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Association of clinical biomarker-based biological age and aging trajectory with cardiovascular disease and all-cause mortality in Chinese adults
Association of clinical biomarker-based biological age and aging trajectory with cardiovascular disease and all-cause mortality in Chinese adults
Fuente:Bmc Public Health
Tipo de trabajo:Estudio de cohortes
Extracto:
Accelerated BA aging is associated with a higher
risk of CVD and mortality, whereas decelerated aging is associated with a lower
risk compared to normal aging. Those persistently at high aging levels are at the
highest risk for both CVD and death; conversely, it is the act of lowering and
continually maintaining a reduced aging state that effectively mitigates these
risks.
institución:(a) National Human Genetic Resources Center, National Research Institute for Family Planning, Beijing, China. (b) National Human Genetic Resources Sharing Service Platform, Beijing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Analysis of the kidney failure risk equation implementation in routine clinical practice and health inequalities in chronic kidney disease care
Analysis of the kidney failure risk equation implementation in routine clinical practice and health inequalities in chronic kidney disease care
Fuente:Bmc Nephrology
Tipo de trabajo:Estudio de cohortes
Extracto:
KFRE could be calculated for less than half
of people due to lack of albuminuria testing. Focus should be given to improving
albuminuria testing and inequities identified to allow wider implementation of
KFRE.
institución:(a) School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Scotland. heather.walker.2@glasgow.ac.uk. (b) Robertson Centre for Biostatistics, University of Glasgow, Glasgow, Scotland.
Conflicto:Declarations. Consent for publication: Not applicable. Competing interests: PBM reports lecture honoraria from Astrazeneca, Pharmacomsos, Bayer, Astellas, GSK and Boehringer Ingelheim outside the submitted work. The other authors have no potential conflicts of interest to declare. Ethics approval and consent to participate: Delegated research ethics approval was granted for linkage to National Health Service (NHS) patient data by the Local...
Privacy and Advisory Committee at NHS Greater Glasgow and Clyde. Cohorts and de-identified linked data were prepared by the West of Scotland Safe Haven Research Database at NHS Greater Glasgow and Clyde (IRAS Project ID 321198, REC reference 22/WS/1063, West of Scotland REC 4, https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/west-of-scotland-safe-haven-research-database/ .). Conflicts of interest: The other authors have no potential conflicts of interest to declare. Rights retention statement: For the purpose of open access, the author(s) has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission.
Confounder adjustment in observational studies investigating multiple risk factors: a methodological study.
Confounder adjustment in observational studies investigating multiple risk factors: a methodological study.
Fuente:Bmc Medicine
Tipo de trabajo:Revisión
Extracto:
There is
substantial variation in the methods for confounder adjustment among studies
investigating multiple risk factors. Mutual adjustment was the most commonly
adopted method, which might lead to overadjustment bias and misleading effect
estimates. Future research should avoid indiscriminately including all risk
factors in a multivariable model to prevent inappropriate adjustment.
institución:(a) Department of Epidemiology and Biostatistics, Xiangya School of Public Health, Central South University, Changsha, China. (b) Department of Epidemiology and Biostatistics, Xiangya School of Public Health, Central South University, Changsha, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between cardiometabolic index and biological ageing among adults: a population-based study.
Association between cardiometabolic index and biological ageing among adults: a population-based study.
Fuente:Bmc Public Health
Extracto:
CMI is positively correlated with biological ageing in adults in the
United States. Prospective studies with larger sample sizes are required to
validate our findings.
institución:(a) Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China. (b) Department of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Long-term trajectory of estimated glomerular filtration rate in ambulatory patients with type 2 diabetes and heart failure: clinical insights and prognostic implications.
Long-term trajectory of estimated glomerular filtration rate in ambulatory patients with type 2 diabetes and heart failure: clinical insights and prognostic implications.
Fuente:Cardiovascular Diabetology
Extracto:
This study offers novel insights into long-term
renal function trajectories in patients with HF and T2D and identifies key
clinical factors associated with accelerated renal decline. Future research is
warranted to validate these results in larger, more diverse cohorts and to
explore potential therapeutic interventions.
