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institución:(a) Centre for Endocrine and Thyroid Diseases, Deyang People's Hospital, Deyang, 618000, China. (b) Department of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Does diabetes modify the triglyceride-glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants.
Does diabetes modify the triglyceride-glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants.
Fuente:Cardiovascular Diabetology
Extracto:
TyG index showed
association with cardiovascular events, mortality, and all-cause mortality
independent of diabetic status, with low to moderate certainty. The associations
for IHD and all-cause death were stronger in diabetic patients than in
individuals without diabetes. Future studies should explore the role of diabetes
in the TyG index-associated CVD outcomes and mortality.
Claves:Cardiovascular disease, Diabetes mellitus, Meta-analysis, Mortality, Triglyceride–glucose index
Cita:Cardiovasc Diabetol 2025 Jan 27; 24 (1) : 42.
Autor/es:Zhang, Jun (a) Zhan, Qiye (b)
institución:(a) Department of Cardiology, Affiliated Hospital of Jiujiang University, Jiujiang, China. (b) Jiujiang Clinical Precision Medicine Research Center, Jiujiang, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Associations of the triglyceride-glucose index and remnant cholesterol levels with the prevalence of Carotid Plaque in patients with type 2 diabetes: a retrospective study.
Associations of the triglyceride-glucose index and remnant cholesterol levels with the prevalence of Carotid Plaque in patients with type 2 diabetes: a retrospective study.
Fuente:Lipids in Health and Disease
Tipo de trabajo:Orientaciones y guía
Extracto:
In patients with T2DM, both TyG index and RC
levels were strongly linked to carotid plaque presence, and could serve as
independent risk factors for this presence. Monitoring the TyG index and RC
levels can help gain a better understanding and knowledge of carotid plaque
presence in patients with T2DM, offering guidance for the clinical prevention and
treatment of cardiovascular and cerebrovascular diseases (CCVDs) in patients with
T2DM.
Claves:Carotid plaque, RC, T2DM, TyG index
Cita:Lipids Health Dis 2025 Jan 27; 24 (1) : 26.
Autor/es:Xu, Xin (a) Pan, Tianrong (b)
institución:(a) Department of Endocrinology, The Second Affiliated Hospital of Anhui Medical University, Hefei Anhui, 230601, China. (b) Department of Endocrinology, The Second Affiliated Hospital of Anhui Medical University, Hefei Anhui, 230601, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between the aromatase (CYP19A1) gene variant rs10046 and cardiovascular risk in postmenopausal women.
Association between the aromatase (CYP19A1) gene variant rs10046 and cardiovascular risk in postmenopausal women.
Fuente:Archives of Endocrinology and Metabolism
Extracto:
The present study
found that the CC genotype of the rs10046 polymorphism in the CYP19A1 gene is
associated with low estradiol levels and an increased ASCVD risk. Additionally,
the results indicated that, among postmenopausal women, age and the CC genotype
of rs10046 were associated with a high prevalence of ASCVD risk, independent of
BMI.
institución:(a) Unidade de Endocrinologia Ginecológica Hospital de Clínicas de Porto Alegre Divisão de Endocrinologia Porto AlegreRS Brasil Unidade de Endocrinologia Ginecológica, Divisão de Endocrinologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brasil. (b) Universidade Federal do Rio Grande do Sul Laboratório de Endocrinologia Molecular Departamento de Fisiologia Porto AlegreRS Brasil Laboratório de Endocrinologia Molecular, Departamento de Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Conflicto:Disclosure: no potential conflict of interest relevant to this article was reported.
Circulating endothelial progenitor cells and inflammatory markers in type 1 diabetes after an acute session of aerobic exercise.
Circulating endothelial progenitor cells and inflammatory markers in type 1 diabetes after an acute session of aerobic exercise.
Fuente:Archives of Endocrinology and Metabolism
Extracto:
Patients with T1DM and healthy controls had comparable EPC responses to aerobic
exercise, most likely due to the absence of a chronic inflammatory state.
institución:(a) Instituto Nacional de Ciência e Tecnologia para Avaliação de Tecnologias em Saúde Hospital de Clínicas de Porto Alegre Porto AlegreRS Brasil Instituto Nacional de Ciência e Tecnologia para Avaliação de Tecnologias em Saúde (IATS) - CNPq/Brasil, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brasil. (b) Universidade Federal do Rio Grande Rio GrandeRS Brasil Universidade Federal do Rio Grande, Rio Grande, RS, Brasil.
Conflicto:Disclosure: no potential conflict of interest relevant to this article was reported.
