare services
Cita:BMC Pregnancy Childbirth 2025 Jan 30; 25 (1) : 100.
Autor/es:Yasobant, Sandul (a) Lekha, K Shruti (b)
institución:(a) Department of Public Health Science, Indian Institute of Public Health Gandhinagar (IIPHG), Gandhinagar, Gujarat, India. yasobant@iiphg.org. (b) Centre for One Health Education, Research & Development (COHERD), Indian Institute of Public Health Gandhinagar (IIPHG), Opp. Air Force Head Quarters, Nr. Lekawada, Gandhinagar, 382042, Gujarat, India. yasobant@iiphg.org.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Identifying novel heterozygous PI4KA variants in fetal abnormalities.
Identifying novel heterozygous PI4KA variants in fetal abnormalities.
Fuente:Bmc Medical Genomics
Tipo de trabajo:Orientaciones y guía
Extracto:
This study
extended the mutational spectrum of PI4KA and may provide guidance for genetic
counseling. Functional studies confirmed that the identified variant induces
alterations in RNA splicing and impairs enzyme activity.
institución:(a) Ultrasound Diagnosis Department, Maternal and Child Health Hospital of Hubei Province, Wuhan, 430070, China. (b) Ultrasound Diagnosis Department, Maternal and Child Health Hospital of Hubei Province, Wuhan, 430070, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Incidence and predictors of adverse birth outcomes among women who gave birth at Assosa general hospital, Northwest Ethiopia
Incidence and predictors of adverse birth outcomes among women who gave birth at Assosa general hospital, Northwest Ethiopia
Fuente:Bmc Pregnancy and Childbirth
Tipo de trabajo:Estudio de cohortes
Extracto:
There was a high incidence of adverse birth outcomes in the study area. This
study revealed that inadequate antenatal care follow-up, malaria, hypertension,
hemoglobin < 11 g/dl, and a mid-upper arm circumference < 23 cm were predictors
of adverse birth outcomes. Governments and health authorities should prioritize
policies and programs that are aimed at reducing adverse birth outcomes.
Improving maternal health services, nutrition education, early diagnosis, and
treatment can help to manage most of these predictors.
institución:(a) Department of Public Health, College of Health Science, Assosa University, Benishangul-Gumuz region, Assosa Town, Ethiopia. oliyadtadesse123@gmail.com. (b) Department of Public Health, College of Health Science, Assosa University, Benishangul-Gumuz region, Assosa Town, Ethiopia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Usp7 contributes to the tail regeneration of planarians via Islet/Wnt1 axis.
Usp7 contributes to the tail regeneration of planarians via Islet/Wnt1 axis.
Fuente:Journal of Translational Medicine
Extracto:
Collectively, Usp7 is necessary for tissue regeneration and tail
blastema formation partially by regulating the cell proliferation and apoptosis
during planarian regeneration. It could also promote the posterior polarity
reconstruction of the regenerative planarians via the Islet/Wnt1 axis.
Claves:Islet, Planarian, Regeneration, USP7, Wnt1
Cita:J Transl Med 2025 Jan 30; 23 (1) : 137.
Autor/es:Liang, Ang (a) Liu, Jinglong (b)
institución:(a) College of Life Science, Henan Normal University, Xinxiang, Henan, China. (b) School of Nursing, Xinxiang Medical University, Xinxiang, Henan, China.
Conflicto:Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: All authors consent to publication. Competing interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Targeting PCSK9, through an innovative cVLP-based vaccine, enhanced the therapeutic activity of a cVLP-HER2 vaccine in a preclinical model of HER2-positive mammary carcinoma.
Targeting PCSK9, through an innovative cVLP-based vaccine, enhanced the therapeutic activity of a cVLP-HER2 vaccine in a preclinical model of HER2-positive mammary carcinoma.
Fuente:Journal of Translational Medicine
Extracto:
The results indicate that cVLP-PCSK9
vaccination shows adjuvant activity when combined with cVLP-HER2 vaccine,
enhancing its therapeutic efficacy against HER2-positive breast cancer and
holding promise in overcoming the challenges posed by resistance and incomplete
responses to HER2-targeted therapy.
Claves:Breast cancer, Cancer progression, HER2, PCSK9, Therapeutic cancer vaccines, Therapy resistance, Virus-like particle (VLP)-based vaccine
Cita:J Transl Med 2025 Jan 30; 23 (1) : 136.
Autor/es:Scalambra, Laura (a) Ruzzi, Francesca (b)
institución:(a) Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy. (b) Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy. francesca.ruzzi2@unibo.it.
