Textos Completos Autorizados

Cardiología
SIIC selecciona textos completos de calidad y de reciente publicación en fuentes prestigiosas del mundo indizadas por SIIC Data Bases, capturadas en las mismas colecciones o en diversas bases especializadas.
La creciente cantidad de artículos con Acceso Abierto (Open Access) amplía la oferta de lectura pero a su vez también, entre tanta abundancia, complica al lector en su encuentro con los estudios fundamentales. Para facilitarlo, profesionales biomédicos de SIIC consultan diariamente una profusa cantidad de documentos que nutrirán Textos completos autorizados (TCA).

Las citas de la sección TCA enlazan de manera legal, autorizada y gratuita con los textos completos (full text) publicados en los sitios oficiales de sus respectivas fuentes.

SIIC creó, produjo y opera con exclusividad el software TCA para la interpretación de los diversos campos documentales que integran la estructura de un estudio: especialidad, modalidad del estudio, fuente, fechas de publicación y selección, definición de la fuente, limitaciones de consulta, resumen en castellano, etc.

Si bien la mayoría de los textos seleccionados corresponden a artículos originales, revisiones y guías, los lectores también encontrarán comentarios, entrevistas, notas periodísticas, cartas a autores u otros textos precursores de debates o aclaratorios.

Con una o todas las palabras
(escribir en inglés)
 
Ej.1: Adipokines Ej.2: Adipokines or Musculoskeletal
Con la frase exacta
(inglés)

Ej.3: Adipokines and Cardiovascular Systems
Con todas de las palabras
(inglés)

Ej.4: Adipokines and Cardiovascular and Systems
Sin las palabras
(inglés)

Ej.5: not Cardiovascular Systems
BMC medicine
Selección SIIC: 7 Marzo, 2025
BMC medicine

Confounder adjustment in observational studies investigating multiple risk factors: a methodological study.

Confounder adjustment in observational studies investigating multiple risk factors: a methodological study.

Fuente:Bmc Medicine

Tipo de trabajo:Revisión

Extracto: There is substantial variation in the methods for confounder adjustment among studies investigating multiple risk factors. Mutual adjustment was the most commonly adopted method, which might lead to overadjustment bias and misleading effect estimates. Future research should avoid indiscriminately including all risk factors in a multivariable model to prevent inappropriate adjustment.

Claves:Confounder adjustment, Methodological study, Multiple risk factors, Observational studies

Cita:BMC Med 2025 Mar 5; 23 (1) : 132.

Autor/es:Gao, Yinyan (a)
Xiang, Linghui (b)

institución:(a) Department of Epidemiology and Biostatistics, Xiangya School of Public Health, Central South University, Changsha, China.
(b) Department of Epidemiology and Biostatistics, Xiangya School of Public Health, Central South University, Changsha, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12916-025-03957-8

Journal of cardiothoracic surgery
Selección SIIC: 7 Marzo, 2025
Journal of cardiothoracic surgery

Application feasibility of virtual models and computational fluid dynamics for the planning and evaluation of aortic repair surgery for Williams syndrome.

Application feasibility of virtual models and computational fluid dynamics for the planning and evaluation of aortic repair surgery for Williams syndrome.

Fuente:Journal of Cardiothoracic Surgery

Tipo de trabajo:Orientaciones y guía

Extracto: Virtual surgery and CFD can predict surgical outcomes, enabling doctors to optimize and rehearse the procedure before the actual surgery. The method of predicting surgery through virtual surgery and CFD is accurate and feasible. TRIAL REGISTRATION: Registered by the Ethics Committee of Peking University International Hospital (No. IRB2019-062).

Claves:Aortic repair, Computational fluid dynamics, Surgical planning, Virtual models, Williams syndrome

Cita:J Cardiothorac Surg 2025 Mar 4; 20 (1) : 144.

