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The efficacy and safety of rhGH treatment combined with letrozole/GnRHa in adolescent boys.
The efficacy and safety of rhGH treatment combined with letrozole/GnRHa in adolescent boys.
Fuente:Bmc Pediatrics
Tipo de trabajo:Estudio clínico
Extracto:
The
combination of letrozole/rhGH in pubertal GHD boys was similar to GnRHa/rhGH in
terms of the progression of BA and FAH, but the former co-therapy was superior in
the gain of height. Disconcertingly, however, this combination may adversely
affect BMI and BMD. CLINICAL TRIAL REGISTRATION NUMBER: ChiCTR2300068405.
Claves:Adolescent boys, Gonadotropin releasing, Growth hormone deficiency, Letrozole, Recombinant human growth hormone, Short stature
Cita:BMC Pediatr 2025 Jan 24; 25 (1) : 59.
Autor/es:Zhang, Ying (a) Yuan, Xin (b)
institución:(a) Department of Endocrinology, Genetics and Metabolism, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou Children's Hospital of Fujian Medical University, Fuzhou, 350005, China. (b) Department of Endocrinology, Genetics and Metabolism, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou Children's Hospital of Fujian Medical University, Fuzhou, 350005, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Non-linear relationship between urinary creatinine and diabetic kidney disease: implications for clinical practice.
Non-linear relationship between urinary creatinine and diabetic kidney disease: implications for clinical practice.
Fuente:Bmc Nephrology
Extracto:
The findings of this study highlight the potential of
UCr as a valuable biomarker for early detection and assessment of DKD in T2DM
patients. Incorporating UCr measurements into routine clinical practice could
enhance early identification of patients at risk for kidney complications,
leading to timely intervention and improved patient outcomes.
Claves:Biomarker, Diabetic kidney disease, Early detection, Renal function, Type 2 diabetes Mellitus, Urinary creatinine
Cita:BMC Nephrol 2025 Jan 24; 26 (1) : 40.
Autor/es:Cao, Huihong (a) Song, Li (b)
institución:(a) Department of Endocrinology of Shanghai Minhang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China. (b) Department of Endocrinology of Shanghai Minhang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Antibiotic exposure is associated with minimal gut microbiome perturbations in healthy term infants.
Antibiotic exposure is associated with minimal gut microbiome perturbations in healthy term infants.
Fuente:Microbiome
Extracto:
Short-term and
long-term gut microbiome perturbations by antibiotic exposure were detectable but
substantially smaller than those associated with breastfeeding and infant age.
Claves:Bifidobacterium, Amoxicillin, Antibiotics, Bile acid, Infant gut microbiota, Metagenomics
Cita:Microbiome 2025 Jan 24; 13 (1) : 21.
Autor/es:Benitez, Alain J (a) Tanes, Ceylan (b)
institución:(a) Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, 19146, USA. (b) Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Conflicto:Declarations. Ethics approval and consent to participate: The study was approved by the Institutional Review Board (IRB) at Children’s Hospital of Philadelphia (IRB 14–010833). Consent for publication: The IGram study enrolled pregnant African American mothers and their newborn infants. The purpose of the research study was to learn more about the bacteria normally living in the child’s gut, how it...
how it is transferred from mother to child, and whether it affects the child’s growth in the first 3 years of life. The IGRAM data used in this publication are consistent with the stated purpose of the research. The Institutional Review Board-approved consent documents included language that allowed participants to indicate whether they would like to have their information included in future research. Subjects may participate in the original research without their information (even if de-identified) being included in future research. Competing interests: Dr Elovitz receives salary support from NIAID, NICHD and NINR. She serves as a consultant with equity for Mirvie. No other disclosures were reported.
Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome.
Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome.
Fuente:Biomolecules
Extracto:
A
combination of upregulated obesity-related CVRPs (ANGPT1/IL/1Ra/XCL1) and
downregulated cardioprotective proteins (sRAGE/BMP6/Mn-SOD/GDF2) in
overweight/obese PCOS women may contribute to the increased risk for CVD. TF and
renin upregulation observed in the BMI- and IR-matched limited sample PCOS
subgroup indicates their potential risk of CVD.
institución:(a) Research Department, Royal College of Surgeons of Ireland, Adliya, Busaiteen 15503, Bahrain. (b) Research Department, Royal College of Surgeons of Ireland, Adliya, Busaiteen 15503, Bahrain.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Polygenic Score Approach to Predicting Risk of Metabolic Syndrome.
Polygenic Score Approach to Predicting Risk of Metabolic Syndrome.
Fuente:Genes
Extracto:
Polygenic scores
could aid in predicting MetS risk and health outcomes, emphasizing the need for
diagnostic tools tailored to specific populations. Additional research is
warranted to corroborate these conclusions and explore the molecular mechanisms
of MetS.
Claves:metabolic syndrome, polygenic score, predictive medicine
Cita:Genes (Basel) 2024 Dec 26; 16 (1)
Autor/es:Timasheva, Yanina (a) Kochetova, Olga (b)
institución:(a) Institute of Biochemistry and Genetics, Ufa Federal Research Centre of Russian Academy of Sciences, 450054 Ufa, Russia. (b) Department of Medical Genetics and Fundamental Medicine, Faculty of General Medicine, Bashkir State Medical University, 450008 Ufa, Russia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Eye Hospital, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia. (b) Clinic for Eye Diseases, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Impairment of Microcirculation Parameters in Patients with a History of Diabetic Foot Ulcers.
Impairment of Microcirculation Parameters in Patients with a History of Diabetic Foot Ulcers.
Fuente:Medicina (kaunas, Lithuania)
Extracto:
Conclusions: The
present study found more retinopathy and a more pronounced alteration to
sudomotor function in Grade 3 patients, suggesting that these parameters could be
considered to better identify patients at high risk of DFUs.
Claves:diabetic foot, microcirculation, neuropathy, sudomotor function
institución:(a) Service d'Endocrinologie, Diabète et Nutrition, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, 69310 Pierre Bénite, France. (b) Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique, CNRS UMR 5305, 69367 Lyon, France.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Joint Group and Multi Institutional Position Opinion: Cirrhotic Cardiomyopathy-From Fundamentals to Applied Tactics.
Joint Group and Multi Institutional Position Opinion: Cirrhotic Cardiomyopathy-From Fundamentals to Applied Tactics.
Fuente:Medicina (kaunas, Lithuania)
Extracto:
This is not only a
review but also a comprehensive distillation of the insights from practicing
clinical hepatologists and other specialties engaged in advanced approaches to
treating liver disease and its sequelae.
institución:(a) Gastroenterology and Liver Unit, Royal Cornwall Hospitals NHS Trust, London TR1 3LJ, UK. (b) Medical School, University of Exeter, Exeter TR10 9FE, UK.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Natural History of Metabolic Dysfunction-Associated Steatotic Liver Disease: From Metabolic Syndrome to Hepatocellular Carcinoma.
Natural History of Metabolic Dysfunction-Associated Steatotic Liver Disease: From Metabolic Syndrome to Hepatocellular Carcinoma.
Fuente:Medicina (kaunas, Lithuania)
Extracto:
Conclusions: MASLD as a metabolic
disorder underscores its impact on public health, necessitating improved
awareness and early management strategies to mitigate its progression to severe
liver diseases.
institución:(a) Endocrinology, Specialized Center for Diabetes, Obesity and Prevention of Cardiovascular Diseases (CEDOPEC), Mexico City 11650, Mexico. (b) Clinical Research, Specialized Center for Diabetes, Obesity and Prevention of Cardiovascular Diseases (CEDOPEC), Mexico City 11650, Mexico.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Characterizing Circulating microRNA Signatures of Type 2 Diabetes Subtypes.
Characterizing Circulating microRNA Signatures of Type 2 Diabetes Subtypes.
Fuente:International Journal of Molecular Sciences
Extracto:
Our study confirms the
heterogeneity of T2D, represented by distinguishable subtypes both clinically and
epigenetically and highlights the potential of miRNAs as markers for
distinguishing the pathophysiology of T2D subtypes.
