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SIIC selecciona textos completos de calidad y de reciente publicación en fuentes prestigiosas del mundo
indizadas por SIIC Data Bases, capturadas en las mismas colecciones o en diversas bases especializadas.
La creciente cantidad de artículos con Acceso Abierto (Open
Access) amplía la oferta de lectura pero a su vez también, entre
tanta abundancia, complica al lector en su encuentro con los estudios
fundamentales. Para facilitarlo, profesionales biomédicos de SIIC
consultan diariamente una profusa cantidad de documentos que nutrirán
Textos completos autorizados (TCA).
Las citas de la sección TCA enlazan de manera legal, autorizada y
gratuita con los textos completos (full text) publicados en
los sitios oficiales de sus respectivas fuentes.
SIIC creó, produjo y opera con exclusividad el software TCA para la
interpretación de los diversos campos documentales que integran la
estructura de un estudio: especialidad, modalidad del estudio,
fuente, fechas de publicación y selección, definición de la fuente,
limitaciones de consulta, resumen en castellano, etc.
Si bien la mayoría de los textos seleccionados corresponden a
artículos originales, revisiones y guías, los lectores también
encontrarán comentarios, entrevistas, notas periodísticas, cartas a
autores u otros textos precursores de debates o aclaratorios.
Sociedad Iberoamericana de Información Científica (SIIC) selects
complete quality-full texts which have been recently published in
renowned sources worldwide and are indexed by SIIC Data
Bases.
The increasing number of Open Access articles widens the reading offer
but, also, such myriad complicates the readers search of fundamental
articles. To facilitate this, SIIC biomedical professionals daily
consult a profuse amount of documents that will feed
Authorized Full Texts (TCA, Spanish acronym).
The citations of the AFT section link legally, authorized and free of
charge with the full texts published in the official web sites of
their corresponding sources.
SIIC created, produced and handles the AFT software that deciphers
the various documentary fields that form part of the structure of a
study: specialty, study style, source, publication and selection
dates, source definition, query limitations, summary in Spanish,
etc.
While most of the selected texts belong to original articles,
reviews, and guidelines, readers will also find commentaries,
interviews, journalistic reports, letters to authors or other texts
that may lead to discussions or clarifications.
A comparison of international clinical practice guidelines for postpartum venous thromboembolism prophylaxis.
A comparison of international clinical practice guidelines for postpartum venous thromboembolism prophylaxis.
Fuente:Bmc Pregnancy and Childbirth
Tipo de trabajo:Guía de recomendaciones
Extracto:
There are considerable differences in the rates of women receiving postpartum
pharmacological venous thromboembolism prophylaxis when recommendations from
different international guidelines are applied. These differences reflect the
wide variation in guideline recommendations for the use of LMWH following birth.
Claves:Heparin, Low-molecular-weight, Postpartum, Practice guideline, Pregnancy, Thromboembolism
Cita:BMC Pregnancy Childbirth 2025 Feb 12; 25 (1) : 150.
Autor/es:Ephraums, Sarah (a) Dasgupta, Amrita (b)
institución:(a) Northern Sydney (Arabanoo) Precinct, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. (b) Northern Sydney (Arabanoo) Precinct, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between atherogenic index of plasma and infertility: a cross-sectional study based on U.S. women.
Association between atherogenic index of plasma and infertility: a cross-sectional study based on U.S. women.
Fuente:Lipids in Health and Disease
Extracto:
Incorporating an assessment of AIP
into the clinical evaluation could potentially refine the accuracy of risk
estimation for infertility patients.
Claves:Atherogenic index of plasma, Cross-sectional study, Infertility, NHANES, Reproduction
Cita:Lipids Health Dis 2025 Feb 14; 24 (1) : 51.
Autor/es:Bao, Zihong (a) Zhang, Yanmei (b)
institución:(a) Department of Infectious Diseases, The First Affiliated Hospital of Kunming University Medical College, Kunming, Yunnan, 650032, China. (b) Department of Infectious Diseases, The First Affiliated Hospital of Kunming University Medical College, Kunming, Yunnan, 650032, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Parent-adolescent sexual and reproductive health information communication in Ghana.
Parent-adolescent sexual and reproductive health information communication in Ghana.
Fuente:Reproductive Health
Tipo de trabajo:Revisión sistemática
Extracto:
The study has provided
information on the components of a culturally sensitive SRH information
communication intervention. The contextual information gathered, which explained
the systematic review findings, will be helpful in the adaptation of SRH
information communication intervention.
Claves:Adolescent, Communication, Information, Intervention, Lower- and middle-income countries, Parent, Sexual and Reproductive Health, Systematic review
Cita:Reprod Health 2025 Feb 19; 22 (1) : 25.
