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SGLT2 inhibitors reduce the risk of renal failure in CKD stage 5 patients with Type 2 DM.
SGLT2 inhibitors reduce the risk of renal failure in CKD stage 5 patients with Type 2 DM.
Fuente:Scientific Reports
Extracto:
In conclusion, we provide evidence suggesting that
SGLT2 inhibitors may offer renal protection and did not increase infection risks
for CKD5 patients with type2 diabetes.
institución:(a) Department of Cardiology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. (b) Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fusing St., Gueishan District, Taoyuan, 333, Taiwan.
Conflicto:Declarations. Competing interests: All authors disclosure there is no financial conflict of interest.
Does low body weight mediate the relationship between tooth loss and cognitive impairment? A longitudinal cohort study of an older Chinese population.
Does low body weight mediate the relationship between tooth loss and cognitive impairment? A longitudinal cohort study of an older Chinese population.
Fuente:Bmc Geriatrics
Tipo de trabajo:Estudio de cohortes
Extracto:
Tooth loss increases the risk of cognitive decline, and low body
weight partially mediates this association. CLINICAL TRIAL NUMBER: This is a
retrospective cohort study targeting a population survey, which does not involve
clinical trials and does not have clinical trial numbers.
Claves:Cognitive impairment, Denture use, Low body weight, Older adults, Tooth loss
Cita:BMC Geriatr 2025 Feb 18; 25 (1) : 111.
Autor/es:Ke, Pan (a) Lu, Zuxun (b)
institución:(a) Cardio-Cerebrovascular & Diabetes Prevention, and Control Dept., Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, 518020, P.R. China. (b) Department of Social Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, P.R. China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Development and validation of prediction models for stroke and myocardial infarction in type 2 diabetes based on health insurance claims: does machine learning outperform traditional regression approaches?
Development and validation of prediction models for stroke and myocardial infarction in type 2 diabetes based on health insurance claims: does machine learning outperform traditional regression approaches?
Fuente:Cardiovascular Diabetology
Extracto:
Discrimination performance of claims-based models reached a ceiling at around
0.09 AUPRC and 0.7 AUROC. While for AUROC this performance was comparable to
existing epidemiological models incorporating clinical information, comparison of
other, potentially more relevant metrics, such as AUPRC, sensitivity and Positive
Predictive Value was hampered by lack of reporting in the literature. The fact
that machine learning including deep learning methods did not outperform more
traditional approaches may suggest that feature richness and complexity were
exploited before the choice of algorithm could become critical to maximize
performance. Future research might focus on the impact of different feature
derivation approaches on performance ceilings. In the absence of other more
powerful screening alternatives, applying transparent regression-based models in
routine claims, though certainly imperfect, remains a promising scalable low-cost
approach for population-based cardiovascular risk prediction and stratification.
Claves:Claims database analysis, Deep learning, Health insurance, Logistic regression, Machine learning, Myocardial infarction, Prediction model, Predictive algorithms, Risk scores, Stroke, Type 2 diabetes
Cita:Cardiovasc Diabetol 2025 Feb 18; 24 (1) : 80.
Autor/es:Stephan, Anna-Janina (a) Hanselmann, Michael (b)
institución:(a) Professorship for Public Health and Prevention, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany. anna-janina.stephan@tum.de. (b) German Center for Diabetes Research (DZD), Munich, Germany. anna-janina.stephan@tum.de.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between atherogenic index of plasma and type 2 diabetic complications: a cross-sectional study.
Association between atherogenic index of plasma and type 2 diabetic complications: a cross-sectional study.
Fuente:Frontiers in Endocrinology
Extracto:
The AIP
may serve as a valuable predictive indicator for evaluating kidney damage in
patients with type 2 diabetes, and regular screening of AIP in this population
could provide significant benefits in the prevention of DKD.
Claves:atherogenic index of plasma, cross-sectional study, diabetic complications, metabolic management center, type 2 diabetes
institución:(a) Department of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University, Luzhou, China. (b) Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Transportation Barriers and Diabetes Outcomes: A Longitudinal Analysis.
Transportation Barriers and Diabetes Outcomes: A Longitudinal Analysis.
Fuente:Journal of Primary Care & Community Health
Tipo de trabajo:Estudio de cohortes
Extracto:
Absence of
transportation barriers was associated with slightly lower hemoglobin A1c and
blood pressure, but the small magnitude of the differences suggests that also
addressing other factors may be needed to improve diabetes outcomes more
meaningfully.
Claves:cardiovascular disease, diabetes mellitus, health inequities, health outcomes, social determinants of health
Cita:J Prim Care Community Health 2025 Jan-Dec; 16 : 21501319251320709.
Autor/es:Berkowitz, Seth A (a) Ochoa, Aileen (b)
institución:(a) University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. (b) University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Conflicto:Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: SAB reports research grants from NIH, North Carolina Department of Health and Human Services, Blue Cross Blue Shield of North Carolina, Feeding America, the American Diabetes Association, and the American Heart Association, and personal fees from the...
Aspen Institute, Rockefeller Foundation, Gretchen Swanson Center for Nutrition, and Kaiser Permanente, outside of the submitted work. ML reports research grant support from North Carolina Department of Health and Human Services. All other authors declare nothing to report.
Phenotype-based clusters, inflammation and cardiometabolic complications in older people before the diagnosis of type 2 diabetes
Phenotype-based clusters, inflammation and cardiometabolic complications in older people before the diagnosis of type 2 diabetes
Fuente:Cardiovascular Diabetology
Tipo de trabajo:Estudio de cohortes
Extracto:
Our
findings extend the knowledge about the previously identified six phenotype-based
clusters in older people without T2D. Differences between clusters were more
pronounced for T2D risk than for prevalent or incident (pre)diabetes-related
complications and absent for mortality. The high cardiometabolic risk
corresponded to the high inflammatory load in cluster 5 but not to the lower
inflammatory load of high-risk clusters 3 and 6.
Cita:Cardiovasc Diabetol 2025 Feb 19; 24 (1) : 83.
Autor/es:Huemer, Marie-Theres (a) Spagnuolo, Maria C (b)
institución:(a) Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. (b) Institute for Clinical Diabetology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine Universität, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany.
Conflicto:Declarations. Ethics approval and consent to participate: The KORA study was carried out in accordance with the Declaration of Helsinki. All study participants gave written informed consent. The Ethics Committee of the Bavarian Medical Association approved the studies (S4 Study: EC No. 99186, F4 study and FF4 study: EC No. 06068). Consent for publication: Not applicable. Competing interests: MR received...
lecture fees or served on advisory boards for AstraZeneca, Echosens, Eli Lilly, Madrigal, Merck-MSD, Novo Nordisk and Target RWE and performed investigator-initiated research with support from Boehringer Ingelheim, Novo Nordisk and Nutricia/Danone to the German Diabetes Center (DDZ). All other authors declare that they have no competing interests.
Associations of estimated glucose disposal rate with frailty progression: results from two prospective cohorts.
Associations of estimated glucose disposal rate with frailty progression: results from two prospective cohorts.
Fuente:Cardiovascular Diabetology
Extracto:
Regardless of diabetes or not, a higher level of eGDR was associated
with the decelerated frailty progression. Our findings highlight the role of eGDR
in frailty progression and recommend taking effective interventions to improve
eGDR for preventing frailty progression.
Cita:Cardiovasc Diabetol 2025 Feb 19; 24 (1) : 81.
Autor/es:Wang, Zhaoping (a) Zhu, Jinghan (b)
institución:(a) Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, Zhejiang, China. (b) Department of Epidemiology and Biostatistics, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Exploring the Acceptance of Just-in-Time Adaptive Lifestyle Support for People With Type 2 Diabetes: Qualitative Acceptability Study.
Exploring the Acceptance of Just-in-Time Adaptive Lifestyle Support for People With Type 2 Diabetes: Qualitative Acceptability Study.
Fuente:Jmir Formative Research
Extracto:
This study showed that an
EMA-driven JITAI can provide motivating and tailored support, but more
personalization is needed to ensure that the lifestyle support more closely fits
each individual's unique needs. Key areas for improvement include developing more
individually tailored interventions, improving assessment methods to balance
active and passive data collection, and integrating JITAIs within comprehensive
lifestyle interventions.
Claves:acceptability, behavior change, eHealth, ecological momentary assessment, formative evaluation, just-in-time adaptive intervention, mobile phone, nutrition, physical activity, type 2 diabetes
Cita:JMIR Form Res 2025 Feb 19; 9 : e65026.
Autor/es:Hietbrink, Eclaire A G (a) Middelweerd, Anouk (b)
institución:(a) Department of Biomedical Signals and Systems, University of Twente, Enschede, The Netherlands. (b) Department of Internal Medicine/Nephrology, Ziekenhuisgroep Twente, Almelo, The Netherlands.
Anti-perilipin-1 autoantibodies in autoimmune Addison's disease and related endocrine disorders.
Anti-perilipin-1 autoantibodies in autoimmune Addison's disease and related endocrine disorders.
Fuente:Autoimmunity
Extracto:
Investigating their role in disease progression and their potential
as therapeutic targets could pave the way for novel interventions in autoimmune
endocrine diseases.
institución:(a) Department of Clinical Science, Endocrine Medicine research group, University of Bergen, Bergen, Norway. (b) Department of Clinical Science, Endocrine Medicine research group, University of Bergen, Bergen, Norway.
Development and validation of machine learning models based on stacked generalization to predict psychosocial maladjustment in patients with acute myocardial infarction.
Development and validation of machine learning models based on stacked generalization to predict psychosocial maladjustment in patients with acute myocardial infarction.
Fuente:Bmc Psychiatry
Extracto:
The LDS-R model is a
practical tool for identifying patients at high risk for psychosocial
maladjustment before discharge. Our identification of significant factors
influencing psychosocial maladjustment may inform future development of
interventions.
institución:(a) School of Nursing, Jinan University, Guangdong, 510632, China. (b) College of Information Science and Technology, Jinan University, Guangdong, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Health outcomes and drug utilisation in children with Noonan syndrome
Health outcomes and drug utilisation in children with Noonan syndrome
Fuente:Orphanet Journal of Rare Diseases
Tipo de trabajo:Estudio de cohortes
Extracto:
Children with NS have high
mortality and morbidity not only in the first year of life but also up to five
years of age. This study evaluated the health burden of NS and provided
information for clinicians, health-care providers and families.
institución:(a) Unit of Epidemiology of Rare Diseases and Congenital Anomalies, Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124, Pisa, Italy. michele.santoro@cnr.it. (b) Children's Hospital Zagreb, Centre of Excellence for Reproductive and Regenerative Medicine, Medical School University of Zagreb, Zagreb, Croatia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Striving Towards Equity in Cardiovascular Genomics Research.
Striving Towards Equity in Cardiovascular Genomics Research.
Fuente:Current Atherosclerosis Reports
Tipo de trabajo:Revisión
Extracto:
This will lead to more
accurate and clinically meaningful strategies for preventing and treating
cardiovascular diseases across all ancestral backgrounds and diverse populations.
Claves:Ancestry, Cardiovascular disease, Cardiovascular genomics, Genetic variability, Genetics, Health equity
Cita:Curr Atheroscler Rep 2025 Feb 18; 27 (1) : 34.
Autor/es:Jurado Vélez, Javier (a) Anderson, Nekayla (b)
institución:(a) Marnix E Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. (b) Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Integrative morphological, phytochemical, and molecular identification of three invasive and medicinal Reynoutria species.
Integrative morphological, phytochemical, and molecular identification of three invasive and medicinal Reynoutria species.
Fuente:Scientific Reports
Extracto:
This
approach can also be used in further studies on the population structure, spread,
diversity, and evolution of invasive species such as Reynoutria spp.
Cita:Sci Rep 2025 Feb 18; 15 (1) : 6001.
Autor/es:Stafiniak, Marta (a) Bielecka, Monika (b)
institución:(a) Department of Pharmaceutical Biology and Biotechnology, Wroclaw Medical University, Wroclaw, Poland. (b) Department of Pharmaceutical Biology and Biotechnology, Wroclaw Medical University, Wroclaw, Poland. monika.bielecka@umw.edu.pl.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Dietary calcium intake in primary hyperparathyroidism and in its normocalcemic variant: a case-control study.