Claves:T2D subtypes, Type 2 diabetes, circulating microRNA, insulin resistance, pathophysiology
institución:(a) College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab Emirates. (b) College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab Emirates.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Genetic Structure of Hereditary Forms of Diabetes Mellitus in Russia.
Genetic Structure of Hereditary Forms of Diabetes Mellitus in Russia.
Fuente:International Journal of Molecular Sciences
Extracto:
This
knowledge provides a foundation for developing region-specific genetic testing
algorithms and personalized therapeutic strategies, which are critical for future
initiatives in precision medicine.
Claves:diabetes mellitus, maturity onset diabetes of the young, neonatal diabetes
Cita:Int J Mol Sci 2025 Jan 16; 26 (2)
Autor/es:Minniakhmetov, Ildar R (a) Khusainova, Rita I (b)
institución:(a) Endocrinology Research Center, Moscow 117292, Russia. (b) Endocrinology Research Center, Moscow 117292, Russia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Guidance on Energy Intake Based on Resting Energy Expenditure and Physical Activity: Effective for Reducing Body Weight in Patients with Obesity.
Guidance on Energy Intake Based on Resting Energy Expenditure and Physical Activity: Effective for Reducing Body Weight in Patients with Obesity.
Fuente:Nutrients
Tipo de trabajo:Orientaciones y guía
Extracto:
Guidance on energy intake based on REE
and physical activity was effective for reducing BW in patients with obesity
without decreasing REE or increasing hunger. This approach may reduce the burden
on patients with obesity while losing BW.
Claves:caloric restriction, energy expenditure, energy intake, hunger, physical activity, resting energy expenditure, weight loss, weight loss program, weight management
Cita:Nutrients 2025 Jan 7; 17 (2)
Autor/es:Handa, Tomoko (a) Onoue, Takeshi (b)
institución:(a) Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. (b) Department of Clinical Research Education, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
High-dose glucocorticoid treatment vs. glucocorticoid replacement in immune checkpoint inhibitor associated hypophysitis (CORTICI)
High-dose glucocorticoid treatment vs. glucocorticoid replacement in immune checkpoint inhibitor associated hypophysitis (CORTICI)
Fuente:Annals of Medicine
Tipo de trabajo:Estudio aleatorizado y controlado
Extracto:
High-dose glucocorticoid treatment was not
effective in restoring adrenal function and leads to adverse effects on glucose
metabolism. We therefore do not recommend its use for the treatment of ICI
associated hypophysitis, except for compressive symptoms.
Autor/es:Theiler-Schwetz, Verena (a) Trummer, Christian (b)
institución:(a) Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria. (b) Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Conflicto:No potential competing interest was reported by the authors.
Ethnic disparities in HbA1c and hypoglycemia among youth with type 1 diabetes: beyond access to technology, social deprivation and mean blood glucose.
Ethnic disparities in HbA1c and hypoglycemia among youth with type 1 diabetes: beyond access to technology, social deprivation and mean blood glucose.
Fuente:Bmj Open Diabetes Research & Care
Extracto:
CYP from Black ethnic backgrounds have a
higher HbA1c compared with their South Asian and White counterparts which is
clinically significant and independent of MBG, potentially contributing to
increased complications risk. Additionally, the Black group experienced a higher
incidence of hypoglycemia, possibly due to a treat-to-HbA1c target approach.
Claves:CGM, Diabetes Mellitus, Type 1, Insulin Pump
Cita:BMJ Open Diabetes Res Care 2025 Jan 25; 13 (1)
Autor/es:Pemberton, John Stuart (a) Fang, Zhide (b)
institución:(a) Diabetes and Endocrinology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK. (b) Biostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Conflicto:Competing interests: JSP: Advisory Board for ROHCE and speaker payments for Dexcom.
Osilodrostat improves blood pressure and glycemic control in patients with Cushing's disease: a pooled analysis of LINC 3 and LINC 4 studies.