Cita:Cardiovasc Diabetol 2025 Mar 5; 24 (1) : 104.
Autor/es:Julián, Maria Teresa (a) Codina, Pau (b)
institución:(a) Department of Endocrinology and Nutrition and Heart Failure Clinic, Hospital Germans Trias i Pujol, Badalona, Spain. (b) Heart Failure Clinic and Cardiology Department, Hospital Germans Trias i Pujol, Badalona, Spain.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Circulating mitochondrial DNA signature in cardiometabolic patients.
Circulating mitochondrial DNA signature in cardiometabolic patients.
Fuente:Cardiovascular Diabetology
Extracto:
Patients with HF and diabetes have an altered circulating
mtDNA signature characterised by higher cell-free mtDNA and lower mtDNA ratio,
whereas cellular mtDNA remains unaffected. Cell-free mtDNA and mtDNA ratio are
associated with impaired response to exercise, higher systemic inflammation and
increased congestion. Circulating mitochondrial profile could be a new biomarker
of mitochondrial status in cardiometabolic diseases.
institución:(a) Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56124, Pisa, Italy. (b) Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Comparison of incidence trends of early-onset and late-onset type 2 diabetes in the Asia-Pacific region, 1990-2021: a join point regression analysis based on the global burden of disease study 2021.
Comparison of incidence trends of early-onset and late-onset type 2 diabetes in the Asia-Pacific region, 1990-2021: a join point regression analysis based on the global burden of disease study 2021.
Fuente:Frontiers in Endocrinology
Extracto:
This study reveals a significant recent increase in
early-onset T2DM incidence in the Asia-Pacific region, highlighting the need for
targeted public health interventions.
Claves:Asia-Pacific region, adolescents, incidence, type 2 diabetes, young adults
institución:(a) Tianjin Union Medical Center, Tianjin Medical University, Tianjin, China. (b) Department of Endocrinology, Health Management Center, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Sex-specific differences in the relationship between fasting plasma glucose and carotid plaque in a cardiovascular high-risk population: a cross-sectional study.
Sex-specific differences in the relationship between fasting plasma glucose and carotid plaque in a cardiovascular high-risk population: a cross-sectional study.
Fuente:Frontiers in Endocrinology
Tipo de trabajo:Estudio de cohortes
Extracto:
There is an association between fasting blood
glucose levels and carotid plaque, with an increased risk of carotid plaque as
fasting blood glucose rises. Moreover, this relationship differs between sexes.
institución:(a) Department of Laboratory Medicine, Wenzhou People's Hospital, The Third Affiliated Hospital of Shanghai University, The Wenzhou Third Clinical College of Wenzhou Medical University, Wenzhou, China. (b) Department of Laboratory Medicine, Wenzhou People's Hospital, The Third Affiliated Hospital of Shanghai University, The Wenzhou Third Clinical College of Wenzhou Medical University, Wenzhou, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
EndoGene database: reported genetic variants for 5,926 Russian patients diagnosed with endocrine disorders.
EndoGene database: reported genetic variants for 5,926 Russian patients diagnosed with endocrine disorders.
Fuente:Frontiers in Endocrinology
Extracto:
DISCUSSION: This publicly
accessible database will be useful to those interested in genetics, epidemiology,
population statistics, and a better understanding of the molecular basis of
endocrine disorders.
Autor/es:Buzdin, Anton A (a) Zolotovskaia, Marianna A (b)
institución:(a) Laboratory of Bioinformatics, Endocrinology Research Center, Moscow, Russia. (b) Laboratory of Clinical and Genomic Bioinformatics, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
Diet, fruit and vegetables and One Health: benefits for health, environment, society and the consumer-proceedings of the 9th edition of EGEA conference.
Diet, fruit and vegetables and One Health: benefits for health, environment, society and the consumer-proceedings of the 9th edition of EGEA conference.
