EFFECT OF ARIPIPRAZOLE WITH CARBAMAZEPINE AND FLUVOXAMINE ON LIVER FUNCTION
Aripiprazole given in combination with fluvoxamine, there was significant hepatotoxicity possibly due to inhibition of aripiprazole metabolizing enzyme CYP3A4. Similarly co-administration of carbamazepine, a CYP3A4 inducer may lead to significant decrease in plasma concentration of aripiprazole and potentially a loss in aripiprazole's clinical efficacy.
Chakrakodi Shastry
Mangalore, In