EFEITO TROFICO DO EXTRATO DE SOJA SOBRE O UTERO DE RATAS CASTRADAS
O uso isolado de extrato de soja tem efeito trofico sobre o utero (endometrio e miometrio) de ratas castradas, semelhante aos estrogenos conjugados. O uso associado com estrogenos conjugados tem ligeiro efeito antagonista em miometrio, porem sem efeito adicional no endometrio.

Antonio Marcos Coldibelli Francisco
Winston-salem, Nc, Ee.uu.

     

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QUALITY CONTROL AT THE ENDOPLASMIC RETICULUM TRANSLOCON
The essential Sec61 translocon brings proteins into and across the endoplasmic reticulum membrane. Little was known about how proteins blocking this channel are removed. New data reveal that the Hrd1 ubiquitin ligase degrades proteins that persistently and abnormally engage Sec61. This quality control pathway may also regulate low-density lipoprotein particle synthesis.

Eric Rubenstein
New Haven, US

  

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ÍNDICE DE MASA CORPORAL MATERNO, VÍA DE RESOLUCIÓN DEL EMBARAZO Y RESULTADOS PERINATALES
La obesidad durante el embarazo es un factor que influye en la mayor frecuencia de operación cesárea, distocia del hombro, infección, hipertensión crónica, preeclampsia, diabetes mellitus, durante y después del embarazo. La obesidad se asocia además con mayor riesgo de macrosomía fetal.

Fred Morgan Ortiz
Culiacán, México

           

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CONCENTRATION OF SEMINAL PLASMA ZINC IN VARIOUS CLASSES OF INFERTILE MALE
The present study was designed to analyze the level of seminal zinc among different groups of infertile males and to correlate it with sperm concentration, active, sluggish and immotile fractions of seminal parameters, with an objective being to establish the role of zinc. This descriptive analytical study was carried out in the Department of Reproductive Physiology/Health, Public Health Laboratories Division, National Institute of Health, Islamabad in a 5 years period from 2002 to 2006. The result showed that seminal zinc was 702.92 ± 10.60, 598.48 ± 12.95, 617.54 ± 9.55, 542.29 ± 22.75, 710.36 ± 7.87, 712.06 ± 7.96, 789.36 ± 21.33 and 762.06 ± 8.99 in azoospermic, oligozoospermic, asthenozoospermic, oligoasthenozoospermic, teratozoospermic, normozoospermic, polyzoospermic and proven fathers group, respectively. Findings of the study showed that semen zinc was several folds higher in polyzoospermic subjects as compared to other groups, while it was found to be lower in oligozoospermic, azoospermic and oligoasthenozoospermic groups. In case of proven fathers, the levels of semen zinc varied non significantly (p > 0.05) with polyzoospermic cases. It is concluded from the results of the study that decreased concentration of seminal plasma zinc affect sperm count while increased level causes decreased sperm motility.

Muhammad Shoaib Khan
Bannu, Pk

  

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HISTOPATHOLOGY OF TYPE 1 DIABETES: EMERGING PARADIGMS
The immunopathology of type 1 diabetes in the pancreas is still poorly understood. Our observations provide the first direct proof for islet autoreactivity within human islets and underscore the heterogeneous and chronic disease course.

Ken Coppieters
Ghent, BE

     

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