RADIACION Y HETEROGENEIDAD DE LA POBLACION COMO CAUSA DE NEOPLASIAS EN NIÑOS

(especial para SIIC © Derechos reservados)
El grupo de casos de leucemia y linfomas no Hodgkin en Seascale es muy probable que se deba a la heterogeneidad de sus habitantes, si bien la irradiación preconcepcional paterna puede también desempeñar un papel.
dickinson9.jpg Autor:
H o Dickinson
Columnista Experto de SIIC
Artículos publicados por H o Dickinson
Coautor
Louise Parker PhD* 
North of England Children’s Cancer Research Unit. Paediatric and Lifecourse Epidemiology Research Group. Sir James Spence Institute of Child Health. University of Newcastle. Royal Victoria Infirmary*
Recepción del artículo
25 de Febrero, 2004
Aprobación
4 de Marzo, 2004
Primera edición
10 de Marzo, 2005
Segunda edición, ampliada y corregida
7 de Junio, 2021

Resumen
Objetivo: La revisión de datos acerca de las asociaciones entre la heterogeneidad de la población, la irradiación preconcepcional paterna (IPP) y neoplasias infantiles entre los descendientes de trabajadores varones de la industria nuclear. Población y localización: Entre los 266 710 niños nacidos entre 1950 y 1991 en el condado de Cumbria, noroeste de Inglaterra, se produjeron 563 casos de neoplasias; 9 859 de esos niños, entre los que se detectaron 31 casos de neoplasias, tenían padres empleados como trabajadores en la instalación nuclear de Sellafield. Métodos: Estudios de cohorte, analizados con el empleo de modelos lineales generalizados, tomando en consideración las variables demográficas. Resultados: Encontramos asociación entre la heterogeneidad de la población y el riesgo de leucemia infantil y linfoma no Hodgkin; menor asociación entre el riesgo de presentar algunos tumores sólidos y la movilidad parental; una relación entre dosis y respuesta entre la IPP y el riesgo de leucemia y linfoma no Hodgkin que fue independiente de la heterogeneidad de la población, y falta de relación entre la IPP y el riesgo para los tumores sólidos. La heterogeneidad de la población podría ser la causa del exceso importante de casos de leucemia y linfomas no Hodgkin entre los jóvenes en el poblado de Seascale, adyacente a Sellafield. Los niños de los trabajadores de la industria nuclear tienen mayor riesgo de presentar tumores sólidos, que se explica por la movilidad parental. Conclusiones: Es muy probable que el grupo de casos de pacientes con leucemia y linfoma en Seascale sea debido a la heterogeneidad de la población, si bien también puede jugar un papel la IPP.

Palabras clave
Irradiación preconcepcional paterna, neoplasias infantiles, epidemiología, Sellafield


Artículo completo

(castellano)
Extensión:  +/-9.75 páginas impresas en papel A4
Exclusivo para suscriptores/assinantes

Abstract
Objective: To review the evidence for associations between population mixing, paternal preconceptional irradiation (PPI) and childhood cancer in offspring of male radiation workers. Population and setting: 266 710 children born during 1950-91 in the county of Cumbria, north west England, including 563 cancer cases; 9 859 of the children, including 31 cancer cases, had fathers employed as radiation workers at Sellafield nuclear installation. Methods: Cohort studies, analysed using generalised linear models, allowing for demographic variables. Results: We found (i) an association between population mixing and risk of childhood leukaemia and non-Hodgkin’s lymphoma, (ii) a weaker association between risk of some solid tumours and parental mobility, (iii) a dose-response relation between PPI and risk of leukaemia and non-Hodgkin’s lymphoma which was independent of population mixing, and (iv) no association between PPI and risk of solid tumours. Population mixing could account for the marked excess of leukaemia and lymphoma in young people in the village of Seascale, adjacent to Sellafield. Children of radiation workers had an increased risk of solid tumours, which was largely explained by parental mobility. Conclusions: The cluster of leukaemia and lymphoma in Seascale is likely to be largely due to population mixing, but PPI may also play a part.

Key words
Paternal preconceptional irradiation, childhood cancer, epidemiology, Sellafield


Full text
(english)
para suscriptores/ assinantes

Clasificación en siicsalud
Artículos originales > Expertos del Mundo >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Hematología, Medicina Nuclear
Relacionadas: Diagnóstico por Laboratorio, Genética Humana, Medicina Interna, Oncología, Salud Pública



