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Jesús Muñoz-Estrada describes for SIIC the most significant aspects of his article describe para SIIC los aspectos relevantes de su artículo ALTERED SUBCELLULAR DISTRIBUTION OF DISC1, CAMP LEVELS, AND NEURONAL MIGRATION IN SCHIZOPHRENIA AND BIPOLAR DISORDER DISC1 (disrupted-in-schizophrenia-1) is considered a genetic risk factor for neuropsychiatric disorders. In this study, analysis in human olfactory neuronal precursors of schizophrenia and bipolar disorder patients showed decreased DISC1 levels in the cytoplasm, cAMP accumulation and diminished cell migration. The results suggest that these disorders share common molecular pathways that could hinder the neurodevelopmental process. The article was published by El artículo fue publicado por
Principal institution where the research took place Institución principal de la investigación CENTRO DE INVETIGACION Y DE ESTUDIOS AVANZADOS DEL INSTITUTO POLITECNICO NACIONAL, Mexico, Ciudad de México, D.F., Mexico  Authors' Report Crónica del Autor Distribución Subcelular Anormal de DISC1, Niveles de AMPc y Migración Neuronal en la Esquizofrenia y el Trastorno Bipolar El gen DISC1 (disrupted-in-schizophrenia-1) se considera un factor de riesgo de los trastornos neuropsiquiátricos. En este estudio, el análisis de los precursores neuronales olfatorios de pacientes con esquizofrenia y trastorno bipolar reveló niveles reducidos de DISC1 en el citoplasma, acumulación de AMPc y reducción de la migración celular. Los hallazgos sugieren que estas enfermedades comparten mecanismos moleculares que podrían comprometer el proceso del neurodesarrollo. Crónica del Autor Imprimir nota Referencias bibliográficas Green MF. 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Information about the full text Acerca del trabajo completo Altered Subcellular Distribution of the 75-kDa DISC1 Isoform, cAMP Accumulation, and Decreased Neuronal Migration in Schizophrenia and Bipolar Disorder: Implications for Neurodevelopment Author / Autor Jesus Munoz-Estrada1, Gloria Benitez-King2, Isaura Meza3 3 Phd Access to the original source CNS Neuroscience & Therapeutics siic DB: / siic DB: http://www.siicsalud.com/main/distriprinrel.php |
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