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Marigold: a machine learning-based web app for zebrafish pose tracking.
Marigold: a machine learning-based web app for zebrafish pose tracking.
Fuente:Bmc Bioinformatics
Extracto:
In
both biological experiments presented here, the use of Marigold facilitated novel
behavioral findings. Marigold's ease of use, robust pose tracking, amenability to
diverse experimental paradigms, and flexibility regarding hardware requirements
make it a powerful tool for analyzing zebrafish behavior, especially in
low-resource settings such as course-based undergraduate research experiences.
Marigold is available at: https://downeslab.github.io/marigold/ .
Claves:Behavior, Machine learning, Open source, Pose tracking, Software, Web app, Zebrafish
Cita:BMC Bioinformatics 2025 Jan 28; 26 (1) : 30.
Autor/es:Teicher, Gregory (a) Riffe, R Madison (b)
institución:(a) Biology Department, University of Massachusetts Amherst, Amherst, MA, USA. gteicher@umass.edu. (b) Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, MA, USA. gteicher@umass.edu.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Heatstroke characteristics and meteorological conditions in Hefei, China: thresholds and driving factors.
Heatstroke characteristics and meteorological conditions in Hefei, China: thresholds and driving factors.
Fuente:Bmc Public Health
Extracto:
A meteorological threshold
system had been established to forecast heatstroke occurrence in a short-term
time, and a key climate driving factor of heatstroke was found for long-term
heatstroke prediction in Hefei. These findings could facilitate the disease
control department to take preventive and control measures to reduce the impact
of heatstroke on human health and society.
Association between some environmental risk factors and attention-deficit hyperactivity disorder among children in Egypt: a case-control study.
Association between some environmental risk factors and attention-deficit hyperactivity disorder among children in Egypt: a case-control study.
Fuente:Italian Journal of Pediatrics
Extracto:
ADHD is a multi-factorial disorder, where many environmental risk
factors contribute to its development. Future efforts to determine the best
preventive strategy in Egypt must be based on a better knowledge of the role of
environmental risk factors in the etiology of the disorder. Eliminating
non-essential uses of lead and providing public education regarding the
importance of safe disposal of lead-acid batteries and computers are necessary.
Influence of religion and spirituality on head and neck cancer patients and their caregivers
Influence of religion and spirituality on head and neck cancer patients and their caregivers
Fuente:Systematic Reviews
Tipo de trabajo:Revisión
Extracto:
DISCUSSION: This review will aim to explore existing
literature and summarize the findings of studies that examine the influence of
religion and spirituality among HNC patients and their caregivers and vice versa
over a range of physical, psychological, and social outcomes including quality of
life. We also aim to identify existing research gaps. The findings of this review
would generate evidence to better inform health care providers in countries and
cultures in the management of patients diagnosed with HNC in usual oncological
care with due consideration to caregivers.
Claves:Caregivers of HNC patients, Head and neck cancers, Religion, Religiosity, Spiritual well-being, Spirituality
institución:(a) Centre for Cancer Research, University of Sri Jayewardenepura, Nugegoda, Sri Lanka. (b) Department of Community Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Experiences, perceptions and ethical considerations of the malaria infection study in Thailand.
Experiences, perceptions and ethical considerations of the malaria infection study in Thailand.
Fuente:Bmc Medical Ethics
Tipo de trabajo:Estudio clínico
Extracto:
Our study revealed widespread concerns about long-term health
effects and safety. Ethical considerations, including obtaining valid informed
consent and ensuring participant inclusivitiy, were deem essential. Despite some
debate regarding eligibility criteria, most participants agreed that the informed
consent process was robust, accompanied by a strong sense of responsibility to
contribute to the greater good. We emphasize the importance of continuously
gathering participants' feedback for quality control, such as improving
information materials to clarify the purpose of initial phases, their
contributing to later phases, and the rationale behind each selection criterion.
TRIAL REGISTRATION: This manuscript is part of the clinical trials registered
under ClinicalTrials.gov IDs NCT04083508 (MIST1) registered on 5 Sep 2019 and
NCT05071079 (MIST2) registered on 28 July 2021. However, the manuscript pertains
to a qualitative study that does not require trial registration.
