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CLINICAL CHARACTERISTICS IDENTIFYING BRAIN ATROPHY IN OLDER PATIENTS WITH BIPOLAR DISORDER
Clinical characteristics that may identify bipolar patients at high risk for developing brain atrophy in late life remain undiscovered. Forty-four bipolar I patients aged beyond 60 years were recruited in this study. Thirty-three of them had brain atrophy on structural magnetic resonance imaging at 1.5 T. The positive history of rapid cycling and lower hemoglobin levels during affective episodes provided the greatest predictive validity for brain atrophy.