Autor/es:Agyei, Frank Bediako (a) Kaura, Doreen K (b)
institución:(a) Department of Nursing and Midwifery, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. frankagyei89@gmail.com. (b) Department of Nursing and Midwifery, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Journal of intellectual & developmental disability
Selección SIIC: 20 Febrero, 2025
Journal of intellectual & developmental disability
Tacit knowledge in medical consultations for patients with profound intellectual and multiple disabilities: An exploratory qualitative study.
Tacit knowledge in medical consultations for patients with profound intellectual and multiple disabilities: An exploratory qualitative study.
Fuente:Journal of Intellectual & Developmental Disability
Extracto:
This study underscores
the important role of TK in consultations for patients with PIMD. Parents' TK
help to shape medical-decisions, urging physicians to validate parents' TK while
relating this TK to other types of medical knowledge.
Claves:PIMD, Tacit knowledge, intellectual disability physician, interdisciplinary consultation, medical care, parents
Cita:J Intellect Dev Disabil 2025 Mar; 50 (1) : 106-115.
Autor/es:Zaal-Schuller, Ilse Harmina (a) Kruithof, K (b)
institución:(a) Department of Ethics, Law & Humanities, Amsterdam UMC, Amsterdam, The Netherlands. (b) Department of Pediatrics, Amsterdam UMC, Emma Children's Hospital, Amsterdam, The Netherlands.
Extracto:
So, vaccination is
only one component: A comprehensive prevention strategy additionally includes
transparent outbreak communication, general hygiene measures, avoiding shared
housing in insufficiently ventilated stables, especially at competition events,
separating animals of different origin wherever possible and, above all,
isolating horses that are already sick or at particular risk of infection.
Autor/es:So, vaccination is
only one component: A comprehensive prevention strategy additionally includes
transparent outbreak communication, general hygiene measures, avoiding shared
housing in insufficiently ventilated stables, especially at competition events,
separating animals of different origin wherever possible and, above all,
isolating horses that are already sick or at particular risk of infection.
institución:So, vaccination is
only one component: A comprehensive prevention strategy additionally includes
transparent outbreak communication, general hygiene measures, avoiding shared
housing in insufficiently ventilated stables, especially at competition events,
separating animals of different origin wherever possible and, above all,
isolating horses that are already sick or at particular risk of infection.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Prenatal gene editing for neurodevelopmental diseases: Ethical considerations.
Prenatal gene editing for neurodevelopmental diseases: Ethical considerations.
Fuente:American Journal of Human Genetics
Extracto:
In considering these alongside current criteria for postnatal gene therapies for
NDDs, we discuss a path forward for prenatal gene editing interventions of NDDs.
institución:(a) Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: ramim@live.unc.edu. (b) Department of Social Medicine and Center for Bioethics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Health Economic Evaluations of Obesity Interventions: Expert Views on How We Can Identify, Interpret, Analyse and Translate Effects.
Health Economic Evaluations of Obesity Interventions: Expert Views on How We Can Identify, Interpret, Analyse and Translate Effects.
Fuente:Applied Health Economics and Health Policy
Extracto:
The creation of a core outcomes set for obesity would standardise
measures for economic evaluations, thereby facilitating more robust cross-country
comparisons of intervention effects and improving the evidence base and overall
quality of future obesity research.
Cita:Appl Health Econ Health Policy 2025 Mar; 23 (2) : 161-169.
Autor/es:Jabakhanji, Samira B (a) Valentelyte, Gintare (b)
institución:(a) Centre for Preventive Medicine and Digital Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, Germany. (b) School of Population Health, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Surgical risk stratification and outcome analysis of Tenckhoff catheter implantations in paediatric patients: a single-centre experience.
Surgical risk stratification and outcome analysis of Tenckhoff catheter implantations in paediatric patients: a single-centre experience.
Fuente:European Journal of Pediatrics
Extracto:
Infants, male patients with kidney disease, prolonged
use of catheter, and those with a GFR of 15-29 ml/kg/1.73 m(2) were at increased
risk. The presence of peritonitis, inguinal hernia, and gastric tubes were
adverse prognostic factors. WHAT IS KNOWN: • Omentectomy can serve as a
protective factor and correlates with a lower incidence of catheter malfunction.