Autor/es:Lewiecki, E Michael (a) Bilezikian, John P (b)
institución:(a) New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, USA. Electronic address: mlewiecki@gmail.com. (b) Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Liver international official journal of the International Association for the Study of the Liver
Selección SIIC: 31 Enero, 2025
Liver international official journal of the International Association for the Study of the Liver
Value and Kinetics of Virological Markers in the Natural Course of Chronic Hepatitis D Virus Infection.
Value and Kinetics of Virological Markers in the Natural Course of Chronic Hepatitis D Virus Infection.
Fuente:Liver International Official Journal of The International Association For The Study of The Liver
Extracto:
In chronic HDV infection, neither
baseline values nor kinetics of HBV RNA, HBcrAg and anti-HBc were independently
associated with clinical outcome, while stage of liver disease and age were
predictors of liver-related events.
Autor/es:Sandmann, Lisa (a) Ohlendorf, Valerie (b)
institución:(a) Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hanover, Germany. (b) D-SOLVE Consortium, an EU Horizon Europe Funded Project, partner site Hannover, Germany.
Conflicto:Lisa Sandmann reports lecture honoraria and personal fees from Falk Pharma e.V., Gilead and Roche, and travel support from AbbVie. Markus Cornberg reports personal fees from AbbVie, Falk Foundation, Gilead, Janssen‐Cilag, GSK, MSD, Spring Bank and SOBI. Katja Deterding received lecture and personal fees from Gilead, Falk Pharma e.V., AbbVie, MSD/Merck and Alnylam. Heiner Wedemeyer reports grants/research support from AbbVie,...
e, Biotest, BMS, Gilead, Merck/MSD, Novartis, Roche and personal fees from Abbott, AbbVie, Altimmune, Biotest, BMS, BTG, Dicerna, Gilead, Janssen, Merck/MSD, MYR GmbH, Novartis, Roche and Siemens. Benjamin Maasoumy served as a speaker and/or advisory board member for AbbVie, Fujirebio, Gilead, Luvos, MSD, Norgine, Roche and W. L. Gore & Associates and received research support from Altona, EWIMED, Fujirebio and Roche. Anke R.M. Kraft, Birgit Bremer, Alena Ehrenbauer and Valerie Ohlendorf have nothing to disclose.
Liver international official journal of the International Association for the Study of the Liver
Selección SIIC: 31 Enero, 2025
Liver international official journal of the International Association for the Study of the Liver
Phase 2 Randomised Study of Bulevirtide as Monotherapy or Combined With Peg-IFN?-2a as Treatment for Chronic Hepatitis Delta.
Phase 2 Randomised Study of Bulevirtide as Monotherapy or Combined With Peg-IFN?-2a as Treatment for Chronic Hepatitis Delta.
Fuente:Liver International Official Journal of The International Association For The Study of The Liver
Extracto:
BLV combined
with Peg-IFNα-2a was well tolerated and resulted in high rates of HDV RNA
undetectability off-treatment. TRIAL REGISTRATION: NCT02888106.
Autor/es:Lampertico, Pietro (a) Bogomolov, Pavel O (b)
institución:(a) Division of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. (b) CRC "A. M. And A. Migliavacca" Center for Liver Disease, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Associations of early-onset coronary heart disease and genetic susceptibility with incident dementia and white matter hyperintensity
Associations of early-onset coronary heart disease and genetic susceptibility with incident dementia and white matter hyperintensity
Fuente:The Journal of Prevention of Alzheimer's Disease
Tipo de trabajo:Estudio de cohortes
Extracto:
Early-onset CHD and genetic susceptibility are
associated with a higher risk of incident dementia and a larger WMH volume.
Additional attention should be paid to the neurocognitive status of individuals
with early-onset CHD.
institución:(a) School of Nursing, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. (b) Department of Endocrinology, Peking University First Hospital, Beijing, China; Clinical Research Institute, Institute of Advanced Clinical Medicine, Peking University, Beijing, China; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China.
Conflicto:Declaration of competing interest All other authors declare that there are no competing interests.
[Search for new immunohistochemical and circulating markers of insulinoma].
[Search for new immunohistochemical and circulating markers of insulinoma].
Fuente:Problemy Endokrinologii
Extracto:
The markers CART, MTNR1b and rGLP1
are of primary interest for further study in a larger sample of patients with
insulinoma. Other markers (TPD52, XgB, NESP55, melatonin, AA-NAT) have not been
shown to be associated with an insulin-producing tumor, therefore they are not
promising for future researches. At the same time, it is necessary to continue
research aimed at finding new both circulating and IHC markers in order to early
diagnose the manifestation of the disease and its recurrence, and more accurately
determine the malignant and proliferative potential of the tumor.
Cita:Probl Endokrinol (Mosk) 2024 May 13; 70 (6) : 15-26.
Autor/es:Yukina, M Yu (a) Troshina, E A (b)
institución:(a) Endocrinology Research Centre. (b) Endocrinology Research Centre.
