Expertos Invitados





MANEJO TERAPEUTICO DE LA INFECCION CRONICA POR VIRUS DE LA HEPATITIS C

(especial para SIIC © Derechos reservados)
El trabajo intenta recopilar toda la información práctica necesaria para valorar el tratamiento de los pacientes con esta prevalente enfermedad, tanto de los que nunca fueron tratados como de aquellos tratados pero con circunstancias especiales.
Autor:
Nicolás García gonzález
Columnista Experto de SIIC

Institución:
Clínica Universitaria, Universidad de Navarra

Artículos publicados por Nicolás García gonzález
Coautores
Marta Gómez Llorente* Manuel Herrero Trujillano* Amaya Ros Abando* Eliana Rueda Mesa* 
Médico, Departamento de Medicina Interna, Unidad de Hepatología, Clínica Universitaria, Universidad de Navarra, Pamplona, España*
Recepción del artículo
22 de Mayo, 2006 		Aprobación
8 de Junio, 2006
Primera edición
20 de Julio, 2007 		Segunda edición, ampliada y corregida
7 de Junio, 2021

MANEJO TERAPEUTICO DE LA INFECCION CRONICA POR VIRUS DE LA HEPATITIS C

Resumen
En las últimas cuatro décadas se prodjeron indudables avances en el tratamiento de la hepatitis crónica por virus C, que permitieron al menos triplicar las tasas de respuesta sostenida. A pesar de ello, son numerosos los interrogantes aún sin despejar. En este artículo se revisa someramente el estado actual del tratamiento de la infección crónica por virus C, con especial alusión a cuestiones debatidas, como la selección de los candidatos a recibir tratamiento médico, el tratamiento de situaciones especiales como la coinfección por el virus de la inmunodeficiencia humana o la hepatitis postrasplante y el papel del tratamiento en la prevención de complicaciones.

Palabras clave
Hepatitis, virus C, interferón, ribavirina, cirrosis


Artículo completo
(castellano)
Extensión:  +/-4.51 páginas impresas en papel A4
Exclusivo para suscriptores/assinantes

MANAGEMENT OF CHRONIC HEPATITIS C VIRAL INFECTION

Abstract
In the last four decades, a huge improvement in the treatment of chronic hepatitis C has been achieved and the complete response rate has almost tripled. However, there are still some fields of discussion, such as the adequate dose and ideal duration of the treatment, the treatment of non responder patients or those coinfected with HIV, the management of the postransplant hepatitis or the use of interferon in children. The last update on some of these issues is presented in this revision.

Key words
Hepatitis, ribavirin, C virus, interferon, cirrosis, hepatitis

Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Infectología
Relacionadas: Farmacología, Gastroenterología, Medicina Farmacéutica, Medicina Interna



Comprar este artículo
Extensión: 4.51 páginas impresas en papel A4

file05.gif (1491 bytes) Artículos seleccionados para su compra



Enviar correspondencia a:
Nicolás García González, Clínica Universitaria de Navarra, 31008, Avenida Pío XII 36, Pamplona, España
Bibliografía del artículo
1. Hoofnagle JH, Mullen KD, Jones DB, et al. Treatment of chronic non-A, non-B hepatitis with recombinant human alpha interferon. A preliminary report. N Engl J Med 1986; 315:1575-8.
2. Manns MP, McHutchinson JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001; 358:958-65.
3. Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2ª plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347:975-982.
4. Poynard T, McHutchinson JG, Manns M, et al. Impact of pegylated alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C. Gastroenterology 2002; 122(5):1303-13.
5. Berg T, Von Wagner N, Nasser S, et al. Extended treatment duration for hepatitis C virus type 1: Comparing 48 versus 72 weeks of peginterferon-alfa-2a plus ribavirin. Gastroenterology 2006; 130:1086-1097.
6. Zeuzem S, Buti M, Ferenci P, Sperl J, Horsman Y, Cianciara J et al. Efficacy of 24 weeks treatment with peginterferon alfa-2b plus ribavirin in patients with chronic hepatitis C infected with genotype 1 and low pretreatment viremia. J Hepatol 2006; 44:97-103.
7. Mangia A, Santoro R, Minerva N, Ricci GL, Caretta V, Perisco M et al. Peginterferon alfa-2b and ribavirin for 12 vs 24 weeks in HCV genotype 2 or 3. N Engl J Med 2005; 352:2609-2617.
8. Von Wagner M, Huber M, Berg T, Hinrichsen H, Rasenack J, Heintges T, et al. Peginterferon alpha-2a (40KD) and ribavirin for 16 or 24 weeks in patients with genotype 2 or 3 chronic hepatitis C. Gastroenterology 2005; 129:522-527.
9. Davis GL. Tailoring antiviral therapy in hepatitis C. Hepatology 2006; 43:909-911.
10. Nishiguchi S, Shiomi S, Nakatani S et al. Prevention of hepatocellular carcinoma in patients with chronic active hepatitis C and cirrosis. Lancet 2001; 357:196-197.
11. Takimoto M, Ohkoshi S, Ichida T et al. Interferon inhibits progression of liver fibrosis and reduces the risk of hepatocarcinogenesis in patients with chronic hepatitis C: a retrospective multicenter analysis of 652 patients. Dig Dis Sci 2002; 47:170-6.
12. Ikeda K, Saitoh S, Kobayashi M et al. Long-term interferon therapy for 1 year or longer reduces the hepatocellular carcinogenesis rate in patients with liver cirrhosis caused by hepatitis C virus: a pilot study. J Gastroenterol Hepatol 2001; 16:406-15.
13. Papatheodoridis GV, Papadimitropoulos VC, Hadziyannis SJ. Effect of interferon therapy on the development of hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis: a meta-analysis. Aliment Pharmacol Ther 2001; 15:689-98.
14. Camma C, Giunta M, Andreone P, Craxi A. Interferon and prevention of hepatocellular carcinoma in viral cirrhosis: an evidence-based approach. J Hepatol 2001; 34:593-602.
15. Soga K, Shibasaki K, Aoyagi Y. Effect of interferon on incidence of hepatocelullar carcinoma in patients with chronic hepatitis C. Hepatogastroenterology 2005; 52:1154-8.
16. Hino K, Kitase A, Satoh Y, et al. Interferon retreatment reduces or delays the incidence of hepatocellular carcinoma in patients with chronic hepatitis C. J Viral Hepat 2002; 9:370-376.
17. Schaefer M, Schmidt F, Folwaczny C, et al. Adherence and mental side effects during hepatitis C treatment with interferon alfa and ribavirin in psychiatric risk groups. Hepatology 2003; 37:443-451.
18. Patel K, Muir AJ, McHutchison JG. Diagnosis and treatment of chronic hepatitis C. BMJ 2006; 332:1013-1017.
19. Shiffman ML, Di Bisceglie AM, Lindsay KL, Morishima C, Wright EC, Everson GT, et al. Peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatment. Gastroenterology 2004; 126:1015-1023.
