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The increasing number of Open Access articles widens the reading offer
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SIIC created, produced and handles the AFT software that deciphers
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Combined inhibition of ribonucleotide reductase and WEE1 induces synergistic anticancer activity in Ewing's sarcoma cells.
Combined inhibition of ribonucleotide reductase and WEE1 induces synergistic anticancer activity in Ewing's sarcoma cells.
Fuente:Bmc Cancer
Extracto:
Our findings show that combined
inhibition of RNR and WEE1 was effective against Ewing's sarcoma in vitro. They
thus provide a rationale for the evaluation of the potential of combined
targeting of RNR and WEE1 in Ewing's sarcoma in vivo.
institución:(a) Department of Paediatric and Adolescent Medicine, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany. (b) Research Centre Lobeda, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Attitudes of polish medical students toward organ donation.
Attitudes of polish medical students toward organ donation.
Fuente:Frontiers in Public Health
Extracto:
1. The reluctance to donate the organs of loved ones for
transplantation is accompanied by a lack of a sense of moral obligation and a
lack of solidarity with those in need. Conversely, conversations among loved ones
about organ donation are thought-provoking, causing a sense of moral obligation
and solidarity with those in need. 2. Regardless of the stance on organ donation
and family discussions on the subject, the respondents do not care what happens
to the body after organ donation, but they also do not know the opinions of their
loved ones about ODT. 3. Conversations with loved ones contribute to the
acceptance of circumstances in which organs would be harvested for
transplantation without consent.
Claves:brain death, knowledge, medical students, organ donation, transplantation
Cita:Front Public Health 2025; 13 : 1531140.
Autor/es:Mikla, Marzena (a) Cybulska, Anna Maria (b)
institución:(a) Faculty of Nursing, University of Murcia, Murcia, Spain. (b) Department of Nursing, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Placental quantitative susceptibility mapping and T2* characteristics for predicting birth weight in healthy and high-risk pregnancies.
Placental quantitative susceptibility mapping and T2* characteristics for predicting birth weight in healthy and high-risk pregnancies.
Fuente:European Radiology Experimental
Extracto:
Our findings underscore
the potential of mean placental T2* as a more sensitive marker for detecting
placental dysfunction in high-risk pregnancies than mean placental
susceptibility. Moreover, the high-risk status emerged as a significant predictor
of BW. These results call for further research with larger and more diverse
populations to validate these findings and enhance prediction models for improved
pregnancy management. RELEVANCE STATEMENT: This study highlights the potential of
placental T2* magnetic resonance imaging measurements as reliable indicators for
detecting placental dysfunction in high-risk pregnancies, aiding in improved
prenatal care and birth weight prediction. KEY POINTS: Placental dysfunction in
high-risk pregnancies is evaluated using MRI T2* values. Lower T2* values
significantly correlate with pre-eclampsia and fetal growth restriction. T2* MRI
may predict birth weight, enhancing prenatal care outcomes.
institución:(a) Developing Brain Institute, Division of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, USA. (b) Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, MedStar Washington Hospital Center, Washington, DC, USA.
Conflicto:Declarations. Ethics approval and consent to participate: Institutional Review Board approval was obtained (Children’s National Medical Center Institutional Review Board, Protocol 11077, Approved 8/25/2018). Written informed consent was obtained from all subjects or patients in this study. Consent for publication: Not applicable. Competing interests: All authors declare that they have no competing interests.
Respiratory Syncytial Virus Vaccine and Nirsevimab Uptake Among Pregnant People and Their Neonates.
Respiratory Syncytial Virus Vaccine and Nirsevimab Uptake Among Pregnant People and Their Neonates.
Fuente:Jama Network Open
Extracto:
AND RELEVANCE: In this cohort
study, uptake of the RSVpreF vaccine and infant nirsevimab was high. Nirsevimab
uptake was high even among individuals who did not receive routine prenatal or
infant vaccines. There was no significant association between RSVpreF vaccination
and preterm birth. This study suggests that an RSV prevention strategy that
included both prenatal vaccination and infant monoclonal antibody administration
had high uptake and reassuring perinatal outcomes.
Cita:JAMA Netw Open 2025 Feb 3; 8 (2) : e2460735.
Autor/es:Blauvelt, Christine A (a) Zeme, Molly (b)
institución:(a) Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco. (b) School of Medicine, University of California, San Francisco.
Surgical outcomes after gender-affirming hysterectomies: a consecutive case series of 72 patients.
Surgical outcomes after gender-affirming hysterectomies: a consecutive case series of 72 patients.
