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APLICACION DE LA TECNOLOGIA DE MICROMATRICES DE ADN AL ESTUDIO DE LA ENDOMETRIOSIS

(especial para SIIC © Derechos reservados)
Las nuevas técnicas de investigación del genoma, así como las destinadas a extraer información de bases de datos permitirán avanzar en el diagnóstico y el tratamiento de la endometriosis.
eyster9.jpg Autor:
Kathleen m. Eyster
Columnista Experto de SIIC
Artículos publicados por Kathleen m. Eyster
Coautores
John D. Brannian*  Keith A. Hansen** 
Ph.D. University of South Dakota School of Medicine, Sioux Falls, SD*
MD University of South Dakota School of Medicine, Sioux Falls, SD**
Recepción del artículo
18 de Diciembre, 2003 		Aprobación
11 de Junio, 2004
Primera edición
6 de Octubre, 2004 		Segunda edición, ampliada y corregida
7 de Junio, 2021

APLICACION DE LA TECNOLOGIA DE MICROMATRICES DE ADN AL ESTUDIO DE LA ENDOMETRIOSIS

Resumen
La endometriosis es una enfermedad muy difundida y debilitante. A pesar de las investigaciones realizadas, aún quedan muchas preguntas por responder. Por ejemplo, ¿por qué algunas mujeres tienen endometriosis y otras no ¿Es posible elaborar un método no invasivo para diagnosticar la endometriosis ¿Es posible elaborar tratamientos médicos para la endometriosis, que alivien el dolor, restauren la fertilidad y causen menos reacciones adversas ¿Las diferencias y similitudes en las propiedades invasivas del endometrio ectópico y del cáncer pueden ayudar a comprender ambas entidades Es fundamental la comprensión total de cómo funcionan y se comunican las células endometriales ectópicas y en qué se diferencian de las células eutópicas, para poder lograr las respuestas a las cuestiones anteriores. Una tecnología de evaluación global del genoma, como la de micromatrices de ADN, es una herramienta excelente para examinar las cuestiones planteadas por la endometriosis. Esta tecnología, junto con otras como el estudio del proteoma y la prospección informática de datos, permitirán avanzar en el diagnóstico y el tratamiento de la enfermedad.

Palabras clave
Endometriosis, micromatrices, endometrio, vimentina


Artículo completo
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THE APPLICATION OF DNA MICROARRAY TECHNOLOGY TO THE INVESTIGATION OF ENDOMETRIOSIS

Abstract
Endometriosis is a widespread and debilitating disease. Despite intense research, a variety of questions remain unanswered. For example, why do some women get endometriosis and not others Can we develop a noninvasive method for diagnosis of endometriosis Can we develop medical treatments for endometriosis that relieve pain, restore fertility, and cause fewer adverse reactions Can the similarities and differences in the invasive properties of the ectopic endometrium and cancer provide insight into both of these diseases For each of these questions, a more thorough fundamental understanding of how eutopic endometrial cells function and communicate, and how ectopic endometrial cells differ from eutopic endometrial cells, will build the foundation to provide answers. A global genome-screening technology such as the DNA microarray is an excellent tool for examining the questions posed by endometriosis. DNA microarray analysis is beginning to be applied to the questions of endometriosis. This technology, along with other technologies such as proteomics and data mining, holds promise to advance diagnosis and treatment of this disease.

Key words
Endometriosis, microarray, endometrium, vimentin


Full text
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Clasificación en siicsalud
Artículos originales > Expertos del Mundo >
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Especialidades
Principal: Medicina Reproductiva, Obstetricia y Ginecología
Relacionadas: Diagnóstico por Laboratorio



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Bibliografía del artículo
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Título español
Resumen
 Palabras clave
 Bibliografía
 Artículo completo
(exclusivo a suscriptores)
 Autoevaluación
  Tema principal en SIIC Data Bases
 Especialidades

 English title
 Abstract
 Key words
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