• The insertion of gastric tubes is commonly associated with complications but
has lower risk of complications if inserted prior to the initiation of peritoneal
dialysis. WHAT IS NEW: • Males have been found to have a 2.14 hazard ratio for
revision in both acute and chronic peritoneal dialysis groups. • The incidence of
revisions seems to be greater in the first 36 months, while the incidence of
peritonitis rises by 7% for each additional year of age.
institución:(a) Department of Paediatric Surgery, University Medical Centre Hamburg-Eppendorf (UKE), 20246, Hamburg, Germany. michail.aftzoglou@gmail.com. (b) Laboratory of Hygiene and Epidemiology, Faculty of Medicine, University of Thessaly, 41222, Larissa, Greece.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Supportive care in cancer official journal of the Multinational Association of Supportive Care in Cancer
Selección SIIC: 13 Febrero, 2025
Supportive care in cancer official journal of the Multinational Association of Supportive Care in Cancer
The effect of non-pharmacological interventions on cognitive function in cancer
The effect of non-pharmacological interventions on cognitive function in cancer
Fuente:Supportive Care in Cancer Official Journal of The Multinational Association of Supportive Care in Cancer
Tipo de trabajo:Revisión sistemática
Extracto:
Overall,
non-pharmacological interventions demonstrated efficacy for improving cognition
in cancer. There were limited intervention characteristics within domains which
were consistently related to efficacy. Three key recommendations are provided for
future research: (1) adopt harmonisation and reporting guidelines; (2) develop
definitional guidelines of cognitive domains for CRCI research; and (3) assess
intervention and participant characteristics associated with positive versus
null/negative findings.
Cita:Support Care Cancer 2025 Feb 4; 33 (2) : 151.
Autor/es:Haywood, Darren (a) Henneghan, Ashley M (b)
institución:(a) Human Performance Research Centre, INSIGHT Research Institute, Faculty of Health, University of Technology Sydney (UTS), Driver Avenue, Moore Park, Sydney, NSW, 2021, Australia. darren.haywood@uts.edu.au. (b) Department of Mental Health, St. Vincent's Hospital Melbourne, Fitzroy, VIC, Australia. darren.haywood@uts.edu.au.
Conflicto:Declarations. Ethics approval: Not Applicable. Consent to participate: Not Applicable. Consent for publication: Not Applicable. Competing interests: This project was completed within a MASCC Cognition Fellowship. NHH is an Associate Editor of the Supportive Care in Cancer journal. DH is a MASCC Cognition Fellow; NHH is Chair of MASCC Fatigue and MASCC Exercise Oncology; NHH is a MASCC Terry Langbaum...
Survivorship Fellow; AC is the MASCC President-Elect; RJC is MASCC Treasurer; MBL is MASCC Immediate Past President.
Clinical benefits of the 5th intercostal incision in uniportal VATS for female patients.
Clinical benefits of the 5th intercostal incision in uniportal VATS for female patients.
Fuente:Scientific Reports
Extracto:
These findings support the 5th intercostal
incision as a preferred approach in this patient population, aligning with
precision surgery principles to optimize outcomes.
Claves:5th intercostal incision, Breast tissue preservation, Postoperative pain, Uniportal VATS
Cita:Sci Rep 2025 Feb 4; 15 (1) : 4158.
Autor/es:Wang, Dalin (a) Luo, Zhilin (b)
institución:(a) Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. (b) Department of Thoracic Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China. 650335@hospital.cqmu.edu.cn.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Intracranial pressure monitoring in patients with spontaneous onset of orthostatic headache.
Intracranial pressure monitoring in patients with spontaneous onset of orthostatic headache.
Fuente:The Journal of Headache and Pain
Extracto:
When appropriately selected, patients with a clinical picture highly suggestive
of SIH, who have a negative diagnostic work-up, may benefit from consideration of
invasive ICP monitoring. Moreover, a significant minority of patients with
orthostatic headache may paradoxically have a high CSF pressure state, which can
be detected using ICP monitoring. MEETING PRESENTATIONS: Portions of this work
were presented in abstract and oral presentation form at the Twenty-eighth
Anglo-Dutch Migraine Association meeting (08/06/2018), the Tenth Meeting of the
International Society for Hydrocephalus and Cerebrospinal Fluid Disorders
(20/10/2018; Bologna, Italy), the Society of British Neurological Surgeons 2018
Autumn Meeting (19/09/2018; London, United Kingdom), and the European Association
of Neurosurgical Societies 2023 congress (27/09/2023; Barcelona, Spain). This
work is also part of the doctoral thesis of one of the authors (LD).
institución:(a) National Hospital for Neurology and Neurosurgery, Victor Horsley Department of Neurosurgery, UCL Queen Square Institute of Neurology, Queen Square, London, WC1N 3BG, UK. linda.d'antona@nhs.net. (b) UCL Queen Square Institute of Neurology, Headache and Facial Pain Group, National Hospital for Neurology and Neurosurgery, London, UK.
