Expertos Invitados





PESQUISA DE NEOPLASIAS ESOFAGICAS SECUNDARIAS EN LOS PACIENTES CON CANCER DE CABEZA Y CUELLO

(especial para SIIC © Derechos reservados)
El riesgo de neoplasia esofágica es alto en los pacientes con cáncer previo de cabeza y cuello (7.4%) en nuestra serie. Es recomendable la observación cuidadosa de este grupo de alto riesgo.
hans9.jpg Autor:
Hans Scherübl
Columnista Experto de SIIC

Institución:
Charité-Universitätsmedizin Berlin Campus Benjamin Franklin Berlin, Germany

Artículos publicados por Hans Scherübl
Recepción del artículo
4 de Agosto, 2004 		Primera edición
19 de Mayo, 2005 		Segunda edición, ampliada y corregida
7 de Junio, 2021

PESQUISA DE NEOPLASIAS ESOFAGICAS SECUNDARIAS EN LOS PACIENTES CON CANCER DE CABEZA Y CUELLO

Resumen
Estudios clínicos prospectivos realizados en Brasil y Japón muestran que 5% a 14% de los pacientes que presentan cáncer de cabeza y cuello (CCC), también evolucionan hacia cáncer esofágico de células escamosas (CECE) invasivo. De manera similar, el riesgo de CECE podría ser tan alto como 3.3% a 8.2% en las personas con antecedentes de consumo intenso de alcohol y tabaco. A pesar de los beneficios en cuanto a la supervivencia obtenidos mediante la pesquisa y el tratamiento precoz del CECE, la vigilancia cuidadosa de los grupos de alto riesgo no está actualmente recomendada en los países occidentales. Para definir el riesgo de CECE en los pacientes con CCC en Berlín, investigamos prospectivamente mediante videoesofagoscopia y biopsias esofágicas tomadas al azar 148 pacientes portadores de CCC para detectar cánceres esofágicos secundarios. Se tomaron 4 muestras para biopsia cada 3 cm, a lo largo de todo el esófago, aun en las regiones de aspecto normal. Además, se tomó muestra para biopsia de toda lesión evidente. Se detectó histológicamente displasia de células escamosas (neoplasia intraepitelial) de grado bajo o alto en 10 de los 148 pacientes (6.8%). Todas las displasias, excepto una, se diagnosticaron sincrónicamente con cáncer de cabeza y cuello. Además, se diagnosticó carcinoma esofágico de células epiteliales en 11 de los 148 pacientes (7.4%). La mayoría de estos cánceres invasivos (63.6%) fueron metacrónicos. Obviamente, el riesgo de neoplasia de células escamosas en el esófago es alto en los pacientes con un cáncer (previo) de cabeza y cuello. Es recomendable la vigilancia cuidadosa en este grupo de alto riesgo. Más aun, en vista del reconocido “riesgo de malignización de campo”, en el futuro debería preconizarse una efectiva prevención mediante quimioterapia.

Palabras clave
Cáncer de cabeza y cuello, cáncer esofágico de células escamosas, videoesofagoscopia


Artículo completo
(castellano)
Extensión:  +/-8.82 páginas impresas en papel A4
Exclusivo para suscriptores/assinantes

SCREENING FOR SECOND ESOPHAGEAL NEOPLASIAS IN PATIENTS WITH HEAD AND NECK CANCER

Abstract
Prospective clinical studies in Brasil and Japan have shown that 5-14% of patients suffering from head and neck cancer (HNC) also develop esophageal squamous cell cancer (ESCC). Similarly, the risk for ESCC may be as high as 3.3% to 8.2% in persons with (previous) heavy alcohol and tobacco consumption. Despite the survival benefit achieved by screening for and treating early ESCC, surveillance of high-risk groups is currently not recommended in Western countries. To define the ESCC risk in HNC patients in Berlin, we prospectively screened 148 HNC patients for second esophageal cancers by videoesophagoscopy and random esophageal biopsies. 4 biopsy specimens were taken every 3 cm throughout the entire length even of normal looking esophagi. In addition, any lesion was biopsied. Low- or high-grade squamous cell dysplasia (= intraepithelial neoplasia) was detected histologically in 10 of the 148 patients (6.8%). All but one dysplasias were diagnosed synchronously with the head and neck cancer. In addition, esophageal squamous cell carcinoma was diagnosed in 11 of the 148 patients (7.4%). The majority of invasive cancers (63.6%) occurred metachronously. Thus, the risk of squamous cell neoplasia of the esophagus is high in patients with (previous) head and neck cancer. Surveillance is recommended in this high-risk group. Moreover, in light of the well known “field-cancerization-risk” effective chemoprevention should be aimed for in the future.

Key words
Chemoprevention, human papilloma virus, field cancerization, squamous cell neoplasm


Full text
(english)
 para suscriptores/ assinantes
Clasificación en siicsalud
Artículos originales > Expertos del Mundo >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Oncología
Relacionadas: Anatomía Patológica, Cirugía, Diagnóstico por Imágenes



Comprar este artículo
Extensión: 8.82 páginas impresas en papel A4

file05.gif (1491 bytes) Artículos seleccionados para su compra



Enviar correspondencia a:
Schrübl, Hans
Bibliografía del artículo
  1. Cooper J, Pajak T, Rubin P, Tupchong L, Brady L, Leibel S, Laramore G, Marcial V, Davis L, Cox J (1989) Second malignancies in patients who have head and neck cancer: Incidence, effect on survival and implications based on the RTOG experience. Int J Radiation Oncology Biol Phys 17:449-456.
  2. Leon X, Quer M, Diez S, Orus C, Lopez-Pousa A, Burgues J. (1999) Second neoplasm in patients with head and neck cancer. Head Neck 21:204-210.
  3. Makuuchi H, Machimura T, Shimada H, Mizutani K, Chino O, Kise Y, Nishi T, Tanaka H, Mitomi T, Horiuchi M, Sakai M, Gotoh J, Sasaki J, Osamura Y (1996) Endoscopic screening for oesophageal cancer in 788 patients with head and neck cancers. Tokai Exp Clin Med 21:139-145.
  4. Agrawal A, Wenig B (1998) Screening for simultaneous oesophageal primary tumors. Esophagoscopy vs esophagography. Arch Otolaryngol Head Neck Surg 124:930-932.
  5. Horiuchi M, Makuuchi H, Machimura T, Tamura Y, Sakai M (1998) Survival benefit of screening for early oesophageal carcinoma in head and neck cancer patients. Dig Endosc 10:110-115.
  6. Mandard AM, Hainaut P, Hollstein M (2000) Genetic steps in the development of squamous cell carcinoma of the oesophagus. Mutation Research 462:335-342.
  7. Sturgis E, Miller R (1995) Second primary malignancies in the head and neck cancer patient. Ann Rhinol Otol Laryngol 104:946-954.
  8. Shiozaki H, Tahara H, Kobayashi K, Yano H, Tamura S, Imamoto H, Yano T, Oku K, Miyata M, Nishiyama K (1990) Endoscopic screening of early oesophageal cancer with the Lugol dye method in patients with head and neck cancers. Cancer 66:2068-2071.
  9. Tincani A, Brandalise N, Altemani A, Scanavini R, Valerio J, Lage H, Molina G, Martins A (2000) Diagnosis of superficial oesophageal cancer and dysplasia using endoscopic screening with a 2% Lugol dye solution in patients with head and neck cancer. Head Neck 22:170-174.
  10. Deleyiannis F, Weymuller E (1998) Screening patients with head and neck cancer for oesophageal cancer. A lack of adequate data. Arch Otolaryngol Head Neck Surg 124:933.
  11. Meyer V, Burtin P, Bour B, Blanchi A, Cales P, Oberti F, Person B, Croue A, Dohn S, Benoit R, Fabiani B, Boyer J (1997) Endoscopic detection of early oesophageal cancer in a high-risk population: does Lugol staining improve videoendoscopy Gastrointest Endosc 45:480-484.
  12. Gabbert H, Shimoda T, Hainaut P, Nakamura Y, Field J, Inoue H (2000) Squamous cell carcinoma of the ooesophagus. In: Pathology and Genetics of Tumours of the Digestive System (Hamilton S & Aaltonen L, eds). WHO classification of tumours, IARC Press, Lyon.
  13. Lewin K, Appelman H (1995) Tumors of the oesophagus and stomach, pp. 43-98. In: Rosai J, Sobin L, eds: Atlas of tumor pathology. AFIP, Washington.
  14. Endo M, Takeshita K, Yoshida M (1986) How can we diagnose early stages of oesophageal cancer Endoscopic diagnosis. Endoscopy 18:11-18.
  15. Sugimachi K, Ohno S, Matsuda H, Mori M, Kuwano H (1988) Lugol-combined endoscopy detection of minute malignant lesions of the thoracic oesophagus. Ann Surg 208:179-183.
  16. Ziegler K, Sanft C, Zeitz M, Friedrich M, Stein H, Häring R, Riecken E-O (1991) Evaluation of endosonography in TN staging of oesophageal cancer. Gut 32:16-20.
  17. Wu YK, Huang GJ, Shao LF, Zhang YD, Lin XS (1982) Honored guest address: progress in the study and surgical treatment of cancer of the oesophagus in China, 1940-1980. J Thorac Cardiovasc Surg 84:30-33.
  18. Fleischer D, Haddad N (1999). Neoplasma of the oesophagus. In: Castell D, Richter J (eds). The oesophagus, pp. 235-259. Lippincott, Philadelphia.
  19. Ina H, Shibuya H, Ohashi I, Kitagawa M (1994) The frequency of a concomitant early oesophageal cancer in male patients with oral and oropharyngeal cancer. Cancer 73:2038-2041.
  20. Fagundes R, De Barros S, Putten A, Mello E, Wagner M, Bassi L, Bombassaro M, Gobbi D, Souto E (1999) Occult dysplasia is disclosed by Lugol chromoendoscopy in alcoholics at high risk for squamous cell carcinoma of the oesophagus. Endoscopy 31:325-328.
  21. Schlemper R, Riddell R, Kato Y, Borchard F, Cooper H, Dawsey S, Dixon M, Fenoglio-Preiser C, Flejou J, Geboes H, Hattori T, Hirota T, Itabashi M, Iwafuchi A, Kim Y, Kirchner T, Klimpfinger M, Koike M, Lauwers G, Lewin K, Oberhuber G, Offner F, Price A, Rubio C, Shimizu M, Shimoda T, Sipponen P, Solcia E, Stolte M, Watanabe H, Yamabe H (2000) The Vienna classification of gastrointestinal epithelial neoplasia. Gut 47:251-255.
  22. Petit T, Georges C, Jung G, Borel C, Bronner G, Flesch H, Massard G, Velten M, Haegele P, Schraub S (2001) Systematic esophageal endoscopy screening in patients previously treated for head and neck squamous-cell carcinoma. Ann Oncology 12:643-646.
  23. Muto M, Hironika S, Natanabe M, Boku N, Ohtsu A, Yoshida S (2002). Association of multiple Lugol-voiding lesions with synchronous and metachronous esophageal squamous cell carcinoma in patients with head and neck cancer. Gastrointest Endosc 56:517-521.
  24. Hashimoto C, Iriya K, Baba E, Navarro-Rodriguez T, Zerbini M, Eisig J, Barbuti R, Chinzon D, Prado J, Moraes-Filho P (2005) Lugol's dye spray chromoendoscopy establishes early diagnosis of esophageal cancer in patients with primary head and neck cancer. Am J Gastroenterol 100:275-82.
  25. Leoni-Parvex S, Mihaescu A, Pellanda A, Monnier P, Bosman F (2000) Esophageal cytology in the follow-up of patients with treated upper aerodigestive tract malignancies. Cancer (Cancer Cytopathol) 90:10-16.
  26. Haringsma J, Tytgat G, Yano H, Iishi H, Tatsuta M, Ogihara T, Watan Sato N, Marcon N, Wilson B, Cline R (2001) Autofluorescence endoscopy: feasibility of detection of GI neoplasia unapparent to white light endoscopy with an evolving technology. Gastroint Endosc 53:642-650.
  27. Georgakoudi I, Jacobson B, van Dam J, Backman V, Wallace M, Müller M, Zhang Q, Badizadegan K, Sun D, Thomas G, Perelman L, Feld M (2001) Fluorescence, reflectance, and light-scattering spectroscopy for evaluating dysplasia in patients with Barrett’s esophagus. Gastroenterology 120:1620-1629.
  28. MacAulay C, Lane P, Richards-Kortum R (2004). In vivo pathology: microendoscopy as a new endoscopic imaging modality. Gastrointest Endosc Clin N Am 14:595-620.
  29. Califano J, Leong P, Koch W, Eisenberger C, Sidransky D, Westra W (1999) Second oesophageal tumors in patients with head and neck squamous cell carcinoma: an assessment of clonal relationships. Clin Cancer Res 5:1862-1867.
  30. De Villiers EM, Gunst K, Stein H, Scherübl H (2004). Esophageal squamous cell cancer in patients with head and neck cancer: Prevalence of human papillomavirus DNA sequences. Int. J. Cancer 109:253-258.
  31. Lu X, Zhang Y, Lin R, Liang X, Zhang Y, Wang X, Zhang Y, Wang Y, Wen H (2005) p53 polymorphism in human papillomavirus-associated Kazakh's esophageal cancer in Xinjiang, China. World J Gastroenterol. 10:2775-8.
  32. Makuuchi H (1996) Endoscopic mucosal resection for early oesophageal cancer. Indications and techniques. Dig Endosc 8:175-179.
  33. Ell C, May A, Gossner L, Pech O, Günter E, Mayer G, Henrich R, Vieth M, Müller H, Seitz G, Stolte M (2000) Endoscopic mucosal resection of early cancer and high-grade dysplasia in Barrett’s oesophagus. Gastroenterology 118:670-677.
  34. Savary J, Grosjean P, Monnier P, Fontolliet C, Wagnieres G, Braichotte D, Van den Bergh H (1998) Photodynamic therapy of early squamous cell carcinomas of the esophagus: A review of 31 cases. Endoscopy 30:258-265.
  35. Shimizu Y, Tsukagoshi H, Fujita M, Hosokawa M, Watanabe A, Kawabori S, Kato M, Sugiyama T, Asaka M (2003) Head and neck cancer arising after endoscopic mucosal resection for squamous cell carcinoma of the esophagus. Endoscopy 35:322-326.
  36. Ishikura S, Nihei K, Ohtsu A, Boku N, Hironaka S, Mera K, Muto M, Ogino T, Yoshida S (2003) Long-term toxicity after definitive chemoradiotherapy for squamous cell carcinoma of the thoracic esophagus J Clin Oncol. 21:2697-702.
  37. Scherübl H, von Lampe B, Faiss S, Däubler P, Bohlmann P, Plath T, Foss HD, Scherer H, Strunz A, Hoffmeister B, Stein H, Zeitz M, Riecken E-O (2002): Screening for oesophageal neoplasia in patients with head and neck cancer. Brit J Cancer 86:239-243.
  38. Scherübl H, Sutter A, Zeitz M (2003). NSAIDs and esophageal cancer. Gastroenterology 125:1875-1876.
  39. Scherübl H, Zeitz M (2004). Esophageal cancer. N Engl J Med 350: 1363-1364.
  40. Maaser K, Däubler P, Barthel B, Heine B, von Lampe B, Stein H, Hoffmeister B, Scherer H, Scherübl H (2003) Esophageal squamous cell neoplasia in head and neck cancer patients. Upregulation of COX-2 during carcinogenesis. Brit J Cancer 88:1217-1222.
  41. Sutter A, Höpfner M, Huether A, Maaser K, Scherübl H (2005). Targeting the epidermal growth factor receptor by erlotinib for the treatment of esophageal cancer. Int J Cancer, in press.
 
 
 
 
 
 
 
 
 
 
 
 
Está expresamente prohibida la redistribución y la redifusión de todo o parte de los contenidos de la Sociedad Iberoamericana de Información Científica (SIIC) S.A. sin previo y expreso consentimiento de SIIC.
ua31618
Inicio/Home

Copyright siicsalud © 1997-2024 ISSN siicsalud: 1667-9008