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LOS RESULTADOS DE LA ADMINISTRACION DE SECRETINA PARA TRATAR EL AUTISMO SE RELACIONARIAN CON LAS CARACTERISTICAS DE CADA PACIENTE

(especial para SIIC © Derechos reservados)
Se propuso la existencia de un "subtipo gastrointestinal" de niños autistas que responden de manera positiva a la administración de secretina. No obstante, los resultados de los estudios efectuados hasta el momento son heterogéneos.
kern9.jpg Autor:
Janet Kern
Columnista Experto de SIIC

Institución:
Department of Psychiatry, University of Texas Southwestern Medical Center

Artículos publicados por Janet Kern
Coautores
Lavanya Bhaskara* Madhukar Trivedi** 
MS, University of Texas Southwestern Medical Center, Dallas, EE.UU.*
MD, University of Texas Southwestern Medical Center, Dallas, EE.UU.**
Recepción del artículo
19 de Septiembre, 2006 		Aprobación
16 de Mayo, 2006
Primera edición
21 de Septiembre, 2006 		Segunda edición, ampliada y corregida
7 de Junio, 2021

LOS RESULTADOS DE LA ADMINISTRACION DE SECRETINA PARA TRATAR EL AUTISMO SE RELACIONARIAN CON LAS CARACTERISTICAS DE CADA PACIENTE

Resumen
El autismo es un trastorno neurológico complejo que altera gravemente la capacidad del niño para comunicarse e interactuar en sociedad. Debido a la heterogeneidad de la población afectada y a la falta de un entendimiento claro de su etiología, se probó la administración de diferentes tratamientos para lograr el alivio de los síntomas. No obstante, el éxito es limitado. Luego de que Horvath y col. informaran, en 1998, la obtención de mejorías sintomáticas en niños autistas que habían recibido secretina, este agente se popularizó como una posible opción terapéutica. Con el objetivo de evaluar la efectividad de la administración de secretina para el tratamiento del autismo se llevaron a cabo muchos estudios. Si bien en algunos de los primeros trabajos efectuados se informaron resultados heterogéneos, en estudios realizados más recientemente se sugirió la falta de efectividad de la secretina para el tratamiento de los pacientes con autismo. No obstante, el estudio sobre la administración de secretina para tratar el autismo continúa. La presente revisión es una actualización de la primera investigación efectuada al respecto. Además, se discuten los estudios no incluidos en la revisión original.

Palabras clave
Autismo, secretina, tratamiento, ensayos


Artículo completo
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EVALUATING SECRETIN IN THE MANAGEMENT OF AUTISM

Abstract
Autism is a complex neurological disorder that severely impacts a child's ability to communicate and interact socially. Due to the heterogeneity of the population and a lack of clear understanding of the etiology, several treatments have been attempted to alleviate the symptoms of autism, though with limited success. After Horvath et al., in 1998, reported improvements in symptoms of children with autism who had received secretin, it became popular as a possible treatment for autism. Many studies were conducted to test the effectiveness of secretin in treating autism. Although some early studies showed mixed results, most recent studies have suggested that secretin may not be effective for the treatment of autism. Studies on secretin in autism continue. The current review is an update on the earlier review and discusses more recent studies not in the original review.

Key words
Autism, secretin, treatment, trials


Full text
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Especialidades
Principal: Bioquímica, Salud Mental
Relacionadas: Bioética, Farmacología, Gastroenterología, Medicina Farmacéutica, Medicina Interna, Pediatría



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Janet Kern, University of Texas Southwestern Medical Center, 75390-9119, American General Tower 6363 Forest Park Rd., Suite 13.354, Dallas, EE.UU.
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