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The association of serum hsa-miR-21-5p expression with the severity and prognosis of heart failure with reduced ejection fraction.
The association of serum hsa-miR-21-5p expression with the severity and prognosis of heart failure with reduced ejection fraction.
Fuente:Bmc Cardiovascular Disorders
Extracto:
Collectively, hsa-miR-21-5p
expression in HFrEF patients is correlated with disease severity and the risk of
cardiovascular re-hospitalization and cardiovascular deaths in HFrEF patients,
indicating a new direction for evaluating the disease situation and prognosis.
Cita:BMC Cardiovasc Disord 2025 Feb 19; 25 (1) : 114.
Autor/es:Wang, Lingmiao (a) Guo, Ailin (b)
institución:(a) Department of Anesthesiology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, No.2000 Xiang'an East Road, Xiamen, 361101, China. (b) Department of Cardiovascular Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, No.2000 Xiang'an East Road, Xiamen, 361101, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Phenotype-based clusters, inflammation and cardiometabolic complications in older people before the diagnosis of type 2 diabetes
Phenotype-based clusters, inflammation and cardiometabolic complications in older people before the diagnosis of type 2 diabetes
Fuente:Cardiovascular Diabetology
Tipo de trabajo:Estudio de cohortes
Extracto:
Our
findings extend the knowledge about the previously identified six phenotype-based
clusters in older people without T2D. Differences between clusters were more
pronounced for T2D risk than for prevalent or incident (pre)diabetes-related
complications and absent for mortality. The high cardiometabolic risk
corresponded to the high inflammatory load in cluster 5 but not to the lower
inflammatory load of high-risk clusters 3 and 6.
Cita:Cardiovasc Diabetol 2025 Feb 19; 24 (1) : 83.
Autor/es:Huemer, Marie-Theres (a) Spagnuolo, Maria C (b)
institución:(a) Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. (b) Institute for Clinical Diabetology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine Universität, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany.
Conflicto:Declarations. Ethics approval and consent to participate: The KORA study was carried out in accordance with the Declaration of Helsinki. All study participants gave written informed consent. The Ethics Committee of the Bavarian Medical Association approved the studies (S4 Study: EC No. 99186, F4 study and FF4 study: EC No. 06068). Consent for publication: Not applicable. Competing interests: MR received...
lecture fees or served on advisory boards for AstraZeneca, Echosens, Eli Lilly, Madrigal, Merck-MSD, Novo Nordisk and Target RWE and performed investigator-initiated research with support from Boehringer Ingelheim, Novo Nordisk and Nutricia/Danone to the German Diabetes Center (DDZ). All other authors declare that they have no competing interests.
Associations of estimated glucose disposal rate with frailty progression: results from two prospective cohorts.
Associations of estimated glucose disposal rate with frailty progression: results from two prospective cohorts.
Fuente:Cardiovascular Diabetology
Extracto:
Regardless of diabetes or not, a higher level of eGDR was associated
with the decelerated frailty progression. Our findings highlight the role of eGDR
in frailty progression and recommend taking effective interventions to improve
eGDR for preventing frailty progression.
Cita:Cardiovasc Diabetol 2025 Feb 19; 24 (1) : 81.
Autor/es:Wang, Zhaoping (a) Zhu, Jinghan (b)
institución:(a) Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, Zhejiang, China. (b) Department of Epidemiology and Biostatistics, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Cita:J Cardiothorac Surg 2025 Feb 20; 20 (1) : 136.
Autor/es:Liu, Yuxin (a) Wang, Junlin (b)
institución:(a) Department of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwu Road, Jinan, Shandong, 250021, China. (b) Department of Anesthesia, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Personality traits and quality of life: a cross-sectional study in a middle-aged Iranian general population.
Personality traits and quality of life: a cross-sectional study in a middle-aged Iranian general population.