Claves:Bioethics, Controlled human infection model (CHIM), Malaria, Social Science, Thailand
E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration.
E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration.
Fuente:Journal of Experimental & Clinical Cancer Research Cr
Extracto:
Taken together, our results
support the hypothesis that the CNF1 toxin from E. coli plays an active role in
colorectal carcinogenesis. Altogether, these findings not only add new knowledge
to the contribution of bacterial toxins to CRC, but also pave the way to the
implementation of current screening programs and preventive strategies.
Cita:J Exp Clin Cancer Res 2025 Jan 29; 44 (1) : 29.
Autor/es:Tozzi, Michela (a) Fiore, Alessia (b)
institución:(a) Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy. (b) Department of Cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Exploring the Credibility of Large Language Models for Mental Health Support
Exploring the Credibility of Large Language Models for Mental Health Support
Fuente:Jmir Research Protocols
Tipo de trabajo:Revisión
Extracto:
This scoping review will map the current evidence on the
credibility of LLMs in mental health support. It will identify factors
influencing the reliability, explainability, and ethical considerations of these
models, providing insights for practitioners, researchers, policy makers, and
users. These findings will fill a critical gap in the literature and inform
future research, practice, and policy development, ensuring the responsible
integration of LLMs in mental health services. INTERNATIONAL REGISTERED REPORT
IDENTIFIER (IRRID): DERR1-10.2196/62865.
Claves:LLM, credibility, explainability, large language model, mental health, mobile phone
Cita:JMIR Res Protoc 2025 Jan 29; 14 : e62865.
Autor/es:Gautam, Dipak (a) Kellmeyer, Philipp (b)
institución:(a) School of Business Informatics and Mathematics, University of Manneim, Mannheim, Germany. (b) Data and Web Science Group, School of Business Informatics and Mathematics, University of Manneim, Mannheim, Germany.
Scaling Up Kangaroo Mother Care Through a Facility Delivery Model in Rural Districts of Pakistan: Protocol for a Mixed Methods Study.
Scaling Up Kangaroo Mother Care Through a Facility Delivery Model in Rural Districts of Pakistan: Protocol for a Mixed Methods Study.
Fuente:Jmir Research Protocols
Extracto:
The integration of KMC into the health care system will
provide valuable insights for policy makers regarding effective implementation
and scaling strategies. The study's findings will highlight facilitators and
barriers to KMC adoption, benefiting regions across Pakistan and globally.
Additionally, these findings will offer valuable insights for the development of
future newborn care programs. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID):
DERR1-10.2196/56142.
Claves:community, health facility, kangaroo mother care, preterm infants, scale up intervention
Cita:JMIR Res Protoc 2025 Jan 29; 14 : e56142.
Autor/es:Muhammad, Shah (a) Soomro, Asif (b)
institución:(a) Centre of Excellence in Women and Child Health, Aga Khan University, Karachi, Pakistan. (b) Centre of Excellence in Women and Child Health, Aga Khan University, Karachi, Pakistan.
Self-reported determinants for subjective financial distress: a qualitative interview study with German cancer patients.
Self-reported determinants for subjective financial distress: a qualitative interview study with German cancer patients.
Fuente:Bmj Open
Extracto:
Subjective financial distress depends
not only on material but also on social, systemic and inner personal
determinants. Knowledge of these determinants can inform a new comprehensive
German-language instrument for measuring self-reported financial effects of a
tumour disease. TRIAL REGISTRATION NUMBER: NCT05319925.
Claves:Patient Reported Outcome Measures, Percieved Social Support, QUALITATIVE RESEARCH
Cita:BMJ Open 2025 Jan 28; 15 (1) : e081432.
Autor/es:Züger, Andrea (a) Mathies, Viktoria (b)
institución:(a) Department of Medical Oncology, Section Translational Medical Ethics, National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany andrea.zueger@histor.med.uni-giessen.de. (b) Department of Hematology/Oncology, Jena University Hospital, Jena, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Methodological considerations for estimating indirect costs in children and adolescents with chronic conditions
Methodological considerations for estimating indirect costs in children and adolescents with chronic conditions
Fuente:Bmc Pediatrics
Tipo de trabajo:Revisión
Extracto:
These indirect costs include both paid and
unpaid activities, as well as absenteeism and presenteeism, not only for
caregivers but also for children and adolescents themselves.
institución:(a) Chair for Institutional Economics and Health Policy, Department of Philosophy, Politics and Economics, Witten/Herdecke University, Witten, Germany. anne.kitschen@uni-wh.de. (b) Chair for Institutional Economics and Health Policy, Department of Philosophy, Politics and Economics, Witten/Herdecke University, Witten, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
AI-based analysis of fetal growth restriction in a prospective obstetric cohort quantifies compound risks for perinatal morbidity and mortality and identifies previously unrecognized high risk clinical scenarios.
AI-based analysis of fetal growth restriction in a prospective obstetric cohort quantifies compound risks for perinatal morbidity and mortality and identifies previously unrecognized high risk clinical scenarios.
Fuente:Bmc Pregnancy and Childbirth
Tipo de trabajo:Guía
Extracto:
PGMs are able to
capture and quantify context-specific risk relationships in FGR and identify
latent variable interactions that are associated with large differences in risk.
FGR scenarios that are separated by nearly 10-fold perinatal morbidity risk would
be managed similarly under current FGR clinical guidelines, highlighting the need
for more precise approaches to risk estimation in FGR.
Cita:BMC Pregnancy Childbirth 2025 Jan 30; 25 (1) : 80.
Autor/es:Zimmerman, Raquel M (a) Hernandez, Edgar J (b)
institución:(a) Department of Biomedical Informatics, University of Utah Health, Salt Lake City, UT, USA. (b) Utah Center for Genetic Discovery, Department of Human Genetics, University of Utah Health, Salt Lake City, UT, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Understanding the experience of the mothers' ability to take care of their preterm infants related to in-hospital and post-discharge: a qualitative content analysis.
Understanding the experience of the mothers' ability to take care of their preterm infants related to in-hospital and post-discharge: a qualitative content analysis.
Fuente:Bmc Pediatrics
Extracto:
Both mothers and professional neonatal nurses
should take responsibility for improving the mothers' ability to take care of
their preterm infants.
Claves:Caring Ability, Infant, Mother, Neonatal Intensive Care Unit, Preterm
Cita:BMC Pediatr 2025 Jan 29; 25 (1) : 72.
Autor/es:Tajalli, Saleheh (a) Parvizy, Soroor (b)
institución:(a) School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran. (b) Nursing and Midwifery Care Research Center, Pediatric Nursing Department, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran. s_parvizy@yahoo.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Clinical performance of class II MOD fiber reinforced resin composite restorations: an 18-month randomized controlled clinical trial.
Clinical performance of class II MOD fiber reinforced resin composite restorations: an 18-month randomized controlled clinical trial.
Fuente:Bmc Oral Health
Tipo de trabajo:Estudio clínico
Extracto:
Class II direct fiber-reinforced resin composite restorations can
offer acceptable performance similar to the nanohybrid resin composite through
18-month of clinical service. CLINICAL SIGNIFICANCE: Fiber reinforcement of resin
composites could be a reliable technique for restoring posterior cavities
considering factors such as application complexity, cost and aesthetic
considerations. TRIAL REGISTRATION: The trial was registered retrospectively on
(19/05/2022) at https://clinicaltrials.gov with the ID (NCT05380973).
Claves:Clinical performance, Ever-X posterior, Polyethylene fiber, Ribbond, Short fiber
Cita:BMC Oral Health 2025 Jan 30; 25 (1) : 159.
Autor/es:Mohamed, Mohamed Hamdy (a) Abouauf, Eman Ali (b)
institución:(a) Conservative Dentistry Department, Faculty of Dentistry, Cairo University, Cairo, Egypt. mohamed_hamdy@dentistry.cu.edu.eg. (b) Conservative Dentistry Department, Faculty of Oral and Dental Medicine, Ahram Canadian University, Giza, Egypt. mohamed_hamdy@dentistry.cu.edu.eg.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A case series on the basic concept and design of removable partial dentures: support and bracing considerations.