Fuente:Journal of Obstetrics and Gynaecology The Journal of The Institute of Obstetrics and Gynaecology
Tipo de trabajo:Estudio multicéntrico
Extracto:
Our
findings support the safety and feasibility of gender-affirming hysterectomies,
particularly when performed laparoscopically, with very few severe complications
observed using a validated scoring system. Extensive follow-up care, as well as
addressing common postoperative concerns, is essential. Despite a relatively
small sample size and lack of a control group, this study provides valuable
insights into transgender healthcare from a previously unstudied region. Future
research should preferably include larger cohorts, multicentre and registry-based
studies.
institución:(a) Department of Gynaecology and Reproductive Medicine, Karolinska University Hospital, Stockholm, Sweden. (b) Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Anxiety among pregnant women in Addis Ababa, Ethiopia.
Anxiety among pregnant women in Addis Ababa, Ethiopia.
Fuente:Plos One
Extracto:
More than 1 in 10
women had anxiety during pregnancy. The prevalence of anxiety was about two-fold
higher among single mothers and among mothers who had an unplanned pregnancy. The
study suggests the importance of integrated mental health assessment and services
in regular antenatal care, with an emphasis on identifying and caring for women
at a disadvantage due to social and obstetric factors.
Cita:PLoS One 2025; 20 (2) : e0318718.
Autor/es:Melesse, Hanna (a) Shifraw, Tigest (b)
institución:(a) Department of Epidemiology and Biostatistics, Addis Continental Institute of Public Health (ACIPH), Addis Ababa, Ethiopia. (b) Department of Reproductive Health and Population, Addis Continental Institute of Public Health (ACIPH), Addis Ababa, Ethiopia.
Conflicto:The authors declare that no competing interest exists.
Extracto:
Based on our study, the overall prevalence of
negative childbirth experiences was calculated to be 16%. However, considering
the short-term and long-term effects of this experience on various aspects of
women's lives, greater attention should be paid to making pregnancy and
childbirth more pleasant and to interventions to improve women's childbirth
experiences.
institución:(a) Reproductive Health, Clinical Research Development Center, Motazedi Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran. (b) Family Health and Population Growth Research Center, Health Policy and Promotion Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. ar_haseli@yahoo.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A predicting model for intrapartum cesarean delivery at admission using a nomogram
A predicting model for intrapartum cesarean delivery at admission using a nomogram
Fuente:Bmc Pregnancy and Childbirth
Tipo de trabajo:Estudio de cohortes
Extracto:
Our model, which utilized admission
indicators, performed well in predicting the risk of intrapartum CD using a
nomogram. These findings have significant practical implications for physicians
seeking to reduce the rate of intrapartum CD.
Cita:BMC Pregnancy Childbirth 2025 Feb 14; 25 (1) : 164.
Autor/es:Zhao, Xinrui (a) Yang, Lijun (b)
institución:(a) Department of Obstetrics, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, China. (b) School of Computer Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
HER2-low status as a distinct breast cancer subtype: myth or truth? Analysis of the WSG trials WSG-ADAPT-HR+/HER2-, WSG-PlanB, and WSG-ADAPT-TN.
HER2-low status as a distinct breast cancer subtype: myth or truth? Analysis of the WSG trials WSG-ADAPT-HR+/HER2-, WSG-PlanB, and WSG-ADAPT-TN.
Fuente:Breast Cancer Research Bcr
Tipo de trabajo:Guía
Extracto:
The prevalence of HER2-low status varied between the
analyzed trials. Our results show that survival does not differ between HER2-low
and HER2-zero tumors in HR + /HER2- cohorts; however, HER2-low status appears to
have an inconsistent impact on survival in TNBC. Therefore, our findings do not
support the characterization of HER2-low status as a distinct BC subtype.
Cita:Breast Cancer Res 2025 Feb 14; 27 (1) : 22.
Autor/es:Schmidt, Gilda (a) Gluz, Oleg (b)
institución:(a) Department of Gynecology, Obstetrics and Reproductive Medicine, Saarland University Medical Center, Homburg, Germany. gilda.schmidt@uks.eu. (b) West German Study Group, Moenchengladbach, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Proportion and factors associated with intra-procedural pain among women undergoing manual vacuum aspiration for incomplete abortion at Mbarara Regional Referral Hospital, Uganda.
Proportion and factors associated with intra-procedural pain among women undergoing manual vacuum aspiration for incomplete abortion at Mbarara Regional Referral Hospital, Uganda.
Fuente:The Pan African Medical Journal
Extracto:
majority of women undergoing MVA at MRRH experienced IPP. Younger women and those
with cervical dilatation 1-2 cm are more likely to experience IPP. We recommend
optimised and personalised pain management strategies for women undergoing MVA.
Autor/es:Opee, Jimmyy (a) Mayanja, Stephen Bawakanya (b)
institución:(a) Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda. (b) Department of Obstetrics and Gynaecology, Mbarara Regional Referral Hospital, Mbarara, Uganda.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The Functions and Implications of MicroRNAs in Premature Ovarian Insufficiency.
The Functions and Implications of MicroRNAs in Premature Ovarian Insufficiency.
Fuente:Molecular Genetics & Genomic Medicine
Tipo de trabajo:Revisión
Extracto:
Elucidating miRNAs' roles in POI
opens new avenues for managing the disease. By understanding how miRNAs influence
the molecular mechanisms of POI, innovative strategies can be developed for
diagnosis and treatment, potentially improving patient outcomes.
Cita:Mol Genet Genomic Med 2025 Feb; 13 (2) : e70074.
Autor/es:Gao, Hui (a) Cao, Xi-Xia (b)
institución:(a) Department of Reproductive Health, Nanjing Maternity and Child Health Care Hospital, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing, China. (b) Department of Reproductive Health, Nanjing Maternity and Child Health Care Hospital, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Spiritual Care Experiences of Nurses Working in Gynecology Clinic: A Qualitative Research.
Spiritual Care Experiences of Nurses Working in Gynecology Clinic: A Qualitative Research.
Fuente:Journal of Evaluation in Clinical Practice
Tipo de trabajo:Guía de práctica clínica
Extracto:
It is vital to train gynecology nurses in
spiritual care, reduce their workload, and develop clinical practice guidelines.
Increasing the awareness of obstetric nurses about the factors affecting their
spiritual care experiences while caring for individuals in clinical practices
will contribute to increasing the quality of nursing care.
Claves:gynecology, nurse, qualitative research, spiritual care
Cita:J Eval Clin Pract 2025 Feb; 31 (1) : e70030.
Autor/es:Başaran, Fatma (a) Şahin, Merve (b)
institución:(a) Department of Midwifery, Faculty of Health Sciences, Ağrı İbrahim Çeçen University, Ağrı, Türkiye. (b) Bergama Necla-Mithat Öztüre State Hospital, İzmir, Türkiye.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Chronic myeloid leukemia during pregnancy complicated by dengue infection and pulmonary embolism.
Chronic myeloid leukemia during pregnancy complicated by dengue infection and pulmonary embolism.
Fuente:Indian Journal of Cancer
Extracto:
This case adds to the literature on CML in pregnancy and reflects the
importance of a multidisciplinary team approach when managing complicated
patients who require timely rational interventions.
Cita:Indian J Cancer 2024 Oct 1; 61 (4) : 832-835.
institución:(a) Clinical Haematology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. (b) University Obstetric Unit, De Soysa Hospital for Women, Colombo, Sri Lanka.
Comparative performance of PROMIS Sleep Disturbance computerized adaptive testing algorithms and static short form in postmenopausal women.
Comparative performance of PROMIS Sleep Disturbance computerized adaptive testing algorithms and static short form in postmenopausal women.
Fuente:Journal of Patient-reported Outcomes
Extracto:
The results of this study support using the PROMIS Sleep Disturbance
item bank in postmenopausal women. The choice of PROMIS SD SF 8b versus CAT can
largely be driven by practical reasons (respondent burden and operational
complexity) rather than concerns of differential reliability and validity.
Conflicto:Declarations. Ethics approval and consent to participate: Not applicable to this secondary analysis of publicly available data. Consent for publication: Not applicable Competing interests: All authors are employees of Bayer.
The TANGO-DM randomized controlled trial study protocol: treatment outcomes for gestational diabetes diagnosed according to WHO 2013 or WHO 1999 thresholds.
The TANGO-DM randomized controlled trial study protocol: treatment outcomes for gestational diabetes diagnosed according to WHO 2013 or WHO 1999 thresholds.
Fuente:Bmc Pregnancy and Childbirth
Extracto:
Registered on 22 September 2018.
Claves:Gestational diabetes mellitus, IADPSG, Large-for-gestational-age, Randomized controlled trial, WHO 1999
Cita:BMC Pregnancy Childbirth 2025 Feb 17; 25 (1) : 173.
Autor/es:Rademaker, Doortje (a) de Wit, Leon (b)
institución:(a) Department of Obstetrics and Gynecology, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands. d.rademaker@amsterdamumc.nl. (b) Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands. d.rademaker@amsterdamumc.nl.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Shortened Relative Leukocyte Telomere Length Is Associated With Polycystic Ovary Syndrome and Metabolic Traits.
Shortened Relative Leukocyte Telomere Length Is Associated With Polycystic Ovary Syndrome and Metabolic Traits.
