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Functional Mitral Valve Regurgitation, Pathophysiology, Leaflet ReModeling, and the Role of Imaging.
Functional Mitral Valve Regurgitation, Pathophysiology, Leaflet ReModeling, and the Role of Imaging.
Fuente:Echocardiography (mount Kisco, N.y.)
Extracto:
This review aims to: (a) describe the
pathophysiology of the most common phenotypes of FMR, (b) challenge the paradigm
that mitral leaflets are structurally normal in FMR, and (c) illustrate the
critical role of both echocardiography and CMR in the comprehensive assessment of
FMR.
Autor/es:Faletra, Francesco Fulvio (a) La Franca, Eluisa (b)
institución:(a) Clinical Cardiology and Heart Failure Unit, Mediterranean Institute for Transplantation and Advanced Therapies (ISMETT), IRCCS, Palermo, Italy. (b) Clinical Cardiology and Heart Failure Unit, Mediterranean Institute for Transplantation and Advanced Therapies (ISMETT), IRCCS, Palermo, Italy.
Conflicto:Francesco F Faletra has received speker fee from Philips.
Psychological indicators for healthy aging: validation of the German short version of Ryff's scales of psychological well-being (SPWB).
Psychological indicators for healthy aging: validation of the German short version of Ryff's scales of psychological well-being (SPWB).
Fuente:Journal of Patient-reported Outcomes
Extracto:
The German SPWB 18-item version shows comparable
psychometric properties to previous large-scale studies from other countries. The
SPWB provides psychological indicators for healthy aging.
institución:(a) Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. (b) Diagnostics in Healthcare and E-Health, Trier University, Trier, Germany.
Conflicto:Declarations. Ethics approval and consent to participate: The protocol and documents of the study were approved by the local data safety commissioner and by the ethics committee of the Medical Chamber of Rhineland Palatinate (reference no. 837.394.17; original vote: December 12, 2017, latest update: September 27, 2021). Study investigations were all conducted in line with the Declaration of Helsinki and...
principles outlined in recommendations for Good Clinical Practice and Good Epidemiological Practice. Written informed consent was obtained from each participant before their inclusion in the study. Informed consent: Written informed consent was obtained from all individual participants included in the study. Consent to publish: Not applicable. Competing interests: P.S.W. is funded by the Federal Ministry of Education and Research (BMBF 01EO1503). P.S.W. and T.M. are PIs of the DZHK (German Center for Cardiovascular Research), Partner Site Rhine-Main, Mainz, Germany. There are no patents, products in development, or marketed products to declare. This does not alter the authors’ adherence to all of the journal policies on sharing data and materials. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The other authors declare no competing interests.
Extracto:
In this manuscript, we describe imaging
techniques to identify and quantify congestion, clarify its origin, and
potentially guide the management of patients with cardio-renal syndrome.
Autor/es:Ei Khin, Htet Htet (a) Cuthbert, Joe J (b)
institución:(a) School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK. (b) Clinical Sciences Centre, Hull York Medical School, University of Hull, Cottingham Road, Kingston-Upon-Hull, East Yorkshire, UK.
Conflicto:Declarations. Human and Animal Rights and Informed Consent: Not applicable. Competing Interests: SS has received consultancy or speaker fees or travel support from Astellas Pharma, AstraZeneca, and CSL Vifor. SS research is funded by the Chief Scientist Office (CSO), Scotland. PP has received consultancy honoraria and/or sponsorship support from Pharmacosmos, Vifor, AstraZeneca and Caption Health in the past 3 years,...
not connected with this manuscript.
Cardiopulmonary Fitness and Physical Activity Among Children and Adolescents With Inherited Cardiac Disease.
Cardiopulmonary Fitness and Physical Activity Among Children and Adolescents With Inherited Cardiac Disease.
Fuente:Jama Network Open
Extracto:
AND RELEVANCE: This cross-sectional study suggests that
levels of cardiopulmonary fitness and physical activity were lower in children
and adolescents with inherited cardiac disease than in healthy controls, even
after adjusting for use of β-blockers and using modern pediatric reference
models. Assessing cardiopulmonary fitness among children with inherited cardiac
disease can contribute to engaging in a shared decision-making process for sports
participation and preventive interventions, such as early cardiac rehabilitation
programs.
Cita:JAMA Netw Open 2025 Feb 3; 8 (2) : e2461795.
Autor/es:Souilla, Luc (a) Werner, Oscar (b)
institución:(a) PhyMedExp, INSERM, CNRS, University of Montpellier, Montpellier, France. (b) Department of Pediatric and Congenital Cardiology, M3C Regional Reference Centre, Montpellier University Hospital, Montpellier, France.
Conflicto:Conflict of Interest Disclosures: Dr Charron reported receiving personal fees from Amicus Therapeutics, Bristol Myers Squibb, Owkin, and Pfizer outside the submitted work. Dr Delinière reported receiving personal fees from Sanofi, Bristol Myers Squibb, and Anlylam Pharmaceuticals outside the submitted work. Dr Sacher reported receiving personal fees from Abbott, Biosense Webster, Boston Scientific, Medtronic, and inHEART outside the submitted work....
. No other disclosures were reported.
Late Adverse Events After Chimeric Antigen Receptor T-Cell Therapy for Patients With Aggressive B-Cell Non-Hodgkin Lymphoma.
Late Adverse Events After Chimeric Antigen Receptor T-Cell Therapy for Patients With Aggressive B-Cell Non-Hodgkin Lymphoma.
Fuente:Jama Network Open
Tipo de trabajo:Estudio de cohortes
Extracto:
AND RELEVANCE: This
cohort study suggests that CAR T-cell therapy has a favorable safety profile.
However, continuous follow-up of patients is needed, as serious AEs can occur
years after infusion.
institución:(a) Department of Clinical Pharmacology, University Hospital Vall d'Hebron, Barcelona, Spain. (b) Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Conflicto:Conflict of Interest Disclosures: Dr Iacoboni reported receiving honoraria and/or travel support from AbbVie, AstraZeneca, Autolus, Bristol Myers Squibb, Kite/Gilead, Miltenyi, and Novartis outside the submitted work. Dr Kwon reported receiving honoraria or travel support from Gilead, Pfizer, Jazz, and Sanofi. Dr Guerreiro reported receiving personal fees from Novartis, Kite/Gilead, and Bristol Myers Squibb outside the submitted work. Dr Barba...
reported receiving personal fees from Amgen, Allogene, Autolus, Bristol Myers Squibb, Incyte, Kite-Gilead, Novartis, and Pfizer outside the submitted work. No other disclosures were reported.
Incidence and Factors Associated With Recurrent Pericarditis in Lupus.
Incidence and Factors Associated With Recurrent Pericarditis in Lupus.
Fuente:Jama Network Open
Tipo de trabajo:Estudio de cohortes
Extracto:
AND RELEVANCE: In this study, recurrence was more likely within 1
year of the onset of pericarditis and among younger patients, those with
uncontrolled disease, and those receiving oral prednisone therapy, with a
dose-dependent association. These findings may set the basis for future studies
to define optimal treatment for recurrent pericarditis in patients with SLE and
suggest that oral corticosteroids should be avoided when treating pericarditis in
patients with SLE.
Cita:JAMA Netw Open 2025 Feb 3; 8 (2) : e2461610.
Autor/es:Kim, Yoo Jin (a) Lovell, Jana (b)
institución:(a) Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland. (b) Center for Cardiac Immunology, Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
Conflicto:Conflict of Interest Disclosures: Dr Goldman reported receiving grants from the Johns Hopkins University School of Medicine during the conduct of the study. Dr Petri reported receiving grants from Johns Hopkins University during the conduct of the study. Dr Adamo reported receiving personal fees from Kiniksa Pharmaceuticals and Novo Nordisk and being a cofounder of I-Cordis LLC outside the submitted...
work. No other disclosures were reported.
Adherence to the Mediterranean Diet and Obesity-Linked Cancer Risk in EPIC.
Adherence to the Mediterranean Diet and Obesity-Linked Cancer Risk in EPIC.
Fuente:Jama Network Open
Tipo de trabajo:Estudio de cohortes
Extracto:
AND RELEVANCE: These findings indicate that higher adherence to the
MedDiet is associated with a modest reduction in the risk of ORCs, independent of
adiposity measures. Further research is needed to clarify the mechanisms by which
the MedDiet may contribute to cancer prevention.
institución:(a) Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain. (b) Navarra Institute for Health Research, Pamplona, Spain.
Conflicto:Conflict of Interest Disclosures: Dr Guevara reported receiving grants from the Health Research Fund–Instituto de Salud Carlos III during the conduct of the study. No other disclosures were reported.
Establishing Syndromic Surveillance of Acute Coronary Syndrome, Myocardial Infarction, and Stroke: Registry Study Based on Routine Data From German Emergency Departments.
Establishing Syndromic Surveillance of Acute Coronary Syndrome, Myocardial Infarction, and Stroke: Registry Study Based on Routine Data From German Emergency Departments.
Fuente:Jmir Public Health and Surveillance
Extracto:
We developed NCD indicators for ACS, MI,
and STR that showed high levels of internal and external validity. The
integration of these indicators into the syndromic surveillance system for EDs
could enable daily monitoring of NCD patterns and trends to enhance timely public
health surveillance in Germany.
Claves:Germany, accuracy, acute coronary syndrome, diagnosis, emergency department, emergency medicine, health surveillance, myocardial infarction, public health, public health surveillance, routine data, routinely collected health data, stroke, syndrome, syndromic surveillance
Cita:JMIR Public Health Surveill 2025 Feb 25; 11 : e66218.
institución:(a) Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany. (b) Institute of Public Health, Charité - Universitätsmedizin Berlin, corporate member of Freie Universiät Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Maternal vitamin D status in relation to cardiometabolic risk factors in children from the Norwegian Environmental Biobank.
Maternal vitamin D status in relation to cardiometabolic risk factors in children from the Norwegian Environmental Biobank.
Fuente:Plos One
Tipo de trabajo:Estudio de cohortes
Extracto:
The results indicate that higher maternal vitamin D status during
pregnancy may be related to higher childhood adiponectin z-score, but not with
any other cardiometabolic risk marker. Whether adiponectin could be one pathway
linking vitamin D to cardiometabolic health remains to be determined.
Cita:PLoS One 2025; 20 (2) : e0318071.
Autor/es:Amberntsson, Anna (a) Bärebring, Linnea (b)
institución:(a) Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. (b) Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Trustworthy diagnosis of Electrocardiography signals based on out-of-distribution detection.
Trustworthy diagnosis of Electrocardiography signals based on out-of-distribution detection.
Fuente:Plos One
Extracto:
The results not only validate the
effectiveness of our approach but also highlight its potential application value
in cardiac health diagnostics.
Cita:PLoS One 2025; 20 (2) : e0317900.
Autor/es:Yu, Bowen (a) Liu, Yuhong (b)
institución:(a) Global Health Research Center, Duke Kunshan University, Jiangsu, China. (b) School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Cardiology involvement and mortality in adult patients with advanced solid cancer complicated by atrial fibrillation.
Cardiology involvement and mortality in adult patients with advanced solid cancer complicated by atrial fibrillation.
Fuente:Plos One
Tipo de trabajo:Estudio de cohortes
Extracto:
In adult patients with advanced solid cancer, AF per se was not independently
associated with increased mortality. Cardiology involvement in patients with
advanced solid cancer and AF was linked to a better overall survival, but with
low certainty that this finding is not attributable to unmeasured confounding.
Cita:PLoS One 2025; 20 (2) : e0319342.
Autor/es:Sato, Takeshi (a) Dai, Zhehao (b)
institución:(a) Department of Cardiology, Nagaoka Chuo General Hospital, Niigata, Japan. (b) Department of Cardiovascular Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Emergency, The Brain Hospital of Guangxi Zhuang Autonomous Region, Liuzhou, China. (b) The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Conflicto:The researchers affirm that the study was carried out without any commercial or financial affiliations that might be perceived as a potential conflict of interest.
Association between cardiometabolic index and albuminuria: Evidence from NHANES 2017-2020.
Association between cardiometabolic index and albuminuria: Evidence from NHANES 2017-2020.
Fuente:Plos One
Extracto:
Our findings indicate that CMI levels are significantly
associated with the risk of albuminuria prevalence, suggesting that CMI could
serve as a valuable biomarker for assessing the risk of albuminuria.
Cita:PLoS One 2025; 20 (2) : e0318736.
Autor/es:Xu, Qiming (a) Lin, Junyan (b)
institución:(a) Institute of Kidney Disease of Shanghai University of Traditional Chinese Medicine, Shanghai, China. (b) Department of Nephrology, Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Measurement accuracy and cutoffs for predicting primary aldosteronism diagnosis using Lumipulse® for renin and aldosterone measurements.
Measurement accuracy and cutoffs for predicting primary aldosteronism diagnosis using Lumipulse® for renin and aldosterone measurements.
Fuente:Plos One
Extracto:
Lumipulse® (Fujirebio®) is a reliable
alternative for measuring PRC, PAC, and 24UA for predicting PA diagnosis with the
use of corresponding cut-off values for each criterion.
institución:(a) Physiology Department, AP-HP, Georges Pompidou European Hospital, Paris, France. (b) Physiology Department, AP-HP, Georges Pompidou European Hospital, Paris, France.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Digital Therapeutics-Based Cardio-Oncology Rehabilitation for Lung Cancer Survivors: Randomized Controlled Trial.
Digital Therapeutics-Based Cardio-Oncology Rehabilitation for Lung Cancer Survivors: Randomized Controlled Trial.
Fuente:Jmir Mhealth and Uhealth
Tipo de trabajo:Estudio aleatorizado y controlado
Extracto:
The 5-month, digital therapeutics-based telerehabilitation improved
cardiorespiratory fitness in lung cancer survivors with good compliance and
safety. Patients receiving telerehabilitation also reported improved QOL with
reduced levels of fatigue, anxiety, and daytime dysfunction. TRIAL REGISTRATION:
Chinese Clinical Trial Registry ChiCTR2200064000;
https://www.chictr.org.cn/showproj.html?proj=180594.
Claves:app, cancer, cardio-oncology rehabilitation, cardiology, cardiopulmonary, cardiorespiratory fitness, digital health, digital technology, digital therapeutics, exercise prescription, non-small cell lung cancer, oncology, physical activity, quality of life, randomized controlled trial, rehabilitation, survivor, telerehabilitation, wearable
Cita:JMIR Mhealth Uhealth 2025 Feb 25; 13 : e60115.
Autor/es:Li, Guangqi (a) Zhou, Xueyan (b)
institución:(a) Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. (b) West China School of Medicine, Sichuan University, Chengdu, China.
Changes in life expectancy at birth during the COVID-19 pandemic and contributions by cause of death in British Columbia, Canada.
Changes in life expectancy at birth during the COVID-19 pandemic and contributions by cause of death in British Columbia, Canada.
Fuente:Health Reports
Extracto:
INTERPRETATION: The COVID-19 pandemic impacted
population health not only through its direct effects but also through indirect
impacts on other health outcomes, including the unregulated drug toxicity crisis,
the combination of which were driving factors in the decline in life expectancy
at birth.
Claves:COVID-19, inequalities, life expectancy, unregulated drug toxicity
Cita:Health Rep 2025 Feb 19; 36 (2) : 3-14.
Autor/es:Ye, Xibiao (a) Sevcenco, Ioana (b)
institución:(a) Office of the Provincial Health Officer, Ministry of Health, British Columbia. (b) University of Victoria.
Diagnosing Complete Response to Preoperative Chemoradiation in Esophageal Cancer Using Dynamic Contrast-Enhanced MRI Response Criteria.
Diagnosing Complete Response to Preoperative Chemoradiation in Esophageal Cancer Using Dynamic Contrast-Enhanced MRI Response Criteria.
Fuente:Korean Journal of Radiology
Extracto:
DCE-MRI-based grading shows
high diagnostic performance for identifying pCR in primary tumors, particularly
in terms of PPV and specificity, and enhances response evaluation when combined
with PET/CT and endoscopy.
Claves:Esophageal neoplasms, Magnetic resonance imaging, Neoadjuvant therapy, Pathologic complete response
Cita:Korean J Radiol 2025 Mar; 26 (3) : 269-280.
Autor/es:Ahn, Yura (a) Choe, Jooae (b)
institución:(a) Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. (b) Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. jooae23@gmail.com.
Conflicto:The authors have no potential conflicts of interest to disclose.
Elevated Soluble Suppressor of Tumorigenicity 2 Levels in Gout Patients and Its Association with Cardiovascular Disease Risk Indicators.
Elevated Soluble Suppressor of Tumorigenicity 2 Levels in Gout Patients and Its Association with Cardiovascular Disease Risk Indicators.
Fuente:Yonsei Medical Journal
Tipo de trabajo:Revisión
Extracto:
Patients with gout and elevated sST2
levels have a higher risk of future cardiovascular disorders, which may provide
insights into risk stratification and the implementation of intervention
strategies.
Claves:Gout, biomarker, cardiovascular, risk, suppressor of tumorigenicity 2
Cita:Yonsei Med J 2025 Mar; 66 (3) : 151-159.
Autor/es:Kim, Jiyoung Agatha (a) Lee, Ji Eun (b)
institución:(a) Department of Emergency Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. (b) Graduate School, Yonsei University College of Medicine, Seoul, Korea.
Conflicto:The authors have no potential conflicts of interest to disclose.
institución:(a) Department of Emergency Medicine, Seoul National University Hospital, Seoul, Korea. (b) Department of Emergency Medicine, Seoul National University Hospital, Seoul, Korea. matewoos@gmail.com.
Conflicto:Joonghee Kim, MD, PhD developed the algorithm. He also founded a start-up company, ARPI Inc., where he serves as the CEO. Youngjin Cho, MD, PhD works for the company as a research director. Eunkyoung Lee and Dahyeon Son work for the company as clinical researchers. The other authors have no conflict of interests.