Dietary calcium intake in primary hyperparathyroidism and in its normocalcemic variant: a case-control study.
Fuente:Frontiers in Endocrinology
Extracto:
All patients with
primary hyperparathyroidism, particularly those with low dietary calcium intake,
should be advised not to restrict dietary calcium to prevent further increase in
PTH levels. Whether maintaining adequate calcium intake might positively impact
bone density or biochemistries in patients refraining from surgery, should be
addressed in longitudinal studies.
institución:(a) Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. (b) Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms.
The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms.
Fuente:Frontiers in Endocrinology
Extracto:
Future research, including epidemiological studies and new
pathogenesis findings, will further clarify the relationship between
musculoskeletal diseases and SU.
institución:(a) Department of Orthopaedics, The First Affiliated Hospital of Dalian Medical University, Dalian, China. (b) Department of Pharmacy, The Third People's Hospital of Dalian, Dalian, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Neural Response to Food Cues in Avoidant/Restrictive Food Intake Disorder.
Neural Response to Food Cues in Avoidant/Restrictive Food Intake Disorder.
Fuente:Jama Network Open
Extracto:
AND
RELEVANCE: Results indicate generalized hyperactivation of ACC, sensory
association cortex, and supplementary motor cortex in response to visual food
stimuli in children, adolescents, and young adults with ARFID, suggesting a novel
neurobiological circuit associated with this disorder. Activation appears
consistent with ARFID phenotypic rationales for food avoidance, with
hyperactivation of fear regions in ARFID-fear and hypoactivation of appetite
regions with increasing ARFID-lack of interest severity.
Cita:JAMA Netw Open 2025 Feb 3; 8 (2) : e2460101.
Autor/es:Thomas, Jennifer J (a) Holsen, Laura (b)
institución:(a) Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston. (b) Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts.
Conflicto:Conflict of Interest Disclosures: Dr Thomas reported receiving grants from the National Institutes of Health (NIH) during the conduct of the study as well as receiving royalties from Cambridge University Press and receiving consulting fees from Equip Health outside the submitted work. Dr Holsen reported receiving grants from NIH during the conduct of the study. Dr Becker reported receiving grants...
from the National Institute of Mental Health during the conduct of the study as well as receiving royalties from Cambridge University Press outside the submitted work. Dr Breithaupt reporting serving as a consultant for Otsuka Pharmaceuticals and HealthiVibe. Dr Burton-Murray reported receiving grants from the National Institute of Diabetes and Digestive and Kidney Diseases during the conduct of the study. Dr Bern reported spousal employment by and stock ownership in Novartis and receiving travel and honoraria from Abbott Nutrition International. Dr Misra reported receiving consulting fees from Regeneron, Sanofi, and AbbVie; receiving royalties UpToDate; serving on an expert panel for Lumos Pharmaceuticals; serving on the scientific advisory board for AbbVie and Ipsen; and receiving a study drug donation from Tonix Pharmaceuticals outside the submitted work. Dr Eddy reported grants from National Institute of Mental Health during the conduct of the study as well as receiving royalties from Cambridge University Press Book and consulting fees from Equip Health outside the submitted work. Prof Micali reported receiving grants from University of Geneva during the conduct of the study. Dr Lawson reported receiving grants from the NIH during the conduct of the study; receiving grants from Tonix Pharmaceuticals outside the submitted work; having patents for 63/413,657 and 63/467,980 pending; receiving royalties from UpToDate; and holding and/or having immediate family with stock in Thermo Fisher Scientific, Zoetis, Danaher Corporation, Intuitive Surgical, and Merck and West Pharmaceutical Services. No other disclosures were reported.
Prevalence and risk of complications in untreated patients with adult growth hormone deficiency.
Prevalence and risk of complications in untreated patients with adult growth hormone deficiency.
Fuente:Pituitary
Extracto:
Untreated patients with AGHD have a
higher prevalence of metabolic complications than the general population despite
no difference in their related risk factors. Given the low use of GHRT in this
study, comprehensive treatment approaches that include GHRT need to be considered
to alleviate the risk of complications.
institución:(a) Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, Hyogo, Japan. (b) Novo Nordisk Pharma Ltd, Meiji Yasuda Seimei Building, 2-1-1, Marunouchi, Chiyoda-ku, Tokyo, 100-0005, Japan. tend@novonordisk.com.
Conflicto:Declarations. Ethical approval: The study was approved by the MINS Research Ethics Committee (MINS-REC-230201; approved on January 19, 2023). Consent to participate: Not applicable. Consent to publish: Not applicable. Competing interests: HF received lecture fees from Novo Nordisk Pharma Ltd. TE and ST are employees of Novo Nordisk Pharma Ltd., and report stock ownership. SF received lecture fees from Novo...
Nordisk Pharma Ltd.
Age at type 1 diabetes onset does not influence attained brain volume.
Age at type 1 diabetes onset does not influence attained brain volume.
Fuente:Bmc Endocrine Disorders
Extracto:
We found no association between age at
diabetes onset and attained intracranial volume or gray or white matter volumes,
indicating that type 1 diabetes may not have a clinically significant influence
on brain growth.
Claves:Age of onset, Brain, Diabetes mellitus, type 1, Gray matter, Magnetic resonance imaging, White matter
Cita:BMC Endocr Disord 2025 Feb 18; 25 (1) : 43.
Autor/es:Claesson, Tor-Björn (a) Mutter, Stefan (b)
institución:(a) Department of Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. (b) Folkhälsan Research Centre, Helsinki, Finland.
Conflicto:Declarations. Ethical approval and consent to participate: All study participants gave written informed consents, and the study was approved by the Ethics Committee of the Helsinki and Uusimaa Hospital District (HUS/3313/2018 and HUS/2184/2017). The study was performed in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: S.M. received lecture honoraria from Encore Medical Education.D.G. Astellas,...
AstraZeneca, Bayer, Boehringer Ingelheim, Fresenius, GE Healthcare, Harald AI, Novo Nordisk, Ratiopharm.P-H.G. has received lecture honoraria from Astellas, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, Elo Water, Genzyme, Medscape, MSD, Novartis, Novo Nordisk, Sanofi, Sciarc, and he is an advisory board member of AbbVie, Astellas, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, Janssen, Medscape, MSD, Nestlé, Novartis, Novo Nordisk, and Sanofi. J.M. has received lecture honoraria from Santen.The other authors declare no conflict of interest. Clinical trial number: Not applicable.
Comparative efficacy of incretin drugs on glycemic control, body weight, and blood pressure in adults with overweight or obesity and with/without type 2 diabetes
Comparative efficacy of incretin drugs on glycemic control, body weight, and blood pressure in adults with overweight or obesity and with/without type 2 diabetes
Fuente:Frontiers in Endocrinology
Tipo de trabajo:Revisión sistemática
Extracto:
Multi-receptor drugs demonstrated substantial therapeutic potential
in weight management, glycemic control, and blood pressure regulation in adults
with overweight or obesity, with or without diabetes, with a generally favorable
safety profile. SYSTEMATIC REVIEW REGISTRATION:
https://www.crd.york.ac.uk/prospero/, identifier CRD42024554005.
institución:(a) Department of Pharmacy, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiao Tong University, Chengdu, Sichuan, China. (b) Department of Pharmacy, Guang'an People's Hospital, Guang'an, Sichuan, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Perinatal Outcomes in Patients With Neural Tube Defects in a Middle-Income Setting.
Perinatal Outcomes in Patients With Neural Tube Defects in a Middle-Income Setting.
Fuente:Birth Defects Research
Tipo de trabajo:Revisión
Extracto:
Managing NTDs involves
preconception strategies, prenatal diagnosis, postnatal care, timely surgical
interventions, and early pediatric rehabilitation. Likewise, proper referral to
complex tertiary care to manage complications and additional morbidity in these
cases could improve short- and long-term patient outcomes.
Autor/es:Velazquez-Torres, Berenice (a) Pacheco-Ruiz, Sandra I (b)
institución:(a) Department of Maternal-Fetal Medicine, Instituto Nacional de Perinatologia, Mexico City, Mexico. (b) Department of Maternal-Fetal Medicine, Instituto Nacional de Perinatologia, Mexico City, Mexico.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