A case series on the basic concept and design of removable partial dentures: support and bracing considerations.
Fuente:Bmc Oral Health
Extracto:
The denture design described
in this study is essential in pre- and postgraduate dental education, and the
author believes that it will be helpful for dental students, interns, or
residents in clinical practice.
Claves:Bracing, Denture design, Frictional control, Path of insertion, Removable partial denture, Support
Cita:BMC Oral Health 2025 Jan 29; 25 (1) : 157.
Autor/es:Bracing, Denture design, Frictional control, Path of insertion, Removable partial denture, Support
institución:Bracing, Denture design, Frictional control, Path of insertion, Removable partial denture, Support
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Visual hermeneutics as a tool to introduce empathy and core physician attributes in doctor-patient relationship for first-year medical undergraduate students.
Visual hermeneutics as a tool to introduce empathy and core physician attributes in doctor-patient relationship for first-year medical undergraduate students.
Fuente:Bmc Medical Education
Extracto:
Introducing a visual hermeneutics approach has the potential to
cultivate empathy and foster a deeper understanding of the doctor-patient
relationship. Introducing this approach during the formative years of medical
training can nurture compassionate and virtuous conduct, reinforcing students'
commitment to delivering empathetic and competent care throughout their medical
careers. TRIAL REGISTRATION: The institutional ethics committee approved the
conduct of the study [IEC180/2023].
Claves:AETCOM, Doctor-patient relationship, First-year medical undergraduates, Paintings, Visual hermeneutics
Cita:BMC Med Educ 2025 Jan 29; 25 (1) : 145.
Autor/es:Prabhath, Sushma (a) Kulkarni, Uma (b)
institución:(a) Department of Anatomy, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. (b) Department of Medical Education, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133?
Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133?
Fuente:Journal of Nanobiotechnology
Extracto:
Prominin-1(+) EVs also mediate intercellular communication during
embryonic development and adult homeostasis in healthy individuals, while
disseminating biological information during diseases.
Cita:J Nanobiotechnology 2025 Jan 29; 23 (1) : 61.
Autor/es:Karbanová, Jana (a) Thamm, Kristina (b)
institución:(a) Biotechnology Center (BIOTEC) and Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Tatzberg 47-49, 01307, Dresden, Germany. jana.karbanova@tu-dresden.de. (b) Tissue Engineering Laboratories, Medizinische Fakultät der Technischen Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany. jana.karbanova@tu-dresden.de.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The triglyceride-glucose index and its obesity-related derivatives as predictors of all-cause and cardiovascular mortality in hypertensive patients: insights from NHANES data with machine learning analysis.
The triglyceride-glucose index and its obesity-related derivatives as predictors of all-cause and cardiovascular mortality in hypertensive patients: insights from NHANES data with machine learning analysis.
Fuente:Cardiovascular Diabetology
Extracto:
The TyG index and its derivatives are significant
predictors of mortality in hypertensive patients. Their inclusion in predictive
models enhances risk stratification and may aid in the early identification of
high-risk individuals in this population. Further studies are needed to validate
these findings in external hypertensive cohorts.
Claves:Hypertension, Machine learning, Mortality, National Health and Nutrition Examination Survey (NHANES), Triglyceride–glucose (TyG) index
Cita:Cardiovasc Diabetol 2025 Jan 29; 24 (1) : 47.
Autor/es:Li, Chenyang (a) Zhang, Zixi (b)
institución:(a) Department of Cardiology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China. (b) Department of Cardiology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People's Republic of China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Predictive factors of fibrotic interstitial lung abnormality on high-resolution computed tomography scans: a prospective observational study.
Predictive factors of fibrotic interstitial lung abnormality on high-resolution computed tomography scans: a prospective observational study.
Fuente:Bmc Pulmonary Medicine
Tipo de trabajo:Estudio multicéntrico
Extracto:
Fine crackles on
auscultation and elevated serum surfactant protein-D levels are predictors of
fibrotic interstitial lung abnormalities in older patients with interstitial lung
abnormalities. These findings may assist non-radiological physicians in referring
patients to specialists for early intervention in progressive fibrotic
interstitial lung diseases. TRIAL REGISTRATION NUMBER/DATE:
UMIN000045149/2021.12.1.
institución:(a) Division of Respiratory Medicine, Saiseikai Kumamoto Hospital, 5-3-1 Chikami, Chu-oh Ku, Kumamoto, 861-4101, Japan. kazuichi6443@gem.bbiq.jp. (b) Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto 1-1-1 Honjo, Chuo-ku, 860-8556, Japan.
Conflicto:Declarations. Ethics approval and consent to participate: This study complied with the Helsinki Declaration and the protocol, and the informed consent forms were approved by the Institutional Review Boards of Kumamoto University Hospital (approval number: 2368), Saiseikai Kumamoto Hospital (approval number: 809), and Kumamoto Red Cross Hospital (approval number: 464). Written informed consent was obtained from all participants. Patient recruitment...
commenced on 20 June 2022. Consent for publication: Consent for publication was obtained from all participants and authors. Competing interests: KI, HI, TJ, and TS received lecture fees from Nippon Boehringer Ingelheim Co. Ltd. Boehringer Ingelheim had no role in the design, analysis, or interpretation of the results in this study. Boehringer Ingelheim was given the opportunity to review the manuscript for medical and scientific accuracy as it relates to Boehringer Ingelheim substances, as well as intellectual property considerations.KI, KK, YY, KA, HO, KA, NH, KF, TS, JM, MY, and KM declare no conflict of interest.
Neurocognitive impact of different irradiation modalities for patients with grade I-II skull base meningioma
Neurocognitive impact of different irradiation modalities for patients with grade I-II skull base meningioma
Fuente:Radiation Oncology (london, England)
Tipo de trabajo:Estudio de cohortes
Extracto:
TRIAL REGISTRATION: The study was
registered on clinicaltrials.gov with the following number: NCT06036706.
Claves:Cognition, Irradiation, Meningioma, Proton therapy, Skull base
Cita:Radiat Oncol 2025 Jan 29; 20 (1) : 16.
Autor/es:Lesueur, Paul (a) Joly, Florence (b)
institución:(a) Department of Radiation Oncology, François Baclesse center, Caen, 14000, France. paul.lesueur89@gmail.com. (b) ISTCT UMR 6030-CNRS, Université de Caen-Normandie, Caen, France. paul.lesueur89@gmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Hernia the journal of hernias and abdominal wall surgery
Selección SIIC: 31 Enero, 2025
Hernia the journal of hernias and abdominal wall surgery
A literature-based cost-effectiveness analysis of device-assisted suturing versus needle-driven suturing during laparotomy closure.
A literature-based cost-effectiveness analysis of device-assisted suturing versus needle-driven suturing during laparotomy closure.
Fuente:Hernia The Journal of Hernias and Abdominal Wall Surgery
Extracto:
Cost-effectiveness was largely due to cost savings. Prior to procurement,
hospitals should test the device to ensure that small-bite rates and reductions
in operation time are replicable within their clinical context. If so, the device
will improve quality of care for laparotomy wound closure.
Autor/es:Lwin, Zin Min Thet (a) Börner, Gabriel (b)
institución:(a) Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Solna (L1:00), Stockholm, 171 76, Sweden. (b) The Swedish Institute for Health Economics, Svartmangatan 18, Stockholm, 111 29, Sweden.
Conflicto:Declarations. Conflict of interest: Gabriel Börner is the founder and Chief Medical Officer of Suturion AB, and Sophia Verheij-Engqvist is an employee at Suturion AB. Smile Incubator, an incubator in Sweden, provided funding to Suturion AB to finance this health economic study. Suturion AB used the Smile funds to contract The Swedish Institute for Health Economics to lead the health...
h economic study. Zin Min Thet Lwin is employed as a research analyst, and George Keel as a research manager, at the Swedish Institute of Health Economics.
