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Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube.
Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube.
Fuente:Nature Communications
Extracto:
This sheds new light into prevention and
early detection of tumorigenesis in populations at high-risk for ovarian cancer.
Cita:Nat Commun 2025 Mar 26; 16 (1) : 2981.
Autor/es:Beddows, Ian (a) Djirackor, Svetlana (b)
institución:(a) Department of Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA. (b) Department of Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA.
Conflicto:Competing interests: J.A.M. is a founder, equity holder, and advisor to Entact Bio, serves on the SAB of 908 Devices, and receives or has received sponsored research funding from Vertex, AstraZeneca, Taiho, Springworks, TUO Therapeutics, and Takeda. R.D. serves as an advisor to Repare Therapeutics. The remaining authors declare no competing interests.
The spiritual health and breastfeeding behavior: a cross-sectional correlational study.
The spiritual health and breastfeeding behavior: a cross-sectional correlational study.
Fuente:Journal of Health, Population, and Nutrition
Extracto:
The study found a positive relationship between spiritual
health and breastfeeding behavior among women. Therefore, promoting spiritual
health could be considered a strategy to improve breastfeeding behavior in
lactating women.
Claves:Breastfeeding, Maternal health, Spiritual health
Cita:J Health Popul Nutr 2025 Mar 26; 44 (1) : 89.
Autor/es:Panahi, Mina (a) Simbar, Masoumeh (b)
institución:(a) Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. (b) Midwifery and Reproductive Health Research Center, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. msimbar@gmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The effect of motivational interviewing on attitude and intention for childbearing in healthcare provider women.
The effect of motivational interviewing on attitude and intention for childbearing in healthcare provider women.
Fuente:Bmc Psychology
Tipo de trabajo:Estudio clínico aleatorizado
Extracto:
The use of the motivational interviewing
method in women providing health care services is associated with an improvement
in attitude toward and intention for childbearing. Hence, it is recommended that
this cost-effective method be used for childbearing counseling by health service
providers. TRIAL REGISTRATION: IRCT Registration Number: IRCT20230308057654N1,
registered on 2023-03-16 ( https://irct.behdasht.gov.ir/trial/69108 ).
institución:(a) Department of Midwifery, School of Nursing and Midwifery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. (b) Departments of Biostatistics and Epidemiology, School of Public Health, Center for Healthcare Data Modeling, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
This
study summarizes 58 independent risk factors for placental abruption, covering
various aspects such as maternal baseline characteristics and pregnancy
complications. For these high-risk populations, it is essential to strengthen the
frequency of prenatal check-ups, establish early warning systems, and provide
targeted health guidance. Future research should further refine risk factor
models and develop more targeted preventive strategies to reduce the incidence of
placental abruption and improve maternal and neonatal outcomes. PROSPERO:
CRD42024546514. CLINICAL TRIAL NUMBER: Not applicable.
Cita:BMC Pregnancy Childbirth 2025 Mar 26; 25 (1) : 351.
Autor/es:Chen, Dexin (a) Gao, Xuelin (b)
institución:(a) Department of Obstetrics, The Second Hospital of Lanzhou University, No. 82, Cuiying Gate, Chengguan District, Lanzhou City, Gansu Province, 730000, P.R. China. (b) Department of Obstetrics, The Second Hospital of Lanzhou University, No. 82, Cuiying Gate, Chengguan District, Lanzhou City, Gansu Province, 730000, P.R. China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Exploring the therapeutic impact of Salvia officinalis on lipid and oxidative stress markers in patients with polycystic ovary syndrome - a randomized placebo-controlled clinical trial.
Exploring the therapeutic impact of Salvia officinalis on lipid and oxidative stress markers in patients with polycystic ovary syndrome - a randomized placebo-controlled clinical trial.
Fuente:Bmc Complementary Medicine and Therapies
Extracto:
The study demonstrates that S.
officinalis extract can significantly reduce triglyceride levels and OS in
patients with PCOS, suggesting its potential as an adjunctive natural therapy for
managing metabolic and oxidative imbalances associated with this condition. While
the extract did not significantly alter other lipid profile markers, the observed
improvements highlight the therapeutic promise of S. officinalis. These findings
support further investigation into the clinical applications S. officinalis for
PCOS and its potential benefits for metabolic health. TRIAL REGISTRATION:
IRCT201504146917N2 on 2015-10-03 (registered while recruiting).
institución:(a) Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. (b) Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. (b) Center for Menopause and Reproductive Medicine Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Formulation and In Vitro Characterization of Granulocyte-Colony-Stimulating-Factor-Loaded Liposomes: Future Prospective in Reproductive Medicine.