[The functional role and properties of transcortin in the human body].
[The functional role and properties of transcortin in the human body].
Fuente:Problemy Endokrinologii
Extracto:
Research results have
shown that the synthesis of transcortin has been detected in some extrahepatic
tissues, including the adrenal glands, however, its role is unknown.
Cita:Probl Endokrinol (Mosk) 2024 Aug 1; 70 (6) : 27-34.
Autor/es:Chevais, A (a) Gadzhimuradova, M M (b)
institución:(a) Endocrinology Research Centre. (b) Endocrinology Research Centre.
[Albumin adjustment of total serum calcium - is it worth doing?].
[Albumin adjustment of total serum calcium - is it worth doing?].
Fuente:Problemy Endokrinologii
Extracto:
The review discusses the history of the
formulas for correcting total calcium for albumin, the factors influencing the
result of correction, as well as its suitability in various conditions.
Cita:Probl Endokrinol (Mosk) 2024 Nov 13; 70 (6) : 45-61.
Autor/es:Mamedova, E O (a) Golounina, O O (b)
institución:(a) Endocrinology Research Centre. (b) Endocrinology Research Centre.
[Development of prognostic clinical and genetic models of the risk of low bone mineral density using neural network training].
[Development of prognostic clinical and genetic models of the risk of low bone mineral density using neural network training].
Fuente:Problemy Endokrinologii
Extracto:
The results
confirm the promising application of machine learning to predict the risk of
osteoporosis at the preclinical stage of the disease based on the analysis of
clinical and genetic factors.
Cita:Probl Endokrinol (Mosk) 2024 Jan 24; 70 (6) : 67-82.
Autor/es:Yalaev, B I (a) Novikov, A V (b)
institución:(a) Endocrinology Research Centre. (b) Endocrinology Research Centre.
[Clinical, hormonal and molecular genetic characteristics of patients with 46,XY disorders of sex development associated with variants in the HSD17B3 gene].
[Clinical, hormonal and molecular genetic characteristics of patients with 46,XY disorders of sex development associated with variants in the HSD17B3 gene].
Fuente:Problemy Endokrinologii
Extracto:
In the structure of 46,XY DSD, patients with biallelic
variants in the HSD17B3 gene were identified in 4.2% of cases, with monoallelic
variants - in 2.3% of cases. 4 novel variants were found in the HSD17B3 gene.
Cita:Probl Endokrinol (Mosk) 2024 Jan 9; 70 (6) : 91-98.
Autor/es:Kalinchenko, N Y (a) Makretskaya, N A (b)
institución:(a) Endocrinology Research Centre. (b) Research Centre for Medical Genetics.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
Selección SIIC: 31 Enero, 2025
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
The Economic Burden of Management of Pituitary Adenomas: A Propensity-Score-Matched Cost Analysis.
The Economic Burden of Management of Pituitary Adenomas: A Propensity-Score-Matched Cost Analysis.
Fuente:Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et de Chirurgie Cervico-faciale
Extracto:
This study provided a comprehensive assessment of the
economic burden of PAs on the publicly-funded healthcare system. Patients with PA
had higher annualized total costs across all observed time periods compared to
the general population and lower annualized total costs compared to patients
admitted to a surgical ward. RELEVANCE: This study highlights the financial
impact of PA management on healthcare resources and provides a basis for future
research aimed at cost-efficiency improvements in long-term PA care.
Cita:J Otolaryngol Head Neck Surg 2025 Jan-Dec; 54 : 19160216251314793.
Autor/es:Caulley, Lisa (a) Lasso, Andrea (b)
institución:(a) Department of Otolaryngology-Head and Neck Surgery, University of Ottawa, Ottawa, ON, Canada. (b) Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.
Conflicto:Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Effect of fezolinetant on patient-reported quality-of-life outcomes: Data from a phase 3b study (DAYLIGHT) of the treatment of moderate to severe vasomotor symptoms associated with menopause in women considered unsuitable for hormone therapy.
Effect of fezolinetant on patient-reported quality-of-life outcomes: Data from a phase 3b study (DAYLIGHT) of the treatment of moderate to severe vasomotor symptoms associated with menopause in women considered unsuitable for hormone therapy.
Fuente:Maturitas
Extracto:
Patient-reported outcomes demonstrate
that reductions in VMS frequency with fezolinetant treatment were associated with
improvements in QOL.
institución:(a) University of Toronto, Toronto, ON, Canada. (b) Astellas Pharma Global Development, Northbrook, IL, USA.