Osilodrostat improves blood pressure and glycemic control in patients with Cushing's disease: a pooled analysis of LINC 3 and LINC 4 studies.
Fuente:Pituitary
Tipo de trabajo:Estudio abierto
Extracto:
Patients with Cushing's disease and comorbid hypertension/diabetes
receiving osilodrostat had rapid and sustained improvements in SBP/DBP and
glycemic control, respectively.
Autor/es:Fleseriu, Maria (a) Pivonello, Rosario (b)
institución:(a) Pituitary Center, Departments of Medicine and Neurological Surgery, Oregon Health and Science University, Portland, OR, USA. fleseriu@ohsu.edu. (b) Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Naples, Italy.
Conflicto:Declarations. Ethical approval: The LINC 3 and LINC 4 studies were conducted in accordance with the Declaration of Helsinki, and study protocols were approved by independent ethics committees/institutional review boards. Consent to participate: Patients provided written informed consent to participate at the start of the core and extension phases of the studies. Consent to publish: Patients provided written informed consent...
for their data to be published anonymously. Competing interests: MF reports grants to her university from Crinetics and Sparrow and occasional scientific consulting fees from Crinetics, Recordati Rare Diseases, Sparrow, and Xeris Pharmaceuticals; she served as a member of the LINC 3 steering committee and is a member of the editorial board of Pituitary. RP has received research funding from Recordati AG, Corcept Therapeutics, Xeris Pharmaceuticals (Strongbridge), Neurocrine Biosciences, and Spruce Biosciences and has served as a consultant for Corcept Therapeutics, Recordati AG, Crinetics Pharmaceuticals, and H Lundbeck A/S. JN-P reports research grants and consultancy payments to his university from Crinetics, Diurnal, HRA Pharma, and Recordati Rare Diseases. MRG has received speaker fees from Recordati, Ipsen, Novo Nordisk, and Camurus and attended advisory boards for Novo Nordisk, Recordati, and Crinetics Pharmaceuticals. BMKB reports occasional consulting honoraria from H Lundbeck A/S, Recordati Rare Diseases, Sparrow, and Xeris Pharmaceuticals; she served on the LINC 3 steering committee. RJA reports grants and personal fees from Xeris Pharmaceuticals, Spruce Biosciences, Neurocrine Biosciences, Corcept Therapeutics, Diurnal Ltd, Sparrow Pharmaceuticals, Crinetics Pharmaceuticals, and Recordati Rare Diseases and personal fees from Adrenas Therapeutics, Quest Diagnostics, H Lundbeck A/S, Novo Nordisk, and Besins Pharmaceuticals. RF reports consultancy for Corcept Therapeutics and Recordati and research grants from Strongbridge and Corcept Therapeutics. AS reports serving as a speaker and consultant for Recordati; he was also a member of the LINC 3 steering committee. PW reports receiving travel grants and speaker fees from Novartis, Ipsen, Recordati, Novo Nordisk, Strongbridge Biopharma, Merck-Serono, Lilly, and Berlin Chemie. MB reports consultancy for and travel grants from Recordati. AP is an employee of Recordati. AMP was an employee of Recordati at the time the analyses were conducted. AL reports grants and personal consulting fees from Novartis, Recordati, Pfizer, and Corcept Therapeutics.
Relationship between plasma urea and copeptin in response to arginine stimulation in healthy adults, patients with vasopressin deficiency and primary polydipsia.
Relationship between plasma urea and copeptin in response to arginine stimulation in healthy adults, patients with vasopressin deficiency and primary polydipsia.
Fuente:Pituitary
Extracto:
We demonstrate a
slight increase in plasma urea levels in response to arginine, but plasma urea
and copeptin levels were weakly correlated. Based on these findings, the
stimulatory effect of arginine on AVP cannot be explained primarily by increasing
urea levels.
institución:(a) Departments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland. (b) Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Research on the application effect of self-transcendence nursing model in patients with gestational diabetes mellitus
Research on the application effect of self-transcendence nursing model in patients with gestational diabetes mellitus
Fuente:Bmc Pregnancy and Childbirth
Tipo de trabajo:Estudio aleatorizado y controlado
Extracto:
Self-transcendence nursing mode intervention can improve
blood sugar, reduce psychological distress, and improve self-efficacy in GDM
patients, thereby reducing the rate of pregnancy-induced hypertension and
premature birth.