Formulation and In Vitro Characterization of Granulocyte-Colony-Stimulating-Factor-Loaded Liposomes: Future Prospective in Reproductive Medicine.
Fuente:International Journal of Molecular Sciences
Extracto:
Such studies will help in
determining the potential of these formulations for specific biomedical purposes
and evaluating their safety and efficacy in living systems.
Autor/es:Obedkova, Kseniia V (a) Khalenko, Vladislava V (b)
institución:(a) D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, 199034 St. Petersburg, Russia. (b) D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, 199034 St. Petersburg, Russia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Visceral and Dysfunctional Adiposity Indices as Predictors of Insulin Resistance and Metabolic Syndrome in Women with Polycystic Ovary Syndrome: A Cross-Sectional Study.
Visceral and Dysfunctional Adiposity Indices as Predictors of Insulin Resistance and Metabolic Syndrome in Women with Polycystic Ovary Syndrome: A Cross-Sectional Study.
Fuente:Medicina (kaunas, Lithuania)
Extracto:
Their integration into clinical
practice may facilitate the early detection of cardiometabolic complications,
offering a more specific metabolic risk assessment compared to traditional
anthropometric measures.
institución:(a) Department of Obstetrics and Gynecology, Faculty of Medicine, Düzce University, 81620 Düzce, Turkey. (b) Department of Obstetrics and Gynecology, Faculty of Medicine, Sağlık Bilimleri University, Ankara Bilkent City Hospital, 06800 Ankara, Turkey.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy. (b) Unit of Gynecology and Obstetrics, Department of Human Pathology of Adult and Childhood "G. Barresi", University of Messina, 98121 Mesina, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Global temporal trends in depression incidence among women of childbearing age: A 30-year analysis and projections to 2030.
Global temporal trends in depression incidence among women of childbearing age: A 30-year analysis and projections to 2030.
Fuente:Social Science & Medicine (1982)
Extracto:
These findings
highlight the need for targeted interventions and further research to mitigate
the growing mental health burden, particularly in women of reproductive age, in
alignment with the WHO's 2030 objectives.
Claves:Age-period-cohort model, Bayesian age-period-cohort, Depression, Global burden of disease, Women of childbearing age
Cita:Soc Sci Med 2025 May; 372 : 118005.
Autor/es:Zhou, Wu (a) Hei, Bo (b)
institución:(a) Jiangxi Key Laboratory of Neurological Diseases, Department of Neurosurgery, The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17 Yongwaizheng Street, Nanchang, 330006, Jiangxi, China. Electronic address: 1198293375@qq.com. (b) Department of Neurosurgery, Peking University People's Hospital, Peking University, No.11 Xizhimen South Street, Beijing, 100044, Beijing, China. Electronic address: heibo12345@126.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Treatment of nephrotic syndrome with anti-CD20 therapies in pregnancy
Treatment of nephrotic syndrome with anti-CD20 therapies in pregnancy
Fuente:Renal Failure
Tipo de trabajo:Revisión
Extracto:
We describe three cases of
patients with glomerular disease treated with anti-CD20 therapies in the context
of pregnancy and review the literature.
Autor/es:Gauci, Pierre-Alexis (a) Cremoni, Marion (b)
institución:(a) Department of Obstetrics and Gynecology, Reproduction and Fetal Medicine, Nice University Hospital, Université Côte d'Azur, Nice, France. (b) Institut de Recherche sur le Cancer et Vieillissement UMR7284 CNRS INSERM U1081, Université Côte d'Azur, Nice, France.
Conflicto:No potential conflict of interest was reported by the author(s).
A randomised feasibility tolerability study of aminophylline for the prevention of preterm labour.
A randomised feasibility tolerability study of aminophylline for the prevention of preterm labour.
Fuente:Bmc Pregnancy and Childbirth
Tipo de trabajo:Estudio aleatorizado
Extracto:
The addition of aminophylline
to the SoC is acceptable to women at high-risk of sPTL confirming that a
randomised trial of aminophylline to reduce preterm delivery in women at
high-risk of PTL is feasible. TRIAL REGISTRATION: Clinical trial gov NCT03152942.
Date of full registration: 15/5/2017.
https://clinicaltrials.gov/ct2/show/NCT03152942?cond=NCT03152942%26;draw=2%26;rank=1
.
institución:(a) Directorate of Women and Children, Department of Metabolism, Digestion and Reproduction, Chelsea and Westminster Hospital London, Imperial College London, London, UK. n.mohammed@imperial.ac.uk. (b) Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK. n.mohammed@imperial.ac.uk.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Anemia and its determinants among non-pregnant women of childbearing age at Tsirae Wonberta district, Tigray, Ethiopia, 2020: a community based cross sectional study.
Anemia and its determinants among non-pregnant women of childbearing age at Tsirae Wonberta district, Tigray, Ethiopia, 2020: a community based cross sectional study.
Fuente:Bmc Public Health
Extracto:
The
overall prevalence of anemia among non-pregnant women of childbearing age in
Tsirae Wonbereta District, Tigray, Ethiopia was 24.3%, indicating anemia as a
moderate public health concern. The majority of the anemia cases were of the mild
type. Making policies and programs gender-responsive to empower women in
agriculture, education, income, and decision-making to improve nutrition is
recommended.
institución:(a) Department of Nutrition and Dietetics, School of Public Health, College of Health Science, Mekelle University, Mekelle, Ethiopia. (b) Department of Nutrition and Dietetics, School of Public Health, College of Health Science, Mekelle University, Mekelle, Ethiopia. tedros.bereket99@gmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Fertility knowledge, desire, and associated factors among Iranian couples: a cross-sectional study in Northwest Iran.
Fertility knowledge, desire, and associated factors among Iranian couples: a cross-sectional study in Northwest Iran.
Fuente:Bmc Public Health
Extracto:
The findings of this study showed that the fertility knowledge and
desire among Iranian couples were linked to their demographic and social
characteristics.
institución:(a) Department of Midwifery, Faculty of Nursing and Midwifery, Golestan University of Medical Sciences, Gorgan, Iran. (b) Department of Psychiatry, Faculty of Medicine, Ardabil University of Medical Science, Ardabil, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Longer operative times but equally safe - a propensity score-matched analysis for laparoscopic procedures in women with early-stage (r-ASRM I-II) endometriosis performed by gynecology residents compared to attending surgeons.
Longer operative times but equally safe - a propensity score-matched analysis for laparoscopic procedures in women with early-stage (r-ASRM I-II) endometriosis performed by gynecology residents compared to attending surgeons.
Fuente:Bmc Medical Education
Extracto:
Gynecology residents and fellows trained on the patient can safely
perform surgery for early-stage endometriosis at the cost of increased operative
times. Additional training options, such as surgical simulation training, should
be explored to shorten learning curves, reduce the financial burden on hospitals
due to prolonged operative times and counter the impending reduction in
intraoperative training possibilities for residents.
Claves:Costs of surgery, Endometriosis, Medical education, Operative time, Residents, Safety, Surgical experience
Cita:BMC Med Educ 2025 Mar 27; 25 (1) : 450.
Autor/es:Schmidt, Mona W (a) Rosin, Anja (b)
institución:(a) Department of Gynaecology and Obstetrics, University Medical Centre Mainz, Langenbeckstraße 1, 55131, Mainz, Germany. mona.schmidt@unimedizin-mainz.de. (b) Department of Gynaecology and Obstetrics, University Medical Centre Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.
Conflicto:Declarations. Ethics approval and consent to participate: Due to the retrospective analysis of clinical routine data no ethics approval was needed according the State Medical Committee of Rheinland-Pfalz, Germany. Consent for publication: Not applicable. Competing interests: Katharina Anic reports paid lectures by Clovis Oncology, AstraZeneca, Pharma Mar, MSD and Eisai not related to this trial. Marco J. Battista reports honoraria...
and expenses from Pharma Mar AG, Astra Zeneca, TesaroBio GmbH, GSK, Roche, Clovis Oncology and consultant activity to AstraZeneca, Clovis Oncology, Eisai, GSK, MSD, PharmaMar, Roche and Tesaro Bio GmbH. Furthermore, he has received research funding by AstraZeneca, Clovis Oncology, MSD, Eisai and Novartis. None were related to this study. Annette Hasenburg reports honoraria and expenses from AstraZeneca, Celgen, GSK, Leo Pharma, MedConcept GmbH, Med update GmbH, Medicultus, Pfizer, Promedicis GmbH, Softconsult, Streamedup! GmbH, Roche Pharma AG, Tesaro Bio Germany GmbH as well as work as a consultant to AstraZeneca, GSK, MSD SHARP & DOHME GmbH, PharmaMar, Promedicis, Roche Pharma AG and Tesaro Bio Germany GmbH. None were related to this study. Roxana Schwab reports honoraria and expenses from RochePharma AG, Sanofi and AstraZeneca GmbH. None were related to this study. Mona W. Schmidt, Anja Rosin, Sabine Schmidt, Joscha Steetskamp, Valerie Linz, Karin Rodewald, Lina Schiestl, Katrin Stewen have no conflict of interest or financial ties to disclose.
Detection of sperm DNA damage in male infertility patients and evaluation of Levocarnitine efficacy using sperm chromatin diffusion (SCD) and AI-DFI methods: a cross-sectional study.
