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ACTUALIZACION SOBRE EL DIAGNOSTICO DE TUMORES CARCINOIDES DEL TRACTO GASTROINTESTINAL

(especial para SIIC © Derechos reservados)
Los estudios para el diagnóstico de tumores carcinoides gastrointestinales incluyen marcadores como la cromogranina A y 5-HIAA urinario, endoscopia, tomografía, resonancia magnética y centellograma con octreotide.
Autor:
Dimitrios Dimitroulopoulos
Columnista Experto de SIIC

Institución:
Department of Gastroenterology, ¨Agios Savvas¨ Cancer Hospital

Artículos publicados por Dimitrios Dimitroulopoulos
Recepción del artículo
26 de Mayo, 2006 		Aprobación
16 de Junio, 2006
Primera edición
9 de Octubre, 2006 		Segunda edición, ampliada y corregida
7 de Junio, 2021

ACTUALIZACION SOBRE EL DIAGNOSTICO DE TUMORES CARCINOIDES DEL TRACTO GASTROINTESTINAL

Resumen
Los tumores carcinoides, argentafinomas, son miembros de una familia particular de tumores conocida como familia de tumores neuroendocrinos o del sistema APUD (amine precursor uptake and decarboxilation: captación y descarboxilación de precursores de aminas). Los tumores carcinoides se originan en los órganos y sistemas derivados del endodermo primitivo, pero más frecuentemente en el tracto gastrointestinal, donde representan aproximadamente la mitad de todos los tumores endocrinos gastrointestinales. Más del 95% de todos los carcinoides gastrointestinales se localizan en tres sitios: el apéndice, el recto y el intestino delgado. Independientemente de su localización, los carcinoides pueden sintetizar varios péptidos. Estos tumores pueden presentarse en diferentes estadios patológicos con síntomas o síndromes hormonales o sin ellos, y pueden presentarse en forma esporádica o como parte de síndromes hereditarios. Su evolución clínica suele ser indolente pero también puede ser agresiva y resistente al tratamiento. Esta revisión describe el progreso realizado en el esclarecimiento de su diagnóstico clínico y de laboratorio e incluye avances recientes en genética, biología molecular, histopatología, marcadores bioquímicos, diagnóstico por imágenes radiológico y centellográfico y endoscopia de los tumores carcinoides gastrointestinales.

Palabras clave
Carcinoide, tumores neuroendocrinos, carcinoide gastrointestinal, somatostatina, octreoscan


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RECENT ADVANCES IN DIAGNOSIS OF GASTROINTESTINAL CARCINOID TUMORS

Abstract
The carcinoid tumor, argentaffinoma, is a member of a very exclusive neoplastic family known as neuroendocrine or amine precursor uptake and decarboxylation (APUD) tumors. Carcinoids have been found to arise from almost every organ and system derived from the primitive endoderm, but most frequently originated from the gastrointestinal tract, accounting for approximately half of all gastrointestinal endocrine tumors. Over 95% of all gastrointestinal carcinoids are located in only three sites: the appendix, rectum and small intestine. Irrespectively to their location, carcinoids are capable of producing various peptides. These tumors may present at different disease stages with either hormonal or hormonal-related symptoms/syndromes, or without hormonal symptoms and may occur either sporadically or as a part of hereditary syndromes. Their clinical course is often indolent but can also be aggressive and resistant to treatment. This review provides a broad outline of progress that has been made in the elucidation of their clinical and laboratory diagnosis including recent advances in genetics, molecular biology, histopathology, biochemical markers, radiologic and scintigraphic imaging and endoscopy of gastrointestinal carcinoid tumors.

Key words
Carcinoid, neuroendocrine tumors, gastrointestinal carcinoid, somatostatin, octreoscan


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Especialidades
Principal: Gastroenterología
Relacionadas: Anatomía Patológica, Diagnóstico por Imágenes, Endocrinología y Metabolismo, Medicina Interna, Oncología



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Enviar correspondencia a:
Dimitrios Dimitroulopoulos, Department of Gastroenterology, "Agios Savvas" Cancer Hospital, GR-152 34, 35 Parnassou str., Halandri, Atenas, Grecia
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