Fuente:Health and Quality of Life Outcomes
Extracto:
This
study provides robust evidence about the significant association of PT with QoL
outcomes in middle aged people. This significant association highlights the
importance of considering these traits in clinical applications, as tailored
interventions based on personality profiles can effectively enhance the
well-being of middle-aged individuals.
Claves:Iran, Middle-aged, Personality Traits, Quality of life, Socioeconomic status
Cita:Health Qual Life Outcomes 2025 Feb 17; 23 (1) : 13.
Autor/es:Habibi, Danial (a) Parsaei, Roqayeh (b)
institución:(a) Department of Epidemiology and Biostatistics, School of Public Health, Babol University of Medical Sciences, Babol, Iran. (b) Department of Biostatistics and Epidemiology, School of Health, Yasuj University of Medical Sciences, Yasuj, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Digital Isolation and Dementia Risk in Older Adults
Digital Isolation and Dementia Risk in Older Adults
Fuente:Journal of Medical Internet Research
Tipo de trabajo:Estudio de cohortes
Extracto:
Our findings
indicate that digital isolation is a significant risk factor for dementia among
older adults. This study underscores the importance of digital engagement in
mitigating dementia risk and suggests that promoting digital literacy and access
to digital resources should be integral components of public health strategies
aimed at dementia prevention.
Claves:aging, cognitive decline, cognitive impairment, dementia, digital engagement, digital isolation, elderly, geriatric, longitudinal cohort study, older adults, risk, social isolation
Cita:J Med Internet Res 2025 Feb 19; 27 : e65379.
Autor/es:Deng, Cheng (a) Shen, Na (b)
institución:(a) Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. (b) Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Striving Towards Equity in Cardiovascular Genomics Research.
Striving Towards Equity in Cardiovascular Genomics Research.
Fuente:Current Atherosclerosis Reports
Tipo de trabajo:Revisión
Extracto:
This will lead to more
accurate and clinically meaningful strategies for preventing and treating
cardiovascular diseases across all ancestral backgrounds and diverse populations.
Claves:Ancestry, Cardiovascular disease, Cardiovascular genomics, Genetic variability, Genetics, Health equity
Cita:Curr Atheroscler Rep 2025 Feb 18; 27 (1) : 34.
Autor/es:Jurado Vélez, Javier (a) Anderson, Nekayla (b)
institución:(a) Marnix E Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. (b) Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Sex difference in the relationship between childhood obesity and abnormal lipid profiles in young adults.
Sex difference in the relationship between childhood obesity and abnormal lipid profiles in young adults.
Fuente:Bmc Endocrine Disorders
Tipo de trabajo:Estudio de cohortes
Extracto:
This study demonstrates a sex difference in the relationship between childhood
obesity and abnormal lipid profiles in young adults. Childhood overweight/obesity
is associated with adverse lipid profiles in adulthood, with different patterns
observed in males and females. These findings highlight the importance of early
intervention and prevention strategies for childhood obesity to mitigate the risk
of future cardiovascular diseases.
Claves:Abnormal lipid profiles, Childhood obesity, Sex differences
Cita:BMC Endocr Disord 2025 Feb 18; 25 (1) : 44.
Autor/es:Zheng, Keyang (a) Yan, Yinkun (b)
institución:(a) Center of Hypertension, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Road, Chaoyang District, Beijing, 100029, China. (b) Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlish Road, Xicheng District, Beijing, 100045, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Valsartan to Prevent Acquired Pulmonary Vein Stenosis in Pediatric Patients After Total Anomalous Pulmonary Venous Connection Surgery.
Valsartan to Prevent Acquired Pulmonary Vein Stenosis in Pediatric Patients After Total Anomalous Pulmonary Venous Connection Surgery.
Fuente:Journal of The American Heart Association
Extracto:
Early
use of valsartan after total anomalous pulmonary venous connection surgery
appears to potentially be a feasible and effective adjunct to reoperation in
treating pediatric acquired PVS.
Cita:J Am Heart Assoc 2025 Feb 18; 14 (4) : e036911.
