ALTERED SUBCELLULAR DISTRIBUTION OF DISC1, CAMP LEVELS, AND NEURONAL MIGRATION IN SCHIZOPHRENIA AND BIPOLAR DISORDER
DISC1 (disrupted-in-schizophrenia-1) is considered a genetic risk factor for neuropsychiatric disorders. In this study, analysis in human olfactory neuronal precursors of schizophrenia and bipolar disorder patients showed decreased DISC1 levels in the cytoplasm, cAMP accumulation and diminished cell migration. The results suggest that these disorders share common molecular pathways that could hinder the neurodevelopmental process.

Jesús Muñoz-Estrada
México, México

     

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  ADESÃO AO TRATAMENTO DA HIPERTENSÃO ARTERIAL: A IMPORTÂNCIA DA ESCOLHA DE UM FÁRMACO BEM TOLERADO
Por ser um composto altamente lipofílico, o lercanidipino age por 24 horas e promove relaxamento prolongado da musculatura lisa vascular, de início lento, o que não provoca taquicardia reflexa nem outros efeitos secundários à ativação simpática. Seu mecanismo de ação resulta em vasodilatação periférica e coronariana, mantendo reduzida a pressão arterial.

Andréa Brandao
Rio de Janeiro, Brasil

     

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HYPOTHYROIDISM IN CLINICAL PRACTICE . CASES HOW TO APPROACH TO PATIENTS IN CLINIC
Hypothyroidism is the most common endocrine disease that was seen in the clinical practice especially for family physicians. Methods: This review article covered the important practical clinical issues for managing overt hypothyroidism, subclinical hypothyroidism and hypothyroidism during pregnancy. Conclusions: The clinical issues were addressed by clinical scenario followed by questions and stressed on the important clinical points

Faiza Qari
Jeddah, Sa

  

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VARIABILIDAD DE LA RESPUESTA PLAQUETARIA A LA ASPIRINA
La respuesta a la aspirina demostró una notoria variabilidad interevaluación, interindividual y temporal. Las evaluaciones repetidas que utilizan distintos ensayos son necesarias para diagnosticar de manera fiable la resistencia a la aspirina.

Sara Fairley
Wellington, Nueva Zelanda

           

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JUNIOR DOCTORS AND PRESCRIPTION WRITING ERRORS
To reduce the danger of prescribing errors, it is necessary to address such factors as training of junior doctors, enforcing good prescription writing practice, supervision and reviewing the workload of junior doctors.

Adetutu Ajemigbitse
Abuja, Ng

  

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