Conflicto:Declarations. Ethics approval and consent to participate: All in vivo experiments were performed according to Italian and European laws and were authorized by the Italian Ministry of Health (letter 714–2017-PR). Consent for Publication: Not applicable. Competing interests: L.G., C.F. and A.F.S. are listed as co-inventors on a patent application covering the Delivery of a cVLP-based modular vaccine platform in a...
a nucleic acid platform (P5856PC00). Employees of AdaptVac (L.G., C.F. and A.F.S.), a company commercializing virus-like particle display technology and vaccine, including several patents.
Putting the broken pieces of life together, Baloch family caregivers' confrontation with schizophrenia: a phenomenological study.
Putting the broken pieces of life together, Baloch family caregivers' confrontation with schizophrenia: a phenomenological study.
Fuente:Bmc Psychology
Extracto:
For a family with a member
with schizophrenia, restoring family life is a top priority. However,
schizophrenia is so debilitating and destructive that it threatens not only the
peace of the family but also the survival of the family, and it requires constant
effort and complete support to restore and maintain life.
Claves:Coping strategies, Family caregiver, Qualitative study, Schizophrenia
institución:(a) Nursing Department, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran. (b) Nursing Department, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran. fatemehdarban@gmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Drug-related macular edema: a real-world FDA Adverse Event Reporting System database study.
Drug-related macular edema: a real-world FDA Adverse Event Reporting System database study.
Fuente:Bmc Pharmacology & Toxicology
Extracto:
This study utilizes the
FAERS database to investigate potential associations between drug use and the
occurrence of ME, rapidly identify drugs that may induce the condition, and
propose research strategies. These findings hold significant value for guiding
clinical medication practices.
Claves:Adverse drug reactions, Disproportional analysis, Drug-induced macular edema, FAERS database, Real-world study
Cita:BMC Pharmacol Toxicol 2025 Jan 30; 26 (1) : 23.
Autor/es:Li, Xiang (a) Sun, Yi-Qing (b)
institución:(a) Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, China. (b) Chongqing Three Gorges Medical College, Wanzhou, 404120, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Discontinuation and Reinitiation of Dual-Labeled GLP-1 Receptor Agonists Among US Adults With Overweight or Obesity.
Discontinuation and Reinitiation of Dual-Labeled GLP-1 Receptor Agonists Among US Adults With Overweight or Obesity.
Fuente:Jama Network Open
Tipo de trabajo:Estudio de cohortes
Extracto:
AND RELEVANCE: In this cohort
study, most patients with overweight or obesity discontinued GLP-1 RA therapy
within 1 year, but those without type 2 diabetes had higher discontinuation rates
and lower reinitiation rates. Inequities in access and adherence to effective
treatments have the potential to exacerbate disparities in obesity.
Cita:JAMA Netw Open 2025 Jan 2; 8 (1) : e2457349.
Autor/es:Rodriguez, Patricia J (a) Zhang, Vincent (b)
institución:(a) Truveta Inc, Bellevue, Washington. (b) Healthcare Transformation Institute, Department of Medical Ethics and Health Policy, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
Conflicto:Conflict of Interest Disclosures: Dr Emanuel reported receiving personal fees from the University of California San Francisco, Advocate Aurora Health, Cain Brothers, Bowdoin College, The Suntory Foundation, Ontario Hospital Association, University of Oklahoma, Sanford Health, Health Plan Alliance, Emory Health Care, and Employer Direct Health Care; nonfinancial support from Galien Foundation, Hlth Inc, National University of Singapore, Hawaii Medical Services...
Association, Tel Aviv University, The Quadrangle, Lazard, University of Bergen, University of Virginia, New York Historical Society, Amangiri, Forerunner Conference, BCEPS International Symposium, Future of Science, Cell and Gene Therapy, and Arendalsuka Meeting during the conduct of the study; and serving as a member of the Board of Advisors for Cellares Corp, advisor for Clarify Health Solutions, advisor for Notable Health, member of the Advisory Board for JSL Health, member of the Advisory Board for Peterson Center of Healthcare, special advisor to the Director General of the World Health Organization (WHO), member of the Expert Advisory Group WHO COVID-19 committee, member of the Advisory Board of the HIEx Health Innovation Exchange Partnership sponsored by the United Nations, member of the WHO Expert Group on Ethics & Governance of Outbreaks/Emergencies, member of the WHO Guideline Development Group on the Use and Indications of GLP-1s for Adults Living With Obesity, member of the Internal Advisory Board of The Penn Parity Center, advisor for Link Health Technologies, advisor for Nuna Health, member of the Board of Advisors of Alto Pharmacy, consultant for Korro/Coach AI, consultant for Aberdeen Inc, member of the Advisory Board of FeelBetter Inc, member of the Advisory Board of Biden’s Transition COVID-19 Committee, and member of the JAMA Editorial Board. No other disclosures were reported.