Fuente:European Journal of Nutrition
Tipo de trabajo:Revisión
Extracto:
Sufficient evidence confirms the
contribution of diet rich in FV to One Health, with some emerging research on
this topic. Concerted actions are required towards an increased consumption of FV
and a more diversified and environmentally neutral FV production.
Claves:Food behaviour, Fruit and vegetable, Human health, One Health, Policies, Sustainability
Cita:Eur J Nutr 2025 Mar 5; 64 (3) : 108.
Autor/es:Komati, Nathalie (a) Riboli, Elio (b)
institución:(a) The Agency for Research and Information on Fruit and Vegetables (APRIFEL), Paris, France. n.komati@aprifel.com. (b) Cancer Epidemiology and Prevention Research Unit, School of Public Health, Imperial College London, London, W2 1PG, UK.
Morning vs. evening growth hormone injections and their impact on sleep-wake patterns and daytime alertness.
Morning vs. evening growth hormone injections and their impact on sleep-wake patterns and daytime alertness.
Fuente:Frontiers in Endocrinology
Tipo de trabajo:Estudio abierto
Extracto:
Sleep-wake patterns and
activity index were not affected by treatment schedules. We recommend that growth
hormone injections take place at any regular time according to the family's
convenience.
institución:(a) Pediatric Endocrinology and Diabetes Unit, HaEmek Medical Center, Afula, Israel. (b) Pediatric Endocrinology and Diabetes Unit, HaEmek Medical Center, Afula, Israel.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Impact of segmental body composition on metabolic dysfunction-associated fatty liver disease in Chinese children.
Impact of segmental body composition on metabolic dysfunction-associated fatty liver disease in Chinese children.
Fuente:Frontiers in Endocrinology
Extracto:
The
decrease in regional muscle percentage, particularly in the limbs, along with the
increase in regional fat percentage, especially in the upper limbs, is associated
with a higher probability of developing MAFLD in prepubertal children. Additional
prospective studies are needed to strengthen and validate these findings.
Claves:BIA, Fibroscan, MAFLD, children, regional body composition
institución:(a) Department of Paediatrics, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, Jiangsu, China. (b) Urologic Nephrology Center, Jiangnan University Medical Center, Wuxi, Jiangsu, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Emergency department presentations related to asthma and allergic diseases in Central Queensland, Australia: a comparative analysis between First Nations Australians and Australians of other descents.
Emergency department presentations related to asthma and allergic diseases in Central Queensland, Australia: a comparative analysis between First Nations Australians and Australians of other descents.
Fuente:Bmj Open
Extracto:
Our findings
highlight a significantly higher rate of asthma and allergic disease-related ED
presentations among First Nations Australians compared with Australians of other
descents. This underscores the urgent need for targeted healthcare interventions
integrating culturally appropriate approaches, alongside additional research to
understand causality.
Autor/es:Shifti, Desalegn Markos (a) Al Imam, Mahmudul Hassan (b)
institución:(a) Child Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia d.shifti@uq.edu.au. (b) Centre for Food Allergy Research (CFAR), Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A one-week reduced-carbohydrate diet to mitigate iatrogenic peripheral hyperinsulinemia does not improve insulin sensitivity or endothelial function in a randomized, crossover trial in patients with type 1 diabetes.
A one-week reduced-carbohydrate diet to mitigate iatrogenic peripheral hyperinsulinemia does not improve insulin sensitivity or endothelial function in a randomized, crossover trial in patients with type 1 diabetes.
Fuente:Cardiovascular Diabetology
Extracto:
Although a one-week RCD
significantly lowered insulin requirements, it failed to enhance insulin
sensitivity or endothelial function in adults with type 1 diabetes. These
findings underscore the complex and dynamic relationship between insulin exposure
and cardiometabolic health. Similar basal overnight insulin delivery may have
masked potential benefits by the time of testing, highlighting the need for
further studies to refine strategies aimed at mitigating hyperinsulinemia's
adverse effects. TRIAL REGISTRATION: ClinicalTrials.gov NCT04118374.
Cita:Cardiovasc Diabetol 2025 Mar 5; 24 (1) : 107.
