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CUALES SON LAS CAUSAS DEL CANCER DE TESTICULO

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El consumo de alimentos contaminados con ocratoxina A durante el embarazo y la lactancia podría provocar lesiones a nivel del ADN testicular en la descendencia. Estas lesiones podrían evolucionar hacia el cáncer de testículo durante la pubertad.
schwartz9.jpg Autor:
Schwartz, gary
Columnista Experto de SIIC

Institución:
Comprehensive Cancer Center Wake Forest University North Carolina, USA

Artículos publicados por Schwartz, gary
Recepción del artículo
14 de Julio, 2004 		Aprobación
21 de Julio, 2004
Primera edición
21 de Febrero, 2005 		Segunda edición, ampliada y corregida
7 de Junio, 2021

CUALES SON LAS CAUSAS DEL CANCER DE TESTICULO

Resumen
La etiología del cáncer de testículo es un misterio desde el punto de vista epidemiológico. Planteamos la hipótesis de que la causa del cáncer de testículo es la ocratoxina A, un carcinógeno genotóxico, contaminante natural de cereales, carne de cerdo y otros alimentos. Los factores clave en la epidemiología descriptiva son: una alta incidencia en los países del Norte de Europa, aumento de la incidencia a lo largo del tiempo, asociación con la clase social alta y mala calidad del semen; todos ellos relacionados con la ocratoxina A. Demostramos que la distribución geográfica del cáncer de testículo se podría correlacionar con el consumo de café y carne porcina, alimentos en los que la contaminación por ocratoxina A es común. La ocratoxina A es un carcinógeno que atraviesa la barrera placentaria y puede provocar la aparición de aductos en el ADN fetal. Proponemos que el consumo de alimentos contaminados con ocratoxina A durante el embarazo y en la niñez o en ambas induce la aparición de lesiones en el ADN testicular que evolucionan hacia el cáncer de testículo durante la pubertad.

Palabras clave
Ocratoxina A, micotoxinas, cáncer de testículo, dieta, epidemiología


Artículo completo
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WHAT CAUSES HUMAN TESTICULAR CANCER

Abstract
The etiology of testicular cancer is an epidemiologic mystery. We hypothesize that testicular cancer is caused by ochratoxin A, a genotoxic carcinogen that is a naturally-occurring contaminant of cereals, pigmeat, and other foods. The key features of the descriptive epidemiology of testicular cancer: a high incidence in northern Europe, increasing incidence over time, and associations with high socioeconomic status and poor semen quality, are all associated with exposure to ochratoxin A. We show that the geographic distribution of testicular cancer is positively correlated with the consumption of pork and coffee, foods commonly contaminated with ochratoxin A. ochratoxin A is a transplacental carcinogen that can cause adducts in fetal DNA. We propose that consumption of foods contaminated with ochratoxin A during pregnancy and/or childhood induces lesions in testicular DNA and that puberty promotes these lesions to testicular cancer.

Key words
Ochratoxin A, mycotoxin, testicular cancer, diet, epidemiology


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Especialidades
Principal: Oncología
Relacionadas: Bioquímica, Diagnóstico por Laboratorio, Medicina Interna, Urología



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Schwartz, Gary
Patrocinio y reconocimiento:
Agradecimientos: El presente trabajo sobre la etiología del cáncer de testículo es respaldado por una beca de investigación para trabajos de campo financiada por Wake Forest University y otra financiada por Lance Armstrong Foundation.
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