Are we capturing individual differences? Evaluating the test-retest reliability of experimental tasks used to measure social cognitive abilities.
Are we capturing individual differences? Evaluating the test-retest reliability of experimental tasks used to measure social cognitive abilities.
Fuente:Behavior Research Methods
Extracto:
Researchers investigating individual differences must assess
the test-retest reliability of their measures.
Claves:Dot Perspective-Taking task, Emotional Go/No-Go task, Experimental social cognition, Explicit bias, Implicit Association Test, Individual differences, Interpersonal Reactivity Index, State Affective Empathy task, Stimulus–Response Compatibility task, Test–retest reliability
Cita:Behav Res Methods 2025 Jan 31; 57 (2) : 82.
Autor/es:Pennington, Charlotte R (a) Birch-Hurst, Kayley (b)
institución:(a) School of Psychology, College of Health & Life Sciences, Aston University, Birmingham, B4 7ET, UK. c.pennington@aston.ac.uk. (b) School of Psychology, College of Health & Life Sciences, Aston University, Birmingham, B4 7ET, UK.
Conflicto:Declarations. Ethics approval: This study received ethical approval from the Institutional Review Board at the University of the West of England (REF: HAS.18.07.21). Consent to participate: All participants provided written informed consent to participate. Consent for publication: All participants provided written informed consent for their data to be reported in aggregate in scientific publications and conference proceedings. Conflicts of Interest:...
None.
Fitness-to-work considerations in the paradigmatic pain condition of headache disorder.
Fitness-to-work considerations in the paradigmatic pain condition of headache disorder.
Fuente:The Journal of Headache and Pain
Extracto:
As clinicians often
struggle with fitness-to-work determinations, a structured approach to
fitness-to-work assessments in headache conditions and other pain conditions
would improve clarity for clinicians and increase the quality of care provided to
patients, with potential benefits for workplace safety and policy in this arena
as well.
Claves:Fitness-to-work, Headache disorders, Occupational health
Cita:J Headache Pain 2025 Jan 31; 26 (1) : 21.
Autor/es:Fan, Xiangning (a) Lytvyak, Ellina (b)
institución:(a) Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. (b) Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Conflicto:Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: XF is employed by Alberta Jobs, Economy and Trade. The content of this paper does not represent an official position of Alberta Jobs, Economy and Trade. CE is funded by the Canadian Centre of Recovery Excellence, has received funding from Workers’ Compensation Board of...
of Alberta, and was previously employed by the College of Physicians and Surgeons of Alberta. SS reports grants from the Workers’ Compensation Board of Alberta, the Government of Alberta, the College of Physicians & Surgeons of Alberta, and the Alberta Medical Association. SS also reports honoraria from the Occupational Medicine Specialist of Canada, the M.S.I. Foundation, the Canadian Centre of Recovery Excellence, and The Policy Works. EL declares no competing interest.
Social vulnerability and genetic service utilization among unaffected BRIDGE trial patients with inherited cancer susceptibility.
Social vulnerability and genetic service utilization among unaffected BRIDGE trial patients with inherited cancer susceptibility.
Fuente:Bmc Cancer
Extracto:
These results underscore the importance of investigating social and structural
mechanisms as potential pathways to increasing genetic testing uptake among
patients with increased inherited risk of cancer. Census information is publicly
available but seldom used to assess social determinants of genetic testing uptake
among unaffected populations. Existing and future cohort studies can incorporate
census data to derive analytic insights for clinical scientists. TRIAL
REGISTRATION: BRIDGE was registered as NCT03985852 on June 6, 2019 at
clinicaltrials.gov.
Claves:Cancer disparities, Cancer predisposition syndromes, Cancer prevention, Carrier screening, Decision making, Early detection, Health technology, Patient experience, Population screening, User interaction
Cita:BMC Cancer 2025 Jan 31; 25 (1) : 180.
Autor/es:Bather, Jemar R (a) Goodman, Melody S (b)
institución:(a) Center for Anti-Racism, Social Justice & Public Health, New York University School of Global Public Health, 708 Broadway, 9th Floor, New York, NY, 10003, USA. jemar.bather@nyu.edu. (b) Department of Biostatistics, New York University School of Global Public Health, New York, NY, USA. jemar.bather@nyu.edu.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