Autor/es:Gregory, Justin M (a) Smith, T Jordan (b)
institución:(a) Ian Burr Division of Pediatric Endocrinology and Diabetes, Vanderbilt University School of Medicine, 1500 21st Avenue South, Suite 1514, Nashville, TN, 37212-3157, USA. justin.m.gregory.1@vumc.org. (b) Ian Burr Division of Pediatric Endocrinology and Diabetes, Vanderbilt University School of Medicine, 1500 21st Avenue South, Suite 1514, Nashville, TN, 37212-3157, USA.
Conflicto:Declarations. Ethics approval and consent to participate: All participants provided written informed consent. The study was approved by the Vanderbilt University Institutional Review Board and registered at ClinicalTrials.gov (NCT04118374). Consent for publication: Not applicable. Competing interests: J.M.G. has received consulting fees from vTV therapeutics, DRI Capital Inc., Beckman Coulter Inc., and Sanofi; reimbursement for serving on scientific advisory committees for...
vTV therapeutics and Sanofi; honoraria for educational events with MJH Life Sciences; and payments for participation on a clinical events committee for Medtronic. J.A.B. has received consulting fees from Cook, JanOne, Merck, Medtronic, Novartis, and Tourmaline. A.D.C. serves on scientific advisory boards or as a consultant for AdipoPharma, Fractyl Health, Inc., Pioneering Medicine, Portal Insulin, Sekkei Bio, and Sensulin Labs, LLC. Abvance, Novo Nordisk, Paratus, and Thetis Pharmaceuticals, LLC; and is receiving research grant support from Abvance, Alnylam, and Novo Nordisk.
Predictors of short stature in Israeli children aged 6-7 years
Predictors of short stature in Israeli children aged 6-7 years
Fuente:Israel Journal of Health Policy Research
Tipo de trabajo:Estudio de cohortes
Extracto:
Public health
services, including Maternal Child Health clinics and primary caregivers, should
prioritize this group and closely monitor for growth faltering during the first
and second years of life.
Claves:Children, Growth gap, Height, Short stature, Socioeconomic
Cita:Isr J Health Policy Res 2025 Mar 5; 14 (1) : 11.
Autor/es:Fisch-Shvalb, Naama (a) Yackobovitch-Gavan, Michal (b)
institución:(a) Institute of Endocrinology and Diabetes, Schneider Children's Medical Center, Petach Tikva, Israel. nammaf@clalit.org.il. (b) Department of Pediatrics, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. nammaf@clalit.org.il.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Cathepsin K inhibition promotes efficient differentiation of human embryonic stem cells to mature cardiomyocytes by mediating glucolipid metabolism and cellular energy homeostasis.
Cathepsin K inhibition promotes efficient differentiation of human embryonic stem cells to mature cardiomyocytes by mediating glucolipid metabolism and cellular energy homeostasis.
Fuente:Stem Cell Research & Therapy
Extracto:
Our study highlights the potential of
cathepsin K inhibition for renewable cardiomyocytes and suggests exploring
metabolic pathways and signaling to improve cardiac regeneration and organoid
development.
Claves:Autophagy, Cardiomyocyte differentiation, Cathepsin K, Energy metabolism, Human embryonic stem cell, Lysosome, Mitochondrion
Cita:Stem Cell Res Ther 2025 Mar 5; 16 (1) : 118.
Autor/es:Wang, Ying (a) Cui, Yang (b)
institución:(a) College of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China. (b) College of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002, China.
Conflicto:Declarations. Ethics approval and consent to participate: H9-hESCs were generously obtained from the Research Center for Eco-Environmental Sciences under the Chinese Academy of Sciences. The protocol was approved by the Hebei University Animal Welfare and Ethical Committee (Project: Role of Cathepsin K in the Development of Diabetic Atherosclerosis by regulating SERCA2-SUMOylation. No. IACUC-2021XG032, approved on Mar. 11, 2021). Competing interests:...
The authors declare no competing financial interests.
Early Risk Stratification of Patients After Successfully Resuscitated Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation-The Angiography After Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation (TOMAHAWK) Risk Score.
Early Risk Stratification of Patients After Successfully Resuscitated Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation-The Angiography After Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation (TOMAHAWK) Risk Score.
Fuente:Critical Care Explorations
Extracto:
The
TOMAHAWK risk score can be easily calculated in daily clinical practice and
strongly correlated with mortality in patients with successfully resuscitated
OHCA without ST-segment elevation on post-resuscitation electrocardiogram.
Cita:Crit Care Explor 2025 Mar 1; 7 (3) : e1221.
Autor/es:Thevathasan, Tharusan (a) Spoormans, Eva (b)
institución:(a) Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité (DHZC), Campus Benjamin Franklin, Berlin, Germany. (b) DZHK (German Centre for Cardiovascular Research), Berlin, Germany.
Conflicto:The authors have disclosed that they do not have any potential conflicts of interest.
Perirenal fat differs in patients with chronic kidney disease receiving different vitamin D-based treatments: a preliminary study.
Perirenal fat differs in patients with chronic kidney disease receiving different vitamin D-based treatments: a preliminary study.
Fuente:Bmc Nephrology
Extracto:
Further research is needed to better understand the mechanistic links
between PAT, BMD, and CVD in this population.
Claves:Analogs, Cardiovascular disease, Chronic kidney disease, Inflammation, Vitamin D
Cita:BMC Nephrol 2025 Mar 5; 26 (1) : 119.
Autor/es:Checa-Ros, Ana (a) Locascio, Antonella (b)
institución:(a) Grupo de Investigación en Enfermedades Cardiorrenales y Metabólicas, Departamento de Medicina y Cirugía, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, 46115, Spain. (b) Aston Institute of Health & Neurodeveloment (AIHN), School of Life & Health Sciences, The Aston Triangle, Aston University, Birmingham, B4 7ET, UK.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Aortic valve calcification across stages of dysglycemia in middle-aged individuals from the general population.
Aortic valve calcification across stages of dysglycemia in middle-aged individuals from the general population.
Fuente:Cardiovascular Diabetology
Extracto:
In this large, contemporary, and randomly selected population of
middle-aged individuals, prediabetes, newly detected diabetes and known diabetes
were all associated with CT-detected AVC. Further studies are warranted to
investigate if managing dysglycemia, even in its early stages, may help slow down
AVC progression.
Cita:Cardiovasc Diabetol 2025 Mar 5; 24 (1) : 105.
Autor/es:Wang, Anne (a) Östgren, Carl Johan (b)
institución:(a) Department of Medicine Solna, Karolinska Institutet, 171 76, Stockholm, Sweden. anne.wang.gottlieb@ki.se. (b) Department of Cardiology, Heart, Vascular and Neuro Theme, Karolinska University Hospital, Stockholm, Sweden. anne.wang.gottlieb@ki.se.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Postoperative Aspiration Pneumonia Among Adults Using GLP-1 Receptor Agonists.
Postoperative Aspiration Pneumonia Among Adults Using GLP-1 Receptor Agonists.
Fuente:Jama Network Open
Tipo de trabajo:Estudio de cohortes
Extracto:
AND
RELEVANCE: This cohort study found no significant association between the
preoperative use of GLP-1 RAs and short-term postoperative aspiration pneumonia
despite growing concerns about the adverse effects of these medications after
surgery. This finding suggests that it may be beneficial to reassess the
preoperative withholding guidelines for GLP-1 RAs.
Cita:JAMA Netw Open 2025 Mar 3; 8 (3) : e250081.
Autor/es:Chen, Yuan-Hsin (a) Zink, Thomas (b)
institución:(a) Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston. (b) Codman Center for Clinical Effectiveness in Surgery, Massachusetts General Hospital, Boston.
Conflicto:Conflict of Interest Disclosures: Dr Smith reported receiving personal fees from Conformis and DePuy, a Johnson & Johnson Company, outside the submitted work. No other disclosures were reported.