Autor/es:Liang, Jixiang (a)
Fang, Xuewei (b)

institución:(a) School of Mechanical Engineering, Xi'an Jiaotong University, No. 99 Yan Cheung Road, Shaanxi, Shaanxi, China.
(b) Institute of 3D Printing, Beijing City University, Beijing, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13019-024-03286-6

Clinical epigenetics
Selección SIIC: 7 Marzo, 2025
Clinical epigenetics

Dissecting the causal effects of smoking, alcohol consumption, and related DNA methylation markers on electrocardiographic indices.

Dissecting the causal effects of smoking, alcohol consumption, and related DNA methylation markers on electrocardiographic indices.

Fuente:Clinical Epigenetics

Extracto: There is a causal relationship between DrnkWk and QT interval prolongation, and targeting specific DNA methylation sites like cg04605617 mapped to PLA2G2C may provide novel targets for preventing QT interval prolongation.

Claves:Alcohol consumption, DNA methylation, Genetic architecture, Mendelian randomization, QT interval

Cita:Clin Epigenetics 2025 Mar 4; 17 (1) : 40.

Autor/es:Zheng, Zequn (a)
Song, Yongfei (b)

institución:(a) Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
(b) Clinical Research Center, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1186/s13148-025-01851-x

Cardiovascular therapeutics
Selección SIIC: 7 Marzo, 2025
Cardiovascular therapeutics

Impacts of CD36 Variants on Plasma Lipid Levels and the Risk of Early-Onset Coronary Artery Disease

Impacts of CD36 Variants on Plasma Lipid Levels and the Risk of Early-Onset Coronary Artery Disease

Fuente:Cardiovascular Therapeutics

Tipo de trabajo:Revisión sistemática

Extracto: Genetic screening of CD36 gene variants may be helpful for early intervention or prevention of EOCAD in individuals with high risk factors.

Claves:CD36, dyslipidemia, early-onset coronary artery disease, genetic polymorphism

Cita:Cardiovasc Ther 2025; 2025 : 8098173.

Autor/es:Luo, Zhi (a)
Lv, Lingwei (b)

institución:(a) Department of Cardiology, Suining Central Hospital, Suining, Sichuan, China.
(b) Department of Orthopedics, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1155/cdr/8098173

Frontiers in public health
Selección SIIC: 7 Marzo, 2025
Frontiers in public health

Exploring the impact of internet use on cognitive abilities in the older adults: evidence from the CHARLS 2020 database.

Exploring the impact of internet use on cognitive abilities in the older adults: evidence from the CHARLS 2020 database.

Fuente:Frontiers in Public Health

Extracto: This study discusses the implications of increasing internet accessibility and provides recommendations for public policy to foster a digitally inclusive society that supports the cognitive health of the aging population.

Claves:CHARLS 2020, cognition, cognitive dysfunction, internet access, older adults, sociodemographic factors

Cita:Front Public Health 2025; 13 : 1510418.

Autor/es:Jiao, Haojin (a)
Guo, Zehui (b)

institución:(a) School of Modern Post, Xi'an University of Posts and Telecommunications, Xi'an, China.
(b) School of Marxism, Yan'an University, Yan'an, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fpubh.2025.1510418

Frontiers in endocrinology
Selección SIIC: 7 Marzo, 2025
Frontiers in endocrinology

Association between Life's Essential 8 and Atherogenic Index of Plasma in adults: insights from NHANES 2007-2018.

Association between Life's Essential 8 and Atherogenic Index of Plasma in adults: insights from NHANES 2007-2018.

Fuente:Frontiers in Endocrinology

Extracto: DISCUSSION: This study suggests that the LE8 may serve as a preventive factor for CVD risk and implies that individuals can actively regulate their metabolic characteristics by optimizing their lifestyle.

Claves:Atherogenic Index of Plasma, Life’s Essential 8, NHANES, cardiovascular disease, cardiovascular health

Cita:Front Endocrinol (Lausanne) 2025; 16 : 1506884.

