LA CONTAMINACION DEL AIRE ATMOSFERICO EN LA RESPUESTA INMUNE INNATA ANTIMICOBACTERIANA

La contaminación del aire de interiores y de exteriores ha sido considerada un serio problema de salud pública a nivel mundial, el cual se asocia anualmente con alrededor de 7 millones de muertes (4.8 millones asociadas con el aire de exteriores y 2.2 millones con el aire de interiores).

Autor:
Bruno Rivas santiago
Columnista Experto de SIIC

Institución:
Instituto Mexicano del Seguro Social

Artículos publicados por Bruno Rivas santiago

Coautores
César Enrique Rivas Santiago* Gretel Mendoza Almanza** Yamilé López Hernández**
Cátedra CONACYT, Consejo Nacional de Ciencia y Tecnología - Universidad Autónoma de Zacatecas, México*
Cátedra CONACYT, Consejo Nacional de Ciencia y Tecnología - Universidad Autónoma de Zacatecas**

Recepción del artículo
19 de Abril, 2019

Aprobación
29 de Agosto, 2019

Primera edición
3 de Septiembre, 2019

Segunda edición, ampliada y corregida
14 de Octubre, 2024

doi: http://dx.doi.org/10.21840/siic/159560

LA CONTAMINACION DEL AIRE ATMOSFERICO EN LA RESPUESTA INMUNE INNATA ANTIMICOBACTERIANA

Resumen
La contaminación del aire de interiores y de exteriores ha sido considerada un serio problema de salud pública a nivel mundial, el cual se asocia anualmente con alrededor de 7 millones de muertes (4.8 millones asociadas con el aire de exteriores y 2.2 millones con el aire de interiores). Entre las principales razones ligadas a estas muertes se encuentran: enfermedad pulmonar obstructiva crónica, neumonía, cardiopatía isquémica y cáncer de pulmón. Además, estudios epidemiológicos han asociado la exposición a este tipo de contaminantes con mayor susceptibilidad para la aparición de enfermedades infecciosas y no infecciosas. Entre las enfermedades infecciosas, una de las más importantes es la tuberculosis, la cual, durante el transcurso de los años, ha empeorado con el surgimiento de cepas resistentes a múltiples fármacos, así como por la asociación con otras afecciones como la diabetes mellitus tipo 2 y el síndrome de inmunodeficiencia adquirida (sida). A pesar del esfuerzo realizado por la Organización Mundial de la Salud (OMS) por detener esta epidemia, aún existen anualmente un gran número de muertes causadas por esta enfermedad: alrededor de 1.7 millones a nivel mundial. En esta revisión se hará un breve resumen de los efectos que tiene la exposición a la contaminación del aire de interiores y de exteriores en la respuesta inmune innata en contra de la tuberculosis, y cómo estas alteraciones pueden estar ligadas a la aparición de tuberculosis pulmonar.

Palabras clave
contaminación del aire, tuberculosis, inmunidad, inmunidad innata, material particulado, SIDA

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Atmospheric air pollution and innate antimycobacterial immunity

Abstract
Indoor and outdoor air pollution has been considered a serious public health problem worldwide, and is associated annually with around 7 million deaths (4.8 million associated with outdoor air and 2.2 million indoor air). The main reasons for these deaths include: chronic obstructive pulmonary diseases, pneumonia, ischemic cardiopathy and lung cancer. In addition, epidemiological studies have associated exposure to this type of pollutants with a greater susceptibility to the development of infectious and non-infectious diseases. One of the most important infectious diseases is tuberculosis, which over the years has worsened with the emergence of resistant multi-drug strains, as well as with association with other diseases such as diabetes mellitus type 2 and the acquired immune deficiency syndrome (AIDS). In fact, despite efforts made by the World Health Organization to stop the epidemic, a large number of deaths (about 1.7 million worldwide) are still caused by this disease. In this review, a brief summary will be made of the effects of exposure to indoor and outdoor air pollution on the innate immune response against tuberculosis, and how these alterations could be linked to the development of pulmonary tuberculosis.

Key words
air pollution, tuberculosis, immunity, innate immunity, particulate matter, AIDS

Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Inmunología, Salud Pública
Relacionadas: Epidemiología, Infectología, Medicina Interna, Neumonología, Toxicología

Enviar correspondencia a:
Bruno Rivas Santiago, 98000, Interior de la Alameda 45, Zacatecas, México

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