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Autor/es:Almeida, Osvaldo P (a) Hankey, Graeme J (b)
institución:(a) Medical School, University of Western Australia, Perth, Australia; WA Centre for Health & Ageing, University of Western Australia, Perth, Australia. Electronic address: osvaldo.almeida@uwa.edu.au. (b) Medical School, University of Western Australia, Perth, Australia; Department of Neurology, Sir Charles Gairdner Hospital, Perth, Australia.
Trends in Alzheimer's-Related Mortality Among Type 2 Diabetes Patients in the United States: 1999-2019.
Trends in Alzheimer's-Related Mortality Among Type 2 Diabetes Patients in the United States: 1999-2019.
Fuente:Endocrinology, Diabetes & Metabolism
Extracto:
This study reveals a
significant rise in T2DM-AD comorbidity-related mortality among older adults,
especially among Hispanics, women and rural residents. These findings underscore
the need for targeted interventions to reduce the burden in vulnerable
populations.
Claves:Alzheimer's disease, health disparities, mortality, trends, type 2 diabetes mellitus
institución:(a) Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan. (b) Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Reappraising prediction of surgical complexity of non-functioning pituitary adenomas after transsphenoidal surgery: the modified TRANSSPHER grade.
Reappraising prediction of surgical complexity of non-functioning pituitary adenomas after transsphenoidal surgery: the modified TRANSSPHER grade.
Fuente:Pituitary
Extracto:
This international multi-center study used validated
ML algorithms to refine predictors of surgical complexity in NFPAs, yielding the
m-TRANSSPHER grade, which demonstrated enhanced prognostic accuracy for surgical
complexity prediction compared to existing scales.
institución:(a) Unit of Neurosurgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. (b) Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Cannabidiol-Induced Autophagy Ameliorates Tau Protein Clearance.
Cannabidiol-Induced Autophagy Ameliorates Tau Protein Clearance.
Fuente:Neurotoxicity Research
Extracto:
Hence, this study may contribute to a better understanding
of how cannabinoids can modulate autophagy and present a potential therapeutic
target in a neurodegeneration model.
Claves:Autophagy, CBD, Neuroprotection, Tau protein
Cita:Neurotox Res 2025 Feb 4; 43 (1) : 8.
Autor/es:Vrechi, Talita A M (a) Guarache, Gabriel C (b)
institución:(a) Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Três de Maio, 100, São Paulo, SP, CEP: 04044-020, Brazil. (b) Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Três de Maio, 100, São Paulo, SP, CEP: 04044-020, Brazil.
Conflicto:Declarations. Competing Interests: J.A.C. reported receiving grants from the National Institute of Translational Science and Technology in Medicine and personal fees from the National Council for Scientific and Technological Development (CNPq 1 A) during the conduct of the study, being a co-owner of a patent for fluorinated cannabidiol compounds (licensed to Phytecs) and having a patent pending for a cannabinoid-containing oral...
l pharmaceutical composition outside the submitted work. J.A.C. is a consultant and/or has received speaker fees and/or sits on the advisory board and/or receives research funding from Janssen-Cilag, EaseLabs Pharm, DSM-Pharm, Torrent, GreenCare, PurMed Global, BioSynthesis Pharma Group (BSPG), and Prati-Donaduzzi. J.A.C. reported receiving grants from FAPESP.
Exploring proteomic immunoprofiles: common neurological and immunological pathways in multiple sclerosis and type 1 diabetes mellitus.
Exploring proteomic immunoprofiles: common neurological and immunological pathways in multiple sclerosis and type 1 diabetes mellitus.
Fuente:Molecular Medicine (cambridge, Mass.)
Extracto:
Compared
with H, patients with T1DM and MS presented a specific expression pattern of
common proteins has been identified. This pattern underscores the shared
mechanisms involved in their immune responses and neurological complications,
alongside dysregulation of the autophagy pathway. Notably, CSTB has emerged as a
differential biomarker, distinguishing between these two autoimmune diseases.
institución:(a) Diabetes Mellitus Laboratory, Institute of Research and Biomedical Innovation of Cadiz (INiBICA), Cádiz, Spain. (b) Psychology Department, Institute of Research and Biomedical Innovation of Cadiz (INiBICA), University of Cadiz, Cádiz, Spain.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Predictors of biochemical and structural response to medical therapy in patients with active acromegaly following surgery: a real-world perspective.
Predictors of biochemical and structural response to medical therapy in patients with active acromegaly following surgery: a real-world perspective.
Fuente:Bmc Endocrine Disorders
Tipo de trabajo:Estudio de cohortes
Extracto:
Post-operative IGF-1,
Knosp grading, and T2-hypointensity could be considered for an individualized
treatment plan in acromegaly. Accordingly, we propose an individual
multidisciplinary treatment approach for patients not achieving remission after
surgery.
institución:(a) Endocrine Research Center, Institute of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. (b) Department of Radiology, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Nonlinear associations of the hs-CRP/HDL-C index with metabolic dysfunction-associated steatotic liver disease and advanced liver fibrosis in US adults: insights from NHANES 2017-2018.
Nonlinear associations of the hs-CRP/HDL-C index with metabolic dysfunction-associated steatotic liver disease and advanced liver fibrosis in US adults: insights from NHANES 2017-2018.
Fuente:Scientific Reports
Extracto:
MASLD and advanced liver fibrosis were
associated with hs-CRP/HDL-C index, indicating its potential utility as a
clinical marker for these conditions.
institución:(a) Department of Gastroenterology, Minzu Hospital of Guangxi Medical University, Nanning, China. (b) Department of Cardiology, The first Affiliated Hospital of Guangxi Medical University, Nanning, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association of glycemic control with Long COVID in patients with type 2 diabetes: findings from the National COVID Cohort Collaborative (N3C).
Association of glycemic control with Long COVID in patients with type 2 diabetes: findings from the National COVID Cohort Collaborative (N3C).
Fuente:Bmj Open Diabetes Research & Care
Tipo de trabajo:Estudio de cohortes
Extracto:
Poor glycemic control (HbA1c≥8%) in people with T2D
was associated with higher risk of Long COVID symptoms 30-180 days following
COVID-19. Notably, this risk increased as HbA1c levels rose. However, this
association was not observed in patients with T2D without a history of COVID-19.
An NLP-based definition of Long COVID identified more patients than diagnosis
codes and should be considered in future studies.
Claves:COVID-19, Database, Diabetes Complications, Diabetes Mellitus, Type 2
Cita:BMJ Open Diabetes Res Care 2025 Feb 4; 13 (1)
Autor/es:Soff, Samuel (a) Yoo, Yun Jae (b)
institución:(a) Stony Brook University Renaissance School of Medicine, Stony Brook, New York, USA. (b) Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia, USA.
Conflicto:Competing interests: TS receives funding and support from the Center for Pharmacoepidemiology (current members: GlaxoSmithKline, UCB BioSciences, Takeda, AbbVie, Boehringer Ingelheim, Astellas, and Sarepta) and owns stock in Novartis, Roche, and Novo Nordisk. JEBR has affiliations with or receives funding from Springer Nature Switzerland-Exercise Book, Medtronic Diabetes, and AstraZeneca.
Medical management pathways for Cushing's disease in pituitary tumors centers of excellence (PTCOEs).
Medical management pathways for Cushing's disease in pituitary tumors centers of excellence (PTCOEs).
Fuente:Pituitary
Tipo de trabajo:Consenso
Extracto:
Adrenal steroidogenesis inhibitors were the most commonly used
medications amongst the centers. Despite the use of combination therapy, up to
25% of patients did not achieve disease control even in PTCOEs, highlighting the
need for either more efficient combination therapies or novel therapeutic
options.
institución:(a) Institute of Endocrine and Metabolic Sciences, San Raffaele Vita-Salute University and San Raffaele IRCCS Hospital, Via Olgettina 60, Milan, 20132, Italy. giustina.andrea@hsr.it. (b) Institute of Endocrine and Metabolic Sciences, San Raffaele Vita-Salute University and San Raffaele IRCCS Hospital, Via Olgettina 60, Milan, 20132, Italy.
Conflicto:Declarations. Competing interests: A. Giustina is the editor-in-chief in Pituitary.
Application of a methodological framework for the development and multicenter validation of reliable artificial intelligence in embryo evaluation.
Application of a methodological framework for the development and multicenter validation of reliable artificial intelligence in embryo evaluation.
Fuente:Reproductive Biology and Endocrinology Rb&e
Extracto:
Strong AI performance across multiple datasets demonstrates the
value of our four-step methodology in developing and validating the AI as a
reliable adjunct to embryo evaluation.
Claves:Artificial intelligence, Embryo ranking, Machine learning, Time lapse imaging
Cita:Reprod Biol Endocrinol 2025 Jan 31; 23 (1) : 16.
Conflicto:Declarations. Ethics approval and consent to participate: All collected data were de-identified and retrospectively collected prior to data analysis. Agreement to share data was authorized in the Software Licensing Agreement between each participating clinic and AIVF. IRB Study approval was obtained from the local independent review boards of IVI Valencia (Spain) (ID number 1902-VLC-018-MM), Assuta Ramat Hachayal (Israel) (ID number...
ASMC 68 − 18), Embryolab (Greece) (ID number 05/2019) and Clevelend Clinic (USA) (ID number 20–766). In Portugal, Ireland, Germany, Korea, and the Czech Republic, the study was deemed negligible risk authorized under the terms of the signed licensing agreement. Consent to participate was not applicable. Consent for publication: Not applicable. Competing interests: D.G., M.S., Y.T., Y.A., and N.L. are paid employees of AIVF. D.G. and D.S.S. have stock and share ownership of AIVF. M.M. is a member of the AIVF scientific advisory board team. C.L.C. is on the editorial board for the Journal of Assisted Reproduction and Genetics.
Life With Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency: Challenges and Burdens.
Life With Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency: Challenges and Burdens.
Fuente:The Journal of Clinical Endocrinology and Metabolism
Extracto:
With access to knowledgeable healthcare providers, sufficient
resources, and psychosocial support, "children with CAH can thrive and live
normal lives." The future challenge is securing mechanisms to decrease the
financial, sociocultural, and health access barriers in other communities
throughout the world.
Claves:adrenal insufficiency, congenital adrenal hyperplasia, quality of life, school, transition
institución:(a) Division of Pediatric Endocrinology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. (b) Medical Student, Edward Via College of Osteopathic Medicine, Blacksburg, VA 24060, USA.
Future Directions in the Management of Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.
Future Directions in the Management of Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.
Fuente:The Journal of Clinical Endocrinology and Metabolism
Tipo de trabajo:Revisión
Extracto:
Circadian delivery of
hydrocortisone improves disease management of 21OHD compared to conventional
glucocorticoids. Glucocorticoid-sparing therapies such as crinecerfont and
atumelnant offer the potential for a block-and-replace strategy, with physiologic
replacement dosing of hydrocortisone. CLINICAL TRIAL REGISTRATION: None.
Claves:11-ketotestosterone, 21-hydroxylase deficiency, congenital adrenal hyperplasia, crinecerfont, drug therapy, hydrocortisone
Autor/es:Sarafoglou, Kyriakie (a) Auchus, Richard J (b)
institución:(a) Departments of Pediatrics, Divisions of Pediatric Endocrinology and Genetics & Metabolism, University of Minnesota Medical School, Minneapolis, MN 55454, USA. (b) Department of Experimental and Clinical Pharmacology, University of Minnesota School of Pharmacy, Minneapolis, MN 55455, USA.
Clinical Manifestations and Challenges in Adolescent and Adult Females With Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.
Clinical Manifestations and Challenges in Adolescent and Adult Females With Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.
Fuente:The Journal of Clinical Endocrinology and Metabolism
Extracto:
In this review, we discuss the challenges
faced by adolescent and adult females with CAH and provide guidance to
health-care professionals to help patients to navigate these challenges.
Autor/es:Engberg, Hedvig (a) Nordenström, Anna (b)
institución:(a) Department of Women's and Children's Health, Karolinska Institutet, SE-171 76 Stockholm, Sweden. (b) Department of Gynecology and Reproductive Medicine, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
Autor/es:Claahsen-van der Grinten, Hedi L (a) Adriaansen, Bas P H (b)
institución:(a) Department of Pediatrics, Division of Pediatric Endocrinology, Amalia Children's Hospital, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands. (b) Department of Pediatrics, Division of Pediatric Endocrinology, Amalia Children's Hospital, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands.
institución:(a) Division of Pediatric Endocrinology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390, USA. (b) Division of Pediatric Endocrinology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Study protocol of the PRINCESS trial-PReoperative INtermittent fasting versus CarbohydratE loading to reduce inSulin resiStance versus standard of care in orthopaedic patients
Study protocol of the PRINCESS trial-PReoperative INtermittent fasting versus CarbohydratE loading to reduce inSulin resiStance versus standard of care in orthopaedic patients
Fuente:Bmj Open
Tipo de trabajo:Estudio aleatorizado y controlado
Extracto:
TRIAL REGISTRATION NUMBER: NCT05760339.
Claves:Anaesthesia in orthopaedics, General endocrinology, NUTRITION & DIETETICS, Nutritional support, ORTHOPAEDIC & TRAUMA SURGERY
Cita:BMJ Open 2025 Jan 21; 15 (1) : e087260.
Autor/es:Stobbe, Ayla Y (a) de Klerk, Eline S (b)
institución:(a) Department of Anaesthesiology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands. (b) Department of Endocrinology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Trends in certifications of overall vision impairment and that due to diabetic retinopathy/maculopathy in England and Wales, 2009/2010 to 2019/2020: a retrospective database analysis.
Trends in certifications of overall vision impairment and that due to diabetic retinopathy/maculopathy in England and Wales, 2009/2010 to 2019/2020: a retrospective database analysis.
Fuente:Bmj Open
Extracto:
The findings
underscore the importance of understanding regional variations in certification
rates, particularly in the context of diabetic retinopathy. Despite fluctuations
in Wales, the overall reduction in certifications due to diabetic retinopathy in
both regions suggests a critical need for ongoing public health initiatives aimed
at preventing vision impairment linked to diabetes. However, to provide a true
reflection of the burden of vision impairment and its various causes, ensuring
that all eligible people are certified is a prerequisite. Continuing attempts to
limit the incidence of vision impairment due to diabetic retinopathy remain a
priority.
institución:(a) Diabetes Resaerch Unit, Cymru, Swansea University, Swansea, UK r.l.thomas@swansea.ac.uk. (b) NHS Wales Shared Services Partnership, Cardiff, UK.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Relationship between the latent profiles of health information-seeking behaviour and glycated haemoglobin levels in patients with type 2 diabetes: a cross-sectional survey in rural areas of China.
Relationship between the latent profiles of health information-seeking behaviour and glycated haemoglobin levels in patients with type 2 diabetes: a cross-sectional survey in rural areas of China.
Fuente:Bmj Open
Extracto:
Patients with
T2D in rural areas had poor glycaemic control and inadequate HISB. Three latent
profile categories were identified that reflect the HISB of this group. We
recommend that clinical medical professionals develop personalised health
management education based on the various latent profile characteristics of
patients to promote HISB and thereby achieve optimal glycaemic control.
institución:(a) Department of Geriatric Endocrinology and Metabolism, Guangxi Academy of Medical Sciences and the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. (b) Department of Geriatric Endocrinology and Metabolism, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Dapagliflozin plus calorie restriction for remission of type 2 diabetes
Dapagliflozin plus calorie restriction for remission of type 2 diabetes
Fuente:Bmj (clinical Research Ed.)
Tipo de trabajo:Estudio multicéntrico
Extracto:
The regimen of dapagliflozin
plus regular calorie restriction achieved a much higher rate of remission of
diabetes compared with calorie restriction alone in overweight or obese patients
with type 2 diabetes. TRIAL REGISTRATION: ClinicalTrials.gov NCT04004793.
Cita:BMJ 2025 Jan 22; 388 : e081820.
Autor/es:Liu, Yuejun (a) Chen, Ying (b)
institución:(a) Ministry of Education Key Laboratory of Metabolism and Molecular Medicine, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China. (b) Ministry of Education Key Laboratory of Metabolism and Molecular Medicine, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
Conflicto:Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/disclosure-of-interest and declare: support from National Nature Science Foundation of China, National Nature Science Foundation of China for Distinguished Young Scholars, and AstraZeneca for the submitted work; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years; no...
other relationships or activities that could appear to have influenced the submitted work.
institución:(a) WIL@NUS Corporate Laboratory, National University of Singapore, Centre for Translational Medicine, Singapore, Singapore. (b) Clinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science Technology and Research (A*STAR), Singapore, Singapore.
Conflicto:Competing interests: X.W., K.J.L., V.S.B.V., K.K., X.L., L.H.W., C.P.L.Y. and H.F. are employees of Wilmar International Limited. The remaining authors declare no competing interests. Inclusion & ethics: This study aligns by the guidelines of Nature Portfolio journals, with contributions of each author as disclosed in Author contributions.
