DIFFERENTIAL DIAGNOSIS OF LUNG CARCINOMA WITH LABEL-FREE IMAGING
This report describes a new class of endomicroscopy that combines chemical selective molecular vibrational imaging techniques, such as coherent anti-Stokes Raman scattering (CARS) imaging, with fiber optic delivery and quantitative analytics for obtaining histology-like images from inside the human body in real-time with no label. Endomicroscopes generally can achieve a resolution on the order of a µm and have a field-of-view of several hundred µm. Current endomicroscope products, however, often require fluorophores, which are excitable using laser lights, and limit their applications in clinics. The objective of the proposed label-free endomicroscope is to sidestep the use of flourophores by visualizing morphological patterns and detecting intrinsic biomarkers of cells and tissues via high-speed, chemical selective CARS imaging. The label-free endomicroscope is developed to post-process and characterize CARS images and provide diagnostic information using disease-related features and classification. The prototype device has shown high accuracy and specificity for differential lung cancer diagnosis and thus demonstrated its potential for clinical translations.
Stephen Wong
Houston, Us
PROTOCOLO DE ACTUACIÓN EN LAS ENFERMEDADES PULMONARES INTERSTICIALES EN LA INFANCIA
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