Conflicto:Declaration of competing interest M.S.C.M. sits on advisory boards for and has received consulting fees and honorariums from Amgen, Aspen, Astellas, BioSyent, Bayer, CCRN, Duchesnay, Eisai, GSK, Idorsia, Merck, Mithra, Novo Nordisk, Organon, Pfizer, Sandoz, and Searchlight; receives support for attending meetings and/or travel from Astellas and The Menopause Society; has a leadership or fiduciary role in other board, society,...
committee, or advocacy group, paid or unpaid, for the International Menopause Society and Terry Fox Research Institute. X. Wu, X. Wang, K. Miyazaki., A.M., and K. Martins are employees of Astellas Pharma. R.E.N. receives grants/contracts from Fidia; consulting fees from Astellas, Bayer Pharma, Besins Healthcare, Fidia, and Theramex; payment or honorariums for lectures, presentations, speakers bureaus, manuscript writing, or educational events from Abbott, Astellas, Exeltis, Fidia, Gedeon Richter, Merck, Novo Nordisk, Shionogi, Theramex, and Viatris; payment for expert testimony from Vichy Laboratories; and is president of the International Menopause Society. P.S. has received grants or contracts from the University of Bern and Swiss National Foundation; consulting fees from Astellas and Theramex; payment or honorariums for lectures, presentations, speakers bureaus, manuscript writing, or educational events for Astellas, Theramex, and Besins Healthcare; leadership or fiduciary role in other board, society, committee, or advocacy group, paid or unpaid for the European Menopause and Andropause Society, Deutsche Menopause Gesellschaft, and Swiss Society for Anti Aging Medicine and Prevention. K.S. has received payment or honorariums for lectures, presentations, speakers bureaus, manuscript writing, or educational events from aidhere, Astellas Pharma, Bayer/Jenapharm, Besins Healthcare, Exeltis, Fidia, Gedeon Richter Pharma, Novo Nordisk, Organon, Theramex, Viatris, and Laborarztpraxis Rhein-Main; participates on a data safety monitoring board or advisory board for Astellas, Bayer, Exeltis, Besins Healthcare, and Viatris; is President of the German Menopause Society organises and lectures at conferences for the society; lectures and participates in conferences for the professional association of gynaecologists in Germany; is honorary member for the German Society of Obstetrics and Gynecology and lectures, is president at conferences, and participates on committees for the society.
Awakening not associated with an increased rate of cortisol secretion.
Awakening not associated with an increased rate of cortisol secretion.
Fuente:Proceedings. Biological Sciences
Extracto:
Based on these results, we strongly suggest caution is needed
when interpreting cortisol measurements solely obtained in the hour after waking.
institución:(a) Laboratory for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol BS1 3NY, UK. (b) Laboratory for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol BS1 3NY, UK.
Conflicto:Stafford Lightman is a co-director and co-founder of Dynamic Therapeutics Limited. The remaining authors declare no competing interests.
Pituitary stalk interruption syndrome with coexistent focal cortical dysplasia in a young boy.
Pituitary stalk interruption syndrome with coexistent focal cortical dysplasia in a young boy.
Fuente:Bmj Case Reports
Extracto:
This discovery is novel in the literature, offers
potential new insights into the pathophysiology of PSIS and emphasises the
importance of considering structural brain abnormalities in PSIS patients with
seizures, thereby opening new avenues for future research on their neurological
consequences.
Claves:Endocrinology, Epilepsy and seizures, Neuroendocrinology, Paediatrics, Pituitary disorders
institución:(a) Bahrain Defence Force Royal Medical Services, Riffa, Bahrain ameenaalaqili@gmail.com. (b) Paediatrics, Bahrain Defence Force Royal Medical Services, Riffa, Bahrain.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Total functioning capacity scale in Huntington's disease: natural course over time.
Total functioning capacity scale in Huntington's disease: natural course over time.
Fuente:Journal of Neurology
Tipo de trabajo:Estudio clínico
Extracto:
Analysis of the
reduced penetrance group suggests potential selection biases in seeking medical
attention earlier and for reasons unrelated to HD.
Claves:Disease progression, Functional status, Huntington's disease, Movement disorders
Cita:J Neurol 2025 Jan 15; 272 (2) : 140.
Autor/es:van der Zwaan, K F (a) Feleus, S (b)
institución:(a) LUMC Department of Neurology, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. k.f.van_der_Zwaan@lumc.nl. (b) LUMC Department of Neurology, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Conflicto:Declarations. Conflicts of Interest: O.M. Dekker is Deputy Editor European Journal of Endocrinology. R.A.C. Roos is member of the DSMB uniQure CT-AMT 130, DSMB Enroll-HD. Susanne T. de Bot is a member of the HD Expert Advisory Panel for the PTC518 phase 3 program (PTC Therapeutics). Ethical Standard Statement: This study was conducted in compliance with the ethical standards outlined...
in the Declaration of Helsinki. All sites obtained and maintained local ethical approval. All participants provided informed consent prior to participation in the study, and their confidentiality and privacy were maintained throughout.