Conflicto:Declarations. Ethics approval and consent to participate: This study has been approved by the North-East Newcastle and North Tyneside 2 Research Ethics Committee and the Health Research Authority (20/NE/0127). Due to its retrospective nature, written consent to take part in this study was waived. All patients provided written consent to undergo the ICP monitoring procedure as part of their standard...
clinical care. Consent for publication: Not applicable. Competing interests: LD is supported by an Academic Clinical Fellowship from the National Institute for Health Research and was the recipient of a research fellowship sponsored by B.Braun. LDW has received honoraria from and served on advisory boards for Medtronic, B.Braun and Codman. AKT research time was supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre. MSM serves on the advisory board for AbbVie, Pfizer, Eli Lilly, Lundbeck and TEVA and has received payment for the development of educational presentations from AbbVie, Eli Lilly, Lundbeck and TEVA. SC, DM and FB report no disclosures.
Global birth prevalence of major congenital anomalies
Global birth prevalence of major congenital anomalies
Fuente:Bmc Public Health
Tipo de trabajo:Revisión sistemática
Extracto:
This systematic review summarizes birth
prevalence of eight major congenital anomalies. The burdens of these anomalies
had variations in the world. Information of this study could help with better
understanding of epidemiology and etiology of these anomalies.
Claves:Congenital anomalies, Global birth prevalence, Meta-analysis, Systematic review
Cita:BMC Public Health 2025 Feb 4; 25 (1) : 449.
Autor/es:Xie, Xiaolong (a) Pei, Jiao (b)
institución:(a) Department of Pediatric Surgery, West China Hospital, Sichuan University, No.37, Guoxue Alley, Chengdu, Sichuan Province, China. (b) Departmentof Clinical Research, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Ethics and end-of-life in pediatric and neonatal ICUs
Ethics and end-of-life in pediatric and neonatal ICUs
Fuente:Bmc Palliative Care
Tipo de trabajo:Revisión sistemática
Extracto:
This review has shown that papers containing guidelines and
recommendations on end-of-life decision-making in the NICU and PICU promote
similar stances. The ethical principle of beneficence is at the core of the
decision-making process, and all decisions are made focusing on the child's best
interests.
institución:(a) Community Health Centre Zagreb - Centre, Zagreb, Croatia. dianaspoljar@gmail.com. (b) Department for Pediatrics, University Hospital Centre Zagreb, Zagreb, Croatia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
Keratoconus is a complex disorder with a multifaceted etiology and pathogenesis,
including genetic, environmental, biomechanical, and cellular factors. Its
treatment usually requires multiple considerations, including the choice of
surgical methods, anti-inflammatory therapy, and correction of eye rubbing habits
to guide patients for subsequent treatment interventions.
institución:(a) Hebei Provincial Key Laboratory of Ophthalmology, Hebei Provincial Clinical Medical Research Center for Ocular Diseases, Hebei Eye Hospital, Xiangdu District, 399 Quanbei East Street, OphthalmologyXingtai, 054001, China. 43807430@qq.com. (b) Hebei Provincial Key Laboratory of Ophthalmology, Hebei Provincial Clinical Medical Research Center for Ocular Diseases, Hebei Eye Hospital, Xiangdu District, 399 Quanbei East Street, OphthalmologyXingtai, 054001, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Patient experience and burden of haemolytic disease of the foetus and newborn
Patient experience and burden of haemolytic disease of the foetus and newborn
Fuente:Bmc Pregnancy and Childbirth
Tipo de trabajo:Revisión sistemática
Extracto:
The current SR provides a clear summary of
the available evidence for the patient experience and economic burden of HDFN.
While the limited evidence indicates that HDFN does confer a significant burden
on patients, the review identifies the need for further well-powered and
representative observational studies using well-defined outcome measures to aid a
greater understanding of the burden and experience of HDFN. TRIAL REGISTRATION:
The protocol for this systematic review was registered in PROSPERO
CRD42022328444.
Claves:Economic burden, Haemolytic disease of the foetus and newborn, Patient burden, Systematic review
Cita:BMC Pregnancy Childbirth 2025 Feb 4; 25 (1) : 114.
Autor/es:Maurice, P (a) McCallion, J (b)
institución:(a) National Center for Perinatal Hemobiology - Fetal Medicine Department - Armand Trousseau Hospital, AP-HP. Sorbonne Université, Paris, France. (b) Janssen-Cilag EMEA, Wycombe, UK.
Conflicto:Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: PM and JMJ received payment from Janssen Pharmaceuticals for other works but not for this publication. JM, AB, MF, JL, WN, WK and JN are employees of Janssen Pharmaceuticals. EJH, CRM and SAM were employees of Mtech Access whilst the project was undertaken and...
received payment from Janssen Pharmaceuticals to carry out this review.
institución:(a) Department of Experimental Medicine, University of Rome Tor Vergata, Rome, 00133, Italy. manuel.scimeca@uniroma2.it. (b) Department of Experimental Medicine, University of Rome Tor Vergata, Rome, 00133, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
"Lost in translation?" Animal research in the era of precision medicine.
"Lost in translation?" Animal research in the era of precision medicine.
Fuente:Journal of Translational Medicine
Extracto:
In this context, replacement emerges as the key
principle-an imperative that should be prioritized over all other considerations.
Claves:3R, Animal ethics, Evidence-based medicine, Murine models, Precision medicine
Cita:J Transl Med 2025 Feb 4; 23 (1) : 152.
Autor/es:Frühwein, Hamideh (a) Paul, Norbert W (b)
institución:(a) Institute for History, Philosophy and Ethics of Medicine, University Medical Center, Am Pulverturm 13, 55131, Mainz, Germany. h.mahdiani@uni-mainz.de. (b) Institute for History, Philosophy and Ethics of Medicine, University Medical Center, Am Pulverturm 13, 55131, Mainz, Germany.
Conflicto:Declarations. Ethics approval: Not applicable. Consent to participate: Not applicable. Consent for publication: Not applicable. Conflict of interest: Both authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. What the article reports: The article critiques the dominant...
use of animal testing in scientific research, arguing that the historical justification, rooted in figures like Rudolf Virchow’s 19th-century principles, is now outdated due to advancements in non-animal methodologies such as organoids, 3D cultures, and computational models. These technologies offer scientifically robust and ethically viable alternatives, challenging the adequacy of the 3Rs (Reduction, Refinement, Replacement) framework. Citing ethical theories from Nussbaum and Korsgaard, the article argues for a paradigm shift that values animals as beings with intrinsic worth, rather than instruments for human benefit, suggesting that the moral and scientific imperatives for replacement are stronger than ever.
Perspectives of substance use disorder counselors on the benefits and drawbacks of medications for opioid use disorder.
Perspectives of substance use disorder counselors on the benefits and drawbacks of medications for opioid use disorder.
Fuente:Addiction Science & Clinical Practice
Extracto:
As the availability and variety of MOUD treatment
options continue to expand, it is important that SUD counselors are equipped with
evidence-based recommendations for OUD care. We identified misalignments with the
MOUD-prescribing evidence base and stigmatizing language toward MOUD within
counselors' responses, highlighting the potential to refine training materials
for MOUD and mitigate stigmatizing beliefs.
Claves:MOUD, Medications for opioid use disorder, Opioid use disorder, Stigma, Substance use disorder counselors
Autor/es:Cardamone, Nicholas C (a) Stewart, Rebecca E (b)
institución:(a) Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA. nicholas.cardamone@va.gov. (b) Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
De-biasing microbiome sequencing data: bacterial morphology-based correction of extraction bias and correlates of chimera formation.
De-biasing microbiome sequencing data: bacterial morphology-based correction of extraction bias and correlates of chimera formation.
Fuente:Microbiome
Extracto:
Our results indicate that higher DNA density increases
chimera formation during PCR amplification. Furthermore, we show that
computational correction of extraction bias based on bacterial cell morphology
would be feasible using appropriate positive controls, thus constituting an
important step toward overcoming protocol biases in microbiome analysis. Video
Abstract.
institución:(a) Institute of Environmental Medicine and Integrative Health, Faculty of Medicine, University of Augsburg, Augsburg, Germany. luise.rauer@tum.de. (b) Chair of Environmental Medicine, Technical University of Munich, Munich, Germany. luise.rauer@tum.de.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Enhancing microbial predator-prey detection with network and trait-based analyses.
Enhancing microbial predator-prey detection with network and trait-based analyses.
Fuente:Microbiome
Extracto:
Our results support the idea of using
network analyses for inferring predator-prey interactions, but at the same time
call for cautionary consideration of the results, by combining them with
trait-based approaches to increase confidence in the prediction of biological
interactions. Video Abstract.
Autor/es:Martínez Rendón, Cristina (a) Braun, Christina (b)
institución:(a) Terrestrial Ecology, Institute of Zoology, University of Cologne, Zülpicher Str. 47B, 50674, Cologne, Germany. (b) Institute of Ecology and Evolution, Friedrich Schiller University Jena, Dornburger Str. 159, 07743, Jena, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
