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UTILIDAD DE LA TERAPIA CON OXIGENO HIPERBARICO PARA MEJORAR LA CICATRIZACION DE HERIDAS

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La terapia con oxígeno hiperbárico (TOH) es uno de los enfoques terapéuticos más importantes en relación con las heridas crónicas. Debería ser considerada si las razones aparentes del déficit de cicatrización son la hipoxia y la infección. Son necesarios estudios adicionales para entender mejor los beneficios de la TOH sobre la cicatrización de heridas.
yildiz9.jpg Autor:
Senol Yildiz
Columnista Experto de SIIC
Artículos publicados por Senol Yildiz
Coautor
Gunalp Uzun* 
MD, Gulhane Military Medical Academy Haydarpasa Training Hospital, Estambul, Turquía*
Recepción del artículo
8 de Octubre, 2006 		Aprobación
5 de Diciembre, 2006
Primera edición
4 de Junio, 2007 		Segunda edición, ampliada y corregida
7 de Junio, 2021

UTILIDAD DE LA TERAPIA CON OXIGENO HIPERBARICO PARA MEJORAR LA CICATRIZACION DE HERIDAS

Resumen
Existen diversos factores locales y sistémicos que pueden afectar negativamente la cicatrización de heridas y provocar una curación prolongada e incompleta. El tratamiento de las heridas crónicas está basado, en parte, en la identificación y el tratamiento de dichos factores. La terapia con oxígeno hiperbárico (TOH) es uno de los enfoques terapéuticos más importantes de las heridas crónicas, ya que estimula la síntesis y maduración del colágeno, la proliferación fibroblástica y la epitelización, aumenta la capacidad bactericida de los leucocitos e induce la angiogénesis. La TOH también ejerce un efecto antibacteriano sobre determinados microorganismos y disminuye la infección de las heridas. Además, en estudios experimentales se demostró que la TOH es útil en heridas empeoradas por drogas como octreotide y 5-fluorouracilo y por el estrés. Son necesarios estudios adicionales para entender mejor los efectos de la TOH sobre los mecanismos básicos de cicatrización de heridas y sobre los factores que la dificultan.

Palabras clave
herida crónica, oxigenación hiperbárica, manejo de la herida


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Effects of Hyperbaric Oxygen Therapy on Impaired Wound Healing

Abstract
Several local and systemic factors may adversely affect wound healing leading to prolonged and incomplete healing. Treatment of chronic wounds in part based on definition and management of these factors. Hyperbaric oxygen therapy (HBO) is one of the important treatment approaches in chronic wounds. HBO therapy enhances collagen synthesis and maturation, fibroblast proliferation, epithelialization, increases leukocyte bacterial killing capacity and induces angiogenesis. HBO therapy also exerts antibacterial effect on selected microorganisms and reduces wound infection. Experimental studies also demonstrated that HBO therapy is beneficial in wounds impaired by drugs, such as octreotide and 5-fluorouracil, and stress. Further studies are needed in order to obtain a better understanding of the effects of HBO therapy on the basic mechanisms that are beneficial in wound healing and on those factors that impair wound healing.

Key words
chronic wound, hyperbaric oxygenation, wound management


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Especialidades
Principal: Cirugía
Relacionadas: Infectología, Medicina Interna



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Senol Yildiz, Department of Underwater and Hyperbaric Medicine, Gulhane Military Medical Academy Haydarpasa Training Hospital, 34668, Estambul, Turquía
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Clasificado en
Artículos originales>
Expertos del Mundo

Especialidad principal:
Cirugía


Relacionadas:
Infectología
Medicina Interna
 
 
 
 
 
 
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