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ENFOQUE CLINICO Y DE LABORATORIO DEL AUMENTO DE LA FUNCION Y NUMERO DE PLAQUETAS

(especial para SIIC © Derechos reservados)
La trombosis es la manifestación clínica principal del síndrome de hiperactividad de las plaquetas y de la trombocitemia esencial. La heterogeneidad de los sitios afectados por la trombosis es una de las características que sugieren estos cuadros.
Autor:
Anna Dyszkiewicz-korpanty
Columnista Experto de SIIC

Institución:
Department of Medicine University Texas Southwestern Medical Center at Dallas Texas, USA

Artículos publicados por Anna Dyszkiewicz-korpanty
Coautores
Yu-Min Shen*  Ravindra Sarode**  Eberhard Mammen***  Eugene Frenkel**** 
MD, Assistant Professor, Internal Medicine. Department of Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas*
MD, Associate Professor of Pathology. Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas**
MD, Professor of Obstetrics and Gynecology. Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI***
MD, Professor, Internal Medicine. Department of Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas****
Recepción del artículo
4 de Noviembre, 2004 		Primera edición
21 de Octubre, 2005 		Segunda edición, ampliada y corregida
7 de Junio, 2021

ENFOQUE CLINICO Y DE LABORATORIO DEL AUMENTO DE LA FUNCION Y NUMERO DE PLAQUETAS

Resumen
Las plaquetas desempeñan un papel crítico en la hemostasia, de manera tal que las alteraciones de la función y del número de plaquetas pueden desencadenar estados trombohemorrágicos. Está demostrado que el aumento de la reactividad plaquetaria (plaquetas hiperactivas) se observa en una variedad de estados clínicos o genéticos que pueden concluir en acontecimientos trombóticos. Además, el aumento de la función de las plaquetas puede coexistir con alteraciones en el número de éstas en situaciones de trombocitosis o trombocitemia. En este trabajo se realiza una revisión de los aspectos clínicos, fisiopatológicos y de laboratorio relacionados con el síndrome de hiperactividad plaquetaria. También se describe cómo reconocer los aspectos clínicos y el enfoque diagnóstico y terapéutico de la trombocitosis benigna con aumento en el número de plaquetas y de la lesión mieloproliferativa de la trombocitemia.

Palabras clave
Síndrome de hiperactividad de plaquetas, trombocitosis, trombocitemia


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CLINICAL AND LABORATORY APPROACH TO PLATELET HYPERFUNCTION AND INCREASED PLATELET NUMBER

Abstract
Platelets play a critical role in hemostasis, thus alterations of platelet function and number may result in clinical thrombohemorrhagic states. It has become clear that increased platelet reactivity (i.e. hyperactive platelets) can be observed in a variety of genetic and clinical states with resultant thrombotic events. In addition, platelet hyperfunction may co-exist with increased platelet number in the circumstances of thrombocytosis and thrombocythemia. Herein we review the clinical, pathophysiological and laboratory issues related to hyperactive platelet syndrome. In addition, clinical recognition, diagnostic and therapeutic approach to increased platelet number in the benign state of thrombocythosis and the myeloproliferative lesion of thrombocythemia are reviewed.

Key words
Hyperactive platelet syndrome, thrombocythosis, thrombocythemia


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Especialidades
Principal: Hematología
Relacionadas: Bioquímica, Diagnóstico por Laboratorio, Medicina Interna



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