Autor/es:Shentu, Jin (a) Zhang, Mingjie (b)
institución:(a) Department of Cardio-thoracic Surgery, Congenital Heart Center, Shanghai Children's Medical Center, School of Medicine Shanghai Jiao Tong University Shanghai China. (b) Department of Cardio-thoracic Surgery, Congenital Heart Center, Shanghai Children's Medical Center, School of Medicine Shanghai Jiao Tong University Shanghai China.
The value of red blood cell distribution width in perioperative cardiac function assessment in children with congenital heart disease
The value of red blood cell distribution width in perioperative cardiac function assessment in children with congenital heart disease
Fuente:Medicine
Tipo de trabajo:Estudio de cohortes
Extracto:
As a
simple and effective biomarker, RDW can assist in the perioperative assessment of
cardiac function in this patient population.
Cita:Medicine (Baltimore) 2024 Dec 27; 103 (52) : e41144.
Autor/es:Wang, Qingsong (a) Yin, Jun (b)
institución:(a) Department of Pediatrics, The First People's Hospital of Jintang County/Jintang Hospital, West China Hospital, Sichuan University, Chengdu, Sichuan, China. (b) Department of Ultrasound, The First People's Hospital of Jintang County/Jintang Hospital, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Conflicto:The authors have no funding and conflicts of interest to disclose.
Paraben exposure related to Staphylococcal enterotoxin IgE sensitization, allergic rhinitis and nasal patency in children.
Paraben exposure related to Staphylococcal enterotoxin IgE sensitization, allergic rhinitis and nasal patency in children.
Fuente:Scientific Reports
Extracto:
This association might influence
allergic rhinitis and nasal response to decongestants, enhancing our
understanding of environmental factors in pediatric allergies.
Claves:Allergic rhinitis, Paraben, Staphylococcal enterotoxin immunoglobulin E
Cita:Sci Rep 2025 Feb 19; 15 (1) : 6038.
Autor/es:Ha, Eun Kyo (a) Kwak, Ji Hee (b)
institución:(a) Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea. (b) Pediatric Cardiologist, Seoul, Korea.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Real-world oral glucocorticoid use in SLE: a nation-wide population-based study using the French medico-administrative (SNDS) claim database.
Real-world oral glucocorticoid use in SLE: a nation-wide population-based study using the French medico-administrative (SNDS) claim database.
Fuente:Lupus Science & Medicine
Extracto:
In total,
48.2% of French patients with SLE were treated with OCS in 2019, including 12.4%
at a mean dose >5 mg/day, with an increased risk of OCS complications and a
limited use of antimalarials, immunosuppressants or biologics. These results
highlight the urgent need for the implementation of more robust OCS-sparing
strategies in SLE.
institución:(a) Service de Rhumatologie, Hôpitaux Universitaires de Strasbourg, Centre National de Référence des Maladies Systémiques Auto-immunes Rares Est Sud-Ouest, INSERM UMRS-1109, Université de Strasbourg, Strasbourg, France laurent.arnaud@chru-strasbourg.fr. (b) AstraZeneca, Tour Carpe Diem, Courbevoie, France.
Conflicto:Competing interests: LA is a consultant for Alexion, Alpine, Amgen, Astra-Zeneca, Abbvie, Biogen, BMS, Boehringer-Ingelheim, GSK, Grifols, Janssen, LFB, Lilly, Menarini France, Medac, Novartis, Pfizer, Roche-Chugaï, Sêmeia and UCB. CFV, RT, BV and GT are employees of Astra-Zeneca. JC, IB and SB are employees of CEMKA.
Future Patient-Telerehabilitation of Patients With Atrial Fibrillation: Protocol for a Multicenter, Mixed Methods, Randomized Controlled Trial.
Future Patient-Telerehabilitation of Patients With Atrial Fibrillation: Protocol for a Multicenter, Mixed Methods, Randomized Controlled Trial.
