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Stephen Wong describes for SIIC the most significant aspects of his article describe para SIIC los aspectos relevantes de su artículo DIFFERENTIAL DIAGNOSIS OF LUNG CARCINOMA WITH LABEL-FREE IMAGING This report describes a new class of endomicroscopy that combines chemical selective molecular vibrational imaging techniques, such as coherent anti-Stokes Raman scattering (CARS) imaging, with fiber optic delivery and quantitative analytics for obtaining histology-like images from inside the human body in real-time with no label. Endomicroscopes generally can achieve a resolution on the order of a µm and have a field-of-view of several hundred µm. Current endomicroscope products, however, often require fluorophores, which are excitable using laser lights, and limit their applications in clinics. The objective of the proposed label-free endomicroscope is to sidestep the use of flourophores by visualizing morphological patterns and detecting intrinsic biomarkers of cells and tissues via high-speed, chemical selective CARS imaging. The label-free endomicroscope is developed to post-process and characterize CARS images and provide diagnostic information using disease-related features and classification. The prototype device has shown high accuracy and specificity for differential lung cancer diagnosis and thus demonstrated its potential for clinical translations. The article was published by El artículo fue publicado por
Principal institution where the research took place Institución principal de la investigación Department of Systems Medicine and Bioengineering, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston TX 77030, USA, Houston, Texas, United States  Authors' Report Crónica del Autor Bibliographic references Referencias bibliográficas Gao L, Hammoudi AA, Li F, Thrall MJ, Cagle PT, Chen Y, et al. Differential diagnosis of lung carcinoma with three-dimensional quantitative molecular vibrational imaging. J Biomed Opt 17(6):066017, 2012. Gao L, Li F, Thrall MJ, Yang Y, Xing J, Hammoudi AA, et al. On-the-spot lung cancer differential diagnosis by label-free, molecular vibrational imaging and knowledge-based classification. J Biomed Opt 16:096004, 2011. Wang ZY, Yang Y, Luo P, Gao L, Wong KK, Wong ST. Delivery of picosecond lasers in multimode fibers for coherent anti-Stokes Raman scattering imaging. Opt Express 18:13017-13028, 2010. Wang ZY, Gao L, Luo PF, Yang YL, Hammoudi AA, Wong KK, Wong ST. Coherent anti-Stokes Raman scattering microscopy imaging with suppression of four-wave mixing in optical fibers. Optics Express 19:7960-7970, 2011. Wang ZY, Liu YJ, Gao L, Chen YX, Luo PF, Wong KK, Wong ST. Use of multimode optical fibers for fiber-based coherent anti-Stokes Raman scattering microendoscopy imaging. Optics Letters 36:2967-2969, 2011. Other articles written by the author Stephen Wong Otros artículos de Stephen Wong 1. L. Gao, A. A. Hammoudi, F. Li, M. J. Thrall, P. T. Cagle, Y. Chen, J. Yang, X. Xia, Y. Fan, Y. Massoud, Z. Wang, and S. T. Wong, "Differential diagnosis of lung carcinoma with three-dimensional quantitative molecular vibrational imaging," J Biomed Opt 17, 066017 (2012). 2. L. Gao, F. Li, M. J. Thrall, Y. Yang, J. Xing, A. A. Hammoudi, H. Zhao, Y. Massoud, P. T. Cagle, Y. Fan, K. K. Wong, Z. Wang, and S. T. Wong, "On-the-spot lung cancer differential diagnosis by label-free, molecular vibrational imaging and knowledge-based classification," J Biomed Opt 16, 096004 (2011). 3. Z. Wang, Y. Yang, P. Luo, L. Gao, K. K. Wong, and S. T. Wong, "Delivery of picosecond lasers in multimode fibers for coherent anti-Stokes Raman scattering imaging," Opt Express 18, 13017-13028 (2010). 4. Z. Y. Wang, L. Gao, P. F. Luo, Y. L. Yang, A. A. Hammoudi, K. K. Wong, and S. T. C. Wong, "Coherent anti-Stokes Raman scattering microscopy imaging with suppression of four-wave mixing in optical fibers," Optics Express 19, 7960-7970 (2011). 5. Z. Y. Wang, Y. J. Liu, L. Gao, Y. X. Chen, P. F. Luo, K. K. Wong, and S. T. C. Wong, "Use of multimode optical fibers for fiber-based coherent anti-Stokes Raman scattering microendoscopy imaging," Optics Letters 36, 2967-2969 (2011). 6. L. Gao, H. Zhou, M. J. Thrall, F. Li, Y. Yang, Z. Wang, P. Luo, K. K. Wong, G. S. Palapattu, and S. T. Wong, "Label-free high-resolution imaging of prostate glands and cavernous nerves using coherent anti-Stokes Raman scattering microscopy," Biomed Opt Express 2, 915-926 (2011). 7. Y. Yang, F. Li, L. Gao, Z. Wang, M. J. Thrall, S. S. Shen, K. K. Wong, and S. T. Wong, "Differential diagnosis of breast cancer using quantitative, label-free and molecular vibrational imaging," Biomed Opt Express 2, 2160-2174 (2011). SIIC System of Assisted Editing (SSEA) / Sistema SIIC de Edición Asistida (SSEA)
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Information about the full text Acerca del trabajo completo Differential Diagnosis of Lung Carcinoma With Coherent Anti-Stokes Raman Scattering Imaging Author / Autor Stephen Wong1, Liang Gao2 2 Applications Scientist, Chroma Technology Corp, Applications Scientist Access to the original source Archives of Pathology & Laboratory Medicine Article URL: / URL del artículo: http://arpa.allenpress.com/arpaonline/?request=index-html URL of Abstract page in Medline: / URL del abstract en Medline: http://www.ncbi.nlm.nih.gov/pubmed/23194042 siic DB: / siic DB: http://www.siicsalud.com/main/distriprinrel.php |
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