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Reference gene selection for real-time qPCR in European flounder (Platichthys flesus) using organ-specific RNA-seq data.
Reference gene selection for real-time qPCR in European flounder (Platichthys flesus) using organ-specific RNA-seq data.
Fuente:Molecular Biology Reports
Extracto:
The proposed approach based on differential
expression analysis and a new bioinformatic tool is an appropriate selection
method of candidates for reference genes in qPCR. The proposed approach,
combining differential expression analysis with a new bioinformatics tool,
provides an effective method for selecting reference gene candidates for qPCR. As
a result, we can propose four genes (polr2f, yif1a, sf3b6, uba52), each with a
set of validated primers, as suitable for consideration as reference genes in
qPCR analysis in European flounder, an emerging model species.
Autor/es:Pomianowski, Konrad (a) Burzyński, Artur (b)
institución:(a) Department of Genetics and Marine Biotechnology, Institute of Oceanology, Polish Academy of Sciences, Powstańców Warszawy 55, Sopot, 81-712, Poland. kpomianowski@iopan.pl. (b) Department of Genetics and Marine Biotechnology, Institute of Oceanology, Polish Academy of Sciences, Powstańców Warszawy 55, Sopot, 81-712, Poland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Justifying Our Credences in the Trustworthiness of AI Systems: A Reliabilistic Approach.
Justifying Our Credences in the Trustworthiness of AI Systems: A Reliabilistic Approach.
Fuente:Science and Engineering Ethics
Extracto:
This approach informs research on the ethics of AI and human-AI
interactions by providing actionable recommendations on how to measure the
reliability of the process through which users perceive the trustworthiness of
the system, investigating its calibration to the actual levels of trustworthiness
of the AI as well as users' appropriate reliance on the system.
Claves:Artificial intelligence, Belief, Credence, Epistemology, Justification, Reliabilism, Trustworthiness, Trustworthy AI
Cita:Sci Eng Ethics 2024 Nov 21; 30 (6) : 55.
Autor/es:Artificial intelligence, Belief, Credence, Epistemology, Justification, Reliabilism, Trustworthiness, Trustworthy AI
institución:(a) Institute of Biomedical Ethics and History of Medicine, University of Zurich, Zurich, Switzerland. aferrario@ethz.ch. (b) ETH Zurich, Zurich, Switzerland. aferrario@ethz.ch.
Conflicto:Declarations. Conflict of interest: No interest to be disclosed. Ethical Approval and Consent to Participate: Not applicable. Consent for Publication: Not applicable.
Know Thyself, Improve Thyself: Personalized LLMs for Self-Knowledge and Moral Enhancement.
Know Thyself, Improve Thyself: Personalized LLMs for Self-Knowledge and Moral Enhancement.
Fuente:Science and Engineering Ethics
Extracto:
Nevertheless, we argue that this approach addresses
limitations in existing AMA proposals reliant on either predetermined values or
introspective self-knowledge.
Claves:Authenticity, Moral AI, Self-knowledge
Cita:Sci Eng Ethics 2024 Nov 21; 30 (6) : 54.
Autor/es:Giubilini, Alberto (a) Porsdam Mann, Sebastian (b)
institución:(a) Uehiro Oxford Institute and Wellcome Centre for Ethics and Humanities, University of Oxford, Oxford, UK. alberto.giubilini@uehiro.ox.ac.uk. (b) Center for Advanced Studies in Bioscience Innovation Law (CeBIL), Faculty of Law, University of Copenhagen, Copenhagen, Denmark.
Conflicto:Declarations. Conflict of interest: Julian Savulescu is a Bioethics Committee consultant for Bayer and a Bioethics Advisor to the Hevolution Foundation.
Exploring the Effects of Variety and Amount of Mindfulness Practices on Depression, Anxiety, and Stress Symptoms: Longitudinal Study on a Mental Health-Focused eHealth System for Patients With Breast or Prostate Cancer.
Exploring the Effects of Variety and Amount of Mindfulness Practices on Depression, Anxiety, and Stress Symptoms: Longitudinal Study on a Mental Health-Focused eHealth System for Patients With Breast or Prostate Cancer.
