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Long-term effect of sodium-glucose cotransporter 2 inhibitors in kidney functions
Long-term effect of sodium-glucose cotransporter 2 inhibitors in kidney functions
Fuente:Medicine
Tipo de trabajo:Revisión sistemática
Extracto:
This meta-analysis concluded that SGLT2 inhibitors have the
potential to prevent eGFR reduction and improve renal function in patients with
compromised renal function and underlying conditions such as chronic kidney
disease or type 1 and 2 diabetes. However, this meta-analysis showed beneficial
results in the prevention of renal deterioration within several follow-up
periods, with an average of 11 to 12 months.
Cita:Medicine (Baltimore) 2025 Feb 14; 104 (7) : e41422.
Autor/es:Zheng, Yanqun (a) Sun, Jia (b)
institución:Zheng, Yanqun (a) Sun, Jia (b)
Conflicto:The authors have no funding and conflicts of interest to disclose.
Diabetes mellitus, metformin's target gene AMPK, and inflammatory bowel disease: A Mendelian randomization study.
Diabetes mellitus, metformin's target gene AMPK, and inflammatory bowel disease: A Mendelian randomization study.
Fuente:Medicine
Extracto:
Furthermore, our
findings revealed that the metformin's target gene AMPK had no significant effect
on the onset of IBD.
Cita:Medicine (Baltimore) 2025 Feb 14; 104 (7) : e41532.
Autor/es:Wu, Wei (a) Tong, Huomu (b)
institución:(a) Department of Geriatrics, Chun'an First People's Hospital (Chun'an Branch of Zhejiang Provincial People's Hospital), Hangzhou, Zhejiang Province, China. (b) Department of Endocrinology, Chun'an First People's Hospital (Chun'an Branch of Zhejiang Provincial People's Hospital), Hangzhou, Zhejiang Province, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between virus exposure and erectile dysfunction in US adults.
Association between virus exposure and erectile dysfunction in US adults.
Fuente:Medicine
Extracto:
This study found that
seropositivity for Hepatitis A or CMV is associated with ED.
Cita:Medicine (Baltimore) 2025 Feb 14; 104 (7) : e41355.
Autor/es:Lian, Juan (a) Xie, Li (b)
institución:(a) Department of Urology, The 3rd Affiliated Hospital of Chengdu Medical College, Pidu District People's Hospital, Chengdu, China. (b) Department of Urology, The 3rd Affiliated Hospital of Chengdu Medical College, Pidu District People's Hospital, Chengdu, China.
Conflicto:The authors declare that the research was conducted without any commercial or financial relationships that could be seen as a potential conflict of interest.
Effect of intensive nutrition training, education and support versus standard therapy in reducing the need for insulin therapy in gestational diabetes (INTENSE-GDM): a protocol for a randomised controlled single-centre trial in Denmark.
Effect of intensive nutrition training, education and support versus standard therapy in reducing the need for insulin therapy in gestational diabetes (INTENSE-GDM): a protocol for a randomised controlled single-centre trial in Denmark.
Fuente:Bmj Open
Tipo de trabajo:Revisión
Extracto:
TRIAL REGISTRATION NUMBER: NCT06127823.
Claves:DIABETES & ENDOCRINOLOGY, Diabetes in pregnancy, Health economics, NUTRITION & DIETETICS, OBSTETRICS
Cita:BMJ Open 2025 Feb 17; 15 (2) : e089231.
Autor/es:Ewers, Bettina (a) Blond, Martin B (b)
institución:(a) Department of Diabetes Care, Steno Diabetes Center Copenhagen, Herlev, Capital Region of Denmark, Denmark bettina.ewers@regionh.dk. (b) Department of Clinical and Translational Research, Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark.
Conflicto:Competing interests: Steno Diabetes Center Copenhagen (SDCC) is a hospital providing health services within the public healthcare system. The research project and SDCC are partially funded by the Novo Nordisk Foundation through unrestricted grants. The Novo Nordisk Foundation has no financial interest in the study and has no influence on the (1) study design; (2) collection, analysis and interpretation of...
data; (3) writing of the study report and publication and (4) decision to submit the paper for publication. The investigators have no financial, personal or professional associations that could be perceived as influencing the study. They will not benefit economically from conducting this study and have no competing interest to declare.
Association of nocturnal oxygen saturation with coronary artery calcification: cross-sectional evidence from the population-based SESSA study among Japanese men.
Association of nocturnal oxygen saturation with coronary artery calcification: cross-sectional evidence from the population-based SESSA study among Japanese men.