Fuente:Endocrinology, Diabetes & Metabolism
Extracto:
Women with PCOS have significantly
reduced rLTL and shorter LTL may be associated with cardiometabolic risk factors
in PCOS subjects. There are no causal relationship between genetically determined
PCOS and TL or vice versa.
institución:(a) Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hongkong, China. (b) Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hongkong, China.
Conflicto:J.C.N.C. received consultancy fees from Astra Zeneca, Bayer, Boehringer Ingelheim, Celltrion, MSD, Pfizer, Servier and Viatris Pharmaceutical, speaker fees from Astra Zeneca, Bayer, Boehringer Ingelheim, MSD, Merck, Sanofi and Servier and research grants through her institutions from Applied Therapeutics, Astra Zeneca, Hua Medicine, Lee Powder, Lilly, Merck and Servier. R.C.W.M. has received research grants for clinical trials from AstraZeneca, Bayer,...
MSD, Novo Nordisk, Sanofi, Tricida Inc. and honoraria for consultancy or lectures from AstraZeneca, Bayer, Boehringer Ingelheim, Merck and Roche Diagnostics, all used to support diabetes research at the Chinese University of Hong Kong. J.C.N.C., C.K.P.L. and R.C.W.M. are co‐founders of GemVCare, a technology start‐up initiated with support from the Hong Kong Government Innovation and Technology Commission and its Technology Start‐up Support Scheme for Universities (TSSSU). A.J.J. has received research grants for clinical trials from Abbott and Sanofi‐Aventis, and honoraria for consultancy for Abbott, Amgen, Medtronic and Sanofi‐Aventis. No other potential conflicts of interest relevant to this article were reported.
Population-level analyses identify host and environmental variables influencing the vaginal microbiome.
Population-level analyses identify host and environmental variables influencing the vaginal microbiome.
Fuente:Signal Transduction and Targeted Therapy
Extracto:
This study
provides a comprehensive overview of the associations between identified
variables and the vaginal microbiome, representing an important step toward
understanding of environment-microbe-host interactions.
institución:(a) State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China. (b) Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Bridging the gap: a comprehensive analysis of inequalities in maternal health facility deliveries and associated factors among women of reproductive age in the Gambia (2013-2019/20).
Bridging the gap: a comprehensive analysis of inequalities in maternal health facility deliveries and associated factors among women of reproductive age in the Gambia (2013-2019/20).
Fuente:Bmc Public Health
Extracto:
Despite overall increase in the prevalence of health facility
deliveries across all sociodemographic dimensions, significant disparities
persist in The Gambia, particularly in relation to economic status, education,
and subnational region. Targeted interventions and policies that address the
social determinants of maternal health and promote equitable access to health
facility delivery services are needed to bridge the inequality gaps and improve
maternal health outcomes in The Gambia.
Claves:Demographic and health surveys, Health facility delivery, Inequality, Maternal health, The Gambia
Cita:BMC Public Health 2025 Feb 18; 25 (1) : 675.
Autor/es:Barrow, Amadou (a) Barrow, Sulayman (b)
institución:(a) Department of Public & Environmental Health, School of Medicine & Allied Health Sciences, University of The Gambia, Kanifing, The Gambia. abarrow@utg.edu.gm. (b) Department of Epidemiology, College of Public Health and Health Profession, University of Florida, Gainesville, USA. abarrow@utg.edu.gm.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Comparative efficacy of pharmacological interventions on metabolic and hormonal outcomes in polycystic ovary syndrome
Comparative efficacy of pharmacological interventions on metabolic and hormonal outcomes in polycystic ovary syndrome
Fuente:Bmc Women's Health
Tipo de trabajo:Metanálisis
Extracto:
Combining standard therapy with GLP-1 receptor agonists offers superior efficacy
in improving metabolic and hormonal outcomes in women with PCOS. Orlistat
effectively reduces androgen levels. These findings support the use of
combination pharmacotherapy for comprehensive management of PCOS.
institución:(a) Department of Gynecology of Chinese Medicine, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510000, China. (b) Department of Pharmacy, Affiliated Mengchao Cancer Hospital of Shanghai University, Shanghai, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Postoperative pulmonary edema and pulmonary hemorrhage following hysteroscopy.
Postoperative pulmonary edema and pulmonary hemorrhage following hysteroscopy.
Fuente:Bmc Women's Health
Extracto:
In
conclusion, the observed upper airway obstruction during hysteroscopic surgery
seemingly reduced the safe absorption threshold of isosmotic uterine distension
media. Therefore, gynecologists and anesthesiologists should remain vigilant
about this potential complication.
institución:(a) Department of Obstetrics and Gynecology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, Zhejiang Province, China. (b) Department of Respiratory, Suzhou Research Center of Medical School, Affiliated Hospital of Medical School, Suzhou Hospital, Nanjing University, Suzhou, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