Fuente:Jmir Mental Health
Extracto:
While more e-MBI practice is linked to reduced anxiety, depression, and stress,
this study emphasizes the crucial role of variety of practice over amount. DM and
DSC are key in shaping intervention effectiveness and may act as protectors
against psychological distress. Using app log data, our research provides a
unique perspective on e-MBI impact, contributing to cancer care understanding and
guiding future studies.
institución:(a) Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, 10043, Italy, 39 0116334200. (b) Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Unit of Biostatistics, University of Padova, Padova, Italy.
Claves:hip, knee, primary prevention, public health, rheumatology, self-management
Cita:BMJ Open 2024 Nov 20; 14 (11) : e083496.
Autor/es:Oomen, Jeanne (a) Schers, Henk (b)
institución:(a) Research and Innovation, Sint Maartenskliniek, Nijmegen, The Netherlands s.oomen@maartenskliniek.nl. (b) Department of Primary and Community Care, Radboudumc, Nijmegen, The Netherlands.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Horticultural Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, P.O. Box: 76169-133, Kerman, Iran. nzeinali@uk.ac.ir. (b) Department of Horticultural Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, P.O. Box: 76169-133, Kerman, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The benefits of septoplasty for patients with deviated nasal septum and allergic rhinitis
The benefits of septoplasty for patients with deviated nasal septum and allergic rhinitis
Fuente:Scientific Reports
Tipo de trabajo:Metanálisis
Extracto:
Patients with a deviated nasal septum and allergic rhinitis benefit
more from septoplasty. However, the procedure should be performed cautiously by
experienced clinicians, taking into account the specific condition of the nasal
septum.
Claves:Allergic rhinitis, Deviated nasal septum, Septoplasty, Systematic review and Meta-analysis
Cita:Sci Rep 2024 Nov 21; 14 (1) : 28855.
Autor/es:Wu, Yu (a) Yu, Tingting (b)
institución:(a) Department of Otolaryngology, Head and Neck Surgery, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130000, Jilin Province, China. (b) Department of Otolaryngology, Head and Neck Surgery, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130000, Jilin Province, China.
Conflicto:Declarations. Ethics approval and consent to participate: This is a systematic review and meta-analysis, ethics approval and consent to participate are not applicable. Consent for publication: Not applicable. This study does not involve human participants. Conflict of interest: The authors declare that they have no conflict of interest.
To investigate endoscopic membranous nasolacrimal duct resection combined with retrograde lacrimal stent placement in the treatment of extremely inferior lacrimal duct obstruction.
To investigate endoscopic membranous nasolacrimal duct resection combined with retrograde lacrimal stent placement in the treatment of extremely inferior lacrimal duct obstruction.
Fuente:Scientific Reports
Extracto:
This approach is recommended for patients with
extremely Inferior lacrimal duct obstruction .
Spontaneous multilevel lumbar pediculolysis associated with spondylolysis
Spontaneous multilevel lumbar pediculolysis associated with spondylolysis
Fuente:Bmc Musculoskeletal Disorders
Tipo de trabajo:Revisión
Extracto:
Multilevel pediculolysis often requires surgical
intervention, and segment instability is an important consideration in the
development of surgical fusion strategies. The etiology of pediculolysis is still
complex and unknown, and the spondylolysis protocol can be used as a reference
for treatment. Surgeons should be cautious in surgical planning to minimize the
likelihood of postoperative instrumentation failure.
Cita:BMC Musculoskelet Disord 2024 Nov 21; 25 (1) : 936.
Autor/es:Chen, Zan (a) Bao, Yusheng (b)
institución:(a) Department of Orthopedics, The Affliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, PR China. (b) Department of Orthopedics, The Affliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, PR China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Problematic alcohol consumption among management undergraduates of Bhaktapur District, Nepal.
Problematic alcohol consumption among management undergraduates of Bhaktapur District, Nepal.