Fuente:Bmj Open
Extracto:
Lower mean SpO(2) and
higher ODI are associated with CAC among Japanese men, independent of age,
lifestyle factors and obesity. The associations became non-significant after
adjusting for diabetes and dyslipidaemia, but were mediated through these
factors.
institución:(a) Department of Advanced Epidemiology, NCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan. (b) Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Japan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Scalable intracellular delivery via microfluidic vortex shedding enhances the function of chimeric antigen receptor T-cells.
Scalable intracellular delivery via microfluidic vortex shedding enhances the function of chimeric antigen receptor T-cells.
Fuente:Scientific Reports
Extracto:
We
demonstrate that scaled-up hydroporation can process 5 × 10(8) cells in less than
10 s, showcasing the platform as a viable solution for high-yield CAR-T
manufacturing with the potential for improved therapeutic outcomes.
Autor/es:Sytsma, Brandon J (a) Allain, Vincent (b)
institución:(a) Indee Labs, Berkeley, CA, USA. (b) Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Conflicto:Declarations. Competing interests: B.J.S., S.B., F.F., L.H.W., and R.S.P. are or were employed by and have an equity interest in Indee Labs. L.M.R.F., J.B., L.L., F.L.P. and J.E. are or were consultants to Indee Labs. R.S.P. is an investor in and a venture partner at both Pioneer Fund and Axial, which have a financial interest in Indee Labs. The Ferreira...
Lab received support from Indee Labs as a subaward from the National Institute of Diabetes and Digestive and Kidney Diseases (Grant No. 1R43DK133029-01). Indee Labs has a commercial interest in developing patents related to HydroporeTM (WO2016109864A1 & WO2019084624A1). M.F. and R.B. are or were employed by and have an equity interest in CellChorus. CellChorus received support from the National Center for Translational Sciences (R44TR005137) and the National Institute of General Medical Sciences (R44GM149106) of the National Institutes of Health and the National Science Foundation (NSF2229323). CellChorus has a commercial interest in developing the TIMING assay. J.E. is a compensated co-founder at Mnemo Therapeutics; owns stocks in Mnemo Therapeutics and Cytovia Therapeutics; is a compensated scientific advisor for Enterome, Treefrog Therapeutics and Resolution Therapeutics; and is a holder of patents pertaining to but not resulting from this work. The Eyquem Lab received research support from Cytovia Therapeutic, Mnemo Therapeutics, Takeda and Indee Labs as a subaward from the National Cancer Institute (Contract No. 7591022C00053). All other authors declare no competing interests.
Diabetes mellitus and its determinants among tuberculosis patients in South Gondar Zone health facilities, Northwest Ethiopia.
Diabetes mellitus and its determinants among tuberculosis patients in South Gondar Zone health facilities, Northwest Ethiopia.
Fuente:Scientific Reports
Extracto:
Integrating TB and DM screening as well as
care delivery in clinical practice is essential to achieving the goal of TB
control and improving the health outcomes of both diseases.
institución:(a) College of Health Sciences, Department of Medical Laboratory Science, Debre Tabor University, Debre Tabor, Ethiopia. yeshiworkazene@yahoo.com. (b) College of Health Sciences, Department of Medical Laboratory Science, Debre Tabor University, Debre Tabor, Ethiopia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Risk assessment of femoral head AVN following reduction and fixation of intracapsular hip fractures in patients younger than 65 years over a 10 year follow up.
Risk assessment of femoral head AVN following reduction and fixation of intracapsular hip fractures in patients younger than 65 years over a 10 year follow up.
Fuente:Scientific Reports
Extracto:
Identifying and addressing these
factors may enhance the overall management of femoral neck fractures in this
population.
Cita:Sci Rep 2025 Feb 17; 15 (1) : 5691.
Autor/es:Benady, Amit (a) Yehiel, Noy (b)
institución:(a) Department of Orthopedics, Tel Aviv Sourasky Medical Center, Affiliated to the Faculty of Medicine at Tel Aviv University, Tel Aviv, Israel. amitbe@tlvmc.gov.il. (b) Levin Center for Surgical Innovation and 3D Printing, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. amitbe@tlvmc.gov.il.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Cachexia Alters Central Nervous System Morphology and Functionality in Cancer Patients.
Cachexia Alters Central Nervous System Morphology and Functionality in Cancer Patients.
Fuente:Journal of Cachexia, Sarcopenia and Muscle
Extracto:
Our results indicate that cachexia compromises CNS morphology mostly causing
changes in the GM of cachectic patients, leading to alterations in regional
volume patterns, functional connectivity, neuronal morphology, neuroglia profile
and inducing neuroinflammation, all of which may contribute to the loss of
homeostasis control and to deficient information processing, as well as to the
metabolic and behavioural derangements commonly observed in human cachexia. This
first human mapping of CNS cachexia responses will now pave the way to
mechanistically interrogate these pathways in terms of their therapeutic
potential.
Claves:central nervous system, grey matter, human cachexia, neuroimaging, neuroinflammation, neuropathology
institución:(a) Cancer Metabolism Research Group (LIM26-HCFMUSP), Department of Surgery, São Paulo, Brazil. (b) Institute for Diabetes and Cancer, Helmholtz Munich, and German Center for Diabetes Research DZD, Neuherberg, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Evaluating the risk of comorbidity onset in elderly patients after a cancer diagnosis.
Evaluating the risk of comorbidity onset in elderly patients after a cancer diagnosis.
Fuente:Bmc Public Health
Extracto:
The above findings
demonstrated the imperative development of enhanced treatment protocols, which
prioritize the overall health of cancer patients, thereby reducing their
susceptibility to additional illnesses.
Autor/es:Islam, Md Tamzid (a) Saif, Md Saiful Islam (b)
institución:(a) Department of Biostatistics & Data Science, The University of Kansas Medical Center, Kansas City, KS, 66160, USA. (b) Department of Biostatistics & Data Science, The University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between triglyceride glucose-body mass index and gestational diabetes mellitus
Association between triglyceride glucose-body mass index and gestational diabetes mellitus
Fuente:Bmc Pregnancy and Childbirth
Tipo de trabajo:Estudio de cohortes
Extracto:
In this South Korean cohort, increased TyG-BMI during early
pregnancy (10-14 weeks) was significantly associated with the onset of GDM
(during pregnancy 24-28 weeks). TyG-BMI could be integrated into clinical
practice as a complementary preliminary screening tool for detecting women who
are at increased risk of GDM.
Claves:Cohort study, Gestational diabetes mellitus, Triglyceride glucose-body mass index
Cita:BMC Pregnancy Childbirth 2025 Feb 17; 25 (1) : 170.
Autor/es:Liang, Xiaomin (a) Lai, Kai (b)
institución:(a) Department of Critical Care Medicine, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China. (b) Department of Critical Care Medicine, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Investigation of the correlation between urinary aromatic amines and the risk of depression through an examination of the NHANES data from 2013 to 2014.
Investigation of the correlation between urinary aromatic amines and the risk of depression through an examination of the NHANES data from 2013 to 2014.
Fuente:Bmc Psychiatry
Extracto:
Elevated levels of certain amino acids in urine were associated with a higher
likelihood of depression. Notably, 2-aminonaphthalene appeared to be a
significant contributing factor, particularly among smokers.
institución:(a) Department of Cardiology, The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou People's Hospital, Wenzhou, China. zhuningccc@126.com. (b) Department of Cardiology, The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, The Third Affiliated Hospital of Shanghai University, Wenzhou People's Hospital, Wenzhou, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Principal components of type 2 diabetes risk: an exploratory factor analysis in an Iranian cohort.
Principal components of type 2 diabetes risk: an exploratory factor analysis in an Iranian cohort.
Fuente:Bmc Public Health
Extracto:
Key metabolic clusters, including "Lipids", "Body Mass", "Chronic
Diseases", and "Glucose/Lipid" align with previous findings. These results
underscore the multifactorial and interconnected nature of T2D risk, highlighting
underlying physiological processes.
Claves:Exploratory Factor Analysis, Principal component analysis, Type 2 diabetes risk factors
Cita:BMC Public Health 2025 Feb 17; 25 (1) : 652.
Autor/es:Geravandi, Sara (a) Emamgholipour, Sara (b)
institución:(a) Department of Health Management, policy and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. (b) Department of Health Management, policy and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. s-emamgholipour@tums.ac.ir.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Global, regional, and national burden of chronic kidney disease and its underlying etiologies from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021.
Global, regional, and national burden of chronic kidney disease and its underlying etiologies from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021.
Fuente:Bmc Public Health
Extracto:
The study unveiled the uneven global distribution of the burden of
CKD and its attributable causes. From 1990 to 2021, an increase in the burden of
incidence, mortality, and DALYs due to CKD was observed. Population growth and
aging will contribute to a further increase in the burden of CKD. Healthcare
providers should develop health policies, and optimize the allocation of medical
resources, based on age, sex, region, and disease type.
Claves:Age and gender distribution, Chronic kidney disease, Etiology, Global burden of disease study, Time trend
Cita:BMC Public Health 2025 Feb 17; 25 (1) : 636.
Autor/es:Deng, Ling (a) Guo, Shujin (b)
institución:(a) Department of Health Management and Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. (b) Department of Health Management and Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Burden of peripheral artery disease and risk factors among patients with diabetes mellitus in sub-Saharan Africa
Burden of peripheral artery disease and risk factors among patients with diabetes mellitus in sub-Saharan Africa
Fuente:Bmc Endocrine Disorders
Tipo de trabajo:Revisión sistemática
Extracto:
Despite the
alarming prevalence of peripheral artery disease among patients with diabetes in
sub-Saharan Africa, it remains underdiagnosed; therefore, increased awareness,
proactive screening initiatives, and management strategies within the clinical
setting are necessary. CLINICAL TRIAL NUMBER: Not applicable. PROSPERO:
CRD42024594577.
Claves:Diabetes mellitus, Lower extremity, Peripheral artery disease, Sub-Saharan Africa
institución:(a) School of Nursing, College of Health Sciences and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia. kiruesha2@gmail.com. (b) School of Public Health, College of Health Sciences and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Total fat intake and fatty acid patterns and prediabetes regression: differential effects across phenotypes in a population-based cohort.
Total fat intake and fatty acid patterns and prediabetes regression: differential effects across phenotypes in a population-based cohort.
Fuente:European Journal of Medical Research
Tipo de trabajo:Estudio de cohortes
Extracto:
Subjects with iIGT phenotype may take
more advantage from adhering a LFD. Dietary fat patterns may differentially
affect chance of returning to NGR across Pre-DM phenotypes.
Claves:Dietary fat, Normoglycemia, Prediabetes phenotypes, Type 2 diabetes
Cita:Eur J Med Res 2025 Feb 17; 30 (1) : 110.
Autor/es:Bahadoran, Zahra (a) Kashani, Zahra (b)
institución:(a) Micronutrient Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. z.bahadoran@sbmu.ac.ir. (b) Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O.Box: 19395-4763, No 23, A'rabi St, Yeman Av, Velenjak, Tehran, Iran. z.bahadoran@sbmu.ac.ir.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A Longitudinal Increase in Serum Gamma-Glutamyl Transferase Levels, but Not in Alanine Aminotransferase Levels, Improves the Prediction of Risk of Impaired Fasting Glucose in Male.
A Longitudinal Increase in Serum Gamma-Glutamyl Transferase Levels, but Not in Alanine Aminotransferase Levels, Improves the Prediction of Risk of Impaired Fasting Glucose in Male.
Fuente:Journal of Korean Medical Science
Extracto:
We revealed that a longitudinal increase
in serum GGT levels was related to an increased risk of IFG in males. Therefore,
monitoring the changes in serum GGT levels is important for predicting new-onset
IFG, and it can be used as an early indicator of onset of overt diabetes in
males.
institución:(a) Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea. (b) Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea.
Conflicto:The authors have no potential conflicts of interest to disclose.
Gestational diabetes mellitus in previous pregnancy associated with the risk of large for gestational age and macrosomia in the second pregnancy.
Gestational diabetes mellitus in previous pregnancy associated with the risk of large for gestational age and macrosomia in the second pregnancy.
Fuente:Frontiers in Endocrinology
Extracto:
Previous GDM is strongly linked to LGA and macrosomia
in subsequent pregnancies. However, this relationship is influenced by GWG, prior
LGA history, fetal sex, and maternal age. Managing weight alone may not
sufficiently reduce the risk of LGA or macrosomia for women with a history of
GDM.
Claves:body mass index, gestational diabetes mellitus, gestational weight gain, large for gestational age, macrosomia, multipara
institución:(a) Center of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China. (b) Institute of Obstetrics and Gynecology, Shenzhen Peking University-Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Shenzhen, Guangdong, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
institución:(a) Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany. (b) Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Conflicto:Author RL has received honoraria for speaking or consulting or has obtained research grants from Novartis, Lilly, Bayer, Dompe, Synthon, Argen-X, Pharmaxis, CSL, TriNetX, Monasterium Laboratories, and Incyte during the last 3 years. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of...
interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
Potential overtreatment in elderly patients with diabetes mellitus: Results from a cross-sectional study in German general practice.
Potential overtreatment in elderly patients with diabetes mellitus: Results from a cross-sectional study in German general practice.
Fuente:The European Journal of General Practice
Extracto:
Overtreatment is a relevant problem in
elderly patients with DM2 for which GPs should regularly check and start
deprescribing. Cluster effects suggest heterogeneity between general practices in
diabetes management and monitoring.
Claves:Elderly, cross-sectional studies, diabetes mellitus type 2, general practice, overtreatment
institución:(a) Institute of General Practice and Family Medicine, Medical Faculty, Martin-Luther-University Halle-Wittenberg, Halle, Saale, Germany. (b) Institute of General Practice and Family Medicine, Medical Faculty, Martin-Luther-University Halle-Wittenberg, Halle, Saale, Germany.
Conflicto:No potential conflict of interest was reported by the author(s).