Fuente:Jmir Research Protocols
Tipo de trabajo:Estudio aleatorizado y controlado
Extracto:
Results
from the FP-AF study will determine whether the FP-AF program can increase
quality of life for patients with AF and increase their knowledge of symptoms and
living with AF in everyday life compared to conventional AF care. The
cost-effectiveness evaluation will determine whether telerehabilitation can be a
viable alternative for rehabilitation of patients with AF. TRIAL REGISTRATION:
ClinicalTrials.gov NCT06101485; https://clinicaltrials.gov/study/NCT06101485.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/64259.
Claves:Future Patient, adult, aging, atrial fibrillation, cardiovascular disease, chronic, co-creation, comorbidity, cost-effectiveness, digital health, health care professional, monitoring, patient education, patient engagement, prevalence, primary outcome, quality of life, randomized controlled trial, remote therapy, research design, telehealth, telerehabilitation
Cita:JMIR Res Protoc 2025 Feb 18; 14 : e64259.
Autor/es:Dinesen, Birthe (a) Albertsen, Andi Eie (b)
institución:(a) Laboratory of Welfare Technology - Digital Health and Rehabilitation, Department of Health Science and Technology, Aalborg Universitet, Gistrup, Denmark. (b) Department of Cardiology, Regional Hospital Viborg, Viborg, Denmark.
AMI-Sleep: protocol for a prospective study of sleep-disordered breathing/sleep apnoea syndrome and incident cardiovascular events after acute myocardial infarction.
AMI-Sleep: protocol for a prospective study of sleep-disordered breathing/sleep apnoea syndrome and incident cardiovascular events after acute myocardial infarction.
institución:(a) Department of Physiology and Functional Exploration - Bichat Hospital, Assistance Publique - Hopitaux de Paris, Paris, Île-de-France, France pauline.balagny@aphp.fr. (b) UMS 011, Population-based Cohorts Unit, INSERM, Paris Saclay University, Université de Versailles Saint-Quentin-en-Yvelines, Paris, France.
Conflicto:Competing interests: PGS has received grants from Amarin, AstraZeneca, Bayer, Sanofi and Servier, consulting fees from Amgen, AstraZeneca, BMS/Myokarddia, Merck, Novo-Nordisk and Regeneron, Steering Comitee or Critical Event Committee from Amarin, AstraZeneca, Bayer, Boerhriger Ingelheim, BristolMyers Squibb, Idorsia, Novartis, PhaseBio, Pfizer, Sanofi and Servier, payments for lectures from AstraZeneca, Novartis and Novo-Nordisk, support for attending meetings from AstraZeneca and participation...
on a Data Safety Monitoring Board or Advisory Board from Servier, Sanofi, PHRI and Monash University and no other relationships or activities that could appear to have influenced the submitted work. All other authors have no competing interests.
Prevalence and risk of complications in untreated patients with adult growth hormone deficiency.
Prevalence and risk of complications in untreated patients with adult growth hormone deficiency.
Fuente:Pituitary
Extracto:
Untreated patients with AGHD have a
higher prevalence of metabolic complications than the general population despite
no difference in their related risk factors. Given the low use of GHRT in this
study, comprehensive treatment approaches that include GHRT need to be considered
to alleviate the risk of complications.
institución:(a) Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, Hyogo, Japan. (b) Novo Nordisk Pharma Ltd, Meiji Yasuda Seimei Building, 2-1-1, Marunouchi, Chiyoda-ku, Tokyo, 100-0005, Japan. tend@novonordisk.com.
Conflicto:Declarations. Ethical approval: The study was approved by the MINS Research Ethics Committee (MINS-REC-230201; approved on January 19, 2023). Consent to participate: Not applicable. Consent to publish: Not applicable. Competing interests: HF received lecture fees from Novo Nordisk Pharma Ltd. TE and ST are employees of Novo Nordisk Pharma Ltd., and report stock ownership. SF received lecture fees from Novo...
Nordisk Pharma Ltd.
The relationship between estimated glucose disposal rate and cognitive function in older individuals.
