ENCAPSULAÇÃO EM ALGINATO COMO NOVA ESTRATÉGIA PARA A CRIOPRESERVAÇÃO DE NEUROESFERAS
Culturas primárias de neuroesferas de células do cérebro são modelos in vitro valiosos para neurotoxicologia e investigação fundamental. Neste trabalho foi desenvolvida uma estratégia integrada que permite a cultura por tempo prolongado e criopreservação de neuroesferas com elevada viabilidade e reduzido tempo de recuperação após o descongelamento.

Paula Alves
Oeiras, Portugal

  

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  CAMBIOS EN LA EXPRESSION DE COLINESTERASAS EN VARIOS TIPOS DE CARCINOMA RENAL
La tumorigénesis puede verse favorecida por la actividad colinérgica. Las señales nicotínicas y muscarínicas varían con la disponibilidad de acetilcolina. En piezas renales cancerosas, la actividad acetilcolinesterasa aumentó en los tumores de tipo papilar y convencional, pero no en los de tipo cromófobo y oncocitoma. El nivel de ARNm y la actividad butirilcolinesterasa aumentaron en el papilar. La mayor actividad colinesterasa y la consiguiente caída de acetilcolina pueden afectar la proliferación celular, la diferenciación, la apoptosis o la quimiorresistencia.

Encarnación Muñoz Delgado
Murcia, España

  

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  ENDOMETRIUM IN MIDDLE-AGED WOMEN WITH ATYPICAL UTERINE BLEEDING
219 perimenopausal women with abnormal uterine bleeding were studied. Endometrial tissue was evaluated. Menorrhagia was most commonly seen and functional causes accounted for majority of the histological diagnoses. Endometrial curettage is important in perimenopausal women with atypical uterine bleeding in the timely diagnosis of preneoplasia and malignancy.

Sujata Jetley
Delhi, In

     

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INTRACARDIAC MASSES IN NIGERIAN ADULTS-AN ECHOCARDIOGRAPHIC STUDY
Intra-cardiac masses are rare in this environment, and transthoracic echocardiography is valuable in the diagnosis and initial characterization of these masses, despite its limitations. Intra-cardiac masses are rare in this environment, and transthoracic echocardiography is valuable in the diagnosis and initial characterization of these masses, despite its limitations. Intra-cardiac masses are rare in this environment, and transthoracic echocardiography is valuable in the diagnosis and initial characterization of these masses, despite its limitations. Intracardiac masses are uncommon in Nigerian adults,but transthoracic echocardiography is valuable in the diagnosis and initial characterization of these masses

Emmanuel Ejim
Enugu, Ng

  

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THE ROLE OF VIRUS, GENES AND TOBACCO IN ORAL CANCER
The prevalence of oral squamous cell carcinoma (OSCC) has significantly increased over decades in several countries and human papilloma virus (HPV) has been indicated as one of the underlying causes. This suggests that HPV plays a role in the early stages of carcinogenesis but is not a requisite for the maintenance and progression of malignant state. p53 is a tumor suppressor gene that checks the cell and promotes apoptosis and cell repair that can be deactivated by mutations and a viral interaction leading to cancer and individuals with particular polymorphic variant of p53 is more susceptible to HPV-induced carcinogenesis. The present study has been carried out to detect and correlate p53 polymorphism/mutation, HPV DNA in the biopsy samples of oral cancer patients who had tobacco habits.

Bidyut Chakrobarty
Visakhapatnam, In

     

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