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The increasing number of Open Access articles widens the reading offer
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consult a profuse amount of documents that will feed
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SIIC created, produced and handles the AFT software that deciphers
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study: specialty, study style, source, publication and selection
dates, source definition, query limitations, summary in Spanish,
etc.
While most of the selected texts belong to original articles,
reviews, and guidelines, readers will also find commentaries,
interviews, journalistic reports, letters to authors or other texts
that may lead to discussions or clarifications.
Guideline for the Use of Natriuretic Peptides in the Early Diagnosis and Management of Heart Failure in Primary Care (Joint Consensus Report by the Eurasian Society of Heart Failure and the Turkish Association of Family Medicine).
Guideline for the Use of Natriuretic Peptides in the Early Diagnosis and Management of Heart Failure in Primary Care (Joint Consensus Report by the Eurasian Society of Heart Failure and the Turkish Association of Family Medicine).
Fuente:Balkan Medical Journal
Extracto:
Thus, this guideline highlights the essential role of primary care physicians in
addressing the growing challenges of HF through the effective and evidence-based
use of NPs.
Cita:Balkan Med J 2025 Mar 3; 42 (2) : 94-107.
Autor/es:Çelik, Ahmet (a) Öztürk, Güzin Zeren (b)
institución:(a) Department of Cardiology, Mersin University Faculty of Medicine, Mersin, Türkiye. (b) Clinic of Family Medicine, University of Health Sciences Türkiye, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Türkiye.
Conflicto:Conflict of Interest: The authors declare that they have no conflict of interest.
Impact of Interval to Esophagectomy After Neoadjuvant Immunochemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma: A Multicenter Retrospective Cohort Analysis.
Impact of Interval to Esophagectomy After Neoadjuvant Immunochemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma: A Multicenter Retrospective Cohort Analysis.
Fuente:Thoracic Cancer
Extracto:
Patients demonstrated tolerance for esophagectomy within 4-6 weeks after nICT.
Based on the present findings regarding pCR, DFS, and OS, extending the time to
surgery beyond 6 weeks was found to be acceptable.
institución:(a) Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China. (b) Key Laboratory of Cardio-Thoracic Surgery(Fujian Medical University), Fujian Province University, Fuzhou, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Echocardiographic Parameters of Right Ventricular Size and Function Associated With Right Heart Failure After Durable Left Ventricular Assist Device Implantation-A Systematic Review and Meta-Analysis.
Echocardiographic Parameters of Right Ventricular Size and Function Associated With Right Heart Failure After Durable Left Ventricular Assist Device Implantation-A Systematic Review and Meta-Analysis.
Fuente:Echocardiography (mount Kisco, N.y.)
Tipo de trabajo:Guía
Extracto:
Based on the available studies,
there was baseline RV dilatation and reduced systolic function in patients with
D-LVADs. Additionally, TAPSE and RVEDD demonstrated a statistically significant
association with the development of RVF post-implantation, indicating a potential
role as prognostic markers. Further studies should also be conducted to establish
post-implantation TTE reference values.
Claves:RVS’, fractional area change, heart failure, non‐invasive cardiac Imaging, right ventricular size, transthoracic echocardiography
Cita:Echocardiography 2025 Mar; 42 (3) : e70119.
Autor/es:Chai, Jia Cheng Kevyn (a) Chew, Jia Le (b)
institución:(a) Department of Cardiology, Blacktown Hospital, Western Sydney Local Health District, Blacktown, New South Wales, Australia. (b) School of Medicine, Western Sydney University, South Penrith, Australia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Precipitating Factors for Functional Cognitive Disorder.
Precipitating Factors for Functional Cognitive Disorder.
Fuente:European Journal of Neurology
Extracto:
Functional
cognitive disorder often begins acutely. The circumstances around onset may have
treatment and prognostic implications. Similar to other functional disorders, the
experience of abnormal cognition from an acute pathophysiological event can act
as powerful precipitating factors for functional cognitive disorder.
Autor/es:Cabreira, Veronica (a) McWhirter, Laura (b)
institución:(a) Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. (b) Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Cardiovascular Medicine, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China. (b) Key Laboratory of Molecular Cardiology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Association between the atherogenic index of plasma and abdominal aortic calcification: results from the National Health and Nutrition Examination Survey 2013-2014.
Association between the atherogenic index of plasma and abdominal aortic calcification: results from the National Health and Nutrition Examination Survey 2013-2014.
Fuente:Frontiers in Endocrinology
Extracto:
This study demonstrates a positive relationship
between AIP and increased AAC scores, as well as a higher risk of AAC and SAAC in
U.S. women. However, these findings require further investigation to confirm the
observed gender-specific differences.
Claves:NHANES, abdominal aortic calcification, atherogenic index of plasma, atherosclerosis, cross-sectional study
institución:(a) Department of Cardiology, Minzu Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. (b) Department of Cardiology, Minzu Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Gender differences in the relationship between cardiometabolic index and all-cause and specific mortality in the United States adults: a national study.
Gender differences in the relationship between cardiometabolic index and all-cause and specific mortality in the United States adults: a national study.
Fuente:Frontiers in Endocrinology
Extracto:
There were gender differences in the correlation between CMI and
all-cause mortality, cardiovascular mortality, and diabetes mortality in the
adult population. The findings indicated that adult females with elevated CMI
levels were at an elevated risk of mortality from all causes, cardiovascular
disease, and diabetes. At the same time, there were no significant associations
in adult males.
Claves:NHANES, all-cause mortality, cardiometabolic index, gender differences, specific mortality
institución:(a) Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. (b) Branch of National Clinical Research Center for Chinese Medicine Cardiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Randomized clinical trial in cancer patients shows immune metabolic effects exerted by formulated bioactive phenolic diterpenes with potential clinical benefits.
Randomized clinical trial in cancer patients shows immune metabolic effects exerted by formulated bioactive phenolic diterpenes with potential clinical benefits.
Autor/es:Gómez de Cedrón, Marta (a) Moreno-Rubio, Juan (b)
institución:(a) Molecular Oncology Group, IMDEA Food, CEI UAM+CSIC, Madrid, Spain. (b) Medical Oncology Department, Infanta Sofia University Hospital-Henares University Hospital-Foundation for Biomedical Research and Innovation (FIIB HUIS HHEN), Madrid, Spain.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
institución:(a) Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. (b) Department of Gastroenterology, Internal Medicine, Yongin Severance Hospital, Yonsei University Health System, Yongin, Republic of Korea.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Unmasking Arrhythmia Mortality: A 25-Year Analysis of Trends and Disparities in the United States (1999-2023).
Unmasking Arrhythmia Mortality: A 25-Year Analysis of Trends and Disparities in the United States (1999-2023).
Fuente:Clinical Cardiology
Extracto:
Despite an overall decline in arrhythmia-related mortality, recent
increases, especially in West Virginia and among certain racial groups, highlight
the need for targeted public health interventions.
Claves:CDC WONDER, USA, arrhythmi, mortality
Cita:Clin Cardiol 2025 Mar; 48 (3) : e70109.
Autor/es:Azeem, Bazil (a) Khurram, Laiba (b)
institución:(a) Department of Internal Medicine, Shaheed Mohtarma Benazir Bhutto Medical College Lyari, Karachi, Pakistan. (b) Department of Internal Medicine, Shaheed Mohtarma Benazir Bhutto Medical College Lyari, Karachi, Pakistan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A Virtual Cardiometabolic Health Program Among African Immigrants in the US
A Virtual Cardiometabolic Health Program Among African Immigrants in the US
Fuente:Jama Network Open
Tipo de trabajo:Estudio clínico aleatorizado
Extracto:
AND RELEVANCE: Trial findings
indicate that interventions incorporating cultural adaptation and virtual
components could help address CMH disparities in this population. TRIAL
REGISTRATION: ClincalTrials.gov Identifier NCT05144737.
Cita:JAMA Netw Open 2025 Mar 3; 8 (3) : e2462559.
Autor/es:Ogungbe, Oluwabunmi (a) Hinneh, Thomas (b)
institución:(a) Johns Hopkins University School of Nursing, Baltimore, Maryland. (b) Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Conflicto:Conflict of Interest Disclosures: Dr Spaulding reported consulting for Corrie Health outside the submitted work. No other disclosures were reported.
Apolipoprotein and sphingolipid measurements: Can be used in the clinical practice of atrial fibrillation diagnosing and evaluating the cryoablation effectiveness?
Apolipoprotein and sphingolipid measurements: Can be used in the clinical practice of atrial fibrillation diagnosing and evaluating the cryoablation effectiveness?
Fuente:Plos One
Extracto:
This is the first study that evaluates such a broad panel of Apo and
sphingolipids in patients with AF undergoing the CBA procedure, however, to
confirm whether any of these parameters could be a clinically useful biomarker
for predicting AF or assessing the effectiveness of treatment, further research
will be necessary due to limitations of the study.
institución:(a) Department of Physiology, Medical University of Bialystok, Białystok, Poland. (b) Department of Physiology, Medical University of Bialystok, Białystok, Poland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Inflammatory stimuli and hypoxia on atherosclerotic plaque thrombogenicity: Linking macrophage tissue factor and glycolysis.
Inflammatory stimuli and hypoxia on atherosclerotic plaque thrombogenicity: Linking macrophage tissue factor and glycolysis.
Fuente:Plos One
Extracto:
Combined inflammatory and
hypoxic conditions in atherosclerotic plaques may markedly enhance procoagulant
activity in macrophages and contribute to coronary thrombus formation following
plaque disruption. Macrophage TF expression may be associated with glycolysis.
institución:(a) Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Miyazaki, Japan. (b) Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Miyazaki, Japan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Correlation Between Diagnosis-Related Group Weights and Nursing Time in the Cardiology Department: Cross-Sectional Study.
Correlation Between Diagnosis-Related Group Weights and Nursing Time in the Cardiology Department: Cross-Sectional Study.
Fuente:Jmir Medical Informatics
Extracto:
DRG weight
showed a strong correlation with nursing time and could be used to predict
nursing time, which may assist in nursing resource allocation in cardiology
departments.
Claves:diagnosis-related groups, human resources, nursing, nursing time, workload
Cita:JMIR Med Inform 2025 Mar 4; 13 : e65549.
Autor/es:Lv, Chen (a) Gong, Yi-Hong (b)
institución:(a) Department of Nursing, Beijing Chest Hospital, Capital Medical University, Beijing, China. (b) Department of Performance and Reform, Beijing Chest Hospital, Capital Medical University, Beijing, China.
Extracto:
The poorer the renal function, the higher the prevalence rate of CI. Patients
with chronic kidney disease (CKD) have multiple risk factors that lead to CI.
Claves:Age, dementia, glomerular filtration rate, kidney function
institución:(a) Department of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. (b) Department of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Conflicto:No potential conflict of interest was reported by the author(s).
Major adverse cardiovascular, thromboembolic and malignancy events in the filgotinib rheumatoid arthritis and ulcerative colitis clinical development programmes.
Major adverse cardiovascular, thromboembolic and malignancy events in the filgotinib rheumatoid arthritis and ulcerative colitis clinical development programmes.
Fuente:Rmd Open
Tipo de trabajo:Estudio clínico
Extracto:
Data are consistent with previous overall safety analyses
demonstrating low rates of AEI in the overall study population. Numerically
increased rates of AEI occurred in patients aged ≥65 years; further data are
needed to assess the effect of CV risk factors. Overall, in this analysis, there
was no consistent filgotinib dose effect on AEI.
institución:(a) Department of Rheumatology, Université Paris-Saclay, AP-HP-Hôpital Bicêtre, Paris, France xavier.mariette@aphp.fr. (b) Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Cologne, Germany.
Conflicto:Competing interests: XM has received consultancy fees from BMS, Galapagos, GSK, Janssen, Novartis and Pfizer. SB has received consultancy fees from Galapagos; and is a founder of, and shareholder in, Liqomics. SA has received consultancy fees (paid to institution) from MSD; honoraria (paid to institution) from BMS, Ipsen, Roche; has participated on a data safety monitoring board or advisory board...
for Astellas; has a leadership role in BITOX network (www.BSMO.bbe/BITOX) and received grants or contracts (paid to BITOX) from AstraZeneca, BMS, Ipsen, MSD, Roche and Sanofi. ZS has received consultancy fees and honoraria from AbbVie, Eli Lilly, Gedeon Richter, Novartis, Pfizer and Sobi; and meeting attendance support from AbbVie, Pfizer and Sobi. CC-S has received consultancy fees from AbbVie, BMS, Boehringer Ingelheim, Octapharma, Pfizer, Recludix and Sana Biotechnology; and grant/research support from AbbVie, Alexion, BMS, CSL Behring, Janssen, Octapharma, Pfizer and Priovant. SS has received honoraria and meeting attendance support from AbbVie, Amgen, Arena, Biogen, BMS, Celgene, Celltrion, Eli Lilly, Falk, Ferring, Fresenius Kabi, Galapagos, Gilead, Hikma, IMAB, Janssen, MSD, Pfizer, Protagonist, Proventin Bio and Sandoz/Hexal; and has participated in an advisory board for Takeda. EHSC has received speaker fees from AbbVie, Amgen, BMS, Chugai, Eli Lilly, Fresenius Kabi, Galapagos, Gilead, Novartis, Pfizer, Regeneron, Roche and Sanofi-Aventis; consultancy fees from AbbVie, Amgen, Biogen Therapeutics, Chugai, Eli Lilly, Fresenius Kabi, Galapagos, Gilead, GSK, Janssen, Novartis, R-Pharm, Roche, Sanofi-Genzyme, SynAct Pharma and UCB and grant/research support from Bio-Cancer, Biogen, Novartis, Pfizer, Roche and Sanofi. LP-B has received grants from Celltrion, Fresenius Kabi, Medac, MSD and Takeda; consultancy fees from AbbVie, Abivax, Adacyte, Alimentiv, Amgen, Applied Molecular Transport, Arena, Banook, Biogen, BMS, Celltrion, Connect Biopharm, Cytoki Pharma, Eli Lilly, Enthera, Ferring, Fresenius Kabi, Galapagos, Genentech, Gilead, Gossamer Bio, GSK, IAC Image Analysis, Index Pharmaceuticals, Inotrem, Janssen, Medac, Mopac, Morphic, MSD, Nordic Pharma, Novartis, Oncodesign Precision Medicine, ONO Pharma, OSE Immunotherapeuthics, Pandion Therapeuthics, Par' Immune, Pfizer, Prometheus, Protagonist, Roche, Samsung, Sandoz, Sanofi, Satisfay, Takeda, Telavant, Theravance, Thermo Fischer, Tigenix, Tillots, Vectivbio, Ventyx, Viatris and Ysopia; honoraria from AbbVie, Alfasigma S.p.A., Amgen, Arena, Biogen, Celltrion, Eli Lilly, Ferring, Galapagos, Genentech, Gilead, Janssen, Kern Pharma, Medac, MSD, Nordic Pharma, Pfizer, Sandoz, Takeda, Tillots and Viatris; meeting attendance support from AbbVie, Alfasigma S.p.A., Amgen, Celltrion, Connect Biopharm, Eli Lilly, Ferring, Galapagos, Genentech, Gilead, Gossamer Bio, Janssen, Medac, Morphic, MSD, Pfizer, Sandoz, Takeda, Thermo Fischer and Tillots and participated in data safety monitoring or advisory boards for AbbVie, Alfasigma S.p.A., Amgen, Arena, Biogen, Celltrion, Eli Lilly, Ferring, Galapagos, Genentech, Gilead, Janssen, Kern Pharma, Medac, MSD, Nordic Pharma, Pfizer, Sandoz, Takeda, Tillots and Viatris. MS has received grants from Chugai and Novartis; honoraria from AbbVie, Alfasigma S.p.A., AstraZeneca, Boehringer Ingelheim, BMS, Chugai, EUSA-Pharma, Galapagos, Gilead, Janssen-Cilag, Mylan, Novartis, Onkowissen.de and Roche; meeting attendance support from Boehringer Ingelheim, Celgene, Chugai, Galapagos, Medac, Mylan, Roche and UCB and participated in data safety monitoring or advisory boards for AbbVie, Alfasigma S.p.A., Amgen, AstraZeneca, Boehringer Ingelheim, Chugai, Eli Lilly, EUSA-Pharma, Galapagos, Gilead, Hexal/Sandoz, Janssen-Cilag, Novartis, Onkowissen.de, Roche and UCB. YT has received honoraria from AbbVie, AstraZeneca, BMS, Boehringer Ingelheim, Chugai, Eisai, Eli Lilly, Gilead, GSK, Pfizer and Taisho and research grants from Chugai, Eisai, Mitsubishi Tanabe and Taisho. HtC received consultancy fees from Alveron, AstraZeneca, Galapagos, Novostia and Viatris and research funding from Bayer and Synapse. All revenues are deposited at the CARIM Institute for Research. He is a shareholder in Coagulation Profile. RW has received consultancy fees and honoraria from Celltrion and Galapagos. CJvdW has received research grants from Benelux, Falk, Ferring, Janssen and Pfizer; consultancy fees from Celltrion and Galapagos and speaker fees from AbbVie and UCB. EVEO received consultancy fees from Alfasigma S.p.A., Galapagos and Janssen; and is a shareholder in UCB. MF is an employee of, and holds stock options in, Galapagos. TM is a former employee of Galapagos. PVH has received consultancy fees from AOP Health, Aspen and Galapagos. CW is a former employee of Alfasigma S.p.A. and Galapagos and holds stock options in Galapagos. CR is a former employee of Galapagos and a current employee of Alfasigma S.p.A. AS has received consultancy fees from AbbVie, BMS and Johnson & Johnson; honoraria from AbbVie, BMS, Galapagos, Johnson & Johnson and Takeda and payments to institute from AbbVie, BMS, Galapagos and Takeda.
Correlation between imaging features of pure ground-glass opacities and pathological subtypes of lung minimally invasive adenocarcinoma and precursor lesions.
Correlation between imaging features of pure ground-glass opacities and pathological subtypes of lung minimally invasive adenocarcinoma and precursor lesions.
Fuente:Scientific Reports
Extracto:
However, these features did not exhibit
satisfactory diagnostic efficiency.
Claves:Lung adenocarcinoma, Pathology, Pure ground-glass opacity, Tomography, X-Ray computed
Cita:Sci Rep 2025 Mar 4; 15 (1) : 7572.
Autor/es:Zhu, Yanqiu (a) Yan, Cui (b)
institución:(a) Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Tianhe District, Guangzhou, 510630, China. (b) Division of Cardiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 261 Longxi Road, Liwan District, Guangzhou, 510130, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association of clinical biomarker-based biological age and aging trajectory with cardiovascular disease and all-cause mortality in Chinese adults
Association of clinical biomarker-based biological age and aging trajectory with cardiovascular disease and all-cause mortality in Chinese adults
Fuente:Bmc Public Health
Tipo de trabajo:Estudio de cohortes
Extracto:
Accelerated BA aging is associated with a higher
risk of CVD and mortality, whereas decelerated aging is associated with a lower
risk compared to normal aging. Those persistently at high aging levels are at the
highest risk for both CVD and death; conversely, it is the act of lowering and
continually maintaining a reduced aging state that effectively mitigates these
risks.
institución:(a) National Human Genetic Resources Center, National Research Institute for Family Planning, Beijing, China. (b) National Human Genetic Resources Sharing Service Platform, Beijing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between neutrophil percentage-to-albumin ratio and mortality in Hemodialysis patients
Association between neutrophil percentage-to-albumin ratio and mortality in Hemodialysis patients
Fuente:Bmc Nephrology
Tipo de trabajo:Estudio de cohortes
Extracto:
High NPAR level was independently
associated with a higher increased risk of death in MHD patients.
Claves:Inflammation, Maintenance Hemodialysis patients, Mortality, Neutrophil percentage-to-albumin ratio
Cita:BMC Nephrol 2025 Mar 4; 26 (1) : 112.
Autor/es:Zhu, Jiaxin (a) Shi, Rui (b)
institución:(a) Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, China. (b) Center for Big Data and Population Health of IHM, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Analysis of the kidney failure risk equation implementation in routine clinical practice and health inequalities in chronic kidney disease care
Analysis of the kidney failure risk equation implementation in routine clinical practice and health inequalities in chronic kidney disease care
Fuente:Bmc Nephrology
Tipo de trabajo:Estudio de cohortes
Extracto:
KFRE could be calculated for less than half
of people due to lack of albuminuria testing. Focus should be given to improving
albuminuria testing and inequities identified to allow wider implementation of
KFRE.
institución:(a) School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Scotland. heather.walker.2@glasgow.ac.uk. (b) Robertson Centre for Biostatistics, University of Glasgow, Glasgow, Scotland.
Conflicto:Declarations. Consent for publication: Not applicable. Competing interests: PBM reports lecture honoraria from Astrazeneca, Pharmacomsos, Bayer, Astellas, GSK and Boehringer Ingelheim outside the submitted work. The other authors have no potential conflicts of interest to declare. Ethics approval and consent to participate: Delegated research ethics approval was granted for linkage to National Health Service (NHS) patient data by the Local...
Privacy and Advisory Committee at NHS Greater Glasgow and Clyde. Cohorts and de-identified linked data were prepared by the West of Scotland Safe Haven Research Database at NHS Greater Glasgow and Clyde (IRAS Project ID 321198, REC reference 22/WS/1063, West of Scotland REC 4, https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/west-of-scotland-safe-haven-research-database/ .). Conflicts of interest: The other authors have no potential conflicts of interest to declare. Rights retention statement: For the purpose of open access, the author(s) has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission.
