Marisa Cabeza Salinas *

Autora invitada por SIIC

Un aporte a la obtención de fármacos con actividad inhibidora de la 5-alfa reductasa y del crecimiento de células prostáticas cancerosas

NUEVOS COMPUESTOS QUE INHIBEN EL CRECIMIENTO DE CELULAS PROSTATICAS CANCEROSAS

Los resultados de diversos experimentos mostraron que los esteroides 4-7 inhibieron la actividad de la 5-alfa reductasa con una CI50 menor de la que tiene la finasterida. Sin embargo, sólo el compuesto 4 disminuyó el peso de la próstata en los experimentos in vivo. Mientras que el crecimiento de las células prostáticas cancerosas y de los linfocitos se inhibió en presencia del compuesto 4 a una concentración de 50 µM, sin embargo los otros esteroides mostraron un efecto de inhibición escaso. En los experimentos in vivo no se observó ningún efecto tóxico producido por los compuestos en estudio.

*Marisa Cabeza Salinas
describe para SIIC los aspectos relevantes de su trabajo
NEW PROGRESTERONE DERIVATIVES AS INHIBITORS OF 5ALPHA-REDUCTASE ENZYME AND PROSTATE CANCER CELL GROWTH
Institución principal de la investigación
*, México D.F., México, México D.F., México
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Otros artículos de Marisa Cabeza Salinas

Cabeza M, Bratoeff E, Flores E, Ramírez E, Calleros J, Montes D, Quiroz A, Heuze I. 5-alpha reductase inhibitory and antiandrogenic activities of novel steroids in hamster seminal vesicles. Chem Pharm Bull 2002; 50(11):1447-1452.
Cabeza M, Flores E, Heuze I, Sánchez M, Bratoeff E, Ramírez E, Francolugo VA. Novel 17 substituted pregnandiene derivatives as 5-alpha reductase inhibitors and their binding affinity for the androgen receptor. Chem Pharm Bull 2004; 52(5):535-539.
Bratoeff E, Ramírez E, Flores E, Sánchez M, Heuze I and Cabeza M. New aromatic esters of progesterona as antiandrogens. J of Enzyme Inhibition and Medicinal Chemistry 2004; 19(2):99-105.
Radhica P, Cabeza M, Bratoeff E, García G. 5-alpha reductase inhibition activity of steroids isolated from marine soft corals. Steroids 2004; 69:439-444.
Cabeza M, Flores M, Bratoeff E, De la Peña A, Méndez E,Ceballos G. Intracellular Ca2+ stimulates binding to androgen receptors in platelets. Steroids 2004; 69:767-772.
Pérez Ornelas V, Cabeza M, Bratoeff E, Heuze I, Sánchez M, Ramírez E, Naranjo Rodríguez E. New 5-alpha reductase inhibitors: In vitro and in vivo effects. Steroids 2005; 70:217-224.
Bratoeff E, Cabeza M, Ramírez E, Heuze I, Flores E. Recent advances in chemistry and pharmacological activity of new steroidal antiandrogens and 5-alpha reductase inhibitors. Current Medicinal Chemistry 2005; 12:927-943.
Cabeza M, Heuze I, Sánchez M, Bratoeff E, Ramírez E, Rojas A, Orozco A, Murguía A, Agustín G, Cuatepotzo L, Gónzalez C, Palma S, Padilla D, Pérez V, Jiménez G. Relative binding affinity of novel steroids to androgen receptors in hamster prostate. J of Enzyme Inhibitionand Medicinal Chemistry 2005; 20(4):357-364.
Ramírez E, Cabeza M, Bratoeff E, Heuze I, Pérez V, Valdéz D, Ochoa M, Terán N, Jiménez G, Ramírez T. Synthesis and pharmacological evaluation of new progesterona esters as 5-alpha reductase inhibitors. Chem Pharm Bull 2005; 53(12):1515-1518.
Cabeza M, Bratoeff E, Heuze I, Rojas A, Terán N, Ochoa M, Ramírez Apan MT, Ramírez E, Pérez V, Gracia I. New progesterona derivatives as inhibitors of 5-alpha reductase enzyme and prostate cancer cell growth. J of Enzyme Inhibition and Medicinal Chemistry 2006; 21(4):371-378.

Para comunicarse con Marisa Cabeza Salinas mencionar a SIIC como referencia:
marisa@correo.xoc.uam.mx

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Acerca del trabajo completo

NUEVOS COMPUESTOS QUE INHIBEN EL CRECIMIENTO DE CELULAS PROSTATICAS CANCEROSAS

Título original en castellano
NUEVOS DERIVADOS DE LA PROGESTERONA COMO INHIBIDORES DE LA ENZIMA 5-ALFA REDUCTASA Y DEL CRECIMIENTO DE CELULAS PROSTATICAS CANCEROSAS

Autores
Marisa Cabeza Salinas¹, Eugene Bratoeff², Ivonne Heuze³, Arely Rojas⁴, Nayeli Terán⁵, Martha Ochoa⁶, Teresa Ramírez Apan⁷, Elena Ramírez⁸, Víctor Pérez⁹
1 Doctor, Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, México D.F., México, Profesor Titular
2 Doctor, National University of Mexico City, México D.F., México, Profesor Titular
3 Maestra, Universidad Autónoma Metropolitana-Xochimilco, México D.F., México, Profesor Titular
4 Maestra, National University of Mexico City, México, D.F., México, Estudiante
5 Maestra, National University of Mexico City, México, D.F., México, Estudiante
6 Maestra, National University of Mexico City, México, D.F., México, Estudiante
7 Doctora, National University of Mexico City, México, D.F., México, Profesor
8 Doctora, National University of Mexico City, México, D.F., México, Técnico Académico
9 Maestro, National University of Mexico City, México, D.F., México, Estudiante

Acceso a la fuente original
Journal of Enzyme Inhibition and Medicinal Chemistry
http://www.tandf.co.uk/journals/titles/14756366.asp

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