Fuente:Bmc Public Health
Extracto:
This study revealed the concerning prevalence of alcohol consumption and
dependency among Nepali undergraduate students. These findings highlight the need
for comprehensive interventions targeting gender, the family environment, and
academic factors to address alcohol misuse among Nepali youth.
Cita:BMC Public Health 2024 Nov 21; 24 (1) : 3238.
Autor/es:Khadka, Prashant (a) Chalise, Anisha (b)
institución:(a) CiST College, Pokhara Univeristy, Kathmandu, Nepal. (b) Center for Research on Environment, Health and Population Activities (CREHPA), Lalitpur, Nepal.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
Student-run clinics like REACH play a key role
in delivering preventative care to underserved populations, bridging critical
gaps in our healthcare system, and benefiting patients and students alike.
However, the ethical principles of beneficence and non-maleficence should be
considered when student-run clinics decide what services to offer. Preventative
care has been successfully implemented at other student-run clinics but requires
careful arrangement of adequate follow-up care, especially when it comes to
cancer screening. Vaccinations are a low-cost, high-impact initiative that can be
feasibly implemented at most student-run clinics.
Claves:Cancer screening, Ethics, Free clinic, Medical education, Preventative care, Student-run clinic, Vaccines
Cita:BMC Med Educ 2024 Nov 21; 24 (1) : 1345.
Autor/es:Vu, Anhmai (a) Hsu, Andrea R (b)
institución:(a) Mayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, MN, USA. (b) Mayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, MN, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Ethnobotanical review of traditional use of wild food plants in Japan.
Ethnobotanical review of traditional use of wild food plants in Japan.
Fuente:Journal of Ethnobiology and Ethnomedicine
Tipo de trabajo:Revisión
Extracto:
A comparison with those of previous studies on wild species
used in other Asian regions revealed a similar preference for vegetables.
However, notably, in Japan, ferns are also consumed in considerable quantities.
Conversely, further elucidation is clearly needed with respect to certain
matters, including the perception of plant sex and the relationships between
diverse ash components and detoxification techniques. It is evident that further
ethnobotanical research is needed, both in the form of an examination of
ethnographic records and in the field, to gain a deeper understanding of the use
of wild food plants in Japan.
Claves:Asia, Ethnobotany, Food, Foraging, Japan, Traditional knowledge, Wild edible plants, Wild food plants, Wild species
Cita:J Ethnobiol Ethnomed 2024 Nov 21; 20 (1) : 100.
Autor/es:Asia, Ethnobotany, Food, Foraging, Japan, Traditional knowledge, Wild edible plants, Wild food plants, Wild species
institución:Asia, Ethnobotany, Food, Foraging, Japan, Traditional knowledge, Wild edible plants, Wild food plants, Wild species
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Three-arm polyrotaxanes with multidirectional molecular motions as the nanocarrier for nitric oxide-enhanced photodynamic therapy against bacterial biofilms in septic arthritis.
Three-arm polyrotaxanes with multidirectional molecular motions as the nanocarrier for nitric oxide-enhanced photodynamic therapy against bacterial biofilms in septic arthritis.
Fuente:Journal of Nanobiotechnology
Extracto:
In-vivo therapeutic
performance of this platform was demonstrated in a rat septic arthritis model by
eliminating the methicillin-resistant Staphylococcus aureus infection, and
potentiating the immune microenvironment regulation and bone loss inhibition,
also providing a promising strategy to numerous obstinate clinical infections
caused by biofilms.
Cita:J Nanobiotechnology 2024 Nov 21; 22 (1) : 727.
Autor/es:Liu, Shixin (a) Jiang, Yuanfang (b)
institución:(a) Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, The Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan, 517000, China. (b) Department of Nuclear Medicine, PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Spatial and temporal distribution of Ixodes scapularis and tick-borne pathogens across the northeastern United States.
Spatial and temporal distribution of Ixodes scapularis and tick-borne pathogens across the northeastern United States.
