Paula Fresco *

Autor invitado por SIIC

O trabalho contribui para sistematizar os mecanismos preventivos (de cancro) utilizados pelos compostos polifenólicos da dieta

POLIFENOIS DA DIETA: MECANISMOS PREVENTIVOS E TERAPÊUTICOS NO CANCRO

Os polifenois da dieta são capazes de activar mecanismos intracelulares que permitem conferir às células uma maior capacidade de resistir aos processos de carcinogenese, pelo que podem ser compostos com um potencial uso na terapêutica de prevenção do cancro.

*Paula Fresco
describe para SIIC los aspectos relevantes de su trabajo
NEW INSIGHTS ON THE ANTICANCER PROPERTIES OF DIETARY POLYPHENOLS
Institución principal de la investigación
*, Porto, Portugal, Porto, Portugal
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Referencias bibliográficas
Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3:768-780, 2003.
Fiuza SM, Girao da Cruz MT, Cordeiro MN, Milhazes N, Borges F, Marques MPM. Phenolic acid derivatives with potential anticancer properties--a structure-activity relationship study. Part 1: methyl, propyl and octyl esters of caffeic and gallic acids. Bioorg Med Chem 12:3581-3589, 2004.
Borges F, Roleira F, Milhazes N, Santana L, Uriarte E. Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity. Curr Med Chem 12:887-916, 2005.
Kong AN, Yu R, Hebbar V, Chen C, Owuor E, Hu R, Ee R, Mandlekar S. Signal transduction events elicited by cancer prevention compounds. Mutat Res 480-481:231-241, 2001.
Eferl R, Wagner EF. AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer 3:859-868, 2003.
Kundu JK, Surh YJ. Molecular basis of chemoprevention by resveratrol: NF-kB and AP-1 as potential targets. Mutat Res 555:65-80, 2004.
Kuo ML, Yang NC. Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes. Biochem Biophys Res Commun 26:767-775, 1995.
Livneh E, Fishman DD. Linking protein kinase C to cell-cycle control. Eur J Biochem 248:1-9, 1997.
Markovits J, Linassier C, Fosse P, Couprie J, Pierre J, Jacquemin-Sablon A, Saucier JM, Le Pecq JB, Larsen AK. Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II. Cancer Res 49:5111-5117, 1989.
Liang YC, Chen YC, Lin YL, Lin-Shiau SY, Ho CT, Lin JK. Suppression of extracellular signals and cell proliferation by the black tea polyphenol, theaflavin-3,3'-digallate. Carcinogenesis 20:733-736, 1999.
Masuda M, Suzui M, Weinstein IB. Effects of epigallocatechin-3-gallate on growth, epidermal growth factor receptor signaling pathways, gene expression, and chemosensitivity in human head and neck squamous cell carcinoma cell lines. Clin Cancer Res 7:4220-4229, 2001.
D'Alessandro T, Prasain J, Benton MR, Botting N, Moore R, Darley-Usmar V, Patel R, Barnes S. Polyphenols, inflammatory response, and cancer prevention: chlorination of isoflavones by human neutrophils. J Nutr 133:3773S-3777S, 2003.
Mahmoud NN, Carothers AM, Grunberger D, Bilinski RT, Churchill MR, Martucci C, Newmark HL, Bertagnolli MM. Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis. Carcinogenesis 21:921-927, 2000.

Otros artículos de Paula Fresco

Da Cruz Fresco P, Kortenkamp A. The formation of DNA cleaving species during the reduction of chromate by ascorbate. Carcinogenesis 15(9):1773-8, 1994.
Da Cruz Fresco P, Shacker F, Kortenkamp A. The reductive conversion of chromium (VI) by ascorbate gives rise to apurinic/apyrimidinic sites in isolated DNA. Chem Res Toxicol 8(6):884-90, 1995.
Kortenkamp A, Casadevall M, Da Cruz Fresco P. The reductive conversion of the carcinogen chromium (VI) and its role in the formation of DNA lesions. Ann Clin Lab Sci 26(2):160-75, 1996.
Casadevall M, Da Cruz Fresco P, Kortenkamp A. Chromium(VI)-mediated DNA damage: oxidative pathways resulting in the formation of DNA breaks and abasic sites. Chem Biol Interact 123(2):117-32, 1999.
Saraiva L, Fresco P, Pinto E, Goncalves J. Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay. Eur J Pharmacol 491(2-3):101-10, 2004.
Fresco P, Diniz C, Gonçalves J. Facilitation of noradrenaline release by activation of adenosine A(2A) receptors triggers both phospholipase C and adenylate cyclase pathways in rat tail artery. Cardiovasc Res 63(4):739-46, 2004.

Para comunicarse con Paula Fresco mencionar a SIIC como referencia:
pfresco@ff.up.pt

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Acerca del trabajo completo

POLIFENOIS DA DIETA: MECANISMOS PREVENTIVOS E TERAPÊUTICOS NO CANCRO

Título original en castellano
Novas prespectivas das propriedades anticancerigenas dos polifenois da dieta

Autores
Paula Fresco¹, Fernanda Borges², Carmen Dinitz³, Maria Paula Marques⁴
1 Professora-Investigadora, Universidade do Porto, Porto, Portugal, Professor Auxiliar com Nomeação Definitiva
2 Professora-Investigadora, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal, Professora Auxiliar
3 Professora-Investigadora, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal, Professora Auxiliar
4 Professora-Investigadora, Universidade de Coimbra, Coimbra, Portugal, Professora Auxiliar

Acceso a la fuente original
Medicinal Research Reviews
http://www3.interscience.wiley.com/cgi-bin/jhome/34185

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