Cita:BMC Pregnancy Childbirth 2025 Jan 25; 25 (1) : 70.
Autor/es:Xu, Mengpei (a) Wu, Ying (b)
institución:(a) Department of Endocrinology, Affiliated Hai'an Hospital of Nantong University, Nantong, Jiangsu, 226600, China. (b) Department of Obstetrics and Gynecology, Hai'an Hospital of Traditional Chinese Medicine, Hai'an County, Nantong City, Jiangsu Province, 226600, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Semaglutide and laparoscopic sleeve gastrectomy in an adolescent with congenital adrenal hyperplasia due to 21-hydroxylase
Semaglutide and laparoscopic sleeve gastrectomy in an adolescent with congenital adrenal hyperplasia due to 21-hydroxylase
Fuente:Journal of Medical Case Reports
Tipo de trabajo:Caso clínico
Extracto:
This case highlights the potential of an integrative,
multidisciplinary approach to address severe obesity and its associated
comorbidities in patients with classic congenital adrenal hyperplasia. The
successful outcomes from both pharmacotherapy and bariatric surgery suggest that
tailored obesity management strategies can optimize health in this unique
population, reinforcing the need for further research into comprehensive obesity
care in individuals with congenital adrenal hyperplasia.
institución:(a) Department of Pediatrics, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles and Keck School of Medicine of USC, 4650 Sunset Boulevard, Mailstop #61, Los Angeles, CA, 90027, USA. avidmar@chla.usc.edu. (b) Department of Pediatrics, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles and Keck School of Medicine of USC, 4650 Sunset Boulevard, Mailstop #61, Los Angeles, CA, 90027, USA.
Conflicto:Declarations. Ethics approval and consent to participate: Written informed consent was obtained from all participants and a parent or guardian involved in the study. The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Institutional Review Board (or Ethics Committee) of Children’s Hospital Los Angeles (CHLA-000243, date of approval—12/20/2023). Consent for publication: Written...
tten informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Competing interests: The authors have no financial relationships or conflict of interest relevant to this article to disclose.
Triglyceride-glucose index in predicting the risk of new-onset diabetes in the general population aged 45 years and older
Triglyceride-glucose index in predicting the risk of new-onset diabetes in the general population aged 45 years and older
Fuente:Bmc Endocrine Disorders
Tipo de trabajo:Estudio de cohortes
Extracto:
TyG
index can be used as a risk factor for predicting new-onset diabetes in the
middle-aged and elderly population in China. In addition, there was a nonlinear
relationship between TyG index and diabetes. Improving insulin resistance by
regulating glucose and lipid metabolism plays an important role in the primary
prevention of diabetes.
Claves:Aged 45years and older, CHARLS database, Chort study, New-onset diabetes, Triglyceride-glucose index
Cita:BMC Endocr Disord 2025 Jan 26; 25 (1) : 25.
Autor/es:Shan, Yingqi (a) Liu, Qingyang (b)
institución:(a) Graduate School of Liaoning, University of Traditional Chinese Medicine, Shenyang, Liaoning, 110033, China. (b) Department of Endocrinology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110033, China. qingyang-tcm@163.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between neutrophil-to-lymphocyte ratio and left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus.
Association between neutrophil-to-lymphocyte ratio and left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus.
Fuente:Frontiers in Endocrinology
Extracto:
Our findings suggest that the NLR
is a potential indicator for assisting clinicians in identifying LVDD in patients
with T2DM. Patients with elevated NLR levels may be at a greater risk of
developing LVDD than those with lower NLR levels, which may require attention and
interventions to prevent patients from progressing into heart failure.
Claves:heart failure, inflammatory biomarkers, left ventricular diastolic dysfunction, neutrophil-to-lymphocyte ratio, type 2 diabetes mellitus
institución:(a) Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. (b) Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