Fuente:Parasites & Vectors
Extracto:
Our efforts
revealed the complications of creating a comprehensive dataset of tick abundance
and pathogen prevalence across time and space due to variations in tick
collection and pathogen testing methods. Although tick abundance has not changed
along the more southern latitudes in our study over this time period, and only
gradually changed in the more northern latitudes of our study, human risk for
exposure to tick-borne pathogens has increased due to increased pathogen
prevalence in I. scapularis. This dataset can be used in future studies of I.
scapularis and pathogen prevalence across the northeastern USA and to evaluate
models of I. scapularis ecology and population dynamics.
Claves:Borrelia burgdorferi, Ixodes scapularis, Northeastern United States, Pathogen prevalence
Cita:Parasit Vectors 2024 Nov 22; 17 (1) : 481.
Autor/es:Price, Lucas E (a) Winter, Jonathan M (b)
institución:(a) Department of Geography, Dartmouth College, 6017 Fairchild, Hanover, NH, 03755, USA. Lucas.E.Price@Dartmouth.edu. (b) Department of Geography, Dartmouth College, 6017 Fairchild, Hanover, NH, 03755, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Creating a data warehouse to support monitoring of NSQHS blood management standard from EMR data.
Creating a data warehouse to support monitoring of NSQHS blood management standard from EMR data.
Fuente:Bmc Medical Informatics and Decision Making
Extracto:
This study prioritises streamlined data modeling
and processing, in contrast to conventional dashboard-centric approaches. It
ensures data readiness for decision-making tools, offering insights to clinicians
and validating hospital compliance with national standards in blood management
through efficient design.
Claves:Blood management, Clinical data warehouse, Dashboard, EMR
Cita:BMC Med Inform Decis Mak 2024 Nov 22; 24 (1) : 353.
Autor/es:Cheng-Zarate, David (a) Burns, James (b)
institución:(a) Faculty of Information Technology, Monash University, Melbourne, Australia. david.chengzarate1@monash.edu. (b) Eastern Health, Melbourne, Australia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Evaluating effects of meal delivery on the ability of homebound older adults to remain in the community via a pragmatic, two-arm, randomized comparative effectiveness trial: study protocol for the Deliver-EE trial.
Evaluating effects of meal delivery on the ability of homebound older adults to remain in the community via a pragmatic, two-arm, randomized comparative effectiveness trial: study protocol for the Deliver-EE trial.
Fuente:Trials
Extracto:
Registered on May 02, 2022.
Claves:Aging in place, Community independence, Food insecurity, Healthcare costs, Healthcare utilization, Meal delivery, Older adults, Quality of life
Cita:Trials 2024 Nov 22; 25 (1) : 787.
Autor/es:Thomas, Kali S (a) Bernard, Kimberly P (b)
institución:(a) Johns Hopkins School of Nursing, 525 North Wolfe Street, Baltimore, MD, 21205, USA. kali.thomas@jhu.edu. (b) Center for Gerontology & Healthcare Research, Brown University, Providence, RI, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Cita:Stem Cell Res Ther 2024 Nov 21; 15 (1) : 447.
Autor/es:Song, Seohyun Jennie (a) Nam, Yoojun (b)
institución:(a) Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul, 08826, Republic of Korea. (b) YiPSCELL Inc., L2 Omnibus Park, Banpo-Dearo 222, Seocho-Gu, Seoul, 06591, Republic of Korea.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Academic vs. industry-sponsored trials: A global survey on differences, similarities, and future improvements.
Academic vs. industry-sponsored trials: A global survey on differences, similarities, and future improvements.
Fuente:Journal of Global Health
Tipo de trabajo:Revisión
Extracto:
Our findings indicate that industry-sponsored trials encounter fewer
issues in set-up, funding, and trial conduct compared to academic trials.
Improving collaboration between academic sponsors and ARIs is essential to
address these challenges. ARIs provide critical support and guidance for academic
researchers, not only in planning and implementing projects, but also in
assessing feasibility and securing funding.
institución:(a) Clinical Trials Center, University of Zurich/University Hospital Zurich, Zurich, Switzerland. (b) Clinical Trials Center, University of Zurich/University Hospital Zurich, Zurich, Switzerland.