The relationship between estimated glucose disposal rate and cognitive function in older individuals.
Fuente:Scientific Reports
Extracto:
This study contributes to the understanding of the
relationship between eGDR and cognitive performance by identifying a potential
non-linear association.
Cita:Sci Rep 2025 Feb 18; 15 (1) : 5874.
Autor/es:Li, Li (a) Li, Chengbo (b)
institución:(a) Department of Neurology, Affiliated Hospital of Chengde Medical College, Hebei, China. 895809697@qq.com. (b) Department of Neurology, Affiliated Hospital of Chengde Medical College, Hebei, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between cardiometabolic index and depression in a stroke population: a cross-sectional study of NHANES.
Association between cardiometabolic index and depression in a stroke population: a cross-sectional study of NHANES.
Fuente:European Journal of Medical Research
Extracto:
This study demonstrates a
positive association between CMI and PSD. CMI may serve as a useful tool for
evaluating the risk of depressive symptom in stroke patients, potentially aiding
in targeted clinical interventions.
Claves:Cardiometabolic index (CMI), Cross-sectional study, Depressive symptom, NHANES, Stroke
Cita:Eur J Med Res 2025 Feb 18; 30 (1) : 112.
Autor/es:Wu, Baofang (a) Li, Shaojie (b)
institución:(a) Department of Neurosurgery, The Second Affiliated Clinical Medical College of Fujian Medical University, Quanzhou, 362000, China. (b) Department of Neurosurgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Atrial fibrillation and the risk of bone fractures
Atrial fibrillation and the risk of bone fractures
Fuente:Medicine
Tipo de trabajo:Metanálisis
Extracto:
Our
results demonstrated that AF was significantly and independently associated with
a higher risk of bone fracture, especially for hip fracture.
Cita:Medicine (Baltimore) 2024 Dec 27; 103 (52) : e41049.
Autor/es:Wang, Yuexiao (a) Wang, Zhaoyan (b)
institución:(a) Department of Endocrinology, The Affiliated Taian City Central Hospital of Qingdao University, Taian City, Shandong Province, P.R. China. (b) Department of Endocrinology, The People's Hospital of Pingyi County, Linyi, Shandong Province, P.R. China.
Conflicto:The authors have no conflict of interest to disclose.
Effects of neuromuscular electrical stimulation during hemodialysis on muscle strength, functional capacity and postural balance in patients with end-stage renal disease: a randomized controlled trial.
Effects of neuromuscular electrical stimulation during hemodialysis on muscle strength, functional capacity and postural balance in patients with end-stage renal disease: a randomized controlled trial.
Fuente:Bmc Nephrology
Tipo de trabajo:Estudio aleatorizado y controlado
Extracto:
This study
supports the effectiveness of intradialytic NMES to improve muscular strength,
functional capacity and postural balance in HD patients. Given the limited
implementation of exercise programs in dialysis clinical practice, NMES during HD
sessions offers a novel therapeutic alternative to enhance physical condition and
quality of life in these patients. TRIAL REGISTRATION: Pan African Clinical Trial
Registry Identifer: PACTR202206634181851 Registered on 21/06/2022. Registered
trial name: Beneficial Effect of Intradialytic Electrical Muscle Stimulation in
Hemodialysis Patients.
Claves:Chronic kidney disease, Electric stimulation therapy, Hemodialysis
Cita:BMC Nephrol 2025 Feb 19; 26 (1) : 86.
Autor/es:Machfer, Amal (a) Fekih, Nadia (b)
institución:(a) Research Laboratory: Education, High Institute of Sport and Physical Education, University of Sfax, Sport et Santé, EM2S, LR19JS01, Motricité, Tunisia. (b) Research Laboratory: Education, High Institute of Sport and Physical Education, University of Sfax, Sport et Santé, EM2S, LR19JS01, Motricité, Tunisia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Neurology, Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China. (b) School of Life Science, Shanxi Normal University, Taiyuan, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación