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ACTUALIZACION EN FORMULACIONES DE PROPOFOL

(especial para SIIC © Derechos reservados)
Para evitar los efectos adversos asociados con la administración de propofol en su formulación original se han logrado grandes avances en su farmacología. No obstante, es preciso conocer las diferencias farmacológicas entre las distintas formulaciones antes de utilizarlas en la práctica clínica.
telletxea9.jpg Autor:
Sorkunde Telletxea
Columnista Experto de SIIC

Institución:
Hospital de Galdakao-Usansolo

Artículos publicados por Sorkunde Telletxea
Recepción del artículo
29 de Mayo, 2008 		Aprobación
15 de Julio, 2008
Primera edición
9 de Abril, 2009 		Segunda edición, ampliada y corregida
7 de Junio, 2021

ACTUALIZACION EN FORMULACIONES DE PROPOFOL

Resumen
En los últimos años se han logrado grandes avances en la farmacología del propofol. Estos avances se han producido con el fin de evitar los efectos adversos colaterales asociados con la administración de propofol en su formulación original. Estos efectos no deseados son: el dolor a la inyección intravenosa, la hiperlipidemia y la contaminación bacteriana. La industria farmacéutica ha introducido formulaciones como el propofol con EDTA, metabisulfito o bencilalcohol para evitar la contaminación bacteriana. También se ha utilizado lipuro para evitar el aumento de los niveles de triglicéridos. Existen formulaciones más avanzadas de propofol en ciclodextrina o en nanopartículas (IDD-propofol). Por último, conoceremos los profármacos del propofol. Es preciso conocer las diferencias farmacológicas entre las distintas formulaciones antes de utilizarlas en la práctica clínica.

Palabras clave
propofol, formulaciones, farmacocinética, farmacodinamia


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Update on Propofol Formulations

Abstract
Great progress has been made in the pharmacology of propofol in recent years. These progress have been developed to avoid adverse side effects associated with the original formulation. The unwanted effects are: pain upon intravenous injection of the drug, hyperlipidemia, and bacterial contamination. Pharmaceutical industries has developed new formulations like propofol-EDTA, metabisulfite or bencyl-alcohol to avoid bacterial contamination. Other formulations use Lipuro to avoid elevated concentrations of triglycerides. More advanced formulations are propofol in Ciclodextrine or in Nanoemulsions. Finally, we will know propofol prodrugs. It is necessary to know the pharmacological differences between formulations before use them in ordinary practice.

Key words
propofol, formulations, pharmacokinetics, pharmacodinamics

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Especialidades
Principal: Anestesiología
Relacionadas: Cirugía, Cuidados Intensivos, Educación Médica, Farmacología, Medicina Farmacéutica



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Sorkunde Telletxea, Hospital de Galdakao-Usansolo, 48960, Barrio Labeaga s/n Usansolo, Usansolo, España
Bibliografía del artículo

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