CLINICAL CHARACTERISTICS IDENTIFYING BRAIN ATROPHY IN OLDER PATIENTS WITH BIPOLAR DISORDER
Clinical characteristics that may identify bipolar patients at high risk for developing brain atrophy in late life remain undiscovered. Forty-four bipolar I patients aged beyond 60 years were recruited in this study. Thirty-three of them had brain atrophy on structural magnetic resonance imaging at 1.5 T. The positive history of rapid cycling and lower hemoglobin levels during affective episodes provided the greatest predictive validity for brain atrophy.

Pao-huan Chen
Taipei, Tw

  

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EVALUATION OF IMPACT OF A CLINICAL PHARMACIST DRIVEN ANTICOAGULATION MANAGEMENT SERVICE
This study shows that the knowledge of patients regarding oral anticoagulation therapy was insufficient before the clinical pharmacist's involvement. Improved patient knowledge helped in avoiding potential food interactions and also helped in timely monitoring of INRs and lead to the achievement of target INR levels. Involvement of a clinical pharmacist can identify potential drug interactions and hence reduce adverse effects. Thus a clinical pharmacist driven anticoagulation service may empower patients to achieve better therapeutic outcome with improved safety. Improved patient knowledge helped in avoiding potential food interactions and timely monitoring of INRs and lead to the achievement of target INR levels. Involvement of a clinical pharmacist can identify potential drug interactions and hence reduce ADRs. Thus a clinical pharmacist driven anticoagulation service may empower patients to achieve better therapeutic outcome.

Lakshmi R
Kochi, In

  

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  PLATELET AGGREGATION IN BETA-THALASSEMIA PATIENTS
Cure of beta-thalassemia is quite expensive and available to minority of patients. In this regard, data about decreased platelet aggregation in majority of subjects is helpful for development in the field of prevention of complications of beta thalassemia, especially when beta-thalassemia is not uncommon in Pakistan.

Hammad Tufail Chaudhary
Taif, Sa

  

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  ERADICATION THERAPY IS EFFECTIVE FOR HELICOBACTER PYLORI-NEGATIVE GASTRIC MALTOMAS
Our analysis suggested that H. pylori eradication therapy is an effective first-line therapy for H. pylori-negative gastric MALT lymphoma patients and that patients with a single lesion are more likely to respond to this therapy.

Naoki Asano
Sendai, Jp

  

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  TRATAMIENTO DE LAS EXTRAVASACIONES POR ANTRACILINAS CON DEXRAZOXANO
En la actualidad, el único fármaco autorizado para tratar las extravasaciones por antraciclinas es el dexrazoxano. A pesar de ello, otras aproximaciones terapéuticas están disponibles y han demostrado su eficacia como es el caso del dimetilsulfóxido (DMSO) al 90-99%. Se plantea una revisión crítica y aséptica de la evidencia publicada de ambos y la situación actual. La conclusión a la que llegamos es que con la evidencia actual no podemos recomendar inequívocamente una alternativa o otra. Debería realizarse un estudio comparativo entre ambas aproximaciones terapéuticas a fin de poder determinar el mejor manejo en el caso de extravasaciones por antraciclinas.

David Conde-estévez
Barcelona, España

     

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