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Deciphering the role of metal ion transport-related genes in T2D pathogenesis and immune cell infiltration via scRNA-seq and machine learning.
Deciphering the role of metal ion transport-related genes in T2D pathogenesis and immune cell infiltration via scRNA-seq and machine learning.
Fuente:Frontiers in Immunology
Extracto:
Our analysis identified genes crucial for T2D, emphasizing
ion transport, signaling, and immune cell interactions. These findings suggest
therapeutic potential to enhance T2D management. The identified pathways and
genes provide valuable insights into the disease mechanisms and potential targets
for intervention.
institución:(a) Department of Endocrinology, Institute of Translational Medicine, Health Science Center, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China. (b) Imaging Department, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Serum High-Density Lipoprotein Cholesterol Concentrations in Pancreatic Ductal Adenocarcinoma and Its Association With Histological Grade in a Chinese Population.
Serum High-Density Lipoprotein Cholesterol Concentrations in Pancreatic Ductal Adenocarcinoma and Its Association With Histological Grade in a Chinese Population.
Fuente:Cancer Control Journal of The Moffitt Cancer Center
Extracto:
Lower HDL-c
levels are associated with high-grade PDAC and lymph node metastasis, suggesting
that HDL-c may play a protective role in the progression of PDAC.
Cita:Cancer Control 2025 Jan-Dec; 32 : 10732748251316602.
Autor/es:Cao, Ying-Ying (a) Lv, Xiao-Jing (b)
institución:(a) Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. RINGGOLD: 688090 (b) Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. RINGGOLD: 688090
Conflicto:Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
A multicenter cross-sectional survey of the role of community pharmacists, attitudes, and perceptions in preventing and controlling cardiovascular diseases.
A multicenter cross-sectional survey of the role of community pharmacists, attitudes, and perceptions in preventing and controlling cardiovascular diseases.
Fuente:Plos One
Extracto:
Besides dispensing
medicine, community pharmacists had varying extent of involvement in health
promotion activities. The provision of these services differed between
socio-demographic groups. Community pharmacists possessed good knowledge,
positive attitudes towards their cardiovascular disease management role. Thus,
they can improve cardiovascular disease outcomes. However, the barriers
potentially limit their scope of practice and encourage inconsistent community
pharmacy services. The findings present pertinent information to policy-makers,
regulators, and pharmacists that can inform the development of frameworks to
improve clinical and pharmacy practice in Lesotho and low- and middle-income
countries.
institución:(a) Discipline of Pharmaceutical Sciences, University of KwaZulu-Natal, Durban, South Africa. (b) Discipline of Pharmaceutical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Prevalence and associated factors of diabetic ketoacidosis among patients with diabetes mellitus at the University of Gondar Comprehensive and Specialized Referral Hospital Northwest, Ethiopia.
Prevalence and associated factors of diabetic ketoacidosis among patients with diabetes mellitus at the University of Gondar Comprehensive and Specialized Referral Hospital Northwest, Ethiopia.
Fuente:Plos One
Extracto:
AND
RECOMMENDATIONS: The prevalence of diabetic ketoacidosis among follow-up diabetes
patients in this study was high, particularly among those aged 20-29 years,
unemployed, or with infections. Increased vigilance, regular monitoring, timely
infection management, and comprehensive diabetes education are essential for
early detection and prevention of DKA. Social and financial support for
unemployed diabetic patients can further enhance access to care and reduce DKA
risk.
institución:(a) Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. (b) Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Implementation and first report of the Brazilian Kidney Biopsy Registry.
Implementation and first report of the Brazilian Kidney Biopsy Registry.
Fuente:Plos One
Extracto:
This is the first report of a Nationwide registry of kidney biopsies
in Brazil. This data provides pivotal information about the kidney disease
profile in this country with continental dimensions.
Cita:PLoS One 2025; 20 (2) : e0312410.
Autor/es:Noronha, Irene L (a) Ramalho, Rodrigo José (b)
institución:(a) Clinical Nephrology Department of the Brazilian Society of Nephrology, São Paulo, Brazil. (b) Renal Division, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil.
Conflicto:ILN has received honoraria for Steering Committee roles, scientific presentations and/or advisory board attendance from Travere, Chinook, Vertex, Roche, and AstraZeneca. In addition, The George Institute for Global Health holds research contracts for trials in kidney disease. OMVN has received speaker’s honoraria from GSK, Takeda and AstraZeneca. All the other authors declare no conflict of interest.
Prevalence and determinants of poor glycemic control among diabetic chronic kidney disease patients on maintenance hemodialysis in Tanzania.
Prevalence and determinants of poor glycemic control among diabetic chronic kidney disease patients on maintenance hemodialysis in Tanzania.
Fuente:Plos One
Extracto:
The high prevalence of poor
glycemic control among diabetic CKD patients, as revealed by this study, has
significant implications. Patients on antidiabetic medication and those with less
than three dialysis sessions per week are at a high risk of HbA1c > 8%.
Conversely, patients dialyzed using glucose-free dialysates are at a high risk of
HbA1c < 6%. Glycemic control in diabetic chronic kidney disease (CKD) patients is
a great challenge due to altered glucose homeostasis, gluconeogenesis, tubular
glucose reabsorption and inaccuracy of glycemic regulation metrics [1].
Furthermore, changed renal pharmacokinetics of antihyperglycemic agents (AHA),
uremic milieu, and dialysis therapy also contribute to this challenge [2]. Based
on the severe risk of hyperglycemia and hypoglycemia in patients with diabetic
end-stage renal disease (ESRD), glycemic control is of paramount importance.
Cita:PLoS One 2025; 20 (2) : e0306357.
Autor/es:Mfundo, Emmanuel Arthur (a) Marealle, Alphonce Ignace (b)
institución:(a) Quality Assurance Department, National Health Insurance Fund, Arusha, Tanzania. (b) Department of Clinical Pharmacy and Pharmacology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Conflicto:The authors declare that there is no competing interest.
institución:(a) Department of Pediatrics, V Buzzi Children's Hospital, Università di Milano, Milan, Italy. (b) Department of Biomedical and Clinical Science, Università di Milano, Milan, Italy.
Conflicto:AS has spoken for Sanofi and Abbott and has served on the advisory board for Medtronic and Movi. RS has spoken for for Medtronic, Movi, Abbott, Theras, Aventis, Novorapid, Lilly, Ypsomed. All other authors declare no competing interests. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
PCK1 and SLC22A2 gene variants associated with response to metformin treatment in type 2 diabetes.
PCK1 and SLC22A2 gene variants associated with response to metformin treatment in type 2 diabetes.
Fuente:Plos One
Extracto:
Additional
genetic and functional studies are necessary to elucidate the variants' impact in
metformin's pharmacological mechanisms.
Cita:PLoS One 2025; 20 (2) : e0305511.
Autor/es:St-Amour, Sophie (a) Tessier, Laurence (b)
institución:(a) Research Center, Centre intégré universitaire de santé et de services sociaux du Saguenay-Lac-Saint-Jean, Saguenay, Quebec, Canada. (b) Department of Pharmacology-physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Saguenay, Quebec, Canada.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between obstructive sleep apnea and chronic kidney disease: A cross-sectional and Mendelian randomization study.
Association between obstructive sleep apnea and chronic kidney disease: A cross-sectional and Mendelian randomization study.
Fuente:Medicine
Extracto:
These findings may inform prevention and intervention strategies against
CKD.
Cita:Medicine (Baltimore) 2025 Feb 7; 104 (6) : e41437.
Autor/es:Wang, Shaokang (a) Cheng, Yupei (b)
institución:(a) First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. (b) National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Endocrinology, Hôtel-Dieu de France Hospital, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon. (b) Department of Endocrinology, Hôtel-Dieu de France Hospital, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.
Conflicto:The authors have no funding and conflicts of interest to disclose.
Glucagon-like peptide-1 receptor agonists therapy to attenuate the risk of knee osteoarthritis and total knee replacement in type 2 diabetes mellitus
Glucagon-like peptide-1 receptor agonists therapy to attenuate the risk of knee osteoarthritis and total knee replacement in type 2 diabetes mellitus
Fuente:Medicine
Tipo de trabajo:Estudio de cohortes
Extracto:
This
study aimed to provide clinicians with the option of GLP-1RA as a treatment for
patients with T2DM with or without KOA to reduce the risk of KOA or TKR among
such patients.
Cita:Medicine (Baltimore) 2025 Feb 7; 104 (6) : e41243.
Autor/es:Lin, Chih-Ping (a) Chung, Chi-Hsiang (b)
institución:(a) Department of Internal Medicine, Division of Endocrinology and Metabolism, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan, ROC. (b) Department of Internal Medicine, Division of Endocrinology and Metabolism, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, ROC.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Understanding the Association Between Home Broadband Connection and Well-Being Among Middle-Aged and Older Adults in China: Nationally Representative Panel Data Study.
Understanding the Association Between Home Broadband Connection and Well-Being Among Middle-Aged and Older Adults in China: Nationally Representative Panel Data Study.
Fuente:Journal of Medical Internet Research
Extracto:
This study highlights the potential additional
health benefits of digital connectivity beyond the known advantages. Our results
suggest the importance of expanding broadband access to enhance social inclusion
and life satisfaction. Further research is needed to understand the broader
implications and digital determinants of health associated with digital
connectivity.
Claves:China, broadband, digital connectivity, digital divide, health inequity, inequality, internet, internet connection, logistic regression, longitudinal study, middle age, older adult, panel data approach, psychosocial, questionnaire, survey, well-being
Cita:J Med Internet Res 2025 Feb 10; 27 : e59023.
Autor/es:Yang, Lu (a) Lynch, Chris (b)
institución:(a) School of Sociology and Population Studies, Nanjing University of Posts and Telecommunications, Nanjing, China. (b) School of Psychology and Public Health, La Trobe University, Melbourne, Australia.
Discrimination and calibration performances of non-laboratory-based and laboratory-based cardiovascular risk predictions
Discrimination and calibration performances of non-laboratory-based and laboratory-based cardiovascular risk predictions
Fuente:Open Heart
Tipo de trabajo:Revisión sistemática
Extracto:
The discrimination and calibration measures
between laboratory-based and non-laboratory-based models show minimal
differences, demonstrating the insensitivity of c-statistics and calibration
metrics to the inclusion of additional predictors. However, in most reviewed
studies, the HRs for these additional predictors were substantial, significantly
altering predicted risk, particularly for individuals with higher or lower levels
of these predictors compared with the average.
institución:(a) National Centre for Epidemiology and Population Health, College of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, Australia yihun.alemu@anu.edu.au. (b) Department of Epidemiology and Biostatistics, School of Public Health, Bahir Dar University College of Medical and Health Sciences, Bahir Dar, Amhara, Ethiopia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Young people and parent or carers views on type 2 diabetes mellitus care in England and Wales: analysis of parent and patient-reported measures survey.
Young people and parent or carers views on type 2 diabetes mellitus care in England and Wales: analysis of parent and patient-reported measures survey.
Fuente:Bmj Paediatrics Open
Extracto:
This analysis describes the experience of CYP and
their parents/carers of T2DM care and highlights areas for improvement. These
findings may help to inform recommendations about the development of better
patient-centred care for young people with T2DM.
institución:(a) Bristol Royal Hospital for Children, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK katherine.hawton@bristol.ac.uk. (b) University of Bristol, Bristol, UK.
Conflicto:Competing interests: No, there are no competing interests.
Impact of public versus non public insurance on hispanic kidney transplant outcomes using UNOS database.
Impact of public versus non public insurance on hispanic kidney transplant outcomes using UNOS database.
Fuente:Scientific Reports
Extracto:
Public
insurance was a significant predictor for reduced graft and patient survival
after kidney transplant.
Claves:Graft failure, Health disparities, Hispanic, Insurance type, Kidney transplant, Non-public insurance, OPTN/UNOS database, Patient survival, Public insurance, Socioeconomic factors
Cita:Sci Rep 2025 Feb 10; 15 (1) : 4879.
Autor/es:Thongprayoon, Charat (a) Garcia Valencia, Oscar A (b)
institución:(a) Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA. (b) Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between glycated hemoglobin A1c levels, control status, and cognitive function in type 2 diabetes
Association between glycated hemoglobin A1c levels, control status, and cognitive function in type 2 diabetes
Fuente:Scientific Reports
Tipo de trabajo:Estudio de cohortes
Extracto:
Maintaining HbA1c levels below 8% may significantly reduce CI risk in T2DM
patients, highlighting the importance of personalized glycemic management.
Claves:Cognitive impairment, Glycemic control, HbA1c fluctuations, Mean HbA1c, Type 2 diabetes mellitus
Cita:Sci Rep 2025 Feb 11; 15 (1) : 5011.
Autor/es:Xiao, Yanhua (a) Hong, Xuezhi (b)
institución:(a) Department of Rheumatology and Immunology, The First Affiliated Hospital of Guangxi Medical University, No 6 Shuangyong Road, Nanning, 530021, Guangxi, People's Republic of China. (b) Department of Rheumatology and Immunology, The First Affiliated Hospital of Guangxi Medical University, No 6 Shuangyong Road, Nanning, 530021, Guangxi, People's Republic of China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Knowledge, attitude, and practice (KAP) of primary health physicians towards glucose self-monitoring in patients with type2 diabetes mellitus in Palestine.
Knowledge, attitude, and practice (KAP) of primary health physicians towards glucose self-monitoring in patients with type2 diabetes mellitus in Palestine.
Fuente:Bmc Primary Care
Extracto:
There was a positive attitude toward glucose
self-monitoring among the respondents in the primary healthcare clinics.
Conversely, the clinicians' glucose self-monitoring practices were suboptimal.
Future research should examine the knowledge, attitudes, and practices of
physicians who provide patient care in the private sector.
Claves:Glucose monitor, Primary healthcare, Type 2 diabetes mellitus
Cita:BMC Prim Care 2025 Feb 10; 26 (1) : 33.
Autor/es:Hamshari, Suha (a) Hamadneh, Sondos (b)
institución:(a) Department of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine. s.hamshari@najah.edu. (b) Department of Family Medicine and Community Medicine, An-Najah National University, Nablus, 44839, Palestine. s.hamshari@najah.edu.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Decline in eGFR and mortality among type II diabetic patients
Decline in eGFR and mortality among type II diabetic patients
Fuente:Bmc Nephrology
Tipo de trabajo:Estudio de cohortes
Extracto:
This study highlights the importance of early detection of CKD in
patients with diabetes, prompting more comprehensive management of risk factors
related to eGFR decline and mortality. Furthermore, it underscores the need for
future research in this patient population, including investigations about other
relevant risk factors and the impact of different medications, such as
anti-diabetic and antihypertensive medications, on the GFR decline and mortality
rate.
institución:(a) Department of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine. (b) Department of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Global prevalence of Fusobacterium nucleatum and Bacteroides fragilis in patients with colorectal cancer
Global prevalence of Fusobacterium nucleatum and Bacteroides fragilis in patients with colorectal cancer
Fuente:Bmc Gastroenterology
Tipo de trabajo:Metanálisis
Extracto:
Our results emphasized the high prevalence of F. nucleatum and B. fragilis in CRC
patients. Based on this meta-analysis review, regulating the gut microbiota in
CRC patients seemed to be a promising approach to improving the efficacy of CRC
therapy.
institución:(a) Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran. (b) Molecular Microbiology Research Center, Faculty of Medicine, Shahed University, Tehran, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A scoping review of photovoice for people living with diabetes.
A scoping review of photovoice for people living with diabetes.
Fuente:Bmc Public Health
Tipo de trabajo:Revisión
Extracto:
The
photovoice method is a useful research approach for yielding vast visual
information to identify divergences on which to focus and then generate policy
recommendations and promote health behavior practices. However, substantial
challenges remain in the implementation of photovoice research, which limits its
practical benefits. Consistent reporting of the research steps and study
findings, such as using a reporting flow diagram, is needed to help maintain
order in the photovoice method.
institución:(a) Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, No.300, Guangzhou Road, Nanjing, Jiangsu Province, 210029, China. (b) School of Nursing, Nanjing Medical University, Nanjing, 211166, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