Conflicto:Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests.
Omphalocele prevalence and co-occurring malformations: a nationwide register-based study of Danish live births in 1997-2021.
Omphalocele prevalence and co-occurring malformations: a nationwide register-based study of Danish live births in 1997-2021.
Fuente:Pediatric Surgery International
Extracto:
Omphalocele birth prevalence in
Denmark was stable over a recent 25-year period. The proportion of infants with
co-occurring major malformations or diagnosed syndrome has important implications
for long-term healthcare demands.
Autor/es:Lausten-Thomsen, Ulrik (a) Hedley, Paula L (b)
institución:(a) Department of Neonatology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. ulrik.lausten-thomsen@regionh.dk. (b) Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. ulrik.lausten-thomsen@regionh.dk.
Conflicto:Declarations. Conflict of interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Previous communication: This is the first submission of the manuscript to the journal. This manuscript or parts of it is not being considered for publication by another journal, nor has...
it been published or posted elsewhere. Ethical considerations: All data were from publicly available sources; thus, approvals from neither scientific ethics committees nor data authorities were required as per Danish law and regulations. Declaration of generative AI in scientific writing: AI and/or AI-assisted technologies were not used in the writing of this manuscript.
Data-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool.
Data-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool.
Fuente:Jama Network Open
Tipo de trabajo:Metanálisis
Extracto:
AND RELEVANCE: This study of
cross-sectional data found that optimal cutoff scores and accuracy estimates
differed substantially from population values when data-driven methods were used
to simultaneously identify an optimal cutoff score and estimate accuracy. Users
of diagnostic accuracy evidence should evaluate studies of accuracy with caution
and ensure that cutoff score recommendations are based on adequately powered
research or well-conducted meta-analyses.
Cita:JAMA Netw Open 2024 Nov 4; 7 (11) : e2429630.
institución:(a) Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada. (b) Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada.
Conflicto:Conflict of Interest Disclosures: Dr Ayalon reported receiving grants from Lundbeck during the conduct of the study. Dr Bernstein reported receiving grants from AbbVie, Eli Lilly, Fresenius Kabi, Janssen, Pfizer, Takeda, Boston Scientific, JAMP Pharma, Organon, and Sandoz and personal fees from AbbVie, Amgen, Bristol Myers Squibb, Eli Lilly, Fresenius Kabi, Janssen, Pfizer, and Takeda outside the submitted work. Dr...
Butterworth reported receiving grants from Safe Work Australia and Australian Research Council during the conduct of the study. Dr J.C.N. Chan reported receiving grants from the European Foundation for Study of Diabetes during the conduct of the study. Dr L.F. Chan reported receiving nonfinancial support from Otsuka and Lundbeck and personal fees from Johnson & Johnson during the conduct of the study and nonfinancial support from Ortho-McNeil-Janssen and Menarini outside the submitted work. Dr Inagaki reported receiving personal fees from Meiji, Mochida, Takeda, Novartis, Yoshitomi, Pfizer, Eisai, Otsuka, MSD, Sumitomo Dainippon, Janssen, and Eli Lilly outside the submitted work. Dr Rancans reported receiving grants from Gedeon Richter; personal fees and nonfinancial support from Gedeon Richter, Lundbeck, Servier, and Janssen Cilag; and personal fees from Zentiva and AbbVie outside the submitted work. Dr Shinn reported receiving grants from the National Cancer Institute (NCI) during the conduct of the study. Dr Simning reported receiving grants from the Agency for Healthcare Research and Quality, National Center for Research Resources, and National Institute of General Medical Sciences during the conduct of the study. Dr Stafford reported receiving a PhD scholarship from The University of Melbourne during the conduct of the study. Dr Wagner reported receiving grants from the State of Pennsylvania tobacco settlement fund and NCI during the conduct of the study and personal fees from Celgene/Bristol Myers Squibb outside the submitted work. Dr Benedetti reported receiving grants from the Canadian Institutes of Health Research (CIHR) during the conduct of the study. No other disclosures were reported.
