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EFEITO DA ALOPREGNANOLONA SOBRE O DESENVOLVIMENTO DA TOLERANCIA RAPIDA AO EFEITO ANSIOLITICO DO ETANOL

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barbosa9.jpg Autor:
Adriana Dias elpo barbosa
Columnista Experto de SIIC

Institución:
Universidade do Vale do Itajaí (UNIVALI)

Artículos publicados por Adriana Dias elpo barbosa
Coautores
Alice Figueiredo Kikko* Paula Karina Vitor Koerich* 
Estudante do Curso de Medicina, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Brasil*
Recepción del artículo
4 de Enero, 2008 		Aprobación
31 de Enero, 2008
Primera edición
30 de Junio, 2008 		Segunda edición, ampliada y corregida
7 de Junio, 2021

EFEITO DA ALOPREGNANOLONA SOBRE O DESENVOLVIMENTO DA TOLERANCIA RAPIDA AO EFEITO ANSIOLITICO DO ETANOL

Resumen
Estudos prévios têm mostrado que o neuroesteróide isopregnanolona bloqueou o desenvolvimento da tolerância rápida ao efeito ansiolítico do etanol. O objetivo do presente estudo foi investigar a influência da alopregnanolona sobre o desenvolvimento da tolerância rápida ao efeito ansiolítico do etanol em camundongos. No primeiro experimento, o objetivo foi investigar o efeito da alopregnanolona (0.05, 0.10 ou 0.20 mg/kg) sobre a tolerância rápida ao etanol (1.5 g/kg). No segundo experimento, o efeito do flumazenil (2.0 mg/kg) sobre a influência da alopregnanolona na tolerância rápida ao etanol foi investigado. Os resultados mostram que o tratamento prévio com alopregnanolona interferiu no desenvolvimento da tolerância rápida ao efeito ansiolítico etanol. Além disso, o tratamento prévio com flumazenil não interferiu na ação inibitória da alopregnanolona sobre o desenvolvimento da tolerância rápida ao etanol.

Palabras clave
álcool, alopregnanolona, tolerância, ansiolítico, flumazenil


Artículo completo
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Effect of Allopregnanolone on Development of Rapid Tolerance to the Anxiolytic Effect of Ethanol

Abstract
It has been shown that the neurosteroid isopregnanolone blocks the development of rapid tolerance to the anxiolytic effect of ethanol. The aim of the present study was to investigate the influence of allopregnanolone on the development of rapid tolerance to the anxiolytic effect of ethanol in mice. In the first experiment, male Swiss mice were pretreated with allopregnanolone (0.05, 0.10 or 0.20 mg/kg) 30 min before administration of ethanol (1.5 g/kg). Twenty-four hours later, all animals were tested using the plus-maze apparatus. In the second experiment, the effect of pretreatment of mice with flumazenil (2.0 mg/kg) 15 min before the administration of allopregnanolone on rapid tolerance to the anxiolytic effect of ethanol was studied. The results show that pretreatment with allopregnanolone interfered with the development of rapid tolerance to the anxiolytic effect to ethanol. Furthermore, the pretreatment with flumazenil did not block the effect of allopregnanolone on the development of rapid tolerance to ethanol.

Key words
alcohol, allopregnanolone, tolerance, anxiolytic, flumazenil

Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Farmacología
Relacionadas: Bioquímica, Medicina Interna, Neurología, Salud Mental, Toxicología



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Enviar correspondencia a:
Adriana Dias Elpo Barbosa, Universidade do Vale do Itajaí Centro de Ciências da Saúde Coordenadoria de Medicina, 89302-202, Rua Uruguai, 458, Itajaí, Brasil
Patrocinio y reconocimiento:
La Dra. Adriana Dias Elpo Barbosa certifica que "agimos de acordo as normas da instituicao apropriada ou do organismo nacional pertinente para o uso de animais de laboratório".
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