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TERAPIA DE REEMPLAZO HORMONAL Y RIESGO DE DEMENCIA

(especial para SIIC © Derechos reservados)
Evaluación de la información reciente y discusión de posibles explicaciones y mecanismos relacionados con el riesgo de demencia en las pacientes que reciben terapia de reemplazo hormonal.
levinean9.jpg Autor:
Andrew j. Levine
Columnista Experto de SIIC

Institución:
Department of Psychiatry and Biobehavioral Science UCLA School of Medicine

Artículos publicados por Andrew j. Levine
Coautor
Karen Miller, Ph.D* 
UCLA School of Medicine. Department of Psychiatry and Biobehavioral Science.*
Recepción del artículo
6 de Diciembre, 2004 		Aprobación
28 de Diciembre, 2004
Primera edición
11 de Octubre, 2005 		Segunda edición, ampliada y corregida
7 de Junio, 2021

TERAPIA DE REEMPLAZO HORMONAL Y RIESGO DE DEMENCIA

Resumen
La terapia de reemplazo hormonal (TRH) ha recibido apoyo generalizado como medida preventiva para la enfermedad de Alzheimer (EA). Sin embargo, estudios recientes indican que la TRH en realidad puede aumentar el riesgo de EA y de otras enfermedades neurodegenerativas en determinadas poblaciones. En el presente informe, revisamos estudios recientes, discutimos explicaciones y mecanismos posibles del aumento del riesgo observado y señalamos vías potenciales para la investigación futura.

Palabras clave
Terapia de reemplazo hormonal (TRH), estrógeno, progestina, demencia, enfermedad de Alzheimer, demencia frontotemporal


Artículo completo
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HORMONE REPLACEMENT THERAPY AND THE RISK OF DEVELOPING DEMENTIA

Abstract
Hormone replacement therapy (HRT) has received widespread support as a preventative measure for Alzheimer’s disease (AD). However, recent studies have indicated that HRT may in fact raise the risk of AD and other neurodegenerative diseases in certain populations. In the current paper, we review these recent studies, discuss possible explanations and mechanisms for the observed increase in risk, and point out potential avenues for future research.

Key words
Hormone replacement therapy (HRT), estrogen, progestin, dementia, Alzheimer’s disease, frontotemporal dementia


Full text
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Especialidades
Principal: Obstetricia y Ginecología
Relacionadas: Atención Primaria, Bioética, Bioquímica, Endocrinología y Metabolismo, Farmacología, Medicina Familiar, Medicina Farmacéutica, Medicina Interna, Salud Mental



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Patrocinio y reconocimiento:
La beca de investigación del Dr. Levine (T-32 MH19535) es financiada por el NIMH. Un agradecimiento especial a Sarah Spina por su arduo trabajo.
Bibliografía del artículo
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