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PAPEL DE LOS BIFOSFONATOS PARA EL TRATAMIENTO DE LAS METASTASIS OSEAS Y EL MANTENIMIENTO DE LA SALUD OSEA

(especial para SIIC © Derechos reservados)
El ácido zoledrónico es el único bifosfonato que mostró una reducción estadísticamente significativa en la incidencia y en el comienzo de las complicaciones esqueléticas, en comparación con placebo, en pacientes con metástasis óseas por cáncer de próstata, de pulmón y otros tumores sólidos.
lipton9.jpg Autor:
Allan Lipton
Columnista Experto de SIIC

Institución:
Milton S. Hershey Medical Center

Artículos publicados por Allan Lipton
Recepción del artículo
10 de Marzo, 2005 		Primera edición
3 de Octubre, 2005 		Segunda edición, ampliada y corregida
7 de Junio, 2021

PAPEL DE LOS BIFOSFONATOS PARA EL TRATAMIENTO DE LAS METASTASIS OSEAS Y EL MANTENIMIENTO DE LA SALUD OSEA

Resumen
La mayoría de los pacientes con cáncer avanzado presentan metástasis óseas dolorosas y debilitantes que están asociadas con morbilidad esquelética a largo plazo. Las lesiones óseas provocan complicaciones esqueléticas clínicamente significativas como dolor óseo, fracturas patológicas y compresión de la médula espinal. El beneficio clínico con ácido zoledrónico –bifosfonato de tercera generación– para la prevención de complicaciones esqueléticas en pacientes con patología ósea metastásica fue revisado previamente (Lipton A. Cancer Invest. 2002; 20[suppl 2]:45-54). Se vio que el ácido zoledrónico es al menos tan efectivo como el pamidronato para el tratamiento de complicaciones esqueléticas en pacientes con metástasis en los huesos secundarias a cáncer de mama, y es el único bifosfonato que mostró una reducción estadísticamente significativa en la incidencia y en el comienzo de dichas complicaciones, en comparación con placebo, en pacientes con metástasis por cáncer de próstata, de pulmón y de otros tumores sólidos. En este trabajo presentamos una importante puesta al día con respecto a nuestra investigación previamente publicada y que mostró el beneficio de los bifosfonatos para la reducción del dolor óseo en pacientes con enfermedad metastásica, para la prevención de la pérdida ósea inducida por el tratamiento del cáncer y metástasis óseas en pacientes con enfermedad no metastásica.

Palabras clave
Bifosfonatos, metástasis óseas, salud ósea


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ROLE OF BISPHOSPHONATES FOR THE MANAGEMENT OF BONE METASTASES AND THE MAINTENANCE OF BONE HEALTH

Abstract
The majority of patients with advanced cancer develop painful and debilitating bone metastases that are associated with long-term skeletal morbidity. Bone lesions lead to clinically significant skeletal complications including bone pain, pathologic fractures, and spinal cord compression. The clinical benefit of the third-generation bisphosphonate zoledronic acid for the prevention of skeletal complications in patients with metastatic bone disease has been previously reviewed (Lipton A. Cancer Invest. 2002;20[suppl 2]:45-54). Zoledronic acid has been shown to be at least as effective as pamidronate for the treatment of skeletal complications in patients with bone metastases secondary to breast cancer, and is the only bisphosphonate that has demonstrated a statistically significant reduction in the incidence and onset of skeletal complications compared with placebo in patients with bone metastases from prostate cancer, lung cancer, and other solid tumors. Herein, we present important updates to the information reviewed in the previous publication, as well as recent data that have emerged demonstrating the benefit of bisphosphonates for the reduction of bone pain in patients with metastatic disease and for the prevention of cancer treatment-induced bone loss and bone metastases in patients with nonmetastatic disease.

Key words
Bisphosphonates, bone metastases, bone health


Full text
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Especialidades
Principal: Oncología
Relacionadas: Medicina Farmacéutica, Medicina Interna



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Bibliografía del artículo
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Título español
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 Bibliografía
 Artículo completo
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