Comprar este artículo
Extensión: 9.75 páginas impresas en papel A4

file05.gif (1491 bytes) Artículos seleccionados para su compra




Patrocinio y reconocimiento:
Agradecemos al Dr. Trevor Dummer por dibujar el mapa.
Bibliografía del artículo
  1. Cutler J. Windscale, the nuclear laundry. Yorkshire Television. 1983.
  2. Black D. Report of the Independent Advisory Group. Investigation of the possible increased incidence of cancer in West Cumbria. London: HMSO, 1984.
  3. Committee on Medical Aspects of Radiation in the Environment (COMARE). Fourth report. The incidence of cancer and leukaemia in young people in the vicinity of the Sellafield site, West Cumbria: further studies and an update of the situation since the publication of the Black Advisory group in 1984. Department of Health, London, 1996.
  4. Draper GJ, Stiller CA, Cartwright RA, et al. Cancer in Cumbria and in the vicinity of the Sellafield nuclear installation, 1963–1990. BMJ 1993;306:89-94.
  5. Gardner MJ, Snee MP, Hall AJ, et al. Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. BMJ 1990;300:423-434.
  6. Kinlen LJ. Can paternal preconceptional radiation account for the increase of leukaemia and non-Hodgkin’s lymphoma in Seascale BMJ 1993;306:1718-1721.
  7. Kinlen LJ. Infection, childhood leukaemia and the Seascale cluster. Radiological Protection Bulletin 2000;226:9-18.
  8. HSE. Investigation of leukaemia and other cancers in the children of male workers at Sellafield. Sudbury, UK: HSE Books, 1993.
  9. HSE. Investigation of leukaemia and other cancers in the children of male workers at Sellafield: Review of results published in October 1993. Sudbury, UK: HSE Books, 1994.
  10. Dickinson HO, Parker L. Leukaemias and non-Hodgkin’s lymphoma in children of Sellafield male radiation workers. International Journal of Cancer 2002;99:437-444.
  11. Dickinson HO, Parker L. Leukaemias and non-Hodgkin’s lymphoma in children of male Sellafield radiation workers (Letter). International Journal of Cancer 2002;101:100.
  12. Dickinson HO, Parker L, Salotti J, et al. Paternal preconceptional irradiation, population mixing and solid tumours in the children of radiation workers. Cancer Causes and Control 2002;13:183-189.
  13. Dickinson HO, Parker L, Binks K, et al. The sex ratio of Cumbrian children in relation to paternal preconceptional radiation dose: a study in Cumbria, Northern England. J Epidemiol Community Health 1996;50:645-652.
  14. Parker L, Pearce MS, Dickinson HO, et al. Stillbirths among the offspring of male radiation workers at the Sellafield nuclear reprocessing plant. Lancet, 1999;354:1407-1414.
  15. Parker L, Craft AW, Pearce MS, et al. Stillbirths among offspring of male radiation workers – Reply Lancet, 2000;355:493.
  16. Pearce MS, Dickinson HO, Aitkin M, et al. Stillbirths among the offspring of male radiation workers at the Sellafield nuclear reprocessing plant: detailed results and statistical aspects. Journal of the Royal Statistical Society A 2002;165:523-548.
  17. Dickinson HO, Parker L. Quantifying the effect of population mixing on childhood leukaemia risk: the Seascale cluster. British Journal of Cancer 1999;81:141-151.
  18. Boutou O, Guizard AV, Slama R, et al. Population mixing and leukaemia in young people around the La Hague nuclear waste reprocessing plant. British Journal of Cancer 2002;87:740-745.
  19. Kinlen LJ, Dickson M, Stiller CA Childhood leukaemia and non-Hodgkin’s lymphoma near large rural construction sites, with a comparison with Sellafield nuclear site BMJ 1995;310:763-768.
  20. Nyari TA, Dickinson HO, Hammal DM, Parker L. Childhood solid tumours in relation to population mixing around the time of birth. British Journal of Cancer 2003;88:1370-1374.
  21. Roman E, Doyle P, Maconochie N et al. Cancer in children of nuclear industry employees: report on children aged under 25 years from nuclear industry family study. BMJ 1999;318:1443-1450.
  22. Draper GJ, Little MP, Sorahan T et al. Cancer in the offspring of radiation workers: a record linkage study. BMJ 1997;315:1181-1188.
  23. Dickinson HO, Hodgson JT, Parker L. Comparison of HSE and Cumbrian birth cohort studies of risk of leukaemia/non-Hodgkin’s lymphoma in relation to paternal preconceptional irradiation. Journal of Radiological Protection 2003;23:385-403.
  24. Committee on Medical Aspects of Radiation in the Environment (COMARE). Seventh report. Parents occupationally exposed to radiation prior to the conception of their children: a review of the evidence concerning the incidence of cancer in their children. National Radiological Protection Board, Didcot, 2002.
  25. Cattenach BM, Papworth D, Patrick G et al. Investigation of lung tumour induction in C3H/HeH mice, with and without tumour promotion with urethane, following paternal X-irradiation. Mutation Research 1998;403:1-12.
  26. Daher A, Varin M, Lamontagne Y et al. Effect of pre-conceptional external or internal irradiation of N5 male mice and the risk of leukaemia in their offspring. Carcinogenesis 1998;19:1553-1558.
  27. Mohr U, Dasenbrock C, Tillman T, et al. Possible carcinogenic effects of X-rays in a transgenerational study with CBA mice. Carcinogenesis 1999;20:325-332 .
  28. Lord BI, Woolford LB, Wang L, et al. Tumour induction by methylnitroso-urea following preconceptional paternal contamination with plutonium-239. Br J Cancer 1998;78:301-11.
  29. Sever LE, Gilbert ES, Tucker K, et al. Epidemiological evaluation of childhood leukaemia and paternal exposure to ionizing radiation. Final report dated 9 October 1997, Centers for Disease Control, Cooperative Agreement U50/CCU012545-01.
  30. Parker L, Smith J, Dickinson H, et al. The creation of a database of children of workers at a nuclear facility: an exercise in record linkage. Applied Occupational and Environmental Hygiene 1997;12:40-45.
  31. Izumi S, Suyama A, Koyama K. Radiation-related mortality among offspring of atomic bomb survivors: a half century of follow-up International Journal of Cancer 2003;107:292-297.
  32. Dubrova YE. Radiation-induced transgenerational instability. Oncogene 2003;22:7087-7093.
  33. Morgan WF, Non-targeted and delayed effects of exposure to ionizing radiation: II radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiation Research 2003;159:581-596.

 
 
 
 
 
 
 
 
 
 
 
 
Está expresamente prohibida la redistribución y la redifusión de todo o parte de los contenidos de la Sociedad Iberoamericana de Información Científica (SIIC) S.A. sin previo y expreso consentimiento de SIIC.
ua31618
Inicio/Home

Copyright siicsalud © 1997-2024 ISSN siicsalud: 1667-9008