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UTILIDAD DEL CALCIPOTRIOL EN DERMATOLOGIA

(especial para SIIC © Derechos reservados)
Esta revisión de trabajos acerca de los usos clínicos del calcipotriol tópico muestra su utilidad en muchos trastornos dérmicos, lo que indica el gran potencial que ofrecen los análogos de la vitamina D3.
holm9.jpg Autor:
Elisabeth Holm,
Columnista Experto de SIIC

Institución:
Division of Dermatology Department of Medicine Roskilde Hospital Roskilde, Denmark

Artículos publicados por Elisabeth Holm,
Coautor
Gregor BE Jemec* 
MD, DmedSci. Division of dermatology, department of Medicine, Roskilde Hospital*
Recepción del artículo
22 de Marzo, 2004 		Aprobación
21 de Abril, 2004
Primera edición
15 de Febrero, 2005 		Segunda edición, ampliada y corregida
7 de Junio, 2021

UTILIDAD DEL CALCIPOTRIOL EN DERMATOLOGIA

Resumen
Antecedentes: El calcipotriol (calcipotrieno) es un análogo de la vitamina D3, con efectos antiproliferativos y antiinflamatorios, que estimula la diferenciación terminal. En Europa se lo emplea en el tratamiento de la psoriasis vulgar desde 1991 y en EE.UU. desde 1994. Objetivo: El objetivo de esta revisión es ofrecer una actualización acerca de las potenciales aplicaciones clínicas del tratamiento con calcipotriol tópico para otras enfermedades, además de la psoriasis. Métodos: Revisión de la bibliografía existente que describe los estudios clínicos de calcipotriol en el período de 2000 a 2004. Resultados: Se encontraron en total 51 artículos originales que nombraban 26 enfermedades diferentes en las que se describía el uso clínico del ungüento de calcipotriol. Los artículos fueron principalmente informes de casos (n = 33) y estudios de observación (n = 12), pero 6 de ellos describieron pequeños ensayos controlados aleatorizados. Catorce de las 26 diferentes enfermedades no fueron descritas en revisiones previas. Conclusión: El calcipotriol generalmente es efectivo en enfermedades caracterizadas por elementos patogénicos como deterioro en la diferenciación o aumento de la proliferación de queratinocitos y lifocitos T activados. Esta revisión de la bibliografía sugiere que los estudios aleatorizados, a doble ciego, controlados con placebo, del tratamiento con calcipotriol pueden ser útiles en varias enfermedades.

Palabras clave
Calcipotriol, tratamiento con calcipotrieno, psoriasis


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CALCIPOTRIOL. THE SPECTRUM OF CLINICAL EXPERIENCE OF A DECADE

Abstract
Background: Calcipotriol (calcipotriene) is a vitamin D3-analogue, which has anti-proliferative and anti-inflammatory effect, and stimulates terminal differentiation. It has been an established treatment of psoriasis vulgaris since 1991 in Europe and 1994 in USA. Objective: The aim of this review was to give an update upon the potential clinical applications of topical calcipotriol treatment for other diseases than psoriasis. Methods: Review of the existing literature describing clinical studies of calcipotriol in the period from 2000 to 2004. Results: A total of 51 original papers were found describing 26 different diseases where the clinical use of calcipotriol ointment was described. These papers were predominantly case reports (n = 33) and observational studies (n = 12), but 6 papers described small-randomised controlled trials. 14 out of the 26 different diseases have not been described in previous reviews. Conclusion: Calcipotriol may generally be effective in diseases characterised by pathogenic elements such as impaired differentiation or increased keratinocytes proliferation, and activated T-lymphocytes. This review of the existing literature suggests that randomised, double blind, placebo-controlled studies of calcipotriol therapy may be worthwhile in a number of diseases.

Key words
Calcipotriol, calcipotriene treatment, not psoriasis


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Especialidades
Principal: Dermatología, Oncología
Relacionadas: Farmacología, Hematología



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Bibliografía del artículo
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