Detection of sperm DNA damage in male infertility patients and evaluation of Levocarnitine efficacy using sperm chromatin diffusion (SCD) and AI-DFI methods: a cross-sectional study.
Fuente:European Journal of Medical Research
Extracto:
This study concludes that men with asthenozoospermia and
oligozoospermia have a high DFI, and Levocarnitine is effective in reducing DNA
damage and improving sperm quality, suggesting that Levocarnitine has potential
for clinical use.
Claves:DFI, Infertility, Levocarnitine, Semen quality, Sperm DNA damage
Cita:Eur J Med Res 2025 Mar 28; 30 (1) : 210.
Autor/es:Liu, Kangsheng (a) Yajunchen (b)
institución:(a) Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shannxi, China. (b) Department of Clinical Laboratory, Women'S Hospital of Nanjing Medical University, Nanjing Women and Children'S Healthcare Hospital, Nanjing, 210029, Jiangsu, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Reproductive Medicine and Biology Department, CECOS of Picardy, Amiens University Hospital, 80000 Amiens, France. (b) Department of Constitutional Genetics, Amiens University Hospital, 80000 Amiens, France.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Reproductive factors as a risk factor for STEMI: A retrospective case-control study.
Reproductive factors as a risk factor for STEMI: A retrospective case-control study.
Fuente:Medicine
Extracto:
However, no
significant differences were found between the case and control groups regarding
menopausal status, age at menopause, age at menarche, reproductive duration, or
oral contraceptive use.
Cita:Medicine (Baltimore) 2025 Mar 28; 104 (13) : e41974.
institución:(a) Cardiac Rehabilitation Department, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. (b) Chamran Cardiovascular Medical and Research Center, Echocardiography Department, Isfahan University of Medical Sciences, Isfahan, Iran.
Conflicto:The authors have no funding and conflicts of interest to disclose.
Advancing maternal and perinatal health through clinical trials: key insights from a WHO global consultation.
Advancing maternal and perinatal health through clinical trials: key insights from a WHO global consultation.
Fuente:The Lancet. Global Health
Tipo de trabajo:Orientaciones y guía
Extracto:
This shift extends beyond pregnancy to
transform the overall trial ecosystem and prioritise the health and wellbeing of
all women and their infants everywhere, to truly achieve equitable access to
health and innovations and leave no one behind.
Cita:Lancet Glob Health 2025 Apr; 13 (4) : e740-e748.
Autor/es:Dey, Teesta (a) Widmer, Mariana (b)
institución:(a) UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, WHO, Geneva, Switzerland. Electronic address: deyt@who.int. (b) UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, WHO, Geneva, Switzerland.
Conflicto:Declaration of interests EC has received payments for expert testimonies from European Foundation for the Care of Newborn Infants (EFCNI) and University of Edinburgh; support for attending meetings and travel from EFCNI; and is a member of the Parent & Patient Advisory Board of EFCNI. AMG is the Executive Director of Concept Foundation; has received a grant from Bill &...
Melinda Gates Foundation entitled Accelerating Innovation for Mothers, coordinating a range of activities including maternal health products pipeline analyses and developing target product profiles. GJH has received royalties from Maternova. MK is a member of the WHO Technical Advisory Group on Development of Guidance on Best Practices for Clinical Trials. ACM has received grants awarded to Johns Hopkins University from the US National Institute of Health (NIH) and Wellcome Trust; and support for travel from The National Academies of Sciences, Engineering, and Medicine, and WHO. FMM has received grants awarded to Baylor College University from NIH and US Center for Disease Control and Prevention for COVID-19 vaccines and respiratory viruses in pregnant women and children, and from Pfizer and Gilead for COVID-19 research projects in children; is a member of Moderna's Vaccine and Pfizer's and Meissa's (respiratory syncytial virus vaccines) Data Safety Monitoring Boards; and has received consulting fees from Sanofi, AstraZeneca, Merck, and GSK. All other authors declare no competing interests.
The attitude of the unvaccinated children's parents toward pediatric COVID-19 vaccination in Tabriz, Iran.
The attitude of the unvaccinated children's parents toward pediatric COVID-19 vaccination in Tabriz, Iran.
Fuente:Bmc Pediatrics
Tipo de trabajo:Revisión
Extracto:
Parents' willingness to vaccinate their children against COVID-19 in Tabriz was
low, primarily due to concerns about the potential side effects of the vaccine.
To address this issue, culturally sensitive public health campaigns should be
designed that specifically target these concerns and involve trusted community
figures. These initiatives could help reduce vaccine hesitancy, particularly
among mothers and parents of children with underlying health conditions.
institución:(a) Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. (b) Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación