EFFECT OF GYMNEMA SYLVESTRE EXTRACT ON DIABETIC CARDIOMYOPATHY IN RATS
Gymnema sylvestre extract (GSE) treatment significantly reduced myocyte loss by suppressing the levels of cardiac caspase-3, DNA laddering; mean arterial blood pressure and heart rate as well as serum LDH, glucose, apolipoprotein B, and lipids levels. Further, it increased the heart weight and cardiac Na+ K+ ATPase activity in diabetic rats. The present study reports the anti-apoptotic potential of GSE in STZ-induced diabetic cardiomyopathy.
Vinay Kumar
Ghaziabad, In