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DESTACAN LA UTILIDAD DE MARCADORES GENETICOS Y MOLECULARES PARA PREDECIR COMPLICACIONES DEL TRASPLANTE RENAL

(especial para SIIC © Derechos reservados)
La personalización del tratamiento podría tener consecuencias positivas para los receptores de trasplantes. Ciertos marcadores de rechazo y de enfermedad cardiovascular podrían ayudar a identificar aquellos individuos con riesgo de presentar esas complicaciones y guiar la implementación de medidas preventivas.
varagunam9.jpg Autor:
Mira Varagunam
Columnista Experto de SIIC

Institución:
Royal London Hospital

Artículos publicados por Mira Varagunam
Coautor
Magdi Mohammed Yaqoob* 
MD, FRCP, Royal London Hospital, Londres, Reino Unido*
Recepción del artículo
2 de Agosto, 2006 		Aprobación
24 de Agosto, 2006
Primera edición
11 de Enero, 2007 		Segunda edición, ampliada y corregida
7 de Junio, 2021

DESTACAN LA UTILIDAD DE MARCADORES GENETICOS Y MOLECULARES PARA PREDECIR COMPLICACIONES DEL TRASPLANTE RENAL

Resumen
El trasplante renal no sólo prolonga la supervivencia, sino que además mejora la calidad de vida y mitiga las complicaciones y las molestias secundarias a la insuficiencia renal en etapa terminal. Sin embargo, el rechazo y la enfermedad cardiovascular constituyen aún desafíos fundamentales. El perfeccionamiento del control y el tratamiento individualizado mejorarían los resultados. El objetivo a largo plazo consiste en optimizar las técnicas de detección sistemática empleadas para evaluar el riesgo de ambas complicaciones y que permitirían a un equipo multidisciplinario centrar el tratamiento y las medidas preventivas en aquellos individuos con mayor riesgo. A pesar de que se identificaron los factores de riesgo que sugieren rechazo o enfermedad cardiovascular, éstos no resultan adecuados. Este hecho motiva la búsqueda de marcadores genéticos y proteicos de predicción, que puedan medirse de manera relativamente no invasiva, como la obtención de una muestra de sangre. Las investigaciones recientes demostraron que ciertos marcadores implicados en el proceso inflamatorio pueden aportar información adicional y, por lo tanto, reforzar el valor de predicción al ser combinados con los factores de riesgo tradicionales.

Palabras clave
polimorfismo genético, trasplante renal, enfermedad cardiovascular, rechazo, insuficiencia renal terminal


Artículo completo
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MOLECULES AND GENES: UTILITY AS MARKERS OF REJECTION AND CARDIOVASCULAR DISEASE IN RENAL TRANSPLANT PATIENTS

Abstract
Transplantation not only confers a survival advantage, but also improves quality of life and alleviates the complications and discomfort resulting from end stage renal failure. However rejection and cardiovascular disease (CVD) remain major challenges. Better monitoring and individualised therapy would improve outcome. The long term goal is to optimise screening techniques that would assess risk of both these complications and enable the multi disciplinary team to focus therapy and preventative measures on those individuals who have high risk scores. Although there are established risk factors that are indicative of rejection and CVD, these are not adequate. This has led to the search for both genetic and protein predictive markers that could be measured from the relatively non-invasive method of obtaining a blood sample. Recent research has shown that certain markers involved in inflammation can give us additional information, thereby enhancing the predictive value in combination with the established risk factors.

Key words
genetic polymorphisms, renal transplant, cardiovascular disease, rejection, end stage renal failure


Full text
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Clasificación en siicsalud
Artículos originales > Expertos del Mundo >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Trasplantes
Relacionadas: Bioquímica, Cardiología, Diagnóstico por Laboratorio, Genética Humana, Inmunología, Medicina Farmacéutica, Medicina Interna, Nefrología y Medio Interno



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Enviar correspondencia a:
Mira Varagunam, Clinical Transplantation Laboratory, 2nd Floor Pathology and Pharmacy Building, E1 2ES, 80 Newark Street, Whitechapel, Londres, Reino Unido
Bibliografía del artículo
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