20. Taliani G, Gemignani G, Ferrari C, Aceti A, Bartolozzi D, Blanc PL, et al. Pegylated interferon alfa-2b plus ribavirin in the retreatment of interferon-ribavirin nonresponder patients. Gastroenterology 2006; 130:1098-1106.
21. Younossi ZM, McCullough AC, Barnes DS, Post A, Ong JP, O'Shea R, et al. Pegylated interferon alpha-2b, ribavirin and amantadine for chronic hepatitis C. Dig Dis Sci. 2005; 50:970-5.
22. Shiffman ML, Diago M, Tran A, Pockros P, Reindollar R, Prati D, et al. Chronic hepatitis C in patients with persistently normal alanine transaminase levels. Clin Gastroenterol Hepatol 2006; 4:645-652.
23. Zeuzem S, Diago M, Gane E, Reddy KR, Pockros P, Prati D, et al. Peginterferon alfa-2a (40 kilodaltons) and ribavirin in patients with chronic hepatitis C and normal aminotransferase levels. Gastroenterology 2004; 127:1724-1732.
24. Alberti A, Clumeck N, Collins S, et al. Short statement of the first European consensus conference on the treatment of chronic hepatitis B and C in HIV co-infected patients. J Hepatol 2005; 42:615-624.
25. Torriani FJ, Rodriguez-Torres M, Rockstroh JK et al. Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection in HIV-Infected patients. N Engl J Med 2004; 351:438-450.
26. Lichterfeld M, Haas S, Fischer HP, Voigt E, Rockstroh JK and Spengler U. Liver histopathology in HIV-hepatitis C virus co-infected patients with fatal liver disease. J Gastroenterol Hepatol 2005; 20:739-745.
27. Moreno A, Bárcena R, García-Garzón S, et al. HCV clearance and treatment outcome in genotipe 1 HCV-monoinfected, HIV-coinfected and liver transplanted patients on peg-IFN-2b/Ribavirin. J Hepatol 2005; 43:783-790.
28. Bräu N. Chronic hepatitis C in patients with HIV/AIDS: a new challenge in antiviral therapy. J Antimicrob Chemother 2005; 56:991-995.
29. Yedibela S, Schuppan D, Muller V, Schellerer V, Tannapfel A, Hohenberger W, et al. Successful treatment of hepatitis C reinfection with interferon- alpha 2b and ribavirin after liver transplantation. Liver Int 2005; 25:717-22.
30. Berenguer M, Prieto M, Palau A, Carrasco D, Rayon JM, Calvo F, et al. Recurrent hepatitis C genotype 1b following liver transplantation: treatment with combination interferon-ribavirin therapy. Eur J Gastroenterol Hepatol 2004; 16:1131-3.
31. Inove K, Yoshiba M. Interferon combined with cyclosporine treatment as an effective countermeasure against hepatitis C virus recurrence in liver transplant patients with end-stage hepatitis C virus related disease. Transplant Proc 2005; 37:1233-4.
32. Bizollon T, Adham M, Pradat P, Chevallier M, Ducerf C, Baulieux J, et al. Triple antiviral therapy with amantadine for IFN-ribavirin nonresponders with recurrent posttransplantation hepatitis C. Transplantation 2005; 79:325-9.
33. Oton E, Bárcena R, García-Garzón S, Moreno Zamora A, Moreno A, García González M, et al. Pegylated interferon and ribavirin for the recurrence of chronic hepatitis C genotype 1 in transplant patients. Transplant Proc 2005; 37:3963-4.
34. Dumortier J, Scoazec JY, Chevallier P, Boillot O. Treatment of recurrent hepatitis C after liver transplantation: a pilot study of peginterferon alfa-2b and ribavirin combination. J Hepatol 2004; 40:669-74.
35. González Peralta RP, Kelly DA, Haber B, Molleston J, Murray KF, Jonas MM et al. Interferon alfa 2b in combination with ribavirin for the treatment of chronic hepatits C in children: efficacy, safety and pharmacokinetics. Hepatology 2005; 42:1010-8. 36. Wirth S, Pipier-Boustani H, Lang T, Ballauff A, Kullmer U, Gerner P et al. Peginterferon alfa-2b plus ribavirin treatment in children and adolescent with chronic hepatits C. Hepatology 2005; 41:1013-8.
 
 
 
 
 
 
 
 
 
 
 
 
Está expresamente prohibida la redistribución y la redifusión de todo o parte de los contenidos de la Sociedad Iberoamericana de Información Científica (SIIC) S.A. sin previo y expreso consentimiento de SIIC.
ua31618
Inicio/Home

Copyright siicsalud © 1997-2024 ISSN siicsalud: 1667-9008