Autor/es:Xu, Long-Hui (a)
Ding, Kai-Wen (b)

institución:(a) School of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
(b) Department of Nursing, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fendo.2025.1506884

Annals of medicine
Selección SIIC: 7 Marzo, 2025
Annals of medicine

Intraoperative hemodynamics in prediction of postoperative kidney injury after type a aortic dissection surgery

Intraoperative hemodynamics in prediction of postoperative kidney injury after type a aortic dissection surgery

Fuente:Annals of Medicine

Tipo de trabajo:Estudio de cohortes

Extracto: Elevated CVP and lower MAP levels were linked to postoperative AKI and AKD risk. CVP showed stronger associations with mortality and stroke. Optimizing perioperative hemodynamic management may improve individualized interventions.

Claves:Acute kidney injury, acute kidney disease, intraoperative hypotension, type A aortic dissection, venous congestion

Cita:Ann Med 2025 Dec; 57 (1) : 2474859.

Autor/es:Chen, Lihai (a)
Cheng, Yi (b)

institución:(a) Department of Anesthesiology, Perioperative and Pain Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
(b) School of International Business, China Pharmaceutical University, Nanjing, Jiangsu, China.

Conflicto:No potential conflict of interest was reported by the author(s).

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1080/07853890.2025.2474859

Lupus science & medicine
Selección SIIC: 7 Marzo, 2025
Lupus science & medicine

Systematic review of the reporting of extrarenal manifestations in observational studies of Saudi patients with systemic lupus erythematosus.

Systematic review of the reporting of extrarenal manifestations in observational studies of Saudi patients with systemic lupus erythematosus.

Fuente:Lupus Science & Medicine

Tipo de trabajo:Revisión sistemática

Extracto: This study explores the prevalence of extrarenal manifestations of SLE among adult Saudi patients, highlighting significant regional variability in musculoskeletal, dermatological, cardiovascular and neurological symptoms. It addresses a gap in the literature for a region where autoimmune diseases are a growing public health concern. The findings emphasise the need for population-based studies to investigate environmental, genetic and lifestyle factors influencing SLE progression.

Claves:Autoimmune Diseases, Lupus Erythematosus, Systemic, Systemic Lupus Erythematosus

Cita:Lupus Sci Med 2025 Mar 5; 12 (1)

Autor/es:Alenzi, Fahidah (a)
Aljohani, Roaa (b)

institución:(a) Department of Internal Medicine, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia fmalenzi@pnu.edu.sa.
(b) Department of Medicine, College of Medicine, Taibah University, Medinah, Saudi Arabia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/lupus-2024-001469

BMC emergency medicine
Selección SIIC: 7 Marzo, 2025
BMC emergency medicine

Unselected cardiac troponin testing and the diagnosis of myocardial infarction in the emergency department.

Unselected cardiac troponin testing and the diagnosis of myocardial infarction in the emergency department.

Fuente:Bmc Emergency Medicine

Extracto: Using a generalized approach to cardiac troponin testing in emergency department patients significantly lowers the diagnostic accuracy for type 1 myocardial infarction, reducing the positive predictive value and frequently indicating non-ischemic myocardial injury.

Claves:Cardiac troponin, Emergency department, Myocardial infarction

Cita:BMC Emerg Med 2025 Mar 5; 25 (1) : 37.

Autor/es:Bardají, Alfredo (a)
Peiro, Oscar M (b)

institución:(a) Department of Cardiology, Joan XXIII University Hospital, Tarragona, Spain. abardaji.hj23.ics@gencat.cat.
(b) Pere Virgili Health Research Institute (IISPV), Tarragona, Spain. abardaji.hj23.ics@gencat.cat.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12873-025-01197-w

BMC cardiovascular disorders
Selección SIIC: 7 Marzo, 2025
BMC cardiovascular disorders

Gender disparities in hypertension prevalence, awareness and healthcare seeking behaviour among young adults in Nigeria.

Gender disparities in hypertension prevalence, awareness and healthcare seeking behaviour among young adults in Nigeria.

Fuente:Bmc Cardiovascular Disorders

Extracto: The study showed gender specific differences with regards to the burden, awareness and health seeking behaviour for hypertension among young adults in Nigeria. There is need for gender specific interventions to control the increasing burden of hypertension in Nigeria.

Claves:Awareness, Gender, Hypertension, Nigeria, Prevalence, Young adults

Cita:BMC Cardiovasc Disord 2025 Mar 5; 25 (1) : 151.

Autor/es:Jalo, Rabiu Ibrahim (a)
Bamgboye, Eniola Adetola (b)

institución:(a) Department of Community Medicine, Bayero University & Aminu Kano Teaching Hospital, Kano, Nigeria.
(b) Department of Epidemiology and Medical Statistics, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12872-025-04603-0

Molecular medicine (Cambridge, Mass.)
Selección SIIC: 7 Marzo, 2025
Molecular medicine (Cambridge, Mass.)

A genome-wide association study identifies a novel East Asian-specific locus for dementia with Lewy bodies in Japanese subjects.

A genome-wide association study identifies a novel East Asian-specific locus for dementia with Lewy bodies in Japanese subjects.

Fuente:Molecular Medicine (cambridge, Mass.)

Tipo de trabajo:Metanálisis

Extracto: This is the first GWAS for DLB in East Asians, and our findings provide new biological and clinical insights into the pathogenesis of DLB.

Claves:Dementia with Lewy bodies, Expression quantitative trait locus analysis, Genome-Wide association study, Trans-Ethnic meta-Analysis, Transcriptome-Wide association analysis

Cita:Mol Med 2025 Mar 6; 31 (1) : 87.

Autor/es:Mitsumori, Risa (a)
Asanomi, Yuya (b)

institución:(a) Medical Genome Center, National Center for Geriatrics and Gerontology, Research Institute, 7-430 Morioka-Cho, Obu, Aichi, 474-8511, Japan.
(b) Medical Genome Center, National Center for Geriatrics and Gerontology, Research Institute, 7-430 Morioka-Cho, Obu, Aichi, 474-8511, Japan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s10020-025-01115-7

BMC plant biology
Selección SIIC: 7 Marzo, 2025
BMC plant biology

Transcriptome analysis of wild olive (Olea Europaea L. subsp. europaea var. sylvestris) clone AC18 provides insight into the role of lignin as a constitutive defense mechanism underlying resistance to Verticillium wilt.

Transcriptome analysis of wild olive (Olea Europaea L. subsp. europaea var. sylvestris) clone AC18 provides insight into the role of lignin as a constitutive defense mechanism underlying resistance to Verticillium wilt.

Fuente:Bmc Plant Biology

Extracto: The research highlights the constitutive defence mechanisms that are effective in protecting against pathogens and our findings may contribute to the deciphering the molecular basis of VW resistance in olive and the conservation and utilization of wild olive genetic resources to tackle future agricultural challenges towards.

Claves:Olea europaea, Verticillium dahliae, Defoliating pathotype, Lignin metabolism, Rootstock, Verticillium wilt, Wild olive

Cita:BMC Plant Biol 2025 Mar 6; 25 (1) : 292.

Autor/es:Mascuñano, Beatriz (a)
Coto-Elena, Jerónimo (b)

institución:(a) Department of Biochemistry and Molecular Biology, University of Cordoba, Edificio Severo Ochoa, Campus de Rabanales, Córdoba, E-14014, Spain.
(b) Departamento de Botánica y Fisiología Vegetal, Instituto de Hortofruticultura Subtropical y Mediterránea 'La Mayora' (IHSM-UMA-CSIC), Universidad de Málaga, Málaga, 29071, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12870-025-06301-7

BMC cancer
Selección SIIC: 7 Marzo, 2025
BMC cancer

Prognostic value of the preoperative prognostic nutritional and systemic immunoinflammatory indexes in patients with colorectal cancer.

Prognostic value of the preoperative prognostic nutritional and systemic immunoinflammatory indexes in patients with colorectal cancer.

Fuente:Bmc Cancer

Extracto: PNI is an independent risk factor for postoperative complications associated with CRC and a powerful tool for predicting survival outcomes in CRC patients.

Claves:Colorectal cancer, Prognosis, Prognostic nutritional index, Systemic immune-inflammation index

Cita:BMC Cancer 2025 Mar 5; 25 (1) : 403.

Autor/es:Li, Haifeng (a)
Sun, Wei (b)

institución:(a) Department of General Surgery, Taizhou School of Clinical Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, 366 Taihu Road, Taizhou, China.
(b) Postgraduate School, Dalian Medical University, Dalian, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12885-025-13828-3

BMC public health
Selección SIIC: 7 Marzo, 2025
BMC public health

Association between cardiometabolic index and biological ageing among adults: a population-based study.

Association between cardiometabolic index and biological ageing among adults: a population-based study.

Fuente:Bmc Public Health

Extracto: CMI is positively correlated with biological ageing in adults in the United States. Prospective studies with larger sample sizes are required to validate our findings.

Claves:Biological ageing, Cardiometabolic index, NHANES

Cita:BMC Public Health 2025 Mar 5; 25 (1) : 879.

Autor/es:Liu, Na (a)
Peng, Shanshan (b)

institución:(a) Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China.
(b) Department of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12889-025-22053-3

BMC complementary medicine and therapies
Selección SIIC: 7 Marzo, 2025
BMC complementary medicine and therapies

Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients

Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients

Fuente:Bmc Complementary Medicine and Therapies

Tipo de trabajo:Revisión sistemática

Extracto: Ca(++) and Mg(++) significantly reduced DBP but had no significant effect on SBP or the pulse rate. Whereas, vitamin D significantly reduced SBP and DBP.

Claves:Calcium, Complementary therapies, Hypertension, Magnesium, Pulse rate, Supplementation, Vitamin D

Cita:BMC Complement Med Ther 2025 Mar 5; 25 (1) : 89.

Autor/es:Amer, Samar A (a)
Abo-Elnour, Dina Essam (b)

institución:(a) Department of Public Health and Community Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt. dr_samar11@yahoo.com.
(b) Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12906-025-04809-x

Cardiovascular diabetology
Selección SIIC: 7 Marzo, 2025
Cardiovascular diabetology

Long-term trajectory of estimated glomerular filtration rate in ambulatory patients with type 2 diabetes and heart failure: clinical insights and prognostic implications.

Long-term trajectory of estimated glomerular filtration rate in ambulatory patients with type 2 diabetes and heart failure: clinical insights and prognostic implications.

Fuente:Cardiovascular Diabetology

Extracto: This study offers novel insights into long-term renal function trajectories in patients with HF and T2D and identifies key clinical factors associated with accelerated renal decline. Future research is warranted to validate these results in larger, more diverse cohorts and to explore potential therapeutic interventions.

Claves:Diabetes mellitus, Estimated glomerular filtrate rate, Heart failure, Kidney function, Slope

Cita:Cardiovasc Diabetol 2025 Mar 5; 24 (1) : 104.

Autor/es:Julián, Maria Teresa (a)
Codina, Pau (b)

institución:(a) Department of Endocrinology and Nutrition and Heart Failure Clinic, Hospital Germans Trias i Pujol, Badalona, Spain.
(b) Heart Failure Clinic and Cardiology Department, Hospital Germans Trias i Pujol, Badalona, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12933-025-02632-9

Journal of health, population, and nutrition
Selección SIIC: 7 Marzo, 2025
Journal of health, population, and nutrition

Ultra-processed foods and coronary artery disease severity: a cross-sectional study of at-risk normal-weight and overweight patients undergoing elective angiography.

Ultra-processed foods and coronary artery disease severity: a cross-sectional study of at-risk normal-weight and overweight patients undergoing elective angiography.

Fuente:Journal of Health, Population, and Nutrition

Extracto: The findings obtained underscore a direct association between UPF and the risk of CAD progression among at-risk patients, independent of BMI. However, further prospective studies are essential to confirm these results and better understand this relationship.

Claves:Obesity, Packaged snacks, Ready-to-eat meals, Severe coronary artery disease (CAD), Sweets

Cita:J Health Popul Nutr 2025 Mar 5; 44 (1) : 63.

Autor/es:Ghorbani, Zeinab (a)
Dashti, Fatemeh (b)

institución:(a) Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
(b) Department of Clinical Nutrition, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Bangladesh

Sitio web:http://dx.doi.org/10.1186/s41043-025-00796-4

Cardiovascular diabetology
Selección SIIC: 7 Marzo, 2025
Cardiovascular diabetology

Circulating mitochondrial DNA signature in cardiometabolic patients.

Circulating mitochondrial DNA signature in cardiometabolic patients.

Fuente:Cardiovascular Diabetology

Extracto: Patients with HF and diabetes have an altered circulating mtDNA signature characterised by higher cell-free mtDNA and lower mtDNA ratio, whereas cellular mtDNA remains unaffected. Cell-free mtDNA and mtDNA ratio are associated with impaired response to exercise, higher systemic inflammation and increased congestion. Circulating mitochondrial profile could be a new biomarker of mitochondrial status in cardiometabolic diseases.

Claves:Circulating mitochondrial DNA, Congestion, Effort intolerance, Heart failure, Type 2 diabetes

Cita:Cardiovasc Diabetol 2025 Mar 5; 24 (1) : 106.

Autor/es:Mengozzi, Alessandro (a)
Armenia, Silvia (b)

institución:(a) Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56124, Pisa, Italy.
(b) Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12933-025-02656-1

Human genomics
Selección SIIC: 7 Marzo, 2025
Human genomics

Exploring the silent connection: unveiling the intricate relationship between gastroesophageal reflux disease and sleep apnea syndrome.

Exploring the silent connection: unveiling the intricate relationship between gastroesophageal reflux disease and sleep apnea syndrome.

Fuente:Human Genomics

Extracto: We discovered compelling evidence indicating an elevated risk of SAS in individuals with GERD, but no significant evidence supporting an increased risk of GERD in those with SAS. Future investigations into SAS risk should take into account the potential therapeutic targeting of GERD. PPI and histamine antagonists can effectively reduce reflux and airway secretions, preventing airway damage and collapse. Furthermore, it is necessary to investigate the underlying mechanisms by which GERD affects SAS. For example, the inflammatory stimulation caused by gastric acid and pepsin in refluxed fluid, as well as the increased tension of bronchial smooth muscle caused by vagus nerve reflex. Thus, early preventive measures can be implemented for potential complications related to SAS.

Claves:Causal effects, Gastroesophageal reflux disease, Mendelian randomization, Meta-analysis, Sleep apnea syndrome

Cita:Hum Genomics 2025 Mar 6; 19 (1) : 23.

Autor/es:Wang, Junming (a)
Wang, Pengfei (b)

institución:(a) Center of Emergency and Critical Care Medicine, Jinshan Hospital, Fudan University, Shanghai, 201508, People's Republic of China.
(b) Research Center for Chemical Injury, Emergency and Critical Medicine of Fudan University, Shanghai, 201508, People's Republic of China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s40246-025-00728-7

Clinical epigenetics
Selección SIIC: 7 Marzo, 2025
Clinical epigenetics

Mendelian randomization provides a multi-omics perspective on the regulation of genes involved in ribosome biogenesis in relation to cardiac structure and function.

Mendelian randomization provides a multi-omics perspective on the regulation of genes involved in ribosome biogenesis in relation to cardiac structure and function.

Fuente:Clinical Epigenetics

Extracto: Our multi-omics MR analysis identified 15 RiboSis-related genes associated with cardiac risk, with 12 further validated through gene set enrichment analysis. These findings suggest a link between RiboSis and cardiac health, enhancing understanding of cardiac disease mechanisms.

Claves:Cardiac structure and function, Mendelian randomization, Multi-omics, Ribosome biogenesis

Cita:Clin Epigenetics 2025 Mar 5; 17 (1) : 42.

Autor/es:Wei, Shuxu (a)
Shen, Ronghuai (b)

institución:(a) Department of Cardiology, The First Affiliated Hospital of Shantou University Medical College, No.57, Changping Road, Shantou, 515041, China.
(b) Laboratory of Molecular Cardiology, The First Affiliated Hospital of Shantou University Medical College, No.57, Changping Road, Shantou, 515041, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1186